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Fátima de Campos Buzzi et al.
European journal of medicinal chemistry, 44(11), 4596-4602 (2009-07-25)
Ten ester derivatives from caffeic acid were synthesized, and their antinociceptive properties are evaluated in mice. The most active compound, dodecyl ester derivative, exhibited potent and dose-related activity against the writhing test, with a calculated ID(50) value of 15.1 (11.9-19.1)micromol/kg
Antonio de Jesus Cenobio-Galindo et al.
Food science and biotechnology, 28(5), 1553-1561 (2019-11-07)
The use of unconventional sources is very relevant in the food area. In the present study the development of active films with the addition of bioextract (BE) or microencapsulated bioextract (MBE) from xoconostle (Opuntia oligacantha) on chayotextle starch was investigated.
Atsufumi Iwanaga et al.
Journal of natural products, 73(4), 609-612 (2010-02-27)
Chemical investigation of the aerial parts of Cimicifuga simplex afforded four new fukinolic acid analogues, cimicifugic acids K-N (1-4), and 10 known compounds, and C. japonica afforded three new fukinolic acid analogues, cimicifugic acids K-M (1-3), a new phenolic glycoside
Xiao-Hong Ma et al.
Chemosphere, 246, 125849-125849 (2020-02-26)
The sodium pyrophosphate (SP)-enhanced Fenton reaction has been proven to have promising potential in remediation of polychlorinated biphenyls in soils by keeping iron ions soluble at high pH and minimizing the useless decomposition of H2O2. However, little information can be
In-Kyoung Lee et al.
Bioorganic & medicinal chemistry letters, 16(21), 5621-5624 (2006-08-16)
New free radical scavengers, inoscavin D (1) and methylinoscavin D (2), were isolated from the methanolic extract of the fruiting bodies of Inonotus xeranticus (Hymenochaetaceae), along with the known compounds phelligridin D (3), 3,4-dihydroxybenzaldehyde (4), and 3,4-dihydroxybenzoic acid (5). Their
Kaisu R Riihinen et al.
Fitoterapia, 97, 78-86 (2014-06-01)
The antimicrobial activity of lingonberry (Vaccinium vitis-idaea L.) was evaluated against two oral pathogens, Streptococcus mutans and Fusobacterium nucleatum. Long-bed gel permeation chromatography (GPC; Sephadex LH-20) yielded purified flavonoids, with the most efficient minimum inhibitory concentrations (MICs) against planktonic cells
María-Ángeles Del-Castillo-Alonso et al.
Journal of the science of food and agriculture, 95(2), 409-416 (2014-05-14)
Ultraviolet (UV) radiation induces adaptive responses that can be used for plant production improvement. The aim of this study was to assess the effect of solar UV exclusion on the physiology and phenolic compounds of leaves and berry skins of
Ericsson David Coy et al.
Bioorganic & medicinal chemistry letters, 19(24), 6922-6925 (2009-11-03)
The anti-inflammatory potential of 26 neolignans (14 of the bicyclooctane-type and 12 of the benzofuran-type), isolated from three Lauraceae species (Pleurothyrium cinereum, Ocotea macrophylla and Nectandra amazonum), was evaluated in vitro through inhibition of COX-1, COX-2, 5-LOX and agonist-induced aggregation
Morshed A Chowdhury et al.
Bioorganic & medicinal chemistry letters, 19(24), 6855-6861 (2009-11-04)
A novel class of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore attached to its C-4 or C-5 position was designed for evaluation as anti-inflammatory (AI) agents. Replacement of the 2,4-difluorophenyl ring in diflunisal by the N-difluoromethyl-1,2-dihydropyrid-2-one moiety provided
Pamela Somers et al.
The Journal of heart valve disease, 24(1), 92-100 (2015-07-18)
Currently, no effective crosslinking reagents are available to treat xenogenic decellularized heart valve matrices. The study aim was to evaluate the crosslinking effect of quercetin, catechin, caffeic acid and tannic acid on porcine aortic valve matrices. Cytotoxicity of the different
Claudia-Crina Toma et al.
Molecules (Basel, Switzerland), 20(6), 9560-9574 (2015-05-29)
This study was performed to evaluate the phenolic profile, antioxidant and diuretic effects of black cumin and lady-in-a-mist seeds. In the phenolic profile, differences between the two species are significant. Qualitative and quantitative analyses of the phenolic compounds were performed
Sung-Yong Yang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 55, 92-99 (2013-01-12)
Perilla frutescens leaves are often used in East Asian gourmet food. In this study, we investigated the hepatoprotective effects of caffeic acid (CA), rosmarinic acid (RA), and their combination. P. frutescens contains 1.32μg CA/mg dry material (DM) and 26.84μg RA/mg
Muhammed Alzweiri et al.
Journal of enzyme inhibition and medicinal chemistry, 30(3), 420-429 (2014-07-30)
An HPLC-size exclusion method was developed as an assay method to evaluate the binding of tested compounds with carbonic anhydrase III (CAIII) enzyme. Inhibition of CAIII by a group of benzoic acid analogues was characterized by vacancy (negative) peak intensity
E Pontiki et al.
Bioorganic & medicinal chemistry, 15(17), 5819-5827 (2007-07-03)
Lipoxygenase catalyzes the first two steps of the transformation of arachidonic acid into leukotrienes which are implicated in host defense reactions. It is well known that many acids possess potent anti-inflammatory activity. Taking into account that compounds bearing a thienyl
Miriam Martínez-Huélamo et al.
