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Rehnuma Islam et al.
Frontiers in cellular neuroscience, 15, 654290-654290 (2021-05-18)
Stroke is a leading cause of death and long-term disability worldwide. Current therapeutic options are limited in terms of their time for implementation and efficacy in promoting recovery. Cell transplantation has been shown to have promise in several animal models
Ourania Zygogianni et al.
Methods in molecular biology (Clifton, N.J.), 2155, 23-39 (2020-06-01)
Stem cell transplantation has attracted great interest for treatment of neurodegenerative diseases to provide neuroprotection, repair the lesioned neuronal network and restore functionality. Parkinson's disease (PD), in particular, has been a preferred target because motor disability that constitutes a core
Stefania Beretta et al.
Cell transplantation, 26(7), 1247-1261 (2017-09-22)
Traumatic brain injury (TBI) is one of the leading causes of death and disability in the population worldwide, with a broad spectrum of symptoms and disabilities. Posttraumatic hyperexcitability is one of the most common neurological disorders that affect people after
Vadanya Shrivastava et al.
Genes, 13(3) (2022-03-26)
Hypoxic ischemic injury to the fetal and neonatal brain is a leading cause of death and disability worldwide. Although animal and culture studies suggest that glutamate excitotoxicity is a primary contributor to neuronal death following hypoxia, the molecular mechanisms, and
Klaus Sellheyer et al.
Journal of cutaneous pathology, 40(5), 463-471 (2013-02-26)
Recently, an intriguing concept was introduced into the literature that defines the area underlying the nail bed as a specific mesenchymal substructure unique to the nail organ. It has been termed onychodermis. The onychodermis expresses CD10 with remarkable specificity. Herein
Jinar Rostami et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(49), 11835-11853 (2017-11-02)
Many lines of evidence suggest that the Parkinson's disease (PD)-related protein α-synuclein (α-SYN) can propagate from cell to cell in a prion-like manner. However, the cellular mechanisms behind the spreading remain elusive. Here, we show that human astrocytes derived from
Maria C Marchetto et al.
eLife, 8 (2019-02-08)
Comparative analyses of neuronal phenotypes in closely related species can shed light on neuronal changes occurring during evolution. The study of post-mortem brains of nonhuman primates (NHPs) has been limited and often does not recapitulate important species-specific developmental hallmarks. We
Parivash Nouri et al.
Cells, 11(2) (2022-01-22)
Advances in the regenerative stem cell field have propelled the generation of tissue-specific cells in the culture dish for subsequent transplantation, drug screening purposes, or the elucidation of disease mechanisms. One major obstacle is the heterogeneity of these cultures, in
Charles A Thomas et al.
Cell stem cell, 21(3), 319-331 (2017-08-15)
Three-prime repair exonuclease 1 (TREX1) is an anti-viral enzyme that cleaves nucleic acids in the cytosol, preventing accumulation and a subsequent type I interferon-associated inflammatory response. Autoimmune diseases, including Aicardi-Goutières syndrome (AGS) and systemic lupus erythematosus, can arise when TREX1
Mariana Martins et al.
International journal of molecular sciences, 24(16) (2023-08-26)
Disruptions in the MBD5 gene have been linked with an array of clinical features such as global developmental delay, intellectual disability, autistic-like symptoms, and seizures, through unclear mechanisms. MBD5 haploinsufficiency has been associated with the disruption of primary cilium-related processes
L Auboyer et al.
Stem cell research, 34, 101381-101381 (2019-01-25)
Induced pluripotent stem cells (iPSC) were generated from skin fibroblasts obtained from a 50 year-old patient suffering from Alzheimer's disease and carrying a G217D causal mutation on presenilin 1 (PSEN1). iPSCs were obtained following reprogramming using the integration-free Sendai Virus system
Catarina M Seabra et al.
Molecular autism, 11(1), 45-45 (2020-06-07)
MBD5, encoding the methyl-CpG-binding domain 5 protein, has been proposed as a necessary and sufficient driver of the 2q23.1 microdeletion syndrome. De novo missense and protein-truncating variants from exome sequencing studies have directly implicated MBD5 in the etiology of autism
Lisa M McGinley et al.
Stem cells translational medicine, 10(1), 83-97 (2020-08-26)
Stem cell transplantation therapies are currently under investigation for central nervous system disorders. Although preclinical models show benefit, clinical translation is somewhat limited by the absence of reliable noninvasive methods to confirm targeting and monitor transplanted cells in vivo. Here, we
Smita Jagtap et al.
Human molecular genetics, 28(21), 3625-3636 (2019-09-14)
The X-linked neurodevelopmental diseases CDKL5 deficiency disorder (CDD) and Rett syndrome (RTT) are associated with intellectual disability, infantile spasms and seizures. Although mitochondrial dysfunction has been suggested in RTT, less is understood about mitochondrial function in CDD. A comparison of
Zixi Qin et al.
International journal of oncology, 63(1) (2023-06-16)
Glioma is the most common primary brain tumor. Glioma stem cells (GSCs) are the origin of gliomagenesis and may develop from normal neural progenitor cells (NPCs). However, how neoplastic transformation occurs in normal NPCs and the role of the Ras/Raf/MAPK
Jenny Lange et al.
