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关键词:'C7397'
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A case of primary skull lymphoma: review of literature.
Sudhansu Sekhar Mishra et al.
Neurology India, 61(3), 334-336 (2013-07-19)
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the
Light chain deposition.
Cyrus C Hsia et al.
Blood, 121(26), 5111-5111 (2013-08-24)
Masahiro Murakami-Nakayama et al.
Journal of pharmacological sciences, 127(2), 223-228 (2015-03-03)
Cav3.2 T-type Ca(2+) channels targeted by H2S, a gasotransmitter, participate in cyclophosphamide-induced cystitis and bladder pain. Given that zinc selectively inhibits Cav3.2 among T-channel isoforms and also exhibits antioxidant activity, we examined whether polaprezinc (zinc-l-carnosine), a medicine for peptic ulcer
Sheroy Minocherhomji et al.
Environmental and molecular mutagenesis, 61(8), 770-785 (2020-02-23)
Genome instability is a hallmark of most human cancers and is exacerbated following replication stress. However, the effects that drugs/xenobiotics have in promoting genome instability including chromosomal structural rearrangements in normal cells are not currently assessed in the genetic toxicology
Sofie Stalmans et al.
Regulatory toxicology and pharmacology : RTP, 70(1), 149-154 (2014-07-08)
Flatworms possess adult pluripotent stem cells, which make them extraordinary experimental model organisms to assess in vivo the undesirable effects of substances on stem cells. Currently, quality practices, implying evaluation of the stability of the test compound under the proposed
Lamprini Skriapa et al.
Journal of neuroimmunology, 276(1-2), 150-158 (2014-09-30)
Antibodies against MuSK seem to be the pathogenic factor in approximately 5-8% of myasthenia gravis (MG) patients. We aim to develop an antigen-specific therapy in which only MuSK antibodies will be removed from patients' plasma using MuSK extracellular domain (MuSK-ECD)
Susmita Kundu et al.
The Indian journal of chest diseases & allied sciences, 55(1), 49-52 (2013-06-27)
We report a case of a 42-year-old patient who presented with Wegener's granulomatosis complicated by pulmonary renal syndrome, i.e., diffuse alveolar haemorrhage and rapidly progressive crescentic glomerulonephritis. The patient was treated with plasmapheresis and immunosuppressive drugs--intravenous cyclophosphamide and methyl prednisolone.
Steven I Park et al.
Targeted oncology, 14(5), 563-575 (2019-08-21)
Aberrant Myc expression plays a critical role in various tumors, including non-Hodgkin lymphoma (NHL). Myc-positive lymphoma is clinically aggressive, more resistant to chemotherapy, and associated with high mortality. The current study aimed to show inhibition of aurora A kinase (AURKA)
Virginie Follin-Arbelet et al.
Scientific reports, 5, 13001-13001 (2015-08-27)
We have previously demonstrated that activation of the cyclic adenosine monophosphate (cAMP) pathway kills multiple myeloma (MM) cells both in vitro and in vivo. In the present study we have investigated the potential of enhancing the killing of MM cell
Leo Luznik et al.
Seminars in oncology, 39(6), 683-693 (2012-12-05)
Allogeneic hematopoietic stem cell transplantation (alloSCT) is a potentially curative therapy for many hematologic and immunologic diseases. Further, partial or full donor hematopoietic chimerism following alloSCT may be sufficient to guarantee immunologic tolerance to solid organs from the same donor
L V Filatova et al.
Voprosy onkologii, 59(2), 59-65 (2013-07-03)
In a retrospective study during the primary mode MOPP to primary patients LH II/IVAB stages with a poor prognosis rate of CR, 5--and 10-year DFS, OS was 69%, 71% and 68%, 74% and 64%, ABVD--76%, 78%, 83% and 68%, BEACOPP-baseline--73%
Unusual case of recurrent extraneural metastatic medulloblastoma in a young adult: durable complete remission with Ewing sarcoma chemotherapy regimen and consolidation with autologous bone marrow transplantation and local radiation.
Jincy Clement et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(19), e316-e319 (2013-05-30)
Jürgen C Becker et al.
The Journal of investigative dermatology, 133(6), 1462-1465 (2013-05-16)
Cancer immune escape is frequently associated with the induction of an inappropriate immune response, i.e., a response that does not inhibit but perhaps even promotes the tumor. Indeed, increased frequencies of tumor-infiltrating regulatory T cells (Tregs) are associated with an
Jared L Crandon et al.
