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Antonella Farina et al.
Arthritis research & therapy, 19(1), 39-39 (2017-03-02)
Monocytes/macrophages are activated in several autoimmune diseases, including systemic sclerosis (scleroderma; SSc), with increased expression of interferon (IFN)-regulatory genes and inflammatory cytokines, suggesting dysregulation of the innate immune response in autoimmunity. In this study, we investigated whether the lytic form
Matthew A Levin et al.
Journal of biomedical informatics, 67, 80-89 (2017-02-15)
Design and implement a HIPAA and Integrating the Healthcare Enterprise (IHE) profile compliant automated pipeline, the integrated Genomics Anesthesia System (iGAS), linking genomic data from the Mount Sinai Health System (MSHS) BioMe biobank to electronic anesthesia records, including physiological data
Gina Cavaliere et al.
PloS one, 11(2), e0149033-e0149033 (2016-02-24)
Omega (ω)-3 polyunsaturated fatty acids (PUFA) are dietary compounds able to attenuate insulin resistance. Anyway, the precise actions of ω-3PUFAs in skeletal muscle are overlooked. We hypothesized that PUFAs, modulating mitochondrial function and efficiency, would ameliorate pro-inflammatory and pro-oxidant signs
Lisa B Haddad et al.
PloS one, 15(3), e0230473-e0230473 (2020-03-28)
While prior epidemiologic studies have suggested that injectable progestin-based contraceptive depot medroxyprogesterone acetate (DMPA) use may increase a woman's risk of acquiring HIV, recent data have suggested that DMPA users may be at a similar risk for HIV acquisition as
Tulasi R Jinka et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(30), 10752-10758 (2011-07-29)
Torpor in hibernating mammals defines the nadir in mammalian metabolic demand and body temperature that accommodates seasonal periods of reduced energy availability. The mechanism of metabolic suppression during torpor onset is unknown, although the CNS is a key regulator of
Alexandre J Parent et al.
The journal of pain : official journal of the American Pain Society, 16(5), 436-444 (2015-02-11)
Descending pain inhibition is an endogenous pain control system thought to depend partially on the activation of bulbospinal monoaminergic pathways. Deficits in descending pain inhibition have been reported in numerous human chronic pain conditions, but there is currently no consensus
Patrick M McCarthy et al.
The Journal of thoracic and cardiovascular surgery, 159(6), 2245-2253 (2019-08-25)
Surgical ablation for atrial fibrillation concomitant with cardiac surgery is now a Class I recommendation for selected patients. Understanding how the revised recommendations will affect appropriate use of surgical ablation is challenging because the reported prevalence of preoperative atrial fibrillation
Carisa M Cooney et al.
Plastic and reconstructive surgery, 146(3), 351e-358e (2020-05-28)
Anecdotally, faculty report that independent residents' operative skills differ from those of their integrated peers. This study compared operative competency between integrated (postgraduate years 4 to 6) and independent plastic surgery residents. The authors compared independent (postgraduate years 1 to
Y He et al.
Oncogene, 37(4), 534-543 (2017-10-11)
Histone H3 lysine-9 (H3K9) methylation is essential for retinoblastoma protein (RB)-mediated heterochromatin formation, epigenetic silencing of S-phase genes and permanent cell cycle arrest or cellular senescence. Besides as an H3K4 demethylase, lysine-specific demethylase-1 (LSD1) has been shown to promote H3K9
D Hühn et al.
Oncogene, 34(30), 3977-3984 (2014-10-14)
MicroRNA-19 (miR-19) was recently identified as the key oncogenic component of the polycistronic miR-17∼92 cluster, also known as oncomiR-1, which is frequently upregulated or amplified in multiple tumor types. However, the gene targets and the pathways underlying the tumor-promoting activity
Liisa Kuula et al.
Journal of sleep research, 27(1), 113-119 (2017-07-21)
Experimental sleep deprivation studies suggest that insufficient sleep and circadian misalignment associates with poorer executive function. It is not known whether this association translates to naturally occurring sleep patterns. A total of 512 of full-term-born members of the Arvo Ylppö
Preparation of novel ring-A fused azole derivatives of betulin and evaluation of their cytotoxicity.
Victoria V Grishko et al.
European journal of medicinal chemistry, 125, 629-639 (2016-10-11)
An efficient scheme to synthesize novel ring-A fused heterocyclic derivatives of betulin was developed. The starting reaction of this synthesis was one-pot selective bacterial oxidation of betulin to betulone used as the key compound to synthesize the substituted azoles such
Nathalie Bitar et al.
Pain research & management, 2018, 1935056-1935056 (2018-07-06)
Inhibitory conditioned pain modulation (ICPM) is one of the principal endogenous pain inhibition mechanisms and is triggered by strong nociceptive stimuli. Recently, it has been shown that feelings of pleasantness are experienced after the interruption of noxious stimuli. Given that
Mio Oshikawa et al.
Development (Cambridge, England), 144(18), 3303-3314 (2017-09-21)
Neuronal differentiation and cell-cycle exit are tightly coordinated, even in pathological situations. When pathological neurons re-enter the cell cycle and progress through the S phase, they undergo cell death instead of division. However, the mechanisms underlying mitotic resistance are mostly
Juan Wang et al.
Molecular pharmaceutics, 16(5), 1874-1880 (2019-04-13)
In this study, the anticancer drug, camptothecin (CPT), was covalently grafted onto polyamidoamine (PAMAM) dendrimer surface and then reacted with polyethylene glycol diacrylate (PEG-DA) to form dendrimer hydrogel (DH-G3-CPT) with low cross-linking density. In this novel drug delivery system, CPT
Cheyenne Allenby et al.
