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C0625
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Liangmian Chen et al.
Journal of pharmaceutical and biomedical analysis, 95, 93-101 (2014-03-25)
A novel three-channel isocratic elution high performance liquid chromatography with electrochemical detection (3LC-ECD) system was developed for the simultaneous determination of various bioactive redox components in Shuang-Huang-Lian (SHL) preparations. This 3LC-ECD system consists of three isocratic elution flow ways, two
Midori Soda et al.
European journal of medicinal chemistry, 48, 321-329 (2012-01-13)
Inhibitors of a human aldo-keto reductase, AKR1B10, are regarded as promising therapeutics for the treatment of cancer, but those with both high potency and selectivity compared to the structurally similar aldose reductase (AKR1B1) have not been reported. In this study
Alexandra Gaspar et al.
European journal of medicinal chemistry, 44(5), 2092-2099 (2008-12-09)
An interdisciplinary research project was developed combining the synthesis of a series of hydroxycinnamic acid derivatives and the evaluation of their physicochemical parameters (namely redox potentials and partition coefficients), along with the corresponding antioxidant activity. A structure-property-activity relationship (SPAR) approach
Muhammed Alzweiri et al.
Journal of enzyme inhibition and medicinal chemistry, 30(3), 420-429 (2014-07-30)
An HPLC-size exclusion method was developed as an assay method to evaluate the binding of tested compounds with carbonic anhydrase III (CAIII) enzyme. Inhibition of CAIII by a group of benzoic acid analogues was characterized by vacancy (negative) peak intensity
Parisa Abbasi-Parizad et al.
Antioxidants (Basel, Switzerland), 9(2) (2020-02-27)
Two tomato pomace (TP) were studied as feedstocks to obtain extracts that are rich in polyphenols. TPs prompt degradation impairs biomass safety, thus naturally present microflora were tested to perform conservation, and own lactic bacteria became predominant after 60 days
Bilal H Abbasi et al.
Applied biochemistry and biotechnology, 168(7), 2057-2066 (2012-10-19)
Gibberellic acid (GA(3)) is reported to have diverse effects on hairy root cultures of many plant species; therefore, the effects of GA(3) on the growth, secondary metabolite production (caffeic acid derivatives and lignin), phenylalanine ammonia lyase (PAL) activity, and free
Amira S El Senousy et al.
Phytochemistry, 108, 67-76 (2014-10-11)
The metabolomic differences in phenolics from leaves derived from 3 artichoke cultivars (Cynara scolymus): American Green Globe, French Hyrious and Egyptian Baladi, collected at different developmental stages, were assessed using UHPLC-MS coupled to chemometrics. Ontogenic changes were considered as leaves
E Pontiki et al.
Bioorganic & medicinal chemistry, 15(17), 5819-5827 (2007-07-03)
Lipoxygenase catalyzes the first two steps of the transformation of arachidonic acid into leukotrienes which are implicated in host defense reactions. It is well known that many acids possess potent anti-inflammatory activity. Taking into account that compounds bearing a thienyl
Ericsson David Coy et al.
Bioorganic & medicinal chemistry letters, 19(24), 6922-6925 (2009-11-03)
The anti-inflammatory potential of 26 neolignans (14 of the bicyclooctane-type and 12 of the benzofuran-type), isolated from three Lauraceae species (Pleurothyrium cinereum, Ocotea macrophylla and Nectandra amazonum), was evaluated in vitro through inhibition of COX-1, COX-2, 5-LOX and agonist-induced aggregation
Tânia B Ribeiro et al.
Food research international (Ottawa, Ont.), 142, 110032-110032 (2021-03-29)
Pulp-enriched powder (POPP) was obtained from olive pomace solid fraction, a derived from the new value chain established for olive by-products. As a multifunctional powder, POPP retains several bioactive compounds (fatty acids, dietary fibre and phenolics) under potential synergic interaction
Hisashi Matsuda et al.
Bioorganic & medicinal chemistry letters, 15(7), 1949-1953 (2005-03-23)
1'S-1'-Acetoxychavicol acetate from the rhizomes of Alpinia galanga inhibited nitric oxide (NO) production in lipopolysaccharide-activated mouse peritoneal macrophages with an IC(50) value of 2.3 microM. To clarify the structure-activity relationship of 1'S-1'-acetoxychavicol acetate, various natural and synthetic phenylpropanoids and synthetic
Antonio de Jesus Cenobio-Galindo et al.
Food science and biotechnology, 28(5), 1553-1561 (2019-11-07)
The use of unconventional sources is very relevant in the food area. In the present study the development of active films with the addition of bioextract (BE) or microencapsulated bioextract (MBE) from xoconostle (Opuntia oligacantha) on chayotextle starch was investigated.
Stella A Ordoudi et al.
Molecules (Basel, Switzerland), 20(10), 17760-17774 (2015-09-26)
The present study aims to examine whether and to what extent the bioaccessibility of the major saffron apocarotenoids, namely crocetin sugar esters (CRTSEs), is affected by the presence of strong water-soluble antioxidants, ingredients of the herbs found in commercial tea
Miriam Martínez-Huélamo et al.
Food chemistry, 173, 864-872 (2014-12-04)
Tomato sauce is the most commonly consumed processed tomato product worldwide, but very little is known about how the manufacturing process may affect the phenolic composition and bioavailability after consumption. In a prospective randomised, cross-over intervention study, we analysed the
Ebubekir Izol et al.
