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C102
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Teresa Di Desidero et al.
Biochemical pharmacology, 164, 94-105 (2019-04-07)
The aim of the study was to evaluate the effects and the related pharmacological mechanisms of switched schedules of antiangiogenic and chemotherapeutic drugs beyond progression after a first-line treatment in a colorectal cancer preclinical model. In vivo studies were performed
Sara Violante et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(3), 4355-4364 (2018-12-13)
Peroxisomes are essential organelles for the specialized oxidation of a wide variety of fatty acids, but they are also able to degrade fatty acids that are typically handled by mitochondria. Using a combination of pharmacological inhibition and clustered regularly interspaced
Evan L Matthews et al.
Experimental physiology, 102(9), 1092-1099 (2017-07-06)
What is the central question of this study? Alterations in blood pressure control at exercise onset are apparent in older adults with established cardiovascular disease. It is currently not known whether these alterations are evident in young adults with a
Jolene Ramsey et al.
PLoS computational biology, 16(11), e1008214-e1008214 (2020-11-03)
In the modern genomic era, scientists without extensive bioinformatic training need to apply high-power computational analyses to critical tasks like phage genome annotation. At the Center for Phage Technology (CPT), we developed a suite of phage-oriented tools housed in open
Aline Wauters et al.
European journal of pain (London, England), 24(9), 1797-1811 (2020-07-04)
Children's negatively biased pain-related memories (i.e. recalling pain as being more intense or fearful than initially reported) have been recognized as a key factor in explaining child pain development. While mechanisms underlying children's pain memory development remain poorly understood, attention
Matthew A Levin et al.
Journal of biomedical informatics, 67, 80-89 (2017-02-15)
Design and implement a HIPAA and Integrating the Healthcare Enterprise (IHE) profile compliant automated pipeline, the integrated Genomics Anesthesia System (iGAS), linking genomic data from the Mount Sinai Health System (MSHS) BioMe biobank to electronic anesthesia records, including physiological data
Antonella Farina et al.
Arthritis research & therapy, 19(1), 39-39 (2017-03-02)
Monocytes/macrophages are activated in several autoimmune diseases, including systemic sclerosis (scleroderma; SSc), with increased expression of interferon (IFN)-regulatory genes and inflammatory cytokines, suggesting dysregulation of the innate immune response in autoimmunity. In this study, we investigated whether the lytic form
Bo Song et al.
International journal of molecular sciences, 21(1) (2019-12-22)
An exopolysaccharides/calcipotriol (EPS/CPT) emulsion was prepared using bacterial EPS as emulsifier, sunflower oil as an oil phase and CPT as the loaded drug, and the effect of this emulsion on psoriasis vulgaris treatment was evaluated. An EPS composed of mannose
María Belén Vallerga et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(48), E6624-E6633 (2015-12-03)
After UV irradiation, DNA polymerases specialized in translesion DNA synthesis (TLS) aid DNA replication. However, it is unclear whether other mechanisms also facilitate the elongation of UV-damaged DNA. We wondered if Rad51 recombinase (Rad51), a factor that escorts replication forks
Yimeng Li et al.
Journal of virology, 94(6) (2020-01-04)
TER94 is a multifunctional AAA+ ATPase crucial for diverse cellular processes, especially protein quality control and chromatin dynamics in eukaryotic organisms. Many viruses, including coronavirus, herpesvirus, and retrovirus, coopt host cellular TER94 for optimal viral invasion and replication. Previous proteomics
Gina Cavaliere et al.
PloS one, 11(2), e0149033-e0149033 (2016-02-24)
Omega (ω)-3 polyunsaturated fatty acids (PUFA) are dietary compounds able to attenuate insulin resistance. Anyway, the precise actions of ω-3PUFAs in skeletal muscle are overlooked. We hypothesized that PUFAs, modulating mitochondrial function and efficiency, would ameliorate pro-inflammatory and pro-oxidant signs
Patrick M McCarthy et al.
The Journal of thoracic and cardiovascular surgery, 159(6), 2245-2253 (2019-08-25)
Surgical ablation for atrial fibrillation concomitant with cardiac surgery is now a Class I recommendation for selected patients. Understanding how the revised recommendations will affect appropriate use of surgical ablation is challenging because the reported prevalence of preoperative atrial fibrillation
Raju Bej et al.
Bioconjugate chemistry, 30(1), 101-110 (2018-12-18)
A bioreducible poly(disulfide)-derived amphiphilic block copolymer-drug conjugate (loading content 31%) was synthesized by post-polymerization modification. It shows redox-responsive polymersome assembly in water with aggregation induced emission property arising from the appended Camptothecin (CPT) drug. Glutathione (GSH), a tripeptide overexpressed in
Hend M Abdel Hamid et al.
BMC cancer, 21(1), 170-170 (2021-02-19)
The concept of personalized therapy has been proven to be a promising approach. A popular technique is to utilize gold nanoparticles (AuNPs) as drug delivery vectors for cytotoxic drugs and small molecule inhibitors to target and eradicate oral cancer cells
Candida J Rebello et al.
Journal of agricultural and food chemistry, 65(50), 10915-10924 (2017-11-28)
Rodent studies suggest that the antiobesity effects of fucoxanthin relate to activation of brown fat and conversion of white adipocytes to the brown phenotype. To evaluate the browning effect in human adipocytes, we investigated the genes involved in browning and measured
Nicole L Batenburg et al.
