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关键词:'C5533'
显示 1-30 共 321 条结果 关于 "C5533" 范围 论文
Daniel J Shiwarski et al.
Molecular biology of the cell, 30(5), 680-690 (2019-01-03)
The delta opioid receptor (DOR), a physiologically relevant prototype for G protein-coupled receptors, is retained in intracellular compartments in neuronal cells. This retention is mediated by a nerve growth factor (NGF)-regulated checkpoint that delays the export of DOR from the
V K Il'in et al.
Vestnik Rossiiskoi akademii meditsinskikh nauk, (2)(2), 56-62 (2013-07-04)
Dysbiotic shifts in intestinal and pharyngeal microflora were studied in 22 normal volunteers in 9-, 14-, 105- and 520-d chamber experiments simulating some of the spaceflight factors. Two preparations were administered to prevent pharyngeal and intestinal dysbiosis: oral dry probiotic
Reply: To PMID 23347371.
Harsha Nagaraj et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 29(6), 377-377 (2013-07-03)
Taisuke Yoshimoto et al.
Biochemical and biophysical research communications, 455(3-4), 251-255 (2014-12-03)
Vinculin regulates a variety of cellular functions partly through stabilization of tumor suppressor PTEN. In order to study the role of vinculin in tumor progression other than PTEN stabilization, vinculin was knocked down in PTEN-deficient squamous cell carcinoma HSC-4 cells.
L Du et al.
Poultry science, 93(4), 989-1000 (2014-04-08)
Gelatins were extracted from mechanically separated turkey meat following 2 different approaches. The first method was based on a 2-stage batch extraction at 50 and 60°C, respectively, whereas the second method consisted of recovering gelatin from a collagen biomass obtained
Iosif Pediaditakis et al.
iScience, 25(8), 104813-104813 (2022-08-20)
Species differences in brain and blood-brain barrier (BBB) biology hamper the translation of findings from animal models to humans, impeding the development of therapeutics for brain diseases. Here, we present a human organotypic microphysiological system (MPS) that includes endothelial-like cells
Manuel Rogg et al.
Cells, 12(13) (2023-07-14)
Glomerular disease due to podocyte malfunction is a major factor in the pathogenesis of chronic kidney disease. Identification of podocyte-specific signaling pathways is therefore a prerequisite to characterizing relevant disease pathways and developing novel treatment approaches. Here, we employed loss
Gary Mok et al.
International journal of radiation oncology, biology, physics, 90(2), 278-288 (2014-10-12)
Dose-escalated radiation therapy for localized prostate cancer improves disease control but is also associated with worse rectal toxicity. A spacer placed between the prostate and rectum can be used to displace the anterior rectal wall outside of the high-dose radiation
Scapular dyskinesis is detrimental to shoulder tendon properties and joint mechanics in a rat model.
Katherine E Reuther et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 32(11), 1436-1443 (2014-07-30)
Shoulder tendon injuries are frequently seen in the presence of abnormal scapular motion, termed scapular dyskinesis. The cause and effect relationship between scapular dyskinesis and shoulder injury has not been directly defined. We developed and used an animal model to
Vichuda Charoensaensuk et al.
Antioxidants (Basel, Switzerland), 11(4) (2022-04-24)
We recently reported that the periodontopathic bacteria Porphyromonas gingivalis (P. gingivalis) initiates an inflammatory cascade that disrupts the balance of reactive oxygen species (ROS), resulting in apoptotic cell death in brain endothelial cells. An extract from Polygonum multiflorum Thunb., 2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside
Assaf Dotan et al.
Experimental eye research, 127, 190-195 (2014-08-12)
Our study demonstrates the effect of scleral cross-linking using riboflavin and ultraviolet-A radiation on the development of axial myopia in a rabbit model. Axial length of the eyeball was measured by A-scan ultrasound in 22 New Zealand white rabbits aged
Eric Y Chang et al.
AJR. American journal of roentgenology, 202(4), W376-W378 (2014-03-26)
The anisotropic fibrous structure of collagen can significantly affect MRI signal intensity. Use of this magic angle effect as a contrast mechanism has been previously termed "dipolar anisotropy fiber imaging." The goal of this pilot study was to use a
Carolina P Bernardes et al.
Peptides, 104, 24-34 (2018-04-24)
Venom small peptides that target neurotrophin receptors might be beneficial in neurodegeneration, including Parkinsońs disease (PD). Their small size, ease of synthesis, structural stability and target selectivity make them important tools to overcome the limitations of endogenous neurotrophins as therapeutic
Liang Zhang et al.
Toxicology and applied pharmacology, 283(1), 50-56 (2015-01-15)
An abnormal high mobility group box 1 (HMGB1) activation and a decrease in receptor for advanced glycation end-product (RAGE) play a key role in the pathogenesis of pulmonary fibrosis. Protocatechuic aldehyde (PA) is a naturally occurring compound, which is extracted
Bassam Felipe Mogharbel et al.
Molecules (Basel, Switzerland), 27(9) (2022-05-15)
Background: Parkinson's disease (PD) is the second most common age-related neurodegenerative disorder. Levodopa (L-DOPA) remains the gold-standard drug available for treating PD. Curcumin has many pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anti-amyloid, and antitumor properties. Copolymers composed of Poly (ethylene
Uchenna Emechebe et al.
