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Eric H Clifton et al.
PloS one, 13(3), e0194815-e0194815 (2018-03-23)
Terrestrial plants can harbor endophytic fungi that may induce changes in plant physiology that in turn affect interactions with herbivorous insects. We evaluated whether the application of entomopathogenic fungi Beauveria bassiana and Metarhizium brunneum to soybean seeds could become endophytic
Ning Wu et al.
PloS one, 6(1), e16264-e16264 (2011-01-26)
MicroRNAs (miRNAs) are short, non-coding RNAs that regulate the expression of multiple target genes. Deregulation of miRNAs is common in human tumorigenesis. Low level expression of miR-26b has been found in glioma cells. However, its underlying mechanism of action has
Teresa M Bernaciak et al.
Breast cancer research : BCR, 11(4), R52-R52 (2009-07-28)
Signal transducer and activator of transcription (STAT) 5b is a transcription factor involved in pro-proliferative and pro-survival signaling in a number of solid tumors, including breast cancer. The contribution of STAT5b to breast cancer cell motility has not been explored.
Dobrin D Draganov et al.
Journal of translational medicine, 17(1), 100-100 (2019-03-29)
Previous studies have identified IFNγ as an important early barrier to oncolytic viruses including vaccinia. The existing innate and adaptive immune barriers restricting oncolytic virotherapy, however, can be overcome using autologous or allogeneic mesenchymal stem cells as carrier cells with
Ricardo L Berrios et al.
Dermatologic clinics, 29(1), 69-73 (2010-11-26)
The term pyoderma encompasses a variety of distinct entities including impetigo (bullous and nonbullous), erysipelas, cellulitis, folliculitis, and staphylococcal scalded skin syndrome. Treatment of pyodermas centers around wound care and appropriate antibiotic selection. Triphenylmethane dyes, such as gentian violet, represent
Jinyu Zhang et al.
Oncology letters, 19(1), 350-358 (2020-01-04)
Cisplatin (DDP) resistance is closely associated with the failure of chemotherapy to manage various different types of human cancer. The GTPase protein Ras-related protein Rap-2a (RAP2A) regulates cancer cell proliferation, migration and invasion; however, little is currently known regarding its
Wuzheng Zhu et al.
Cell death & disease, 9(8), 837-837 (2018-08-08)
Mitochondrial dysfunction and excessive mitochondrial reactive oxygen species (ROS) are fundamental contributors to endothelial injury in diabetic states. Mesenchymal stem cells (MSCs) have exhibited an extraordinary cytoprotective effect that extends to the modulation of mitochondrial homeostasis. However, the underlying mechanisms
Tamas Hatfaludi et al.
Antimicrobial agents and chemotherapy, 52(11), 4166-4171 (2008-08-30)
Two TolC homologs, PM0527 and PM1980, were identified for Pasteurella multocida. A pm0527 mutant displayed increased susceptibility to a range of chemicals, including rifampin (512-fold) and acridine orange (128-fold). A pm1980 mutant showed increased susceptibility to rifampin, ceftazidime, and vancomycin.
Gentian violet - A blessing in disguise for the developing world.
Syed Arsalan Ali et al.
Burns : journal of the International Society for Burn Injuries, 39(6), 1326-1327 (2013-03-08)
L V Lagun et al.
Zhurnal mikrobiologii, epidemiologii, i immunobiologii, (3)(3), 18-23 (2013-09-05)
Study the intensity of formation of microbial biofilms by Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus strains isolated during various forms of pyelonephritis. 150 clinical isolates of microorganisms isolated from urine ofpatientswith acute and chronic pyelonephritiswere included into the
Performance of Gram and Acridine-orange staining in hand phlegmon.
Camillo Theo Müller et al.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 67(10), 1451-1452 (2014-06-11)
Metabolism and mode of action of gentian violet.
S N Moreno
Memorias do Instituto Oswaldo Cruz, 83 Suppl 1, 308-320 (1988-11-01)
Paul Yenerall et al.
Cancer research, 81(18), 4685-4695 (2021-07-25)
Identifying resistance mutations in a drug target provides crucial information. Lentiviral transduction creates multiple types of mutations due to the error-prone nature of the HIV-1 reverse transcriptase (RT). Here we optimized and leveraged this property to identify drug resistance mutations
Jorge Meneses Nunes et al.
Antimicrobial agents and chemotherapy, 57(1), 382-389 (2012-11-02)
Rhodotorula species are emergent fungal pathogens capable of causing invasive infections, primarily fungemia. They are particularly problematic in immunosuppressed patients when using a central venous catheter. In this study, we evaluated the species distribution of 51 clinical and 8 environmental
Feng Long et al.
Antimicrobial agents and chemotherapy, 52(9), 3052-3060 (2008-07-02)
Active efflux of antimicrobial agents is one of the most important adapted strategies that bacteria use to defend against antimicrobial factors that are present in their environment. The NorM protein of Neisseria gonorrhoeae and the YdhE protein of Escherichia coli
Astrid Pérez et al.
Antimicrobial agents and chemotherapy, 51(9), 3247-3253 (2007-07-20)
Enterobacter cloacae is an emerging clinical pathogen that may be responsible for nosocomial infections. Management of these infections is often difficult, owing to the high frequency of strains that are resistant to disinfectants and antimicrobial agents in the clinical setting.