Antimicrobial agents and chemotherapy, 59(5), 2688-2694 (2015-02-26)
The combination of cefepime with AAI101, a novel extended-spectrum β-lactamase inhibitor, possesses potent in vitro activity against many resistant Gram-negative pathogens. Against a panel of 20 mostly carbapenemase-producing cefepime-nonsusceptible strains of the family Enterobacteriaceae, we evaluated the MICs of cefepime
Wei Cui et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(7), 1036-1040 (2013-07-16)
To explore the inhibitory effect of combined administration of bear bile powder (BBP) and cyclophosphamide (Cytoxan, CTX) on colorectal cancer liver metastasis by regulating tumor promotion inflammation microenvironment. The CRC liver metastasis mode in mice was established through in situ
Jaslyn Sian-Siu Soo et al.
Apoptosis : an international journal on programmed cell death, 20(10), 1373-1387 (2015-08-16)
Metformin, an AMPK activator, has been reported to improve pathological response to chemotherapy in diabetic breast cancer patients. To date, its mechanism of action in cancer, especially in cancer stem cells (CSCs) have not been fully elucidated. In this study
Fabrice Jardin et al.
Blood, 121(22), 4433-4434 (2013-06-01)
In this issue of Blood, Li et al report mutations in the 3′ untranslated region (3′UTR) of TP53 that modify the expression of p53 and thus its effect on response to therapy in diffuse large B-cell lymphoma (DLBCL) patients.
L Verfaillie et al.
Acta clinica Belgica, 68(2), 138-139 (2013-08-24)
Anti-N-methyl-D-aspartate receptor (NMDA-R) encephalitis is a severe form of encephalitis that has been identified within the context of acute neuropsychiatric manifestations. We report the case of an 18-year-old adolescent referred for a first episode of acute psychosis. The clinical picture
Yuan Liu et al.
PloS one, 10(5), e0127361-e0127361 (2015-05-15)
Systemic lupus erythematosus (SLE) is a complex, systemic autoimmune disease with a diverse range of immunological and clinical manifestations. The introduction of broad spectrum immunosuppressive therapies and better management of acute disease exacerbations have improved outcomes for lupus patients over
Jia Wang et al.
Cell reports, 25(2), 464-477 (2018-10-12)
The urothelium is an epithelia barrier lined by a luminal layer of binucleated, octoploid, superficial cells. Superficial cells are critical for production and transport of uroplakins, a family of proteins that assemble into a waterproof crystalline plaque that helps protect
Wei-Ting Tseng et al.
Regulatory toxicology and pharmacology : RTP, 71(2), 148-157 (2014-12-08)
The aim of the present work was to assess the genotoxic activity and the potential for toxicity upon repeated dosing of "Vigiis 101" powder, a probiotic consisting of dried bacteria Lactobacillus paracasei subsp. paracasei NTU 101. Results of the Ames
Carlos Alexandre Lutterbeck et al.
Chemosphere, 135, 403-410 (2015-05-24)
Anti-cancer drugs are compounds that are of high environmental relevance because of their lack of specific mode of action. They can be extremely harmful to living organisms even at low concentrations. The present study evaluated the toxic effects of four
Wei Li et al.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 33(2), 233-237 (2013-06-26)
To explore the inhibitory effect of Zishenshengxue capsule (ZSC) on myelosuppression in mice induced by cyclophosphamide. Kunming mice were randomly assigned into a control group, myelosuppression group, or groups for mice with myelosuppression receiving high dose ZSC, middle dose ZSC
Yi-Hu Zheng et al.
Phytotherapy research : PTR, 28(9), 1342-1348 (2014-03-07)
The therapeutic potential of baicalein against hepatoma cells was evaluated in vitro and in vivo. In cell viability assays, baicalein showed significant cytotoxicity against the hepatocellular carcinoma cell lines H22, Bel-7404, and Hep G2 and moderate cytotoxicity against immortalized human
[Treatment of advanced Hodgkin lymphoma].
S Kreissl et al.
Deutsche medizinische Wochenschrift (1946), 138(23), 1212-1214 (2013-05-31)
Sujith Raj Salian et al.
PloS one, 15(6), e0235140-e0235140 (2020-06-24)
Due to improved treatment, there is an increasing focus on the reproductive potential of survivors of childhood cancer. Cytotoxic chemotherapy accelerates the decline in the number of primordial follicles within the mammalian ovary at all ages, but effects on the
Participant-level data and the new frontier in trial transparency.
Deborah A Zarin
The New England journal of medicine, 369(5), 468-469 (2013-08-02)
An atoll variant that mocks.
Francis X McCormack et al.
American journal of respiratory and critical care medicine, 188(1), 110-110 (2013-07-03)
S Chaabouni et al.
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 17(3), 229-232 (2013-05-15)
The extranodal non-Hodgkin lymphomas of maxillofacial soft tissues are rare. We report two cases of maxillofacial soft tissue non-Hodgkin lymphoma treated with chemotherapy followed by localized radiotherapy with complete remission after 3 and 6 months. We study the clinical, radiological
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