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Chris M Kocur et al.
Journal of contaminant hydrology, 145, 17-25 (2012-12-25)
Nano-scale zero valent iron (nZVI) has received significant attention because of its potential to rapidly reduce a number of priority source zone contaminants. In order to effectively deliver nZVI to the source zone the nZVI particles must be stable. Previous
Eric A Shikatani et al.
PloS one, 7(10), e46625-e46625 (2012-10-12)
The angiostatic nature of pharmacological doses of glucocorticoid steroids is well known. However, the consequences of pathophysiological elevation of endogenous glucocorticoids are not well established. In the current study, we hypothesized that the angiostatic effect of corticosterone, an endogenous glucocorticoid
Ayhan Savaşer et al.
Pharmaceutical development and technology, 18(5), 1122-1130 (2012-08-14)
Metoclopramide HCl (MTC) is commonly used for the management of gastrointestinal disorders. It has a short biological half-life and is usually administered four times daily to maintain effective concentrations throughout the day. The aim of this study is to develop
Stefan Jordan et al.
Cell, 178(5), 1102-1114 (2019-08-24)
Caloric restriction is known to improve inflammatory and autoimmune diseases. However, the mechanisms by which reduced caloric intake modulates inflammation are poorly understood. Here we show that short-term fasting reduced monocyte metabolic and inflammatory activity and drastically reduced the number
Deepmoni Deka et al.
Preparative biochemistry & biotechnology, 43(3), 256-270 (2013-02-06)
An extracellular alkaline carboxymethycellulase (CMCase) from Bacillus subtilis was purified by salt precipitation followed by anion-exchange chromatography using DEAE-Sepharose. The cell-free supernatant containing crude enzyme had a CMCase activity of 0.34 U/mg. The purified enzyme gave a specific activity of
B M Moron et al.
Caries research, 47(2), 162-170 (2012-12-14)
This study compared dentine demineralization induced by in vitro and in situ models, and correlated dentine surface hardness (SH), cross-sectional hardness (CSH) and mineral content by transverse microradiography (TMR). Bovine dentine specimens (n = 15/group) were demineralized in vitro with
S S Olmez et al.
Die Pharmazie, 68(2), 110-116 (2013-03-09)
In this study, clozapine orally disintegrating tablets (ODTs) were prepared by direct compression method. Disintegration time, resistance to crushing of tablets, porosity, friability, dissolution tests were performed and dissolution profiles of ODTs were investigated. Morphological and interaction studies were also
Megan E Spurgeon et al.
eLife, 8 (2019-10-18)
Human papillomaviruses (HPVs) are the most common sexually transmitted infectious agents. Because of the species specificity of HPVs, study of their natural transmission in laboratory animals is not possible. The papillomavirus, MmuPV1, which infects laboratory mice (Mus musculus), can cause
Ramesh Sharma et al.
Carbohydrate polymers, 92(2), 1546-1554 (2013-02-13)
Polyion-counterion interactions in sodium carboxymethylcellulose-ethylene glycol-water ternary system have been investigated with special reference to their variations with the polyelectrolyte concentration, the medium relative permittivity and the temperature using electrical conductance measurements. The experimental data have been analyzed on the
Jing Sun et al.
Cell, 182(3), 734-743 (2020-07-10)
COVID-19, caused by SARS-CoV-2, is a virulent pneumonia, with >4,000,000 confirmed cases worldwide and >290,000 deaths as of May 15, 2020. It is critical that vaccines and therapeutics be developed very rapidly. Mice, the ideal animal for assessing such interventions
Alexandra D Torres et al.
Virology, 541, 1-12 (2019-12-13)
The papillomavirus E5 gene contributes to transformation and tumorigenesis; however, its exact function in these processes and viral pathogenesis is unclear. While E5 is present in high-risk mucosotropic HPVs that cause anogenital and head and neck cancers, it is absent
Richard P G Ten Broek et al.
Lancet (London, England), 383(9911), 48-59 (2013-10-01)
Formation of adhesions after peritoneal surgery results in high morbidity. Barriers to prevent adhesion are seldom applied, despite their ability to reduce the severity of adhesion formation. We evaluated the benefits and harms of four adhesion barriers that have been
Zhi-chen Liu et al.
Archives of orthopaedic and trauma surgery, 133(3), 295-301 (2013-01-01)
To evaluate effectiveness of carboxymethylcellulose/polyethylene oxide (CMC/PEO) gel in improving clinical outcomes after the first-time lumbar discectomy. Ninety-three patients with herniated lumbar disc at L4-L5 or L5-S1 were enrolled and randomized into two groups: CMC/PEO gel treatment group and control
Gretchen L Snyder et al.
Psychopharmacology, 233(17), 3113-3124 (2016-06-28)
Therapeutic agents for memory enhancement in psychiatric disorders, such as schizophrenia, are urgently needed. The aim of this study is to characterize the preclinical profile of ITI-214, a potent inhibitor of phosphodiesterase 1 (PDE1). ITI-214 was assayed for inhibition of
Z Pourramezan et al.
