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显示 1-30 #N/A 185 条结果 关于 "C1879" 范围 论文
Jürgen W Schönborn et al.
iScience, 24(11), 103216-103216 (2021-10-30)
We know a lot about varying gut microbiome compositions. Yet, how the bacteria affect each other remains elusive. In mammals, this is largely based on the sheer complexity of the microbiome with at least hundreds of different species. Thus, model
Brook T Chernet et al.
Oncotarget, 5(10), 3287-3306 (2014-05-17)
The microenvironment is increasingly recognized as a crucial aspect of cancer. In contrast and complement to the field's focus on biochemical factors and extracellular matrix, we characterize a novel aspect of host:tumor interaction - endogenous bioelectric signals among non-excitable somatic
Eric M Prager et al.
Neurotoxicology, 44, 335-343 (2014-08-26)
The recent sarin attack in Syria killed 1429 people, including 426 children, and left countless more to deal with the health consequences of the exposure. Prior to the Syrian chemical assault, nerve agent attacks in Japan left many victims suffering
Dominique E Williams et al.
Chembiochem : a European journal of chemical biology, 16(10), 1474-1482 (2015-05-09)
With the goal of designing a lysosomal phospholipase mimic, we optimized experimental variables to enhance Ce(IV) -assisted hydrolysis of phosphatidylcholine (PC) liposomes. Our best result was obtained with the chelating agent bis-tris propane (BTP). Similar to the hydrolytic enzyme, Ce(IV)
Can Peng et al.
Molecular pharmacology, 84(3), 459-475 (2013-07-11)
Positive allosteric modulators (PAMs) of α7 nicotinic acetylcholine receptors can enhance ion channel currents and downstream effects of α7 stimulation. We investigated the approach of using noncompetitive antagonists to regulate α7 receptor function, potentially distinguishing effects requiring ion channel currents
Werner J Geldenhuys et al.
Bioorganic & medicinal chemistry letters, 20(16), 4870-4877 (2010-07-20)
The high affinity neuronal choline transporter (CHT1) is responsible for the uptake of choline into the pre-synaptic terminal of cholinergic neurons. Considering our past experience with modeling the blood-brain barrier choline transporter (BBBCHT) as drug delivery vector to the CNS
Prevention of schizophrenia: an impossible dream?
Judith L Rapoport
The American journal of psychiatry, 170(3), 245-247 (2013-03-02)
Yifan Zhang et al.
Nature communications, 13(1), 7586-7586 (2022-12-10)
L-Ergothioneine (ET), the 2-thioimidazole derivative of trimethylhistidine, is biosynthesized by select fungi and bacteria, notably Mycobacterium tuberculosis, and functions as a scavenger of reactive oxygen species. The extent to which ET broadly functions in bacterial cells unable to synthesize it
Zienab Alrefaie et al.
Behavioural brain research, 287, 156-162 (2015-04-04)
Complications of diabetes mellitus include cognitive impairments and functional changes in the brain. The present study aimed to investigate the possible beneficial effect of vitamin D3 on episodic memory and cholinergic transmission in the prefrontal cortex of streptozotocin-induced diabetic rats.
Veronika Fischer et al.
Journal of colloid and interface science, 453, 186-193 (2015-05-20)
It was recently demonstrated that a nano-clustering was present in the monophasic "pre-Ouzo" region of ternary liquid mixtures without surfactants. The goal of this work is to check if this nano-clustering is also present in the surfactant-free and water-free "green"
L Martin et al.
Oncogene, 34(32), 4211-4218 (2014-11-18)
SLC7A11 encodes a subunit of the xCT cystine/glutamate amino-acid transport system and has a critical role in the generation of glutathione and the protection of cells from oxidative stress. Expression of SLC7A11 promotes tumorigenesis and chemotherapy resistance, but while SLC7A11
Ayano Takeuchi-Yorimoto et al.
Toxicology and applied pharmacology, 268(3), 264-277 (2013-03-14)
Nonalcoholic steatohepatitis (NASH) is characterized by combined pathology of steatosis, lobular inflammation, fibrosis, and hepatocellular degeneration, with systemic symptoms of diabetes or hyperlipidemia, all in the absence of alcohol abuse. Given the therapeutic importance and conflicting findings regarding the potential
Hélène Taiana Darius et al.
Marine drugs, 20(6) (2022-06-24)
Gambierdiscus and Fukuyoa dinoflagellates produce a suite of secondary metabolites, including ciguatoxins (CTXs), which bioaccumulate and are further biotransformed in fish and marine invertebrates, causing ciguatera poisoning when consumed by humans. This study is the first to compare the performance
Artor Niccoli-Asabella et al.
Recenti progressi in medicina, 104(2), 73-75 (2013-03-29)
In a patient with cerebral gliomatosis type II MRI revealed a large area of altered signal in the temporal region, parietal and occipital lobes associated with a single nodule with perilesional contrast enhancement, which showed increased uptake on PET/CT with
Tom Vander Hoogerstraete et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(33), 11757-11766 (2015-07-17)
In a conventional solvent extraction system, metal ions are distributed between two immiscible phases, typically an aqueous and an organic phase. In this paper, the proof-of-principle is given for the distribution of metal ions between three immiscible phases, two ionic
Vignesh Thiagarajan et al.
