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Y S Lin et al.
Journal of neuroendocrinology, 24(3), 477-488 (2011-12-17)
Stress exerts profound inhibitory effects on reproductive function by suppressing the pulsatile release of gonadotrophin-releasing hormone (GnRH) and therefore luteinising hormone (LH). This effect is mediated in part via the corticotrophin-releasing factor (CRF) system, although another potential mechanism is via
Stephanie C Gantz et al.
Neuron, 78(5), 807-812 (2013-06-15)
G protein-coupled receptors (GPCRs) affect many physiological processes by modulating both intrinsic membrane conductances and synaptic transmission. This study describes spontaneous miniature inhibitory postsynaptic currents mediated by vesicular dopamine release acting locally on metabotropic D2 receptors leading to the activation
Kristin L Hillman et al.
Epilepsy research, 84(2-3), 97-109 (2009-02-10)
The endogenous catecholamine norepinephrine (NE) exhibits anti-epileptic properties, however it is not well understood which adrenergic receptor (AR) mediates this effect. The aim of this study was to investigate alpha(1)-adrenergic receptor activation in region CA1 of the hippocampus, a subcortical
Wouter Koek et al.
The Journal of pharmacology and experimental therapeutics, 330(3), 876-883 (2009-07-01)
Gamma-hydroxybutyrate (GHB) is used therapeutically and recreationally. The mechanism by which GHB produces its therapeutic and recreational effects is not entirely clear, although GABA(B) receptors seem to play an important role. This role could be complex, because there are indications
Fan Xiao et al.
Digestive diseases and sciences, 55(2), 261-267 (2009-02-21)
Angiotensin II (Ang II) plays an important role in the activation of hepatic stellate cells (HSCs). In this study it was found that expression of the GABA(B) receptor was elevated in HSCs treated with Ang II. We attempted to elucidate
Yun Wang et al.
Autonomic neuroscience : basic & clinical, 152(1-2), 75-83 (2009-11-21)
GABA receptors in the nucleus tractus solitarius (NTS) are known to play an important role in the mediation/modulation of various cardiovascular/respiratory functions. Vagal afferent activation of these neurones usually evokes an initial excitation followed by a long lasting inhibition. The
Junsung Woo et al.
Experimental neurobiology, 28(1), 30-42 (2019-03-12)
The neuronal activity-dependent change in the manner in which light is absorbed or scattered in brain tissue is called the intrinsic optical signal (IOS), and provides label-free, minimally invasive, and high spatial (~100 µm) resolution imaging for visualizing neuronal activity
P Mareš et al.
Physiological research, 61(3), 325-329 (2012-04-07)
Cortical epileptic foci elicited by local application of bicuculline methiodide represent a model of interictal epileptic activity with a transition into ictal phases. We studied a role of GABA-B receptors in this model using GABA-B receptor antagonist CGP35348 in adult
N G Bowery
Annual review of pharmacology and toxicology, 33, 109-147 (1993-01-01)
In conclusion, GABAB receptors appear to be of major importance in synaptic processing within the brain and are present at both post- and presynaptic sites. Their activation can hyperpolarize neurones and diminish neurotransmitter release from presynaptic terminals. We already know
Zhi-Ao Chen et al.
Cancer biology & medicine, 9(2), 90-98 (2013-05-22)
To investigate the roles of the γ-aminobutyric acid (GABA) in the metastasis of hepatocellular carcinoma (HCC) and to explore the potential of a novel therapeutic approach for the treatment of HCC. The expression levels of GABA receptor subunit genes in
Q Gillani et al.
BioMed research international, 2014, 295215-295215 (2014-05-08)
To study the effect of CGP 35348 on learning and memory in albino mice following hypoxia ischemia insult, 10 days old albino mice were subjected to right common carotid artery ligation followed by 8% hypoxia for 25 minutes. Following brain
Qi Zhang et al.
American journal of physiology. Heart and circulatory physiology, 297(5), H1837-H1844 (2009-09-15)
Angiotensin II (ANG II) increases GABA(B) receptor expression in neuronal cultures from the nucleus tractus solitarii (NTS). In the present study, the chronic effects of ANG II on GABA(B) receptor expression and activity were examined in the NTS of Sprague-Dawley
Miguel A Cortez et al.
Pediatric research, 65(5), 499-503 (2009-02-05)
Infantile spasms is a catastrophic childhood seizure disorder for which few animal models exist. Children with Down syndrome are highly susceptible to infantile spasms. The Ts65Dn mouse is a valid model for Down syndrome; therefore, we tested the hypothesis that
Cristina Romei et al.
Pharmacological research, 59(3), 154-159 (2009-01-13)
Glycine release and modulation of glycine exocytosis by presynaptic receptors have been rarely studied. We here investigate on the existence and the pharmacological profile of GABA(B) receptors regulating glycine release in mouse spinal cord and hippocampus. Synaptosomes were preincubated with
K R Delaney et al.
The European journal of neuroscience, 30(11), 2077-2088 (2010-02-05)
Synaptic responses resulting from stimulation of the main olfactory and vomeronasal (VN) nerves were measured in main and accessory olfactory bulb (AOB) of frog, Rana pipiens, to test the hypothesis that properties of these synapses would reflect the distinct differences
S Nimitvilai et al.
