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Evgenia Dobrinskikh et al.
American journal of physiology. Renal physiology, 306(9), F941-F951 (2014-02-28)
The renal glomerulus forms a selective filtration barrier that allows the passage of water, ions, and small solutes into the urinary space while restricting the passage of cells and macromolecules. The three layers of the glomerular filtration barrier include the
Izabella Kovacs et al.
The New phytologist, 208(3), 860-872 (2015-06-23)
Nitric oxide (NO) is a ubiquitous signaling molecule involved in a wide range of physiological and pathophysiological processes in animals and plants. Although its significant influence on plant immunity is well known, information about the exact regulatory mechanisms and signaling
Jae-Sung Kim et al.
Oncology reports, 33(4), 1775-1782 (2015-01-31)
In the present study, we examined the anticancer properties of berberine in KB oral cancer cells with a specific focus on its cellular mechanism. Berberine did not affect the cell viability of the primary human normal oral keratinocytes that were
Ronak Savla et al.
Pharmaceutical research, 31(12), 3487-3502 (2014-06-13)
Design and synthesis of a tumor responsive nanoparticle-based system for imaging and treatment of various cancers. Manganese oxide nanoparticles (Mn3O4 NPs) were synthesized and modified with LHRH targeting peptide or anti-melanoma antibodies (cancer targeting moieties) and a MMP2 cleavable peptide
Xingsheng Li et al.
Biochimica et biophysica acta, 1852(12), 2700-2705 (2015-10-03)
Primary Hyperoxaluria Type 3 is a recently discovered form of this autosomal recessive disease that results from mutations in the gene coding for 4-hydroxy-2-oxoglutarate aldolase (HOGA1). This enzyme is one of the 2 unique enzymes in the hydroxyproline catabolism pathway.
Weiqi Dai et al.
Oncotarget, 6(15), 13703-13717 (2015-05-06)
Cancer cells exhibit an altered metabolic phenotype known as the aerobic glycolysis. The expression of HK2 changes the metabolic phenotype of cells to support cancerous growth. In the present study, we investigated the inhibitory effect of resveratrol on HK2 expression
Jackeline L Pereira et al.
PloS one, 9(5), e98234-e98234 (2014-06-01)
The present study was carried out to evaluate the ability of Trichoderma harzianum (ALL 42-isolated from Brazilian Cerrado soil) to promote common bean growth and to modulate its metabolism and defense response in the presence or absence of the phytopathogenic
Takayuki Ueno et al.
PloS one, 10(6), e0130206-e0130206 (2015-06-18)
The hypopharyngeal glands (HPGs) of worker honeybees undergo physiological changes along with the age-dependent role change from nursing to foraging: nurse bee HPGs secrete mainly major royal jelly proteins, whereas forager HPGs secrete mainly α-glucosidase III, which converts the sucrose
Siddharth Manvati et al.
Gene, 567(2), 217-224 (2015-05-07)
MicroRNAs the small (18-22 in length) noncoding RNA molecules are negative regulators of gene expression, modulating biological processes of cell differentiation, survival and death. The latter two phenomena are critical in tumour biology. We provide here the results of human
Kaitlin C Murphy et al.
Cell and tissue research, 357(1), 91-99 (2014-05-02)
Mesenchymal stem cells (MSCs) have great therapeutic potential for the repair of nonhealing bone defects, because of their proliferative capacity, multilineage potential, trophic factor secretion and lack of immunogenicity. However, a major challenge to the translation of cell-based therapies into
Majid Motovali-Bashi et al.
Avicenna journal of medical biotechnology, 7(4), 173-178 (2015-11-26)
The risk of developing female infertility has been associated with gene polymorphisms that decrease the activity of enzymes involved in systemic Oxidative Stress (OS). In this study, PON1 L55M polymorphism for association with susceptibility to infertility was investigated among Iranian
E van den Bogaart et al.
Parasite immunology, 37(9), 453-469 (2015-07-16)
Functional impairment of dendritic cells (DCs) is part of a survival strategy evolved by Leishmania and Plasmodium parasites to evade host immune responses. Here, the effects of co-exposing human monocyte-derived DCs to Leishmania donovani promastigotes and Plasmodium falciparum-infected erythrocytes were investigated. Co-stimulation
Matthias R Meyer et al.
Scientific reports, 4, 7564-7564 (2014-12-24)
Coronary atherosclerosis and myocardial infarction in postmenopausal women have been linked to inflammation and reduced nitric oxide (NO) formation. Natural estrogen exerts protective effects on both processes, yet also displays uterotrophic activity. Here, we used genetic and pharmacologic approaches to
Sabrina Waibel et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 37(5), 1973-1982 (2015-11-20)
The antiretroviral protease inhibitor saquinavir is used for the treatment of HIV infections. Effects of saquinavir include induction of apoptosis, the suicidal death of nucleated cells. Saquinavir treatment may further lead to anemia. In theory, anemia could result from accelerated
Marnie L Fusco et al.
PLoS pathogens, 11(6), e1005016-e1005016 (2015-06-27)
The filoviruses, which include the marburg- and ebolaviruses, have caused multiple outbreaks among humans this decade. Antibodies against the filovirus surface glycoprotein (GP) have been shown to provide life-saving therapy in nonhuman primates, but such antibodies are generally virus-specific. Many
Luis Valmor Portela et al.
