C5241

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Interaction of a cyclic peptide, Ro09-0198, with phosphatidylethanolamine in liposomal membranes.

S Y Choung et al.

Biochimica et biophysica acta, 940(2), 180-187 (1988-05-24)

Ro09-0198 is a cyclic peptide isolated from Streptoverticillium griseoverticillatum. This peptide caused permeability increase and aggregation of liposomes containing phosphatidylethanolamine. Liposomes containing phosphatidylserine, phosphatidylinositol or cardiolipin instead of phosphatidylethanolamine were, however, not appreciably reactive with the peptide. Among the structural

Complex formation of peptide antibiotic Ro09-0198 with lysophosphatidylethanolamine: 1H NMR analyses in dimethyl sulfoxide solution.

K Wakamatsu et al.

Biochemistry, 29(1), 113-118 (1990-01-09)

Ro09-0198 is a peptide antibiotic and immunopotentiator produced by Streptoverticillium griseoverticillatum which exhibits antitumor and antimicrobial activities. The chemical structure has been determined [Kessler et al. (1988) Helv. Chim. Acta 71, 1924-1929; Wakamiya et al. (1988) Tetrahedron Lett. 37, 4771-4772].

The structure of Ro 09-0198 in different environments.

H Kessler et al.

Biopolymers, 32(4), 427-433 (1992-04-01)

The constitution and configuration of Ro 09-0198 (cinnamycin) have been determined in DMSO. Further investigations in aqueous solution, in SDS micelles and in a lipid bilayer have been done to study the influence of different environments on the conformation of

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease.

Estela Area-Gomez et al.

The EMBO journal, 31(21), 4106-4123 (2012-08-16)

Alzheimer disease (AD) is associated with aberrant processing of the amyloid precursor protein (APP) by γ-secretase, via an unknown mechanism. We recently showed that presenilin-1 and -2, the catalytic components of γ-secretase, and γ-secretase activity itself, are highly enriched in

Roles for the Drs2p-Cdc50p complex in protein transport and phosphatidylserine asymmetry of the yeast plasma membrane.

Sophie Chen et al.

Traffic (Copenhagen, Denmark), 7(11), 1503-1517 (2006-09-08)

Drs2p, a P-type adenosine triphosphatase required for a phosphatidylserine (PS) flippase activity in the yeast trans Golgi network (TGN), was first implicated in protein trafficking by a screen for mutations synthetically lethal with arf1 (swa). Here, we show that SWA4

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

Area-Gomez E, et al.

The Embo Journal, 31(21), 4106-4123 (2012)

Redistribution of phosphatidylethanolamine at the cleavage furrow of dividing cells during cytokinesis.

K Emoto et al.

Proceedings of the National Academy of Sciences of the United States of America, 93(23), 12867-12872 (1996-11-12)

Ro09-0198 is a tetracyclic polypeptide of 19 amino acids that recognizes strictly the structure of phosphatidylethanolamine (PE) and forms a tight equimolar complex with PE on biological membranes. Using the cyclic peptide coupled with fluorescence-labeled streptavidin, we have analyzed the

A novel peptide probe for studying the transbilayer movement of phosphatidylethanolamine.

Y Aoki et al.

Journal of biochemistry, 116(2), 291-297 (1994-08-01)

Ro09-0198 is a cyclic peptide isolated from Streptoverticillium griseoverticillatum which recognizes strictly the structure of phosphatidylethanolamine (PE) and forms an equimolar complex with the phospholipid on biological membranes. To use the peptide as a probe for analyzing the transbilayer movement

Manipulation of the phosphatidylethanolamine pool in the human red cell membrane affects its Mg2+-ATPase activity.

W P Vermeulen et al.

Molecular membrane biology, 13(2), 95-102 (1996-04-01)

Decreasing the size of the outer leaflet pool of phosphatidylethanolamine (PE) in the erythrocyte membrane by treatment of intact cells with either phospholipase A2, or trinitrobenzenesulphonic acid (TNBS), causes a corresponding decrease in Mg(2+)-ATPase activity as determined in their respective

Exposure of phosphatidylethanolamine on the surface of apoptotic cells.

K Emoto et al.

Experimental cell research, 232(2), 430-434 (1997-05-01)

In the early stages of apoptosis, phosphatidylserine (PS) is translocated from the inner side of the plasma membrane to the outer layer, which allows phagocytes to recognize and engulf the apoptotic cells. In this study we have analyzed the cell

Fast atom bombardment mass spectrometry of some lantibiotics.

M Lipták et al.

