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Lene K Vestby et al.
BMC veterinary research, 5, 43-43 (2009-11-26)
Biofilm has been shown to be one way for Salmonella to persist in the feed factory environment. Matrix components, such as fimbriae and cellulose, have been suggested to play an important role in the survival of Salmonella in the environment.
Gian Carlo Alghisi et al.
PloS one, 4(2), e4449-e4449 (2009-02-13)
Cilengitide is a high-affinity cyclic pentapeptdic alphaV integrin antagonist previously reported to suppress angiogenesis by inducing anoikis of endothelial cells adhering through alphaVbeta3/alphaVbeta5 integrins. Angiogenic endothelial cells express multiple integrins, in particular those of the beta1 family, and little is
Maximilian W Schenk et al.
Nature communications, 12(1), 6652-6652 (2021-11-19)
Small cell lung cancer (SCLC) has a 5-year survival rate of <7%. Rapid emergence of acquired resistance to standard platinum-etoposide chemotherapy is common and improved therapies are required for this recalcitrant tumour. We exploit six paired pre-treatment and post-chemotherapy circulating
Leilani Ireland Way et al.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001), 23(1), 23-28 (2013-01-16)
To determine the utility of performing urine Gram stain for detection of bacteriuria compared to routine urine sediment examination and bacterial aerobic urine culture. Prospective, observational study. University teaching hospital. Urine samples acquired via cystocentesis through convenience sampling from 103
Pingping Mao et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 26(22), 5974-5989 (2020-07-30)
To identify clinically relevant mechanisms of resistance to ER-directed therapies in ER+ breast cancer. We conducted a genome-scale functional screen spanning 10,135 genes to investigate genes whose overexpression confer resistance to selective estrogen receptor degraders. In parallel, we performed whole-exome
Zhanqi Gao et al.
Journal of separation science, 36(6), 1112-1118 (2013-02-26)
A simple, environment friendly and efficient technique, ionic liquid-based microwave-assisted extraction was first used to determine malachite green and crystal violet (CV) from water samples coupled to HPLC. The key parameters influencing extraction efficiency were investigated, such as the type
Roman Makarov et al.
Methods in molecular biology (Clifton, N.J.), 961, 201-218 (2013-01-18)
The characterization of the quality and quantity of cell death has gained substantial interest over the past decades. More recently necroptosis as a programmed form of necrosis has been identified as an important additional form of cell death with relevance
Diego Benitez et al.
Journal of medicinal chemistry, 54(10), 3624-3636 (2011-04-22)
For a fourth approach of quinoxaline N,N'-dioxides as anti-trypanosomatid agents against T. cruzi and Leishmania, we found extremely active derivatives. The present study allows us to state the correct requirements for obtaining optimal in vitro anti-T. cruzi activity. Derivatives possessing
Dan Vershkov et al.
Cell reports, 26(10), 2531-2539 (2019-03-07)
Fragile X syndrome (FXS) is caused primarily by a CGG repeat expansion in the FMR1 gene that triggers its transcriptional silencing. In order to investigate the regulatory layers involved in FMR1 inactivation, we tested a collection of chromatin modulators for
Adam Martin et al.
Bio-protocol, 7(22) (2017-12-26)
Over the past 15 years, the free-living nematode, Caenorhabditis elegans has become an important model system for exploring eukaryotic innate immunity to bacterial and fungal pathogens. More recently, infection models using either natural or non-natural nematode viruses have also been
Ying C Henderson et al.
The Journal of clinical endocrinology and metabolism, 106(10), 2962-2978 (2021-06-14)
Despite the use of aggressive multimodality treatment, most anaplastic thyroid carcinoma (ATC) patients die within a year of diagnosis. Although the combination of BRAF and MEK inhibitors has recently been approved for use in BRAF-mutated ATC, they remain effective in
Shannon K Bromley et al.
Cell reports, 32(9), 108085-108085 (2020-09-03)
CD8+ tissue-resident memory T cells (TRM) persist at sites of previous infection, where they provide rapid local protection against pathogen challenge. CD8+ TRM expressing the α1 chain (CD49a) of integrin VLA-1 have been identified within sites of resolved skin infection and
Yueping Mao et al.
International journal of stem cells, 13(1), 93-103 (2020-03-03)
The application of adipose derived stem cells (ADSCs) in skin repair has attracted much attention nowadays. Epidermal growth factor (EGF) participates in the progress of skin proliferation, differentiation and so forth. We aimed to explore the role of EGF in
Audrey Berthe et al.
Cell cycle (Georgetown, Tex.), 15(24), 3402-3412 (2016-10-19)
We have previously shown that Δ2-Troglitazone (Δ2-TGZ) displayed anticancer effects on breast cancer cell lines grown in low serum conditions (1% fetal calf serum (FCS)). The present study was performed in order to characterize the effects of Δ2-TGZ in high
Yi-Fan Lian et al.