Neuroscience, 226, 29-39 (2012-09-19)
Neurons of the ventral tegmental area (VTA) are critical in the rewarding and reinforcing properties of drugs of abuse. Desensitization of VTA neurons to moderate extracellular concentrations of dopamine (DA) is dependent on protein kinase C (PKC) and intracellular calcium
Wouter Koek et al.
The Journal of pharmacology and experimental therapeutics, 335(1), 163-171 (2010-07-16)
In vivo effects of GABA(B) receptor-positive modulators suggest that they have therapeutic potential for treating central nervous system disorders such as anxiety, depression, and drug abuse. Although these effects generally are thought to be mediated by positive modulation of GABA(B)
S E Sander et al.
Neuroscience, 162(2), 423-430 (2009-05-12)
The GABA(B) receptor (GABA(B)R) agonist baclofen is known to have a beneficial potency in patients who suffer from dystonia, a neurological syndrome characterized by involuntary co-contractions of opposing muscles. The underlying mechanisms of this movement disorder are still unclear. Previous
GABAB receptor antagonists: from synthesis to therapeutic applications.
H Bittiger et al.
Trends in pharmacological sciences, 14(11), 391-394 (1993-11-01)
Wouter Koek et al.
The Journal of pharmacology and experimental therapeutics, 344(3), 553-560 (2013-01-01)
GABA(B) receptor-positive modulators are thought to have advantages as potential medications for anxiety, depression, and drug addiction. They may have fewer side effects than GABA(B) receptor agonists, because selective enhancement of activated receptors could have effects different from nonselective activation
Pavel Mareš
Epilepsy research, 92(2-3), 125-133 (2010-09-25)
Epileptic seizures activate not only excitatory but also inhibitory systems what results in an arrest of seizures. Our recent data indicate that GABAergic inhibition plays an important role in this process in cortically elicited seizures. We started to study the
Abigail J Houston et al.
European journal of pharmacology, 674(2-3), 327-331 (2011-12-07)
The effects of subcutaneous (s.c.) administration of the GABA(B) receptor agonist baclofen were investigated on primary drinking in rats. Baclofen (1-4 mg/kg) produced a dose-related reduction in cumulative water intake in 16 h water-deprived rats during the 120 min measurement
Madhu P Sirivelu et al.
Brain research, 1248, 107-114 (2008-11-19)
Interleukin-1beta (IL-1beta), a cytokine that is closely associated with inflammation and immune stress, is known to interfere with reproductive functions. Earlier studies have demonstrated that IL-1beta inhibits the luteinizing hormone (LH) surge during the afternoon of proestrus in female rats.
Guillermo Gonzalez-Burgos et al.
Journal of neurophysiology, 101(2), 533-547 (2008-12-17)
The plasma membrane GABA transporter GAT1 is thought to mediate uptake of synaptically released GABA. In the primate dorsolateral prefrontal cortex (DLPFC), GAT1 expression changes significantly during development and in schizophrenia. The consequences of such changes, however, are not well
Zhiyang Song et al.
Pain, 147(1-3), 241-248 (2009-10-20)
The aim of the present study was to examine the role of the spinal serotonergic system in the pain relieving effect of spinal cord stimulation (SCS) using a rat model of mononeuropathy. Tactile withdrawal thresholds, cold responses and heat withdrawal
H Sun et al.
Neuroscience, 160(1), 198-211 (2009-05-05)
In the inferior colliculus (IC), GABAergic inhibition mediated by GABA(A) receptors has been shown to play a significant role in regulating physiological responses, but little is known about the physiological role of GABA(B) receptors in IC neurons. In the present
Bin Luo et al.
Hearing research, 280(1-2), 157-165 (2011-06-15)
The medial geniculate body (MGB) receives ascending inputs from the inferior colliculus and descending inputs from the auditory cortex. In the present study, we intended to determine whether activation of presynaptic GABA(B) receptors modulates GABAergic and glutamatergic inputs to the
Chirag R Patel et al.
Frontiers in neurology, 5, 235-235 (2014-12-03)
Sodium salicylate (SS) is a widely used medication with side effects on hearing. In order to understand these side effects, we recorded sound-driven local-field potentials in a neural structure, the dorsal cortex of the inferior colliculus (ICd). Using a microiontophoretic
Clotilde Lecrux et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(27), 9836-9847 (2011-07-08)
The whisker-to-barrel cortex is widely used to study neurovascular coupling, but the cellular basis that underlies the perfusion changes is still largely unknown. Here, we identified neurons recruited by whisker stimulation in the rat somatosensory cortex using double immunohistochemistry for
Fulvia Bongianni et al.
Brain research, 1344, 134-147 (2010-05-21)
The respiratory role of GABA(A), GABA(B) and glycine receptors within the Bötzinger complex (BötC) and the pre-Bötzinger complex (preBötC) was investigated in alpha-chloralose-urethane anesthetized, vagotomized, paralysed and artificially ventilated rabbits by using bilateral microinjections (30-50 nl) of GABA and glycine
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