Neurochemical research, 40(3), 514-523 (2014-12-11)
Metformin (Met), which is an insulin-sensitizer, decreases insulin resistance and fasting insulin levels. The precise molecular target of Met is unknown; however, several reports have shown an inhibitory effect on mitochondrial complex I of the electron transport chain (ETC), which
D R J Arachchillage et al.
Journal of thrombosis and haemostasis : JTH, 13(7), 1264-1273 (2015-04-09)
Rivaroxaban can affect lupus anticoagulant (LA) testing and antiphospholipid antibodies (aPL) may interfere with the anticoagulant action of rivaroxaban. To establish the influence of rivaroxaban on LA detection and of aPL on the anticoagulant action of rivaroxaban. Rivaroxaban and 52
Nikolas M Stasulli et al.
mBio, 6(5), e01530-e01515 (2015-10-16)
During pneumonic plague, the bacterium Yersinia pestis elicits the development of inflammatory lung lesions that continue to expand throughout infection. This lesion development and persistence are poorly understood. Here, we examine spatially distinct regions of lung lesions using laser capture
Kenji Uno et al.
Nature communications, 6, 7940-7940 (2015-08-14)
Metabolism is coordinated among tissues and organs via neuronal signals. Levels of circulating amino acids (AAs), which are elevated in obesity, activate the intracellular target of rapamycin complex-1 (mTORC1)/S6kinase (S6K) pathway in the liver. Here we demonstrate that hepatic AA/mTORC1/S6K
Katarzyna Pietraszek et al.
FEBS letters, 588(23), 4319-4324 (2014-10-12)
We previously showed that lumican regulates MMP-14 expression. The aim of this study was to compare the effect of lumican and decorin on MMP-14 activity. In contrast to decorin, the glycosylated form of lumican was able to significantly decrease MMP-14
Abd El-Shafey I Ahmed et al.
Carbohydrate polymers, 92(2), 1934-1941 (2013-02-13)
New N-halamines (I-Cl and II-Cl) based on cellulose extracted from rice straw have been evaluated in single and multistage filtration systems against bacteria and viruses. Escherichia coli and Staphylococcus aureus were used as examples of Gram-negative and Gram-positive bacteria respectively
Evandro Martins et al.
Journal of microencapsulation, 32(1), 86-95 (2014-11-22)
A promising technique for oil encapsulation in Ca-alginate capsules by inverse gelation was proposed by Abang et al. This method consists of emulsifying calcium chloride solution in oil and then adding it dropwise in an alginate solution to produce Ca-alginate
H Ono et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(10), 1396-1407 (2014-07-22)
Although opioids induce intestinal muscle contraction and provoke constipation, the intestinal region(s) that contribute to the constipation have remained unclear. We report here a region-specific response of intestinal muscle contraction to morphine and its correlation with in vivo constipation. Regions
Xiao Sun et al.
Reproduction (Cambridge, England), 148(6), 559-568 (2014-09-05)
In our previous study, we have demonstrated that the epithelial sodium channel (ENaC) mediates the embryo-derived signals leading to the activation of CREB and upregulation of cyclooxygenase type 2 (COX2) required for embryo implantation. This study aims to investigate whether
Xiaodong Weng et al.
International urology and nephrology, 47(7), 1067-1074 (2015-05-06)
The majority of renal ischemic/reperfusion (I/R) and ischemic postconditioning (IPO) studies have been based on animal models. To gain mechanistic insights into ischemic postconditioning-induced alterations at the cell level, a novel in vitro model of I/R and IPO is set
Chien-Chun Li et al.
Nutrition and cancer, 67(5), 771-782 (2015-05-15)
Urokinase plasminogen activator (uPA) and matrix metalloproteinase 9 (MMP-9) play crucial roles in tumor metastasis. Despite the well-known anticancer role of docosa-hexaenoic acid (DHA), its specific effect on ErbB2-mediated breast cancer metastasis is not fully clarified. In this study, we
Simon Hohenester et al.
Liver international : official journal of the International Association for the Study of the Liver, 34(8), 1224-1231 (2013-10-30)
Hydrophobic bile salts such as glycochenodeoxycholate (GCDC) accumulate in cholestatic liver disease and induce hepatocellular apoptosis, promoting profibrotic signalling. The tissue microenvironment is an integral player in cellular pathophysiology, but it is not routinely incorporated into laboratory studies. Tissue oxygen
C Harkin et al.
Journal of applied microbiology, 118(4), 954-965 (2015-02-04)
To isolate bacteria from soil for microbial pretreatment of brown crab (Cancer pagurus) shell waste and the production of chitin. Isolates were screened for protease enzymes and acid production in order to facilitate the removal of protein and calcium carbonate
Claudia Karus et al.
Channels (Austin, Tex.), 9(4), 200-208 (2015-06-04)
Recently, we established that recurrent activity evokes network sodium oscillations in neurons and astrocytes in hippocampal tissue slices. Interestingly, metabolic integrity of astrocytes was essential for the neurons' capacity to maintain low sodium and to recover from sodium loads, indicating
Maria I Georgi et al.
Pflugers Archiv : European journal of physiology, 466(9), 1689-1712 (2013-11-19)
It has long been established that the absorption of short-chain fatty acids (SCFA) across epithelia stimulates sodium proton exchange. The apically released protons are not available as countercations for the basolateral efflux of SCFA anions and a suitable transport model
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