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Yun-Jin Hong et al.
Biological & pharmaceutical bulletin, 38(2), 201-207 (2014-11-18)
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is formed as a by-product of the Maillard reaction during cooking and frying of protein-rich foods at high temperatures. PhIP is metabolized in the liver by cytochrome P450 1A1/2 to carcinogenic metabolite N-hydroxy PhIP, which can form DNA
Xiaoxia Li et al.
The Analyst, 144(5), 1777-1788 (2019-01-24)
New types of two-dimensional (2D) boron nitride (BN) were developed as a 2D scaffold material. After modification with ternary deep eutectic solvents (DES, ChCl-caffeic acid-ethylene glycol), the processed BN was applied to the preparation of magnetic molecularly imprinted polymers (MMIPs).
Jorge Jesús Veloz et al.
BioMed research international, 2015, 291351-291351 (2015-08-08)
The chemical composition of propolis varies according to factors that could have an influence on its biological properties. Polyphenols from propolis have demonstrated an inhibitory effect on Streptococcus mutans growth. However, it is not known if different years of propolis
A V Ivanova et al.
Critical reviews in analytical chemistry, 45(4), 311-322 (2015-04-02)
The increasing interest in the study of the antioxidant activity of different objects is caused by an unbalance between the formation of reactive oxygen species (ROS) and the performance of the antioxidant system in humans under certain conditions, which leads
See-Hyoung Park et al.
Bioorganic & medicinal chemistry, 15(11), 3938-3950 (2007-04-10)
The antagonists for the SH2 domain are regarded as novel therapeutic candidates for cancer, autoimmune disease, and chronic inflammatory disease. Previously, we identified rosmarinic acid (alpha-o-caffeoyl-3,4-dihydroxyphenyl-lactic acid; RosA) from Prunella vulgaris as an antagonist for the p56lck SH2 domain by
Seon-Yeong Kwak et al.
Amino acids, 46(12), 2777-2785 (2014-09-15)
Caffeic acid (CA) is one of the antioxidants found in plants, which protects vascular cells against vascular injuries from oxidative stress. In our previous study, caffeoyl-prolyl-histidine amide (CA-L-Pro-L-His-NH2; CA-PH; a CA derivative) was synthesized, which exhibited a strong antioxidant activity
Wanpeng Xi et al.
International journal of food sciences and nutrition, 66(8), 858-866 (2015-11-26)
The phenolic compounds in different fruit parts including the flavedos, albedos, segment membranes, juice vesicles and seeds of nine grapefruit varieties cultivated in China were determined and their antioxidant capacities were evaluated using three methods. Naringin and neohesperedin were the
Yasuhiro Ishihara et al.
The Journal of biological chemistry, 290(37), 22805-22817 (2015-08-02)
Microglia are activated quickly in response to external pathogens or cell debris and clear these substances via the inflammatory response. However, excessive activation of microglia can be harmful to host cells due to the increased production of reactive oxygen species
Isabella F D Pinto et al.
Journal of medicinal food, 18(7), 802-809 (2015-02-05)
Coconut water (CW) is a natural nutritious beverage, which contains several biologically active compounds that are traditionally used in the treatment of diarrhea and rehydration. Several works with CW have been related with antioxidant activity, which is very important in
In-Kyoung Lee et al.
Bioorganic & medicinal chemistry letters, 16(21), 5621-5624 (2006-08-16)
New free radical scavengers, inoscavin D (1) and methylinoscavin D (2), were isolated from the methanolic extract of the fruiting bodies of Inonotus xeranticus (Hymenochaetaceae), along with the known compounds phelligridin D (3), 3,4-dihydroxybenzaldehyde (4), and 3,4-dihydroxybenzoic acid (5). Their
Atsufumi Iwanaga et al.
Journal of natural products, 73(4), 609-612 (2010-02-27)
Chemical investigation of the aerial parts of Cimicifuga simplex afforded four new fukinolic acid analogues, cimicifugic acids K-N (1-4), and 10 known compounds, and C. japonica afforded three new fukinolic acid analogues, cimicifugic acids K-M (1-3), a new phenolic glycoside
Marienca Femenía-Ríos et al.
Bioorganic & medicinal chemistry letters, 16(22), 5836-5839 (2006-09-05)
A novel metabolite (-)-1 was isolated as its peracetylated derivative, (-)-2-(3',4'-diacetoxyphenyl)-3,4-diacetoxytetrahydrofuran (2), from a strain of the phytopathogenic fungus Colletotrichum gloeosporioides CECT 20122. The synthesis of (-)-1 was carried out by ring-closing metathesis of diene 6 and stereoselective dihydroxylation of
Muhammad Jahangir Hossen et al.
Journal of ethnopharmacology, 168, 217-228 (2015-04-04)
Phyllanthus acidus (L.) Skeels (Phyllanthaceae) has traditionally been used to treat gastric trouble, rheumatism, bronchitis, asthma, respiratory disorders, and hepatitis. Despite this widespread use, the pharmacological activities of this plant and their molecular mechanisms are poorly understood. Therefore, we evaluated
Asunción Burguete et al.
Bioorganic & medicinal chemistry letters, 17(23), 6439-6443 (2007-10-19)
We report the synthesis, anti-inflammatory and antioxidant activities of novel ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives and of their 4,5-dihydro-(1H)-pyrazole analogues. The tested compounds inhibit the carrageenin-induced rat paw edema (4.5-56.1%) and present important scavenging activities. Compound 2a is the most
Yi Liu et al.