Chemistry & biodiversity, 18(1), e2000560-e2000560 (2020-11-15)
Allium species are widely consumed as food all over the world. The phenolic profile of ethanol extracts of aerial parts and roots of 12 Allium species, collected from five different Eastern Anatolia regions, were studied using LC-MS/MS. In vitro antioxidant
Debora Giordano et al.
Food chemistry, 233, 483-491 (2017-05-23)
In this study, the chemical composition of pigmented wheats (yellow, purple and blue types), and the distribution of the bioactive compounds in their roller-milled and pearled fractions, were compared with conventional wheats (red and white types). Roller-milling promoted the recovery
Giuseppe M Lombardo et al.
Dalton transactions (Cambridge, England : 2003), 41(47), 14337-14344 (2012-10-10)
The vast literature concerning caffeic acid and its derivatives lacks any reference to the solid state structures of its inorganic salts as these crystals are quite difficult grow. Most of the already published works deal with computational studies of these
Haoran Zhang et al.
Applied microbiology and biotechnology, 97(8), 3333-3341 (2012-11-28)
Caffeic acid is a valuable aromatic compound that possesses many important pharmacological activities. In structure, caffeic acid belongs to the hydroxycinnamic acid family and can be biosynthesized from the aromatic amino acid tyrosine. In the present paper, the caffeic acid
Sinéad Currivan et al.
Journal of chromatography. A, 1402, 82-93 (2015-05-30)
Zwitterionic methacrylate based polymeric monolithic columns were prepared in two-step polymerizations, with reduced polymerization times. Characteristic properties such as hydrodynamic permeability, porosity, retention factors, and pore size distribution charts were used for column evaluation. A scaffold column was fabricated by
Rosemary Vuković et al.
Plant science : an international journal of experimental plant biology, 199-200, 18-28 (2012-12-26)
The accumulation of phenolic compounds in plants is often part of the defense response against stress and pathogen attack, which can be triggered and activated by elicitors. Oomycetal proteinaceous elicitor, β-cryptogein, induces hypersensitive response and systemic acquired resistance against some
Mao-Liang Chen et al.
Immunopharmacology and immunotoxicology, 36(6), 390-396 (2014-10-15)
Tournefortia sarmentosa, a Chinese herbal medicine, is considered an antioxidant or a detoxicating agent. Recently T. sarmentosa has received attention for its effects on the immune response. Here we provide evidence that aqueous extract of T. sarmentosa can induce increased
In-Kyoung Lee et al.
Bioorganic & medicinal chemistry, 17(13), 4674-4680 (2009-05-20)
New p-terphenyls, curtisians R (1)-V (5), have been isolated together with known compounds, curtisians E, I-P, and kynapcin-12, from the methanolic extract of the fruiting bodies of Paxillus curtisii (Paxillaceace). Their structures were established by various spectroscopic analyses including 1D-
Junming Luo et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 52, 168-177 (2019-01-03)
Salvia miltiorrhiza Bunge (S. miltiorrhiza), a traditional Chinese medicine, has demonstrated antioxidant, anti-inflammatory, and antibacterial activities. However, its effects against asthma that shows chronic inflammation and oxidative damage remain unknown. To assess the effects of S. miltiorrhiza extracts on airway
Verena Hess et al.
Applied and environmental microbiology, 79(6), 1942-1947 (2013-01-15)
The anaerobic acetogenic bacterium Acetobacterium woodii couples reduction of caffeate with electrons derived from molecular hydrogen to the synthesis of ATP by a chemiosmotic mechanism with sodium ions as coupling ions. Caffeate is activated to caffeyl coenzyme A (caffeyl-CoA) prior
Julheli R Girardelo et al.
Food research international (Ottawa, Ont.), 137, 109615-109615 (2020-11-26)
Eugenia involucrata DC. (Myrtaceae) is a native tree species from Brazil that has been scarcely studied. We investigated the phenolic composition, the antioxidant capacity and the antitumoral activity of ethanolic extracts from fruits (FE) and seeds (SE) of E. involucrata.
Arnold A Shamilov et al.
Life (Basel, Switzerland), 12(12) (2022-12-24)
(1) Background: Two Caucasian blueberries Vaccinium myrtillus L. and Vaccinium arctostaphylos L. are famous berry bushes growing in the Caucasus region and used to treat neurological diseases, but the chemistry and bioactivity of leaf extracts are still poorly studied. (2)
Yu Chen et al.
Nature chemical biology, 5(5), 358-364 (2009-03-24)
Fragment screens have successfully identified new scaffolds in drug discovery, often with relatively high hit rates (5%) using small screening libraries (1,000-10,000 compounds). This raises two questions: would other noteworthy chemotypes be found were one to screen all commercially available
Oleh Koshovyi et al.
Plants (Basel, Switzerland), 10(2) (2021-01-29)
The prospect of creating a new medicine with psychotropic activity is shown as a result of studying the chemical composition and pharmacological activity of modified dry extracts of motherwort (Leonurus cardiaca L.) tincture. The most promising substances were the dry
Thiago C Genaro-Mattos et al.
PloS one, 10(6), e0129963-e0129963 (2015-06-23)
Caffeic acid (CA) is a phenolic compound widely found in coffee beans with known beneficial effects in vivo. Many studies showed that CA has anti-inflammatory, anti-mutagenic, antibacterial and anti-carcinogenic properties, which could be linked to its antioxidant activity. Taking in
Chaowanee Chupeerach et al.
Foods (Basel, Switzerland), 10(1) (2021-01-13)
Fermented tea (Cha-miang in Thai) is a local product made by traditional food preservation processes in Northern Thailand that involve steaming fresh tea leaves followed by fermenting in the dark. Information on changes in nutritive values, bioactive compounds, antioxidant activities
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