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Osvaldo E Sponton et al.
Food chemistry, 146, 577-582 (2013-11-02)
β-Lactoglobulin (BLG) is a member of lipocalin family, proteins with ability to bind small hydrophobic ligands, such as retinol, vitamins and fatty acids. Moreover, BLG is susceptible to protease action producing a wide range of polypeptides depending on the hydrolysis
Jyotica Batra et al.
The Journal of biological chemistry, 288(14), 9848-9859 (2013-02-23)
Human chymotrypsin C (CTRC) is a pancreatic serine protease that regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. In cleaving these regulatory sites, which are characterized by multiple flanking acidic residues
Saad Khan et al.
PloS one, 7(11), e50547-e50547 (2012-12-12)
In the present study, withaferin A (WA), a steroidal lactone with anti-inflammatory and anti-tumor properties, inhibited proteasome activity and induced endoplasmic reticulum (ER) and cytoplasmic HSP accumulation in Xenopus laevis A6 kidney epithelial cells. Proteasomal inhibition by WA was indicated
Llinos G Harris et al.
Applied and environmental microbiology, 79(4), 1393-1395 (2012-12-12)
Staphylococcus aureus and Staphylococcus epidermidis biofilms cause chronic infections due to their ability to form biofilms. The excretions/secretions of Lucilia sericata larvae (maggots) have effective activity for debridement and disruption of bacterial biofilms. In this paper, we demonstrate how chymotrypsin
M V Kolodzeĭskaia et al.
Ukrainskii biokhimicheskii zhurnal (1978), 60(4), 103-117 (1988-07-01)
Recent data on the nature of trypsin-, chymotrypsin-like proteinases of fish are generalized. Localization and secretion of these enzymes in pyloric appendages of fish are considered in detail. Trypsin and chymotrypsin are in the state of proenzymes and transform into
Lakshmi Swarnalatha Jasti et al.
Biotechnology progress, 30(2), 317-323 (2014-01-23)
Allyl glycidyl ether (AGE)-ethylene glycol dimethacrylate (EGDM) copolymer with 25% crosslink density (AGE-25) shows excellent bovine serum albumin (BSA) adsorption (up to 16% (w/w)) at pH 8.0 and the adsorbed BSA is strongly bound. This protein-coated polymer provides a novel
T J Caperna et al.
Domestic animal endocrinology, 45(3), 154-162 (2013-09-10)
Hepatic responses to proinflammatory signals are controlled by the activation of several transcription factors, including, nuclear factor-κ B (NF-κB). In this study, hepatocytes prepared from suckling pigs and maintained in serum-free monolayer culture were used to define a novel proinflammatory
Farrukh Mansoor et al.
Journal of Asian natural products research, 16(2), 210-215 (2013-11-26)
The bioassay-guided fractionation of Daphne retusa Hemsl. has led to the isolation of a new aryl tetrahydronaphthalene lignan derivative named as daphnretusic acid (1), along with six new source compounds such as 5,7-dihydroxyflavone (2), 7-hydroxyflavone (3), 6-methoxyflavone (4), (+) pinoresinol
Estela Maria Gonçalves et al.
Cytokine, 64(1), 343-350 (2013-06-12)
Cancer-cachexia causes severe weight loss, particularly from the wasting of skeletal muscle, which occurs due to increased protein catabolism and/or decreased protein synthesis. The muscle protein degradation observed in cancer patients is mediated by a specific cytokine, proteolysis-inducing factor (PIF)
S Yamashita et al.
The British journal of surgery, 100(9), 1220-1228 (2013-06-15)
Pancreatic fistula (PF) remains the most serious complication after digestive surgery. It is difficult to prevent because of the inability to visualize the leakage of pancreatic juice during surgery or to evaluate the protease activity of leaked fluid, which is
Caitlin A Kelly et al.
Oecologia (2018-07-14)
Many insect herbivores are dietary specialists capable of sequestering the secondary metabolites produced by their host plants. These defensive compounds have important but complex implications for tritrophic interactions between plants, herbivores, and natural enemies. The sequestration of host plant secondary
N Tomita et al.
Biochemical and biophysical research communications, 158(2), 569-575 (1989-01-31)
The cDNA clone encoding human prechymotrypsinogen was isolated from a human pancreas cDNA library and its nucleotide sequence was determined. The sequence consists of a 16 bp 5' non-coding region, a 789 bp amino acid coding region and a 60
Chen Zhang et al.
Biotechnology progress, 29(2), 493-504 (2013-01-16)
Delayed wound healing in many chronic wounds has been linked to the degradation of fibronectin (FN) by abnormally high protease levels. We sought to develop a proteolytically stable and functionally active form of FN. For this purpose, we conjugated 3.35
Pharmacogenetic perturbations in humans as a tool to generate mechanistic insight.
Jose C Florez
Diabetes, 62(9), 3019-3021 (2013-08-24)
J Abrudan et al.
Insect molecular biology, 22(2), 211-232 (2013-02-13)
As important vectors of human disease, phlebotomine sand flies are of global significance to human health, transmitting several emerging and re-emerging infectious diseases. The most devastating of the sand fly transmitted infections are the leishmaniases, causing significant mortality and morbidity
J Robyn et al.