Journal of colloid and interface science, 462, 334-340 (2015-10-18)
Choline, a type of Vitamin B, is an important nutrient in the human body and is involved in key metabolic pathways. Abnormal levels of choline leads to diseased conditions. The levels of choline and its associated compounds are found to
L Van den Bergh et al.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 189(9), 789-795 (2013-06-26)
The aim of this work was to determine whether 11C-choline positron emission tomography (PET)-computed tomography (CT) makes a positive contribution to multiparametric magnetic resonance imaging (MRI) for localisation of intraprostatic tumour nodules. A total of 73 patients with biopsy-proven intermediate-
Kim M Yonemori et al.
The Journal of nutrition, 143(6), 894-899 (2013-04-26)
Choline and betaine are important nutrients for human health, but reference food composition databases for these nutrients became available only recently. We tested the feasibility of using these databases to estimate dietary choline and betaine intakes among ethnically diverse adults
Tobias W M Keil et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 158, 359-364 (2020-12-19)
With the approval of the first siRNA-based drugs, non-viral siRNA delivery has gained special interest in industry and academia in the last two years. For non-viral delivery, positively charged lipid and polymer formulations play a central role in research and
Akiko Mizuno-Yasuhira et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1456-1465 (2014-07-10)
A strategy for assessing potential drug-drug interactions (DDIs) based on a simulated intestinal concentration is described. The proposed prediction method was applied to the DDI assessment of luseogliflozin, a novel antidiabetic drug, against miglitol absorbed via the intestinal sodium-glucose cotransporter
William M Howe et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(20), 8742-8752 (2013-05-17)
We previously reported involvement of right prefrontal cholinergic activity in veridical signal detection. Here, we first recorded real-time acetylcholine release in prefrontal cortex (PFC) during specific trial sequences in rats performing a task requiring signal detection as well as rejection
Soraia Poloni et al.
Gene, 546(2), 443-447 (2014-05-13)
Classical homocystinuria is a rare genetic disease caused by cystathionine β-synthase deficiency, resulting in homocysteine accumulation. Growing evidence suggests that reduced fat mass in patients with classical homocystinuria may be associated with alterations in choline and homocysteine pathways. This study
Yilei Zhao et al.
International journal of biological sciences, 9(3), 295-302 (2013-03-16)
Although inadequate intake of essential nutrient choline has been known to significantly increase cardiovascular risk, whether additional supplement of choline offering a protection against cardiac hypertrophy remain unstudied. The effects of choline supplements on pathological cardiac hypertrophic growth induced by
Marina Orevi et al.
Clinical nuclear medicine, 39(12), 1033-1038 (2014-10-08)
This prospective pilot study was aimed to evaluate ¹¹C-choline PET/CT (choline) as a tool for localization of parathyroid adenoma (PTA). Forty patients with biochemical hyperparathyroidism underwent choline and ⁹⁹mTc-MIBI imaging within a median interval of 56 days. Choline and MIBI
Jacob C Nordman et al.
Journal of neurochemistry, 129(4), 649-662 (2013-12-20)
Cholinergic signaling plays an important role in regulating the growth and regeneration of axons in the nervous system. The α7 nicotinic receptor (α7) can drive synaptic development and plasticity in the hippocampus. Here, we show that activation of α7 significantly
J Li et al.
Clinical radiology, 70(1), 37-41 (2014-12-03)
To assess the role of proton MR spectroscopy (MRS) in the detection of changes in metabolite levels of the cerebellum after heat stroke (HS). The study group consisted of eight patients after HS, with a Glasgow Coma Scale (GCS) score
Durgesh V Wagle et al.
The journal of physical chemistry letters, 6(15), 2924-2928 (2015-08-13)
From macroscopic measurements of deep eutectic solvents such as glyceline (1:2 molar ratio of choline chloride to glycerol), the long-range translational diffusion of the larger cation (choline) is known to be slower compared to that of the smaller hydrogen bond
Benjamin Kolisnyk et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(37), 14908-14920 (2013-09-13)
One of the key brain regions in cognitive processing and executive function is the prefrontal cortex (PFC), which receives cholinergic input from basal forebrain cholinergic neurons. We evaluated the contribution of synaptically released acetylcholine (ACh) to executive function by genetically
Andreas Hecker et al.
Journal of immunology (Baltimore, Md. : 1950), 195(5), 2325-2334 (2015-07-24)
IL-1β is a potent proinflammatory cytokine of the innate immune system that is involved in host defense against infection. However, increased production of IL-1β plays a pathogenic role in various inflammatory diseases, such as rheumatoid arthritis, gout, sepsis, stroke, and
Coralie Berthoux et al.
EMBO molecular medicine, 12(5), e10605-e10605 (2020-04-25)
Cannabis abuse during adolescence confers an increased risk for developing later in life cognitive deficits reminiscent of those observed in schizophrenia, suggesting common pathological mechanisms that remain poorly characterized. In line with previous findings that revealed a role of 5-HT6
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