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V K Il'in et al.
Vestnik Rossiiskoi akademii meditsinskikh nauk, (2)(2), 56-62 (2013-07-04)
Dysbiotic shifts in intestinal and pharyngeal microflora were studied in 22 normal volunteers in 9-, 14-, 105- and 520-d chamber experiments simulating some of the spaceflight factors. Two preparations were administered to prevent pharyngeal and intestinal dysbiosis: oral dry probiotic
Iosif Pediaditakis et al.
iScience, 25(8), 104813-104813 (2022-08-20)
Species differences in brain and blood-brain barrier (BBB) biology hamper the translation of findings from animal models to humans, impeding the development of therapeutics for brain diseases. Here, we present a human organotypic microphysiological system (MPS) that includes endothelial-like cells
Manuel Rogg et al.
Cells, 12(13) (2023-07-14)
Glomerular disease due to podocyte malfunction is a major factor in the pathogenesis of chronic kidney disease. Identification of podocyte-specific signaling pathways is therefore a prerequisite to characterizing relevant disease pathways and developing novel treatment approaches. Here, we employed loss
Carolina P Bernardes et al.
Peptides, 104, 24-34 (2018-04-24)
Venom small peptides that target neurotrophin receptors might be beneficial in neurodegeneration, including Parkinsońs disease (PD). Their small size, ease of synthesis, structural stability and target selectivity make them important tools to overcome the limitations of endogenous neurotrophins as therapeutic
L Du et al.
Poultry science, 93(4), 989-1000 (2014-04-08)
Gelatins were extracted from mechanically separated turkey meat following 2 different approaches. The first method was based on a 2-stage batch extraction at 50 and 60°C, respectively, whereas the second method consisted of recovering gelatin from a collagen biomass obtained
Liang Zhang et al.
Toxicology and applied pharmacology, 283(1), 50-56 (2015-01-15)
An abnormal high mobility group box 1 (HMGB1) activation and a decrease in receptor for advanced glycation end-product (RAGE) play a key role in the pathogenesis of pulmonary fibrosis. Protocatechuic aldehyde (PA) is a naturally occurring compound, which is extracted
Serafim Tsitsilonis et al.
Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons, 20(2), 94-99 (2014-05-07)
The effect of anabolic androgenic steroids on tendons has not yet been fully elucidated. Aim of the present study was the evaluation of the impact of anabolic androgenic steroids on the biomechanical and histological characteristics of Achilles tendons. Twenty-four male
Assaf Dotan et al.
Experimental eye research, 127, 190-195 (2014-08-12)
Our study demonstrates the effect of scleral cross-linking using riboflavin and ultraviolet-A radiation on the development of axial myopia in a rabbit model. Axial length of the eyeball was measured by A-scan ultrasound in 22 New Zealand white rabbits aged
Daniel J Shiwarski et al.
Molecular biology of the cell, 30(5), 680-690 (2019-01-03)
The delta opioid receptor (DOR), a physiologically relevant prototype for G protein-coupled receptors, is retained in intracellular compartments in neuronal cells. This retention is mediated by a nerve growth factor (NGF)-regulated checkpoint that delays the export of DOR from the
Eric Y Chang et al.
AJR. American journal of roentgenology, 202(4), W376-W378 (2014-03-26)
The anisotropic fibrous structure of collagen can significantly affect MRI signal intensity. Use of this magic angle effect as a contrast mechanism has been previously termed "dipolar anisotropy fiber imaging." The goal of this pilot study was to use a
Vichuda Charoensaensuk et al.
Antioxidants (Basel, Switzerland), 11(4) (2022-04-24)
We recently reported that the periodontopathic bacteria Porphyromonas gingivalis (P. gingivalis) initiates an inflammatory cascade that disrupts the balance of reactive oxygen species (ROS), resulting in apoptotic cell death in brain endothelial cells. An extract from Polygonum multiflorum Thunb., 2,3,5,4'-Tetrahydroxystilbene-2-O-β-glucoside
Scapular dyskinesis is detrimental to shoulder tendon properties and joint mechanics in a rat model.
Katherine E Reuther et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 32(11), 1436-1443 (2014-07-30)
Shoulder tendon injuries are frequently seen in the presence of abnormal scapular motion, termed scapular dyskinesis. The cause and effect relationship between scapular dyskinesis and shoulder injury has not been directly defined. We developed and used an animal model to
Matthias Imboden et al.
Nature communications, 10(1), 834-834 (2019-02-21)
Systematic investigations of the effects of mechano-electric coupling (MEC) on cellular cardiac electrophysiology lack experimental systems suitable to subject tissues to in-vivo like strain patterns while simultaneously reporting changes in electrical activation. Here, we describe a self-contained motor-less device (mechano-active
Amanda K Hare et al.
Biochemical and biophysical research communications, 456(1), 257-261 (2014-12-03)
The hyaluronan receptor for endocytosis (HARE), or Stabilin-2, is the mammalian endocytic clearance receptor for HA, heparin, advanced glycation end-products, acetylated and oxidized low-density lipoproteins and collagen N-terminal propeptides. This large 2551 amino acid receptor is encoded by a gene
Thomas Colunga et al.
