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Yaowu Hu et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(1), 116-120 (2013-12-18)
Domestic cats are one of the most popular pets globally, but the process of their domestication is not well understood. Near Eastern wildcats are thought to have been attracted to food sources in early agricultural settlements, following a commensal pathway
Takeshi Imamura et al.
Clinical calcium, 23(12), 1767-1773 (2013-12-03)
Intravital optical imaging technique is a promising method that allows us to investigate complex vital phenomena in vivo . In particular, discovery and development of unique fluorescent proteins and smart fluorescent dyes in conjunction with appropriate equipment such as two-photon
Brittany J Behar et al.
Journal of wound care, 23(7), S15-S19 (2014-08-27)
Lower extremity traumatic wounds can be difficult to treat owing to limb ischaemia and large zones of injury. Often, muscle or fasciocutaneous flaps are used in the presence of severe open orthopaedic injuries with soft tissue defects. Sometimes local flaps
Alejandro Arboleda et al.
Investigative ophthalmology & visual science, 55(4), 2731-2738 (2014-03-29)
To evaluate the efficacy of coulomb-controlled iontophoresis (CCI) for delivery of riboflavin prior to corneal collagen cross-linking (CXL). The eyes of 20 8-week-old Lewis rats, subject to epithelium-ON (epi-ON, n = 20 eyes) or epithelium-OFF (epi-OFF, n = 20 eyes)
[The role of electrothermoadhesion in creation of artificial vocal cord, and the voice quality improvement following chordectomy for laryngeal cancer].
R A Abyzov et al.
Klinichna khirurhiia, (2)(2), 77-77 (2013-05-28)
S Bhattacharya et al.
Journal of biomedical nanotechnology, 10(5), 811-819 (2014-04-17)
Controlled size, shape and dispersibility of superparamagnetic iron oxide nanoparticles (SPIONs), has been achieved in a protein-polymer colloidal dispersion. Stable ferrofluid (FF) is synthesized in an aqueous medium of collagen, bovine serum albumin and poly(vinyl) alcohol that equilibrates with time
Olivier Richoz et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 29(12), 842-845 (2014-01-10)
To investigate the effect of fluorescein on the antimicrobial efficacy of photoactivated riboflavin in corneal collagen cross-linking (CXL) in vitro. The ultraviolet light-A (UVA) absorption by fluorescein and riboflavin in different concentrations was analyzed with a spectrophotometer. The killing rate
He Ren et al.
Cancer letters, 354(1), 172-180 (2014-08-19)
The aim of this study is to investigate the regulatory mechanism of leptin receptors (Ob-R) in pancreatic cancer. We found that the over-expression of hypoxia inducible factor (HIF-1)α and hypoxia up-regulated the expression of Ob-R in pancreatic cancer cells. When
Marco Esposito et al.
European journal of oral implantology, 6(2), 169-179 (2013-08-09)
To compare the clinical effectiveness of two implant systems: Way Milano and Kentron (Geass, Pozzuolo del Friuli, UD, Italy). A total of 64 patients requiring at least two single crowns or partial fixed dental prostheses supported by a maximum of
Christina A Pacak et al.
Tissue engineering. Part C, Methods, 17(9), 879-885 (2011-04-14)
Acid-solubilized collagen type I (COL1) can form highly organized, three-dimensional scaffolds for a wide variety of bioengineering and cell culture applications. A rapid COL1 isolation method would be a valuable tool for both basic and translational researchers because conventional techniques
Justin W Griffin et al.
The Journal of bone and joint surgery. American volume, 95(23), 2144-2151 (2013-12-07)
When possible, direct repair remains the current standard of care for the repair of peripheral nerve lacerations. In large nerve gaps, in which direct repair is not possible, grafting remains the most viable option. Nerve scaffolds include autologous conduits, artificial
David A Brafman et al.
Nature protocols, 7(4), 703-717 (2012-03-17)
During the development of an organism, cells are exposed to a myriad of signals, structural components and scaffolds, which collectively make up the cellular microenvironment. The majority of current developmental biology studies examine the effect of individual or small subsets
Riina Harjumäki et al.
Scientific reports, 9(1), 7354-7354 (2019-05-16)
In vitro cell culture or tissue models that mimic in vivo cellular response have potential in tissue engineering and regenerative medicine, and are a more economical and accurate option for drug toxicity tests than animal experimentation. The design of in
Farhad Hafezi et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 30(7), 498-500 (2014-06-04)
To report the long-term clinical outcome of a patient diagnosed as having Terrien marginal degeneration (TMD) who was subjected to corneal collagen cross-linking (CXL) with ultraviolet-A and riboflavin in both eyes. Topographical changes were assessed by high-resolution Scheimpflug imaging and
Yuanming Ouyang et al.
Journal of biomedical nanotechnology, 9(6), 931-943 (2013-07-19)
An ideal nerve scaffold should supply structural guidance and trophic support to facilitate nerve regeneration. Aligned electrospun nanofibers have shown considerable promise for the precise guidance of regenerating axons in vitro and in vivo. Therefore, uniaxially aligned three-dimension (3D) nanofiberous
Helen A Shaw et al.