ACS applied materials & interfaces, 7(35), 19709-19717 (2015-08-26)
Although enzyme-like nanomaterials have been extensively investigated over the past decade, most research has focused on the peroxidase-like, catalase-like, or SOD-like activity of these nanomaterials. Identifying nanomaterials having oxidase-like activities has received less attention. In this study, we demonstrate that
Miriam Cristina Díaz-García et al.
Journal of the science of food and agriculture, 95(6), 1283-1293 (2014-07-22)
Anthocyanins and other polyphenols from flowers and bracts of Thymus sp. are studied. An anthocyanin-rich food colourant with interesting high antioxidant activity from Thymus moroderi has been obtained, and applied to colour foods. Anthocyanins and other polyphenols from T. moroderi
Eva Ramírez et al.
Journal of agricultural and food chemistry, 62(39), 9569-9575 (2014-09-12)
The main Spanish table olive varieties supplied by different olive cooperatives were investigated for their polyphenol compositions and the endogenous enzymes involved in their transformations during two growing seasons. Olives of the Manzanilla variety had the highest concentration in total
Longhai Dai et al.
Plant & cell physiology, 56(6), 1172-1182 (2015-03-12)
Mogrosides, the major bioactive components isolated from the fruits of Siraitia grosvenorii, are a family of cucurbitane-type tetracyclic triterpenoid saponins that are used worldwide as high-potency sweeteners and possess a variety of notable pharmacological activities. Mogrosides are synthesized from 2,3-oxidosqualene
Chloé Roullier-Gall et al.
PloS one, 9(5), e97615-e97615 (2014-05-27)
The chemical composition of grape berries is influenced by various environmental conditions often considered to be representative of a "terroir". If grapes from a given terroir are assumed to reflect this origin in their chemical compositions, the corresponding wine should
Alejandro Cáceres-Mella et al.
Journal of agricultural and food chemistry, 62(29), 7255-7262 (2014-07-02)
The chemical and sensory effects of storing Sauvignon Blanc in colored bottles and exposing them to artificial light were examined. The colors of the bottles chosen were Dead Leaf Green, Antique Green, Amber, and Flint. The light was provided by
Fakhria M Razeq et al.
Phytochemistry, 106, 188-196 (2014-08-02)
Camelina sativa (L.) Crantz is an emerging low input, stress tolerant crop with seed oil composition suitable for biofuel and bioproduct production. The chemical compositions and ultrastructural features of surface waxes from C. sativa aerial cuticles, seeds, and roots were
Qian Xie et al.
ACS chemical biology, 10(1), 262-268 (2014-09-24)
Kinases control many aspects of cellular signaling and are therefore therapeutic targets for numerous disease states. Monitoring the conformational changes that drive activation and inactivation of the catalytic kinase core is a challenging experimental problem due to the dynamic nature
Inês M Valente et al.
Food research international (Ottawa, Ont.), 116, 888-896 (2019-02-06)
For the first time, seven European varieties of Vicia faba L. seeds were investigated for (1) their phytonutrients profile by HPLC-DAD-MS/MS, (2) total phenolic content (TPC), and (3) antioxidant capacity (DPPH and FRAP assays). A wide range of compounds were
Nguyen Huu Tung et al.
The American journal of Chinese medicine, 42(5), 1245-1260 (2014-09-03)
The crude extract of Alnus japonica bark exhibited a strong effect on the growth of Trypanosoma brucei. Subsequent chromatographic separation resulted in the isolation of two novel diarylheptanoids, known as alnuside C (2) and alnuside D (3), and three known
Sindhu Mathew et al.
Journal of food science and technology, 52(9), 5790-5798 (2015-09-08)
The free radical scavenging activity and reducing power of 16 phenolic compounds including four hydroxycinnamic acid derivatives namely ferulic acid, caffeic acid, sinapic acid and p-coumaric acid, benzoic acid and its derivatives namely protocatechuic acid, gallic acid and vanillic acid
Yingjuan Huang et al.
Neuroscience letters, 535, 146-151 (2013-01-15)
Acrolein-induced oxidative stress is hypothesized to involve in the etiology of Alzheimer's disease (AD). Caffeic acid (CA) and caffeic acid phenethyl ester (CAPE) have antioxidative and neuroprotective properties. The present study investigated the protective effects of CA/CAPE on acrolein-induced oxidative
Ren-Wang Jiang et al.
Current medicinal chemistry, 12(2), 237-246 (2005-01-11)
Caffeic acid (3,4-dihydroxycinnamic acid), one of the most common phenolic acids, frequently occurs in fruits, grains and dietary supplements for human consumption as simple esters with quinic acid or saccharides, and are also found in traditional Chinese herbs. Caffeic acid
Elena Kurin et al.
Molecules (Basel, Switzerland), 17(12), 14336-14348 (2012-12-05)
The well-known antioxidant activity of red wine is explained mostly by its polyphenols content, where the final effect is based on the wine components' interaction. The aim of our work was the study of the interaction of three red wine
Hsi-Chuan Chen et al.
Plant physiology, 161(3), 1501-1516 (2013-01-25)
4-Coumaric acid:coenzyme A ligase (4CL) is involved in monolignol biosynthesis for lignification in plant cell walls. It ligates coenzyme A (CoA) with hydroxycinnamic acids, such as 4-coumaric and caffeic acids, into hydroxycinnamoyl-CoA thioesters. The ligation ensures the activated state of
Kui Zeng et al.
Bioorganic & medicinal chemistry letters, 19(18), 5458-5460 (2009-08-14)
Quinic acid (QA) esters found in hot water extracts of Uncaria tomentosa (a.k.a. cat's claw) exert anti-inflammatory activity through mechanisms involving inhibition of the pro-inflammatory transcription factor nuclear factor kappa B (NF-kappaB). Herein, we describe the synthesis and biological testing
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