Brain stimulation, 11(5), 974-981 (2018-06-11)
Impulsivity is a core deficit in attention deficit hyperactivity disorder (ADHD). Transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC) has been shown to modulate cognitive control circuits and could enhance DLPFC activity, leading to improved impulse control
Darrin V Bann et al.
Clinical anatomy (New York, N.Y.), 30(2), 205-212 (2016-10-30)
Thyroid disease is common among elderly patients, frequently necessitating thyroid gland examination, imaging, and surgery. However, no prior studies have determined the effect of age on the anatomic position of the thyroid gland in the anterior neck. We hypothesized that
Yuan Meng et al.
Nucleic acids research, 47(14), 7564-7579 (2019-06-20)
The multifunctional human DNA2 (hDNA2) nuclease/helicase is required to process DNA ends for homology-directed recombination repair (HDR) and to counteract replication stress. To participate in these processes, hDNA2 must localize to the nucleus and be recruited to the replication or
Tammy D Kim et al.
Experimental neurobiology, 28(1), 1-16 (2019-03-12)
Cognitive enhancement refers to the improvement of cognitive function related to deficits that occurred as part of a certain illness. However, the term cognitive enhancement does not yet have a definitive meaning, and its connotations often vary depending on the
Shima Zeynali-Moghaddam et al.
Gene, 684, 30-38 (2018-10-14)
Anti-proliferative, anti-metastatic and anti-angiogenic effects of 17‑allylamino‑17‑demethoxy geldanamycin (17-AAG) were studied alone and in combination with Capecitabine (Cap) and/or Irinotecan (IR) on HT-29 human colorectal carcinoma cells. Expression of MMP-9 (matrix metalloproteinase‑9) and VEGF (vascular endothelial growth factor) mRNA was
Yoshihiko Hagiwara et al.
Human immunology, 79(8), 627-631 (2018-06-03)
Programmed cell death-1 (PD-1) and its ligand (programmed death-ligand 1, PD-L1) are key factors that regulate a cytotoxic immune reaction. Anti-PD-1 therapy provides significant clinical benefits for patients with cancer, even those with advanced-stage cancer. We have recently demonstrated that
Kristin Heuschkel et al.
Frontiers in psychiatry, 11, 224-224 (2020-04-17)
Depression is a major public health problem that affects approximately 4.4% of the global population. Since conventional pharmacotherapies and psychotherapies are only partially effective, as demonstrated by the number of patients failing to achieve remission, alternative treatments are needed. Mindfulness
Cryptotanshinone, a Stat3 inhibitor, suppresses colorectal cancer proliferation and growth in vitro.
Weidong Li et al.
Molecular and cellular biochemistry, 406(1-2), 63-73 (2015-04-29)
Cryptotanshinone (CPT) is a natural compound extracted from herbal medicine that has been previously shown to possess antitumor properties in various types of human cancer cells. In the present study, we examined the potential role of CPT in the treatment
Johanna Höper et al.
International journal of environmental research and public health, 17(9) (2020-05-06)
To investigate sensory changes, physical function (pF), quality of life (QoL) and pain intensity of patients with osteoarthritis (OA) in the natural course of disease, and patients undergoing total joint replacement therapy (TJR) 31 (20 females, mean age 64.6 ±
Yaya Wang et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(9), 2403-2414 (2015-05-29)
Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) is associated with an increased risk of systemic lupus erythematosus (SLE). PTPN22 encodes Lyp, and a disease-associated coding variant bears an R620W substitution (LypW). LypW carriage is associated with impaired production of type
Yu-Ying Zhao et al.
Toxicology, 390, 53-60 (2017-09-09)
Kupffer cells (KCs) have been suggested to play critical roles in chronic ethanol induced early liver injury, but the role of KCs in binge drinking-induced hepatic steatosis remains unclear. This study was designed to investigate the roles of KCs inhibitor
Ruben C Gur et al.
Schizophrenia research, 163(1-3), 17-23 (2014-11-30)
Neurocognitive deficits in schizophrenia (SZ) are established and the Consortium on the Genetics of Schizophrenia (COGS) investigated such measures as endophenotypes in family-based (COGS-1) and case-control (COGS-2) studies. By requiring family participation, family-based sampling may result in samples that vary
Vincent J Major et al.
BMC medical informatics and decision making, 20(1), 214-214 (2020-09-08)
Automated systems that use machine learning to estimate a patient's risk of death are being developed to influence care. There remains sparse transparent reporting of model generalizability in different subpopulations especially for implemented systems. A prognostic study included adult admissions
Kyle T Householder et al.
International journal of pharmaceutics, 479(2), 374-380 (2015-01-07)
Effective treatment of glioblastoma multiforme remains a major clinical challenge, due in part to the difficulty of delivering chemotherapeutics across the blood-brain barrier. Systemically administered drugs are often poorly bioavailable in the brain, and drug efficacy within the central nervous
Razieh Kebriaei et al.
Antimicrobial agents and chemotherapy, 63(4) (2019-01-24)
Glycopeptides such as vancomycin have been used as the first-line therapy against MRSA infections for over half a century. Reduced susceptibility and emergence of resistance to first-generation glycopeptides has led to development of second-generation lipoglycopeptide derivatives such as dalbavancin which
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