Data in brief, 38, 107343-107343 (2021-09-17)
Cardiac endothelial cells respond to both ischemia and therapeutic ultrasound; the proteomic changes underlying these responses are unknown. This data article provides raw and processed data resulting from our global, unbiased phosphoproteomics investigation conducted on primary mouse cardiac endothelial cells
R K Dutta et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 142, 112090-112090 (2021-09-01)
MicroRNAs play an important role in health and disease. TGF-β signaling, upregulated by HIV Tat, and in chronic airway diseases and smokers upregulates miR-145-5p to suppress cystic fibrosis transmembrane conductance regulator (CFTR). CFTR suppression in chronic airway diseases like Cystic
Piotr Siupka et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37(7), 2598-2613 (2017-03-25)
Brain capillary endothelium mediates the exchange of nutrients between blood and brain parenchyma. This barrier function of the brain capillaries also limits passage of pharmaceuticals from blood to brain, which hinders treatment of several neurological disorders. Receptor-mediated transport has been
Eugene J Sato et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 32(9), 1111-1116 (2014-05-20)
Rotator cuff tears can cause irreversible changes (e.g., fibrosis) to the structure and function of the injured muscle(s). Fibrosis leads to increased muscle stiffness resulting in increased tension at the rotator cuff repair site. This tension influences repairability and healing
Steinunn Sara Helgudottir et al.
Molecular neurobiology, 57(8), 3526-3539 (2020-06-17)
Ferroportin plays an essential role for iron transport through the blood-brain barrier (BBB), which is formed by brain capillary endothelial cells (BCECs). To maintain the integrity of the BBB, the BCECs gain support from pericytes and astrocytes, which together with
Tirosh Shapira et al.
bioRxiv : the preprint server for biology (2021-05-12)
The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced against emerging variants of concern (VOCs) 1,2 . Development of host-directed therapeutics and prophylactics could limit
Meret Schmidhauser et al.
Stem cell reviews and reports (2022-07-19)
Two different types of epithelial cells constitute the inner surface of the endometrium. While luminal epithelial cells line the uterine cavity and build the embryo-maternal contact zone, glandular epithelial cells form tubular glands reaching deeply into the endometrial stroma. To
HSP90 modulates actin dynamics: inhibition of HSP90 leads to decreased cell motility and impairs invasion
Taiyab A and Rao CM
Biochimica et Biophysica Acta - Molecular Cell Research, 1813(1), 213-221 (2011)
Jianping Li et al.
Hypertension (Dallas, Tex. : 1979), 65(2), 328-334 (2014-11-19)
Estrogen regulation of myocardial chymase and chymase effects on cardiac remodeling are unknown. To test the hypothesis that estrogen prevents pressure overload-induced adverse cardiac remodeling by inhibiting mast cell (MC) chymase release, transverse aortic constriction or sham surgery was performed
Pseudorabies virus-induced expression and antiviral activity of type I or type III interferon depend on the type of infected epithelial cell.
Yin, et al.
Frontiers in Immunology, 13, 1016982-1016982 (2022)
Alexander H Nave et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(7), 1446-1458 (2014-05-17)
Pulmonary vascular remodeling, the pathological hallmark of pulmonary arterial hypertension, is attributed to proliferation, apoptosis resistance, and migration of vascular cells. A role of dysregulated matrix cross-linking and stability as a pathogenic mechanism has received little attention. We aimed to
Fabiano Ribeiro Cirano et al.
The Journal of oral implantology, 40(6), 655-659 (2014-12-17)
This study analyzed the role of recombinant human bone morphogenetic protein 2 (rhBMP-2) and recombinant human bone morphogenetic protein 7 (rhBMP-7) in the adhesion and differentiation of rat osteoblast-like (osteo-1) cells cultured on chemically modified titanium surfaces. Osteo-1 cells were
Jun Shimizu et al.
Biochemical and biophysical research communications, 456(2), 626-630 (2014-12-17)
Oral supplementation with collagen hydrolysate (CH) has been shown to improve the condition of the skin in humans and experimental animals. Several hydroxyproline-containing oligo-peptides were previously detected in human peripheral blood after the ingestion of CH, and the two dipeptides
Murali K Yanda et al.
American journal of physiology. Gastrointestinal and liver physiology, 318(1), G120-G129 (2019-11-12)
Clostridiumdifficile (CD) is a common pathogen that causes severe gastrointestinal inflammatory diarrhea in patients undergoing antibiotic therapy. Its virulence derives from two toxins, toxin CD, A and B (TcdA and TcdB) (Borriello et al. Rev Infect Dis 12, Suppl 2:
Konrad Schwefel et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(7), 9018-9033 (2020-06-10)
Loss-of-function variants in CCM1/KRIT1, CCM2, and CCM3/PDCD10 are associated with autosomal dominant cerebral cavernous malformations (CCMs). CRISPR/Cas9-mediated CCM3 inactivation in human endothelial cells (ECs) has been shown to induce profound defects in cell-cell interaction as well as actin cytoskeleton organization.
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