Ze-Bei Zhang et al.
Diabetes, 67(8), 1549-1560 (2018-05-26)
Obesity increases the risk of vascular diseases, including aortic aneurysm (AA). Perivascular adipose tissue (PVAT) surrounding arteries are altered during obesity. However, the underlying mechanism of adipose tissue, especially PVAT, in the pathogenesis of AA is still unclear. Here we
Farah Naz Qamar et al.
JPMA. The Journal of the Pakistan Medical Association, 63(11), 1364-1369 (2014-01-08)
To describe the clinical profile and outcome in newborns with omphalitis managed with home or clinic-based therapy. The descriptive study was conducted from September 2004 to August 2007 in three low-income communities in Karachi, Pakistan. Newborns with omphalitis detected by
Daniela Trisciuoglio et al.
Journal of the National Cancer Institute, 100(17), 1233-1246 (2008-08-30)
Candidaspongiolide (CAN), a novel polyketide from a marine sponge, is the active component of a mixture that was found to be potently cytotoxic in the National Cancer Institute's 60-cell-line screen. Effects of CAN on U251 glioma and HCT116 colorectal cancer
Abhijith Biji et al.
EBioMedicine, 70, 103525-103525 (2021-08-16)
While our battle with the COVID-19 pandemic continues, a multitude of Omics data have been generated from patient samples in various studies. Translation of these data into clinical interventions against COVID-19 remains to be accomplished. Exploring host response to COVID-19
Melanie C McKell et al.
Frontiers in immunology, 12, 653571-653571 (2021-06-01)
Macrophages are indispensable immune cells tasked at eliminating intracellular pathogens. Mycobacterium tuberculosis (Mtb), one of the most virulent intracellular bacterial pathogens known to man, infects and resides within macrophages. While macrophages can be provoked by extracellular stimuli to inhibit and
Ya-Fang Wang et al.
Nature communications, 8(1), 274-274 (2017-08-19)
G9a, a H3K9 methyltransferase, shows elevated expression in many types of human cancers, particularly breast cancer. However, the tumorigenic mechanism of G9a is still far from clear. Here we report that G9a exerts its oncogenic function in breast cancer by
Dominique Hurtaud-Pessel et al.
Journal of AOAC International, 96(5), 1152-1157 (2013-11-29)
During the AOAC Annual Meeting held from September 30 to October 3, 2012 in Las Vegas, NV, the Expert Review Panel (ERP) on Veterinary Drug Residues reviewed data for the method for determination of residues of three triphenylmethane dyes and
Jean Jerley Nogueira Silva et al.
Journal of medicinal chemistry, 51(14), 4104-4114 (2008-06-24)
The ruthenium complex, trans-[Ru(Bz)(NH 3) 4SO 2](CF 3SO 3) 2 1, Bz = benznidazole ( N-benzyl-2-(2-nitro-1 H-imidazol-1-yl)acetamide), is more hydrosoluble and more active (IC 50try/1 h = 79 +/- 3 microM) than free benznidazole 2 (IC 50try/1 h > 1
Flávio Rodrigues Ferreira Alves et al.
Brazilian oral research, 27(1), 20-25 (2013-01-12)
This study evaluated the in vitro effects of four natural substances on the biomass of bacterial biofilms to assess their potential use as root canal irrigants. The following substances and their combinations were tested: 0.2% farnesol; 5% xylitol; 20% xylitol;
Phyllis Fung Yi Cheung et al.
PloS one, 6(12), e28246-e28246 (2011-12-24)
Increasing evidence has suggested that hepatocellular carcinoma (HCC) might originate from a distinct subpopulation called cancer stem cells (CSCs), which are responsible for the limited efficacy of conventional therapies. We have previously demonstrated that granulin-epithelin precursor (GEP), a pluripotent growth
Xingxing Gu et al.
Journal of nanoscience and nanotechnology, 14(6), 4655-4663 (2014-04-18)
In this study, hexadecyltrimethyl ammonium bromide and triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) were used as co-templates and tetraethoxysilane was used as silica source to synthesize mesoporous MCM-48, which was employed to adsorb methyl violet dye from water. The prepared MCM-48
Tsz Wai Ngai et al.
International journal of molecular sciences, 22(19) (2021-10-14)
Niclosamide is an oral anthelmintic drug, approved for use against tapeworm infections. Recent studies suggest however that niclosamide may have broader clinical applications in cancers, spurring increased interest in the functions and mechanisms of niclosamide. Previously, we reported that niclosamide
António Lourenço et al.
Applied and environmental microbiology, 79(19), 6075-6082 (2013-07-31)
The food-borne pathogen Listeria monocytogenes is the causative agent of the severe human and animal disease listeriosis. The persistence of this bacterium in food processing environments is mainly attributed to its ability to form biofilms. The search for proteins associated
Jordan R Jensen et al.
Bioorganic & medicinal chemistry, 19(17), 5147-5154 (2011-08-02)
Whole brain imaging of tau-bearing neurofibrillary lesions has the potential to improve the premortem diagnosis and staging of Alzheimer's disease. Diverse compounds with high affinity for tau aggregates have been reported from high-throughput screens, but the affinity driving features common
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