Theranostics, 9(26), 8392-8408 (2019-11-23)
Calcyclin-binding protein (CACYBP) is a multi-ligand protein implicated in the progression of various human cancers. However, its function in hepatocellular carcinoma (HCC) remains unknown. Methods: The expression of CACYBP and RNF41 (RING finger protein 41) in HCC cancer and adjacent
Mateja Mikulčić et al.
International journal of molecular sciences, 22(21) (2021-11-14)
Osteosarcoma (OS) is the most common type of bone tumor, and has limited therapy options. 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) has striking anti-tumor effects in various tumors. Here, we investigated molecular mechanisms that mediate anti-tumor effects of 15d-PGJ2 in different OS cell
Downregulation of survivin expression exerts antitumoral effects on mouse breast cancer cells in vitro and in vivo.
Ma WH, et al.
Oncology Letters, 11, 159-159 (2016)
Waleska K Martins et al.
Autophagy, 15(2), 259-279 (2018-09-04)
Cells challenged by photosensitized oxidations face strong redox stresses and rely on autophagy to either survive or die. However, the use of macroautophagy/autophagy to improve the efficiency of photosensitizers, in terms of inducing cell death, remains unexplored. Here, we addressed
Rong Tan et al.
Molecular cell, 65(5), 818-831 (2017-02-22)
Telomeric repeat binding factor 1 (TRF1) is essential to the maintenance of telomere chromatin structure and integrity. However, how telomere integrity is maintained, especially in response to damage, remains poorly understood. Here, we identify Nek7, a member of the Never
Yi-Fan Lian et al.
Aging, 10(8), 1884-1901 (2018-08-14)
Anillin (ANLN) is an actin-binding protein essential for assembly of cleavage furrow during cytokinesis. Although reportedly overexpressed in various human cancers, its role in hepatocellular carcinoma (HCC) is unclear. To address this issue, we confirmed that in 436 liver samples
Huimin Ma et al.
PloS one, 11(9), e0162840-e0162840 (2016-09-21)
Mammalian p53 is a super tumor suppressor and plays a key role in guarding genome from DNA damage. However, p53 has not been found in plants which do not bear cancer although they constantly expose to ionizing radiation of ultraviolet
Ziru Lian et al.
Journal of separation science, 36(5), 980-985 (2013-02-08)
A highly selective sample cleanup procedure combined with molecularly imprinted SPE was developed for the isolation of crystal violet from seawater and seafood samples. The molecularly imprinted polymer was prepared using crystal violet as the template molecule, methacrylic acid as
J X Zhang et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 67(4), 737-744 (2013-01-12)
The adsorption of crystal violet dye from aqueous solutions onto an activated carbon prepared from peanut shells was analyzed in this study. The effects of particle size, initial concentration, time and temperature on crystal violet removal were studied in batch
F Jahan et al.
The Malaysian journal of pathology, 36(3), 175-180 (2014-12-17)
Urethritis is one of the most important causes of morbidity and mortality in developing countries. The aim of this study was to detect common bacterial causes of urethritis in men by Gram stain, culture and multiplex PCR.185 male patients who
Elaine Sanij et al.
Nature communications, 11(1), 2641-2641 (2020-05-28)
Acquired resistance to PARP inhibitors (PARPi) is a major challenge for the clinical management of high grade serous ovarian cancer (HGSOC). Here, we demonstrate CX-5461, the first-in-class inhibitor of RNA polymerase I transcription of ribosomal RNA genes (rDNA), induces replication
Hidemasa Nakaminami et al.
Antimicrobial agents and chemotherapy, 54(10), 4107-4111 (2010-07-28)
Plasmids that carry the multidrug efflux genes qacA and qacB are widely distributed in methicillin-resistant Staphylococcus aureus (MRSA). Although the QacA and QacB proteins are similar to each other, their respective substrate specificities may differ. We investigated the variability and
Henry M Wu et al.
BMC infectious diseases, 13, 26-26 (2013-01-24)
Although cerebrospinal fluid (CSF) culture is the diagnostic reference standard for bacterial meningitis, its sensitivity is limited, particularly when antibiotics were previously administered. CSF Gram staining and real-time PCR are theoretically less affected by antibiotics; however, it is difficult to
Lise Crémet et al.
Diagnostic microbiology and infectious disease, 75(3), 252-255 (2013-01-15)
Biofilm formation seems to be a key factor in many bacterial infections, particularly those involving prosthetic implants or urinary catheters, where Escherichia coli is frequently involved. We have determined the ability to form biofilm in vitro of 34 E. coli
Hyung-Sup Shim et al.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 149(3), 399-401 (2013-07-17)
Preauricular sinus is a relatively common congenital anomaly that mainly exists on the anterior aspect of the anterior limb of the ascending helix. Although many surgical techniques have been developed, extirpation of the sinus is not easy because of the
Christopher A Elkins et al.
Antimicrobial agents and chemotherapy, 51(3), 923-929 (2007-01-11)
AcrAB-TolC is the major, constitutively expressed tripartite multidrug efflux system in Escherichia coli that recognizes various structurally unrelated molecules, including many antibiotics, dyes, and steroids. The AcrB inner membrane pump portion of the efflux system has been shown in recent
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