Glia, 70(3), 466-490 (2021-11-14)
In addition to progressive muscular degeneration due to dystrophin mutations, 1/3 of Duchenne muscular dystrophy (DMD) patients present cognitive deficits. However, there is currently an incomplete understanding about the function of the multiple dystrophin isoforms in human brains. Here, we
Lisa M McGinley et al.
Clinical and translational medicine, 12(9), e1046-e1046 (2022-09-15)
As the field of stem cell therapy advances, it is important to develop reliable methods to overcome host immune responses in animal models. This ensures survival of transplanted human stem cell grafts and enables predictive efficacy testing. Immunosuppressive drugs derived
Ana Rafaela Oliveira et al.
Biomedicines, 10(8) (2022-08-27)
Mutations in granulin (GRN) have been associated with neurodegenerative diseases, such as frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis (NCL). In Portugal, GRN mutations account for around half of all FTLD cases with known genetic origin. Here, we describe
Lucas Simões Machado et al.
Journal of tissue engineering and regenerative medicine, 14(12), 1880-1891 (2020-10-14)
In this study, porcine embryonic fibroblasts (pEFs) were reprogrammed into porcine-induced pluripotent stem cells (piPSCs) using either human or mouse specific sequences for the OCT4, SOX2, c-Myc, and KLF4 transcription factors. In total, three pEFs lines were reprogrammed, cultured for
Juli R Bagó et al.
Science translational medicine, 9(375) (2017-02-06)
Engineered neural stem cells (NSCs) are a promising approach to treating glioblastoma (GBM). The ideal NSC drug carrier for clinical use should be easily isolated and autologous to avoid immune rejection. We transdifferentiated (TD) human fibroblasts into tumor-homing early-stage induced
Maike R Pollmanns et al.
Frontiers in cellular neuroscience, 16, 861202-861202 (2022-07-26)
Background: Protein aggregates are degraded via the autophagy-lysosome pathway and alterations in the lysosomal system leading to the accumulation of pathogenic proteins, including aggregates of α-synuclein in Parkinson's disease (PD). The importance of the endolysosomal transient receptor potential cation channel
Yulun Huang et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8(23), e2101923-e2101923 (2021-11-02)
Diffuse invasion is the primary cause of treatment failure of glioblastoma (GBM). Previous studies on GBM invasion have long been forced to use the resected tumor mass cells. Here, a strategy to reliably isolate matching pairs of invasive (GBMINV )
Intraspinal transplantation of mouse and human neural precursor cells.
Weinger, JG; Chen, L; Coleman, R; Leang, R; Plaisted, WC; Loring, JF; Lane, TE
Current Protocols in Stem Cell Biology null
Anne-Florence Blandin et al.
Cancers, 11(12) (2019-11-30)
Pediatric high-grade gliomas (pHGGs) are facing a very dismal prognosis and representative pre-clinical models are needed for new treatment strategies. Here, we examined the relevance of collecting functional, genomic, and metabolomics data to validate patient-derived models in a hypoxic microenvironment.
Zong-Yu Xiao et al.
Turkish neurosurgery, 28(6), 910-914 (2018-01-26)
To investigate the expression of cancer stem cell markers in meningiomas. CD133, Nestin and Sox2 expression levels in 35 paraffin-embedded meningioma tissue samples were assessed using immunohistochemistry. In this study, five cases were atypical (WHO Grade II), two were anaplastic
Sara B Linker et al.
Current biology : CB, 32(22), 4797-4807 (2022-10-14)
Unique aspects of human behavior are often attributed to differences in the relative size and organization of the human brain: these structural aspects originate during early development. Recent studies indicate that human neurodevelopment is considerably slower than that in other
Aneel R Bhagwani et al.
PloS one, 14(3), e0213890-e0213890 (2019-03-19)
Uncontrolled proliferation of endothelial cells is essential to the pathogenesis of pulmonary arterial hypertension (PAH). Both proliferation and cytoskeleton reorganization are associated with upregulation of the intermediate filament protein Nestin. Recently, accumulation of Nestin-expressing cells was found in pulmonary vascular
Lorna A Farrelly et al.
Nature communications, 13(1), 2195-2195 (2022-04-24)
Schizophrenia (SZ) is a psychiatric disorder with complex genetic risk dictated by interactions between hundreds of risk variants. Epigenetic factors, such as histone posttranslational modifications (PTMs), have been shown to play critical roles in many neurodevelopmental processes, and when perturbed
Weili Kong et al.
mBio, 13(6), e0230822-e0230822 (2022-11-01)
Coronavirus disease 2019 (COVID-19) is frequently associated with neurological deficits, but how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces these effects remains unclear. Here, we show that astrocytes are readily infected by SARS-CoV-2, but surprisingly, neuropilin-1, not angiotensin-converting enzyme
Matteo Setti et al.
Journal of the National Cancer Institute, 105(21), 1644-1655 (2013-10-12)
Chloride channels are physiologically involved in cell division and motility. Chloride intracellular channel 1 (CLIC1) is overexpressed in a variety of human solid tumors compared with normal tissues, suggesting a potential involvement of CLIC1 in the regulation of tumorigenesis. This
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