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Salamatu S Mambula et al.
Methods (San Diego, Calif.), 43(3), 168-175 (2007-10-09)
Heat shock protein 70 (Hsp70) is released from cells of many types and plays a significant signaling role, particularly in the inflammatory and immune responses. However, Hsp70 does not contain a consensus secretory signal and thus cannot traverse the plasma
Patricia Blundell et al.
Methods in molecular biology (Clifton, N.J.), 1904, 417-421 (2018-12-13)
Engineering the fragment crystallizable (Fc) of human IgG can bring improved effector functions to monoclonal antibodies and Fc-fusion-based medicines and vaccines. Such Fc-effector functions are largely controlled by posttranslational modifications (PTMs) within the Fc, including the addition of glycans that
Laura L Healy et al.
Scientific reports, 4, 7060-7060 (2014-11-15)
Cells generate inflammatory responses to bacteria when pattern recognition receptors bind pathogen-associated molecules such as lipopolysaccharide. Cells may also respond to tissue damage by sensing damage-associated molecules. Postpartum bacterial infections of the bovine uterus cause endometritis but the risk of
Lubna Kouser et al.
Molecular immunology, 73, 76-87 (2016-04-10)
Properdin upregulates the alternative complement pathway by binding and stabilising the C3 convertase complex (C3bBb). Properdin is a soluble glycoprotein and its flexible rod-like 53kDa monomers form cyclic polymers (dimers, trimers, tetramers and pentamers). The properdin monomer consists of seven
Sylvain Cecchini et al.
Clinical and vaccine immunology : CVI, 16(5), 597-604 (2009-02-27)
Recently, molecular screening for pathogenic agents has identified a partial genome of a novel parvovirus, called human bocavirus (HBoV). The presence of this newly described parvovirus correlated with upper and lower respiratory tract infections in children. Lower respiratory tract infections
R M Jaafar et al.
Journal of fish diseases, 41(1), 117-123 (2017-07-15)
Teleosts are able to raise a protective immune response, comprising both innate and adaptive elements, against various pathogens. This is the basis for a widespread use of vaccines, administered as injection or immersion, in the aquaculture industry. It has been
Huseyin Yilmaz et al.
Applied biochemistry and biotechnology, 187(2), 506-517 (2018-07-11)
The avian coronavirus-infectious bronchitis virus (AvCoV-IBV) is recognized as an important avian pathogen, and new viral variants are a continuous threat to the poultry industry worldwide. Sensitive diagnostics and efficacious vaccines are necessary to combat IBV infections in chickens. The
Randall Burton et al.
Journal of dairy science, 99(6), 4739-4749 (2016-04-05)
The use of hyper-immune bovine colostrum as a human therapeutic platform is an emerging technology with potential to deliver the efficacy of antibody therapeutics with the convenience and safety of oral or topical application. It is necessary to understand how
Rebekah M Dedrick et al.
Nature medicine, 27(8), 1357-1361 (2021-07-10)
An 81-year-old immunocompetent patient with bronchiectasis and refractory Mycobacterium abscessus lung disease was treated for 6 months with a three-phage cocktail active against the strain. In this case study of phage to lower infectious burden, intravenous administration was safe and
Jun-Ichi Sakamaki et al.
Molecular cell, 66(4), 517-532 (2017-05-20)
Autophagy is a membrane-trafficking process that directs degradation of cytoplasmic material in lysosomes. The process promotes cellular fidelity, and while the core machinery of autophagy is known, the mechanisms that promote and sustain autophagy are less well defined. Here we
Christine Robinson et al.
Human vaccines & immunotherapeutics, 15(4), 909-917 (2019-01-10)
Opioid use disorders (OUD) and fatal overdoses are a national emergency in the United States. Therapeutic vaccines offer a promising strategy to treat OUD and reduce the incidence of overdose. Immunization with opioid-based haptens conjugated to immunogenic carriers elicits opioid-specific
Kenichi Serizawa et al.
Journal of neuroimmunology, 319, 71-79 (2018-04-25)
Chronic pain is a prevalent symptom in patients with autoimmune encephalomyelitis such as multiple sclerosis and neuromyelitis optica. Although IL-6 is involved in various inflammatory and immune diseases, the roles of IL-6 in autoimmune-related pain have not been clarified. Therefore
Claudia M Freitag et al.
Cellular microbiology, 19(6) (2016-12-23)
Flagella are nanofibers that drive bacterial movement. The filaments are generally composed of thousands of tightly packed flagellin subunits with a terminal cap protein, named FliD. Here, we report that the FliD protein of the bacterial pathogen Campylobacter jejuni binds to
Experimental evidence for direct in situ binding of IgM and IgT to early trophonts of Ichthyophthirius multifiliis (Fouquet) in the gills of rainbow trout, Oncorhynchus mykiss (Walbaum)
von Gersdorff J, et al.
Journal of Fish Diseases, 34(10), 749-755 (2011)
A Kieninger-Gräfitsch et al.