Food chemistry, 173, 864-872 (2014-12-04)
Tomato sauce is the most commonly consumed processed tomato product worldwide, but very little is known about how the manufacturing process may affect the phenolic composition and bioavailability after consumption. In a prospective randomised, cross-over intervention study, we analysed the
Debora Giordano et al.
Food chemistry, 233, 483-491 (2017-05-23)
In this study, the chemical composition of pigmented wheats (yellow, purple and blue types), and the distribution of the bioactive compounds in their roller-milled and pearled fractions, were compared with conventional wheats (red and white types). Roller-milling promoted the recovery
Giuseppe M Lombardo et al.
Dalton transactions (Cambridge, England : 2003), 41(47), 14337-14344 (2012-10-10)
The vast literature concerning caffeic acid and its derivatives lacks any reference to the solid state structures of its inorganic salts as these crystals are quite difficult grow. Most of the already published works deal with computational studies of these
Tânia B Ribeiro et al.
Food research international (Ottawa, Ont.), 142, 110032-110032 (2021-03-29)
Pulp-enriched powder (POPP) was obtained from olive pomace solid fraction, a derived from the new value chain established for olive by-products. As a multifunctional powder, POPP retains several bioactive compounds (fatty acids, dietary fibre and phenolics) under potential synergic interaction
Ebubekir Izol et al.
Chemistry & biodiversity, 18(1), e2000560-e2000560 (2020-11-15)
Allium species are widely consumed as food all over the world. The phenolic profile of ethanol extracts of aerial parts and roots of 12 Allium species, collected from five different Eastern Anatolia regions, were studied using LC-MS/MS. In vitro antioxidant
Miloš Ilić et al.
Bioorganic & medicinal chemistry letters, 21(16), 4705-4709 (2011-07-16)
Vascular oxidative stress, endothelial injury, and thrombosis are intertwined processes that display a synergistic pathological effect in many cardiovascular diseases. Antithrombotic therapy with anticoagulant and/or antiplatelet agents, combined with interventions against vascular oxidative stress and/or inflammation, both boosting endothelial antithrombotic
Giuliano E Pereira et al.
Frontiers in plant science, 11, 707-707 (2020-07-01)
Girdling is a traditional horticultural practice applied at fruit set or other phenological stages, and is used mostly as a vine management. In grapevines, it is used primarily for table grapes to improve berry weight, sugar content, color, and to
Dongping Liu et al.
Bioorganic & medicinal chemistry letters, 21(22), 6833-6837 (2011-10-04)
Src homology-2 domain-containing protein tyrosine phosphatase (Shp2), a novel proto-oncogenic protein, is an important target in cancer therapy research. Approximately 2000 plant extracts were screened to find its natural specific inhibitors, with the ethyl acetate (EtOAc) active extract of the
Abdullah Al Maruf et al.
Chemico-biological interactions, 234, 96-104 (2014-12-03)
Glyoxal (GO) and methylglyoxal (MGO) cause protein and nucleic acid carbonylation and oxidative stress by forming reactive oxygen and carbonyl species which have been associated with toxic effects that may contribute to cardiovascular disease, complications associated with diabetes mellitus, Alzheimer's
Fuad Al-Rimawi et al.
Journal of AOAC International, 98(5), 1335-1339 (2015-11-04)
A simple, precise, accurate, and selective method was developed and validated for determination of eight phenolic compounds (gallic acid, p-hydroxybenzoic acid, vanilic acid, caffeic acid, syringic acid, p-coumaric acid, ferulic acid, and sinapic acid) in date palms. Separation was achieved
A V Ivanova et al.
Critical reviews in analytical chemistry, 45(4), 311-322 (2015-04-02)
The increasing interest in the study of the antioxidant activity of different objects is caused by an unbalance between the formation of reactive oxygen species (ROS) and the performance of the antioxidant system in humans under certain conditions, which leads
Wanpeng Xi et al.
International journal of food sciences and nutrition, 66(8), 858-866 (2015-11-26)
The phenolic compounds in different fruit parts including the flavedos, albedos, segment membranes, juice vesicles and seeds of nine grapefruit varieties cultivated in China were determined and their antioxidant capacities were evaluated using three methods. Naringin and neohesperedin were the
See-Hyoung Park et al.
Bioorganic & medicinal chemistry, 15(11), 3938-3950 (2007-04-10)
The antagonists for the SH2 domain are regarded as novel therapeutic candidates for cancer, autoimmune disease, and chronic inflammatory disease. Previously, we identified rosmarinic acid (alpha-o-caffeoyl-3,4-dihydroxyphenyl-lactic acid; RosA) from Prunella vulgaris as an antagonist for the p56lck SH2 domain by
Sabrina Okombi et al.
Bioorganic & medicinal chemistry letters, 16(8), 2252-2255 (2006-01-31)
Melanin play a major role in human skin protection and their biosynthesis is vital. Due to their color, they contribute to the skin pigmentation. Tyrosinase is a key enzyme involved in the first stage of melanin synthesis, catalyzing the transformation
Jianming Ren et al.
International journal of biological macromolecules, 53, 77-81 (2012-11-21)
In this work, two kinds of phenolic antioxidants-functionalized quaternized chitosan were synthesized in order to develop aqueous soluble antioxidant-polymer conjugates. Quaternized chitosan conjugated with gallic acid or caffeic acid was carried out and the antioxidant properties of the products (namely
Flávia Santi Stefanello et al.
Food chemistry, 239, 385-401 (2017-09-07)
Brewer's spent grain (BSG) could be tested as an alternative source of polyphenols in animal nutrition. Proper extraction and analytical methods are critical for quantification. Thus, extraction for BSG, corn silage, and brans of rice, corn, and wheat were studied
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