Biological mass spectrometry, 23(11), 701-706 (1994-11-01)

Four lantibiotics namely epidermin, gallidermin, lanthiopeptin and mersacidin, have been studied by fast atom bombardment mass spectrometry. The molecular ion clusters of these compounds can be detected with reasonable abundance. The low-mass regions of the spectra show the presence of

Lanthiopeptin, a new peptide antibiotic. Production, isolation and properties of lanthiopeptin.

N Naruse et al.

The Journal of antibiotics, 42(6), 837-845 (1989-06-01)

A strain of Streptoverticillium cinnamoneum produced a peptide antibiotic named lanthiopeptin, which contained four unusual amino acids, erythro-beta-hydroxyaspartic acid, mesolanthionine, threo-beta-methyllanthionine and lysinoalanine. Lanthiopeptin showed antiviral activity against herpes simplex virus type 1 KOS strain infection in Vero cells by

A novel membrane protein, Ros3p, is required for phospholipid translocation across the plasma membrane in Saccharomyces cerevisiae.

Utako Kato et al.

The Journal of biological chemistry, 277(40), 37855-37862 (2002-07-23)

Ro09-0198 (Ro) is a tetracyclic peptide antibiotic that binds specifically to phosphatidylethanolamine (PE) and causes cytolysis. To investigate the molecular basis of transbilayer movement of PE in biological membranes, we have isolated a series of budding yeast mutants that are

Hemolytic activity of a cyclic peptide Ro09-0198 isolated from Streptoverticillium.

S Y Choung et al.

Biochimica et biophysica acta, 940(2), 171-179 (1988-05-24)

Ro09-0198, a cyclic peptide isolated from culture filtrates of Streptoverticillium griseoverticillatum, induced lysis of erythrocytes. Preincubation of the peptide with phosphatidylethanolamine reduced the hemolytic activity, whereas other phospholipids present in erythrocytes in nature had no effect. A study of the

Involvement of Golgi-associated retrograde protein complex in the recycling of the putative Dnf aminophospholipid flippases in yeast.

Keiko Takagi et al.

Biochemical and biophysical research communications, 417(1), 490-494 (2011-12-20)

It is widely accepted that phosphatidylethanolamine (PE) is enriched in the cytosolic leaflet of the eukaryotic plasma membranes. To identify genes involved in the establishment and regulation of the asymmetric distribution of PE on the plasma membrane, we screened the

Nine post-translational modifications during the biosynthesis of cinnamycin

O?kesli A, et al.

Journal of the American Chemical Society, 133(34), 13753-13760 (2011)

An essential role for a membrane lipid in cytokinesis. Regulation of contractile ring disassembly by redistribution of phosphatidylethanolamine.

K Emoto et al.

The Journal of cell biology, 149(6), 1215-1224 (2000-06-13)

Phosphatidylethanolamine (PE) is a major membrane phospholipid that is mainly localized in the inner leaflet of the plasma membrane. We previously demonstrated that PE was exposed on the cell surface of the cleavage furrow during cytokinesis. Immobilization of cell surface

Effects of docosahexaenoic and arachidonic acids on the synthesis and distribution of aminophospholipids during neuronal differentiation of PC12 cells.

A Ikemoto et al.

Archives of biochemistry and biophysics, 364(1), 67-74 (1999-03-24)

We have shown previously that docosahexaenoic acid (DHA) promotes and arachidonic acid (AA) suppresses neurite outgrowth of PC12 cells induced by nerve growth factor (NGF) and that incorporation of [3H]ethanolamine into phosphatidylethanolamine (PE) is suppressed in PC12 cells by AA

Stimulation of sodium transport by duramycin in cultured human colonic epithelia.

M Roberts et al.

The Journal of pharmacology and experimental therapeutics, 259(3), 1050-1058 (1991-12-01)

Effects of two peptide antibiotics, duramycin and Ro 09-0198, on ion transport in cultured human colonic epithelia were investigated. Both peptides acted on the apical face of epithelial monolayers, causing an increase in ion transport measured as short circuit current.

Capacitation induces cyclic adenosine 3',5'-monophosphate-dependent, but apoptosis-unrelated, exposure of aminophospholipids at the apical head plasma membrane of boar sperm cells.

B M Gadella et al.

Biology of reproduction, 67(1), 340-350 (2002-06-25)

The capacitating agent bicarbonate/CO(2) has been shown to induce profound changes in the architecture and dynamics within the sperm's plasma membrane lipid bilayer via a cAMP-dependent protein phosphorylation signaling pathway. Here we have investigated the effect of bicarbonate on surface

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