Beneficial microbes, 3(4), 299-308 (2012-12-14)
Thermotolerant Campylobacter spp., specifically Campylobacter jejuni and Campylobacter coli, are the most common bacterial causes of human gastroenteritis in developed countries. Consumption of improperly prepared poultry products and cross contamination are among the main causes of human campylobacteriosis. The aim
J C Leman et al.
Journal of evolutionary biology, 22(1), 163-171 (2009-01-08)
A growing body of evidence suggests that resources invested in reproduction often come at the expense of the ability to mount an immune response. During mating, female sagebrush crickets, Cyphoderris strepitans, consume the ends of the male's hind wings and
Kamaldeen A Muili et al.
The Journal of biological chemistry, 288(1), 570-580 (2012-11-14)
Biliary pancreatitis is the leading cause of acute pancreatitis in both children and adults. A proposed mechanism is the reflux of bile into the pancreatic duct. Bile acid exposure causes pancreatic acinar cell injury through a sustained rise in cytosolic
Zongyun Chen et al.
PloS one, 8(3), e57529-e57529 (2013-03-28)
Serine protease inhibitors act as modulators of serine proteases, playing important roles in protecting animal toxin peptides from degradation. However, all known serine protease inhibitors discovered thus far from animal venom belong to the Kunitz-type subfamily, and whether there are
Angela M Mitchell et al.
Journal of virology, 87(23), 13035-13041 (2013-09-13)
Proteasome inhibitors (e.g., bortezomib, MG132) are known to enhance adeno-associated virus (AAV) transduction; however, whether this results from pleotropic proteasome inhibition or off-target serine and/or cysteine protease inhibition remains unresolved. Here, we examined recombinant AAV (rAAV) effects of a new
Hu Wan et al.
PloS one, 8(1), e53343-e53343 (2013-01-12)
Kunitz-type serine protease inhibitors are involved in various physiological processes, such as ion channel blocking, blood coagulation, fibrinolysis, and inflammation. While spider-derived Kunitz-type proteins show activity in trypsin or chymotrypsin inhibition and K(+) channel blocking, no additional role for these
Sevil Ozcan et al.
Journal of medicinal chemistry, 56(10), 3783-3805 (2013-04-04)
Screening of the 50000 ChemBridge compound library led to the identification of the oxadiazole-isopropylamide 1 (PI-1833) which inhibited chymotrypsin-like (CT-L) activity (IC50 = 0.60 μM) with little effects on the other two major proteasome proteolytic activities, trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like
Takashi Namba et al.
Neuron, 105(5), 867-881 (2019-12-31)
The human-specific gene ARHGAP11B is preferentially expressed in neural progenitors of fetal human neocortex and increases abundance and proliferation of basal progenitors (BPs), which have a key role in neocortex expansion. ARHGAP11B has therefore been implicated in the evolutionary expansion
Ana-Isabel Mulet-Cabero et al.
Food & function, 11(2), 1702-1720 (2020-02-11)
The link between food and human health is increasingly a topic of interest. One avenue of study has been to assess food disintegration and interactions within the gastrointestinal tract. In vitro digestion models have been widely used to overcome the
Alpha-chymotrypsin: a case study of substituent constants and regression analysis in enzymic structure--activity relationships.
C Hansch et al.
Journal of pharmaceutical sciences, 59(6), 731-743 (1970-06-01)
Jiayi Zhou et al.
Journal of gastroenterology and hepatology, 26(8), 1238-1246 (2011-06-03)
Chronic pancreatitis is a persistent inflammatory disorder characterized by destruction of the pancreatic parenchyma, maldigestion, and chronic pain. Mutations in the chymotrypsin C (CTRC) gene encoding the digestive enzyme CTRC have been shown to increase the risk of chronic pancreatitis
Asad Raza et al.
Journal of visualized experiments : JoVE, (70)(70), e50081-e50081 (2012-12-18)
Hydrogels are hydrophilic crosslinked polymers that provide a three-dimensional microenvironment with tissue-like elasticity and high permeability for culturing therapeutically relevant cells or tissues. Hydrogels prepared from poly(ethylene glycol) (PEG) derivatives are increasingly used for a variety of tissue engineering applications
Y Birk
International journal of peptide and protein research, 25(2), 113-131 (1985-02-01)
Four decades of studies on the isolation, characterization, properties, structure, function and possible uses of the Bowman-Birk trypsin- and chymotrypsin-inhibitor from soybeans are reviewed. Starting from Bowman's Acetone Insoluble factor, designated Ai, AA and SBTIAA, the Bowman-Birk inhibitor (BBI) was
Adrian Velazquez-Campoy et al.
Methods in molecular biology (Clifton, N.J.), 261, 35-54 (2004-04-06)
Isothermal titration calorimetry (ITC) is a powerful technique to study both protein-ligand and protein-protein interactions. This methods chapter is devoted to describing protein-protein interactions, in particular, the association between two different proteins and the self-association of a protein into homodimers.
Vanessa Tubero Euzebio Alves et al.
Infection and immunity, 81(12), 4399-4407 (2013-09-18)
Protease-activated receptor 2 (PAR2) is implicated in the pathogenesis of chronic inflammatory diseases, including periodontitis; it can be activated by gingipain and produced by Porphyromonas gingivalis and by neutrophil protease 3 (P3). PAR2 activation plays a relevant role in inflammatory
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