Mikrobiologiia, 81(6), 796-802 (2013-04-25)
The aim of the present study was to isolate and characterize the cellulose-degrading bacteria from the gut of the local termite, Microcerotermes diversus (Silvestri), inhabiting the Khuzestan province of Iran. The microorganisms capable of growing in the liquid medium containing
Regina Renner et al.
Dermatitis : contact, atopic, occupational, drug, 24(2), 60-63 (2013-03-12)
Patients with chronic leg ulcers typically experience contact allergy to topical treatments. Although declared as hypoallergenic, modern wound dressings have caused several reported cases of contact allergy. The aim of the study was to evaluate any allergenic potential of modern
Thet Nyonyo et al.
FEMS microbiology ecology, 88(3), 528-537 (2014-03-13)
The phylotypes of rumen bacteria have increased by the accumulation of 16S rRNA gene sequences, and they show a complex microbial community structure in the rumen. However, most of the biochemical properties of rumen bacteria defined by phylotypes are still
Lindsay A Wegiel et al.
Pharmaceutical development and technology, 19(8), 976-986 (2013-11-07)
We have investigated the physical stability of amorphous curcumin dispersions and the role of curcumin-polymer intermolecular interactions in delaying crystallization. Curcumin is an interesting model compound as it forms both intra and intermolecular hydrogen bonds in the crystal. A structurally
Piyada Supasa et al.
Cell, 184(8), 2201-2211 (2021-03-22)
SARS-CoV-2 has caused over 2 million deaths in little over a year. Vaccines are being deployed at scale, aiming to generate responses against the virus spike. The scale of the pandemic and error-prone virus replication is leading to the appearance
'Clinical and cost-effectiveness of absorbent dressings in the treatment of highly exuding VLUs'.
Stephen Bishop et al.
Journal of wound care, 22(11), 644-644 (2013-11-15)
Babak Ghanbarzadeh et al.
International journal of biological macromolecules, 48(1), 44-49 (2010-10-06)
Glycerol and oleic acid (OA) were incorporated into carboxymethyl cellulose (CMC) films by an emulsification method. Films containing different amounts of glycerol and OA were examined for mechanical properties, water vapor permeability (WVP), and moisture uptake, optical and thermal properties.
Shigeru Kawabata et al.
Oncotarget, 6(13), 11357-11368 (2015-06-02)
Adenomatous tumors in the middle ear and temporal bone are rare but highly morbid because they are difficult to detect prior to the development of audiovestibular dysfunction. Complete resection is often disfiguring and difficult because of location and the late
Jarod A Fincher et al.
The Journal of comparative neurology, 527(13), 2101-2121 (2018-10-26)
Mass spectrometry imaging (MSI) is capable of detection and identification of diverse classes of compounds in brain tissue sections, whereas simultaneously mapping their spatial distributions. Given the vast array of chemical components present in neurological systems, as well as the
Is there still a need for silver sulfadiazine in small burns?
L P Kamolz et al.
Burns : journal of the International Society for Burn Injuries, 39(3), 535-536 (2012-12-26)
Guo-Sheng Li et al.
Biological & pharmaceutical bulletin, 34(5), 644-654 (2011-05-03)
The diabetic "lipotoxicity" hypothesis presents that fat-induced visceral white adipose tissue insulin resistance plays a central role in the pathogenesis of type 2 diabetes. Berberine, a hypolipidemic agent, has been reported to have antidiabetic activities. The molecular mechanisms for this
Jitendra Kumar et al.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 45(4), 330-335 (2010-04-20)
Controlled release (CR) formulations of metribuzin in Polyvinyl chloride [(PVC) (emulsion)], carboxy methyl cellulose (CMC), and carboxy methyl cellulose-kaolinite composite (CMC-KAO), are reported. Kinetics of its release in water and soil was studied in comparison with the commercial formulation (75
Yong Bum Park et al.
Plant physiology, 158(4), 1933-1943 (2012-03-01)
Xyloglucan is widely believed to function as a tether between cellulose microfibrils in the primary cell wall, limiting cell enlargement by restricting the ability of microfibrils to separate laterally. To test the biomechanical predictions of this "tethered network" model, we
Donna Z Bliss et al.
Research in nursing & health, 37(5), 367-378 (2014-08-27)
Dietary fiber supplements are used to manage fecal incontinence (FI), but little is known about the fiber type to recommend or the level of effectiveness of such supplements, which appears related to the fermentability of the fiber. The aim of
Wanwisa Dejnirattisai et al.
Cell, 184(8), 2183-2200 (2021-03-24)
Antibodies are crucial to immune protection against SARS-CoV-2, with some in emergency use as therapeutics. Here, we identify 377 human monoclonal antibodies (mAbs) recognizing the virus spike and focus mainly on 80 that bind the receptor binding domain (RBD). We
Timothy Notton et al.
mBio, 12(1) (2021-01-21)
It has long been known that noncoding genomic regions can be obligate cis elements acted upon in trans by gene products. In viruses, cis elements regulate gene expression, encapsidation, and other maturation processes, but mapping these elements relies on targeted
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