C5614

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关键词:'C5614'

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Non-viral environmental risk factors for nasopharyngeal carcinoma: a systematic review.

Wei-Hua Jia et al.

Seminars in cancer biology, 22(2), 117-126 (2012-02-09)

This review aims to systematically summarize the epidemiological studies on nasopharyngeal carcinoma (NPC) conducted over the past half century, covering descriptive epidemiological studies and reports on non-viral risk factors. Multiple lines of epidemiologic evidence for established risk factors are systematically

Time- and NADPH-dependent inhibition of cytochrome P450 3A4 by the cyclopentapeptide cilengitide: significance of the guanidine group and accompanying spectral changes.

Mirza Bojić et al.

Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1438-1446 (2014-07-06)

Cilengitide is a stable cyclic pentapeptide containing an Arg-Gly-Asp motif responsible for selective binding to αVβ3 and αVβ5 integrins. The candidate drug showed unexpected inhibition of cytochrome P450 (P450) 3A4 at high concentrations, that is, a 15-mM concentration caused attenuation

Carbon monoxide releasing molecule 401 (CORM-401) modulates phase I metabolism of xenobiotics.

Moritz Walter et al.

Toxicology in vitro : an international journal published in association with BIBRA, 59, 215-220 (2019-04-21)

Next to its well-studied toxicity, carbon monoxide (CO) is recognized as a signalling molecule in various cellular processes. Thus, CO-releasing molecules (CORMs) are of considerable interest for basic research and drug development. Aim of the present study was to investigate

Cytochrome p450-mediated metabolic activation of diosbulbin B.

Dongju Lin et al.

Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1727-1736 (2014-07-16)

Diosbulbin B (DIOB), a furan-containing diterpenoid lactone, is the most abundant component of Dioscorea bulbifera L. (DB), a traditional Chinese medicine herb. Administration of purified DIOB or DB extracts has been reported to cause liver injury in animals. The mechanisms

SCYPPred: a web-based predictor of SNPs for human cytochrome P450.

Li Li et al.

Protein and peptide letters, 19(1), 57-61 (2011-09-17)

Human cytochrome P450(CYP 450) enzymes mediate over 60% of the phase I-dependent metabolism of clinical drugs. They are also known for the polymorphism functions that have significant impacts on the enzyme activities. In this study, a web-server called SCYPPred was

Dynamics and hydration of the active sites of mammalian cytochromes P450 probed by molecular dynamics simulations.

Tereza Hendrychova et al.

Current drug metabolism, 13(2), 177-189 (2012-01-03)

The flexibility, active site volume, solvation, and access path dynamics of six metabolically active mammalian cytochromes P450 (human 2A6, 2C9, 2D6, 2E1, 3A4 and rabbit 2B4) are extensively studied using molecular dynamics (MD) simulations. On average, the enzymes' overall structures

In vitro metabolism of 20(R)-25-methoxyl-dammarane-3, 12, 20-triol from Panax notoginseng in human, monkey, dog, rat, and mouse liver microsomes.

Xiangrong Zhang et al.

PloS one, 9(4), e94962-e94962 (2014-04-17)

The present study characterized in vitro metabolites of 20(R)-25-methoxyl-dammarane-3β, 12β, 20-triol (20(R)-25-OCH3-PPD) in mouse, rat, dog, monkey and human liver microsomes. 20(R)-25-OCH3-PPD was incubated with liver microsomes in the presence of NADPH. The reaction mixtures and the metabolites were identified

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