Cell reports, 26(10), 2566-2579 (2019-03-07)
In this report we describe a human pluripotent stem cell-derived vascular progenitor (MesoT) cell of the mesothelium lineage. MesoT cells are multipotent and generate smooth muscle cells, endothelial cells, and pericytes and self-assemble into vessel-like networks in vitro. MesoT cells transplanted
Utilization of commercial collagens for preparing well-differentiated human beta cells for confocal microscopy.
Brennecke, et al.
Frontiers in Endocrinology, 14, 1187216-1187216 (2023)
Hillary C Valley et al.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 18(4), 476-483 (2018-12-20)
Assessment of approved drugs and developmental drug candidates for rare cystic fibrosis (CF)-causing variants of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) requires abundant material from relevant models. Isogenic cell lines harboring CFTR variants in the native genomic context were
Luigi Martino et al.
Nucleic acids research, 43(1), 645-660 (2014-12-10)
The La-related proteins (LARPs) form a diverse group of RNA-binding proteins characterized by the possession of a composite RNA binding unit, the La module. The La module comprises two domains, the La motif (LaM) and the RRM1, which together recognize
Piotr Siupka et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37(7), 2598-2613 (2017-03-25)
Brain capillary endothelium mediates the exchange of nutrients between blood and brain parenchyma. This barrier function of the brain capillaries also limits passage of pharmaceuticals from blood to brain, which hinders treatment of several neurological disorders. Receptor-mediated transport has been
Self-organizing stem cells.
Natalie de Souza
Nature methods, 11(1), 31-31 (2014-02-14)
Débora Lopes Salles Scheffel et al.
American journal of dentistry, 27(6), 330-334 (2015-02-25)
To evaluate the influence of the time elapsed between the application and photoactivation of Single Bond 2 (SB) on microtensile bond strength (μTBS) and collagen exposure at the adhesive interface produced in the presence of intrapulp pressure. Dentin occlusal surfaces
Richard P Redvers et al.
Methods in molecular biology (Clifton, N.J.), 289, 15-22 (2004-10-27)
In vitro cell culture is a necessary prerequisite in acquiring a thorough understanding of the biology and behavior of the cells of interest and is a critical first step in developing cellular therapies. Somatic stem cell biology is concerned with
Laura P Frazão et al.
Biomolecules, 10(9) (2020-08-23)
Although some placenta-derived products are already used for tissue regeneration, the human chorion membrane (HCM) alone has been poorly explored. In fact, just one study uses decellularized HCM (dHCM) with native tissue architecture (i.e., without extracellular matrix (ECM) suspension creation)
Tirosh Shapira et al.
bioRxiv : the preprint server for biology (2021-05-12)
The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced against emerging variants of concern (VOCs) 1,2 . Development of host-directed therapeutics and prophylactics could limit
Bassam Felipe Mogharbel et al.
Molecules (Basel, Switzerland), 27(9) (2022-05-15)
Background: Parkinson's disease (PD) is the second most common age-related neurodegenerative disorder. Levodopa (L-DOPA) remains the gold-standard drug available for treating PD. Curcumin has many pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, anti-amyloid, and antitumor properties. Copolymers composed of Poly (ethylene
Winfried Neuhaus et al.
Frontiers in molecular neuroscience, 10, 149-149 (2017-06-13)
The blood-brain barrier (BBB) is damaged during ischemic insults such as traumatic brain injury or stroke. This contributes to vasogenic edema formation and deteriorate disease outcomes. Enormous efforts are pursued to understand underlying mechanisms of ischemic insults and develop novel
A B Shori et al.
Pakistan journal of biological sciences : PJBS, 15(24), 1160-1167 (2013-06-13)
There is an increasing demand of functional foods in developed countries. Yogurt plays an important role in the management of blood pressure. Several bioactive peptides isolated from Allium sativum or fish collagen have shown antihypertensive activity. Thus, in the present
Alexander H Nave et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(7), 1446-1458 (2014-05-17)
Pulmonary vascular remodeling, the pathological hallmark of pulmonary arterial hypertension, is attributed to proliferation, apoptosis resistance, and migration of vascular cells. A role of dysregulated matrix cross-linking and stability as a pathogenic mechanism has received little attention. We aimed to
Fabiano Ribeiro Cirano et al.
The Journal of oral implantology, 40(6), 655-659 (2014-12-17)
This study analyzed the role of recombinant human bone morphogenetic protein 2 (rhBMP-2) and recombinant human bone morphogenetic protein 7 (rhBMP-7) in the adhesion and differentiation of rat osteoblast-like (osteo-1) cells cultured on chemically modified titanium surfaces. Osteo-1 cells were
Jerome P Sullivan
Primary dental journal, 2(4), 49-55 (2014-01-29)
In the front of the mouth, the treatment of such a bony defect carries the risk of a poor aesthetic outcome. High patient expectations, combined with the difficulty of recreating a large mass of viable bone in which a dental
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