Scientific reports, 10(1), 3693-3693 (2020-03-01)
Cardiovascular (CV) morbidity is the major cause of death in patients with Systemic Lupus Erythematosus (SLE). Previous studies on mannose-binding lectin (MBL) gene polymorphisms in SLE patients suggest that low levels of complement MBL are associated with cardiovascular disease (CVD).
Yuki Noguchi et al.
Scientific reports, 11(1), 8383-8383 (2021-04-18)
Evaluation of the binding and uptake of an antibody in liver non-parenchymal cells (NPC), including liver sinusoidal endothelial cells, is important for revealing its pharmacokinetic (PK) behavior, since NPC has important roles in eliminating an antibody from the blood via
April M Lewis et al.
Bio-protocol, 6(14) (2017-05-12)
Nitric Oxide (NO) is a highly-reactive radical gas that can modify a variety of cellular targets in both eukaryotes and bacteria. NO is produced endogenously by a wide variety of organisms: For example, as a cell-signaling molecule in mammals and
William A Eckert et al.
European journal of pharmacology, 880, 173171-173171 (2020-05-22)
Cathepsin S (CatS) is a cysteine protease found in lysosomes of hematopoietic and microglial cells and in secreted form in the extracellular space. While CatS has been shown to contribute significantly to neuropathic pain, the precise mechanisms remain unclear. In
T J Caperna et al.
Domestic animal endocrinology, 60, 75-82 (2017-05-30)
A simple, reproducible sandwich, ELISA was developed to measure porcine alpha-1 acid glycoprotein (pAGP, ORM-1) in pig plasma. Porcine AGP isolated from serum was purchased and a polyclonal antisera was prepared in rabbits using the whole pAGP molecule as immunogen.
Natasha N Gaudreault et al.
Emerging microbes & infections, 9(1), 2322-2332 (2020-10-09)
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the cause of Coronavirus Disease 2019 (COVID-19) and responsible for the current pandemic. Recent SARS-CoV-2 susceptibility studies in cats show that the virus can replicate in these companion animals and transmit to
Hannah M Rowe et al.
Cell host & microbe, 25(6), 884-891 (2019-05-28)
The capacity of Streptococcus pneumoniae to successfully transmit and colonize new human hosts is a critical aspect of pneumococcal population biology and a prerequisite for invasive disease. However, the bacterial mechanisms underlying this process remain largely unknown. To identify bacterial factors
Rachel Myers et al.
International journal of nanomedicine, 13, 337-349 (2018-02-03)
The treatment of cancer using nanomedicines is limited by the poor penetration of these potentially powerful agents into and throughout solid tumors. Externally controlled mechanical stimuli, such as the generation of cavitation-induced microstreaming using ultrasound (US), can provide a means
Evolution of a physiological pH 6.8 bicarbonate buffer system: application to the dissolution testing of enteric coated products
Liu F, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 78(1), 151-157 (2011)
Quantifying and comparing constitutive immunity across avian species
Millet S, et al.
Developmental and Comparative Immunology, 31(2), 188-201 (2007)
Yoav Gal et al.
Antibodies (Basel, Switzerland), 9(1) (2020-02-12)
Abrin and ricin are potent AB toxins, which are considered biological threats. To date, there are no approved treatments against abrin or ricin intoxications. Previously, we showed that the administration of polyclonal anti-abrin antibodies to mice that were intranasally exposed
Jana Svobodová et al.
PeerJ, 9, e12401-e12401 (2021-11-27)
Microbiome formation and assemblage are essential processes influencing proper embryonal and early-life development in neonates. In birds, transmission of microbes from the outer environment into the egg's interior has been found to shape embryo viability and hatchling phenotype. However, microbial
Nina Brenden et al.
Journal of pharmaceutical sciences, 102(3), 1116-1124 (2013-01-15)
Avoiding unwanted immunogenicity is of key importance in the development of therapeutic drug proteins. Animal models are of less predictive value because most of the drug proteins are recognized as foreign proteins. However, different methods have been developed to obtain
Randall E Burton et al.
The Journal of biological chemistry, 295(34), 12317-12327 (2020-07-16)
Bovine colostral antibodies, purified from cow's milk produced immediately after calving, have enhanced resistance to degradation by intestinal proteases relative to antibodies from human or bovine serum, making them of particular interest as orally administered therapeutic agents. However, the basis
Vincent Pavot et al.
Human vaccines & immunotherapeutics, 17(7), 2336-2348 (2021-01-12)
Adjuvants are central to the efficacy of subunit vaccines. Although several new adjuvants have been approved in human vaccines over the last decade, the panel of adjuvants in licensed human vaccines remains small. There is still a need for novel
Naotoshi Kuninaga et al.
The Journal of veterinary medical science, 81(2), 328-337 (2018-12-28)
The small Indian mongoose (Herpestes auropunctatus) was introduced to Japanese islands and has impacted on the island's biodiversity. Population control has been attempted through capturing but its efficiency has rapidly declined. Therefore, new additional control methods are required. Our focus
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