Vaccines, 9(9) (2021-09-29)
Group A Streptococcus (GAS) is an important global human pathogen, with a wide range of disease presentations, from mild mucosal infections like pharyngitis to invasive diseases such as toxic shock syndrome. The effect on health and mortality from GAS infections
Ahmad Kutkut et al.
Journal of the International Academy of Periodontology, 15(4), 113-124 (2013-12-25)
The aim of this report was to clinically and radiographically evaluate changes to the hard and soft tissues around implants placed in extraction sockets grafted with medical grade calcium sulfate hemihydrate (MGCSH) mixed with platelet-rich plasma (PRP) and a collagen
Kiyomi Koike et al.
Clinical immunology (Orlando, Fla.), 150(1), 78-87 (2013-12-18)
Inflammation is involved in renal fibrosis, a final common pathway for kidney diseases. To clarify how JAK/STAT/SOCS system was involved in renal fibrosis, UUO was induced in BALB/c or SOCS3(+/-) mice in the presence or absence of JAK inhibitor-incorporated nanoparticle
Amir Sedigh et al.
The Journal of surgical research, 191(2), 455-462 (2014-05-14)
Endothelial glycocalyx regulates the endothelial function and plays an active role in maintaining vascular homeostasis. During ischema and reperfusion, the glycocalyx is rapidly shed into the blood stream. A Corline heparin conjugate (CHC; Corline systems AB, Uppsala, Sweden) consists of
Jonathan E Moore et al.
The British journal of ophthalmology, 98(2), 270-274 (2013-11-30)
Cross-linking of the cornea is usually carried out at a young age as a treatment to manage ectasia. The corneal limbal region contains delicate long-lived stem cells, which could potentially be deleteriously affected by Ultraviolet A (UV-A) radiation. Damage to
Joanne B Tayapad et al.
Current opinion in ophthalmology, 24(4), 288-290 (2013-05-25)
This review presents current data regarding the use of collagen cross-linking in the management of corneal infections. Infectious keratitis can lead to blindness without proper antimicrobial therapy. The disease can still progress and lead to corneal melt despite early detection
Shulei Liu et al.
The Canadian journal of cardiology, 30(12), 1689-1699 (2014-11-25)
Micro-RNA 21 (miR-21) has been shown to contribute to cardiac fibrosis in many diseases. In this study we investigated the role of miR-21 in excessive production of collagen in diabetic cardiomyopathy. The proliferation rate of cardiac fibroblasts was analyzed by
Marco Rossi et al.
Investigative ophthalmology & visual science, 54(6), 4148-4157 (2013-05-25)
To evaluate the effect of corneal deswelling prior to a microkeratome and femtosecond (fs) laser cut and the impact of the fs laser energy settings on the tissue surface and collagen quality. Porcine and human corneas were incubated in THIN-C
Yuzhu Hou et al.
Journal of immunology (Baltimore, Md. : 1950), 193(1), 130-138 (2014-06-08)
The high temperature requirement A1 (HTRA1) is a potent protease involved in many diseases, including rheumatoid arthritis (RA). However, the regulatory mechanisms that control HTRA1 expression need to be determined. In this study, we demonstrated that IFN-γ significantly inhibited the
PACK-CXL: defining CXL for infectious keratitis.
Farhad Hafezi et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 30(7), 438-439 (2014-07-02)
Paolo Vinciguerra et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 30(11), 746-753 (2014-11-07)
To report initial clinical results of transepithelial corneal collagen cross-linking with iontophoresis (I-CXL). Twenty eyes of 20 patients diagnosed as having progressive keratoconus who underwent I-CXL were included in this prospective non-randomized clinical study. Corrected distance visual acuity (CDVA), spherical
Ken Nakata et al.
Clinical calcium, 23(12), 1731-1739 (2013-12-03)
Meniscus is one of the most important tissues in knee joint from the biomechanical point of view. Meniscus injury is well known to cause osteoarthritis. At moment, there is a limitation of operative repair procedure especially for the meniscus injury
James R W Conway et al.
Nature reviews. Cancer, 14(5), 314-328 (2014-04-18)
Integrating biological imaging into early stages of the drug discovery process can provide invaluable readouts of drug activity within complex disease settings, such as cancer. Iterating this approach from initial lead compound identification in vitro to proof-of-principle in vivo analysis
Xinghuo Wu et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 37(2), 439-448 (2018-10-30)
Intervertebral disc (IVD) degeneration is caused by a decrease in nucleus pulposus (NP) cells, due mainly to apoptosis. Focal adhesion kinase (FAK) is involved in the integrin (ITG)-mediated control of cell adhesion and anoikis (apoptosis). To explore the involvement of
Jun-Hui Choi et al.
Journal of bioscience and bioengineering, 118(4), 372-377 (2014-04-22)
A thrombolytic protease named kitamase possessing anticoagulant property was purified from edible and medicinal plant Aster yomena (Kitam.) Honda. Kitamase showed a molecular weight of 50 kDa by SDS-PAGE and displayed a strong fibrin zymogram lysis band corresponding to the similar
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