The EMBO journal, 34(10), 1399-1416 (2015-03-31)
Mutations of CSB account for the majority of Cockayne syndrome (CS), a devastating hereditary disorder characterized by physical impairment, neurological degeneration and segmental premature aging. Here we report the generation of a human CSB-knockout cell line. We find that CSB
Yi-Ting Chen et al.
Journal of tissue engineering and regenerative medicine, 15(2), 163-175 (2020-12-02)
At present, no definitive treatment for articular cartilage defects has been perfected. Most of the previous treatments involved multiple drilling and microfracture over defect sites with repair-related substances, which poses a limited therapeutic effect. End-stage therapy includes artificial knee joint
Agnes Miermont et al.
Development (Cambridge, England), 146(12) (2019-04-13)
Embryonic development involves extensive and often rapid cell proliferation. An unavoidable side effect of cell proliferation is DNA damage. The consequences of spontaneous DNA damage during development are not clear. Here, we define an approach to determine the effects of
Karun S Arora et al.
Ophthalmology, 122(8), 1615-1624 (2015-06-21)
Determine how procedural treatments for glaucoma have changed between 1994-2012. Retrospective, observational analysis. Medicare Part B beneficiaries. We analyzed Medicare fee-for-service paid claims data between 1994-2012 to determine the number of surgical/laser procedures performed for glaucoma in the Medicare population
J Trevitt et al.
Pharmacology, biochemistry, and behavior, 94(1), 24-29 (2009-07-16)
Adenosine A(1) and A(2A) receptors are colocalized with dopamine D(1) and D(2) receptors on striatal projection neurons and adenosine antagonists have been proposed as adjunctive therapies to l-DOPA treatment in Parkinson patients. We present here two studies examining the effects
Magdalena Keindl et al.
Frontiers in endocrinology, 11, 575469-575469 (2020-11-17)
Type 1 diabetes (T1D) is largely considered an autoimmune disease leading to the destruction of insulin-producing pancreatic β cells. Further, patients with T1D have 3-4-fold increased risk of developing micro- and macrovascular complications. However, the contribution of immune-related factors contributing
Bo-Ram Jin et al.
Biology, 9(2) (2020-02-07)
Many epidemiological observational studies suggest that a high-fat diet (HFD) accelerates the risk of colorectal cancer (CRC). Inflammation can play a key role in the relationship between colon cancer and HFD. Although reported by several studies, controlled experimental studies have
Sofiane Fatmi et al.
Acta poloniae pharmaceutica, 72(1), 179-192 (2015-04-09)
Abstract: The present work focused on the solubility enhancement of the poorly water-soluble anti-cancer agent camptothecin which, in its natural state, presents poor solubility inducing lack of activity with a marked toxicity. A new approach is adopted by using a
Lisa B Haddad et al.
PloS one, 15(3), e0230473-e0230473 (2020-03-28)
While prior epidemiologic studies have suggested that injectable progestin-based contraceptive depot medroxyprogesterone acetate (DMPA) use may increase a woman's risk of acquiring HIV, recent data have suggested that DMPA users may be at a similar risk for HIV acquisition as
Tulasi R Jinka et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(30), 10752-10758 (2011-07-29)
Torpor in hibernating mammals defines the nadir in mammalian metabolic demand and body temperature that accommodates seasonal periods of reduced energy availability. The mechanism of metabolic suppression during torpor onset is unknown, although the CNS is a key regulator of
Alexandre J Parent et al.
The journal of pain : official journal of the American Pain Society, 16(5), 436-444 (2015-02-11)
Descending pain inhibition is an endogenous pain control system thought to depend partially on the activation of bulbospinal monoaminergic pathways. Deficits in descending pain inhibition have been reported in numerous human chronic pain conditions, but there is currently no consensus
Le Li et al.
Aging, 12(10), 9585-9603 (2020-05-28)
The cardiotoxicity of doxorubicin (DOX) reduces the quality of life and prognosis of cancer patients, and therefore its clinical application has been largely restricted. This study aimed to assess the effects of cryptotanshione (CPT) on DOX-induced rat cardiac insufficiency. CPT
Haoyue Zhang et al.
PloS one, 11(12), e0167454-e0167454 (2016-12-03)
Compelling evidence suggests that defective DNA damage response (DDR) plays a key role in the premature aging phenotypes in Hutchinson-Gilford progeria syndrome (HGPS). Studies document widespread alterations in histone modifications in HGPS cells, especially, the global loss of histone H3
Andreas C Chrysostomou et al.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 81, 104243-104243 (2020-02-18)
Comprehensive PCR assays for the genotypic drug resistance analysis of all HIV-1 antiretroviral agents (reverse transcriptase, protease and integrase inhibitors) are increasingly in demand due to introduction of integrase inhibitors in the first line regimens and the increasing presence of
D Hühn et al.
Oncogene, 34(30), 3977-3984 (2014-10-14)
MicroRNA-19 (miR-19) was recently identified as the key oncogenic component of the polycistronic miR-17∼92 cluster, also known as oncomiR-1, which is frequently upregulated or amplified in multiple tumor types. However, the gene targets and the pathways underlying the tumor-promoting activity
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