C85409

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Stimulation by caffeic acid, coumalic acid, and corilagin of the germination of resting spores of the clubroot pathogen Plasmodiophora brassicae.

Michio Ohi et al.

Bioscience, biotechnology, and biochemistry, 67(1), 170-173 (2003-03-07)

Some chemicals were examined for their effects on the germination of resting spores of the clubroot pathogen Plasmodiophora brassicae, and on the control of clubroots in Chinese cabbage. Caffeic acid, coumalic acid, and corilagin stimulated the germination of Plasmodiophora spores

Identification and Functional Verification of Differences in Phenolic Compounds Between Resistant and Susceptible Populus Species.

Yongxia Li et al.

Phytopathology, 110(4), 805-812 (2020-03-03)

Poplar canker, mainly caused by Botryosphaeria species, is a serious disease that has resulted in the reduced productivity and death of poplar worldwide. Different Populus species have varied resistance levels to poplar canker; however, whether phenolic compounds in poplar are

The inhibiting activity of areca inflorescence extracts on human low density lipoprotein oxidation induced by cupric ion.

Weijun Chen et al.

International journal of food sciences and nutrition, 63(2), 236-241 (2011-09-29)

The oxidative modification of human low density lipoprotein (LDL) plays a significant role in atherosclerosis. In this study, the inhibiting activity of areca inflorescence extracts (AIEs) on LDL oxidation was investigated by an in vitro study with Trolox as the

RNA-Seq Based De Novo Transcriptome Assembly and Gene Discovery of Cistanche deserticola Fleshy Stem.

Yuli Li et al.

PloS one, 10(5), e0125722-e0125722 (2015-05-06)

Cistanche deserticola is a completely non-photosynthetic parasitic plant with great medicinal value and mainly distributed in desert of Northwest China. Its dried fleshy stem is a crucial tonic in traditional Chinese medicine with roles of mainly improving male sexual function

Aminodeoxychorismate synthase inhibitors from one-bead one-compound combinatorial libraries: "staged" inhibitor design.

Seth Dixon et al.

Journal of medicinal chemistry, 49(25), 7413-7426 (2006-12-08)

4-Amino-4-deoxychorismate synthase (ADCS) catalyzes the first step in the conversion of chorismate into p-aminobenzoate, which is incorporated into folic acid. We aim to discover compounds that inhibit ADCS and serve as leads for a new class of antimicrobial compounds. This

Time-dependent inactivation of chick-embryo prolyl 4-hydroxylase by coumalic acid. Evidence for a syncatalytic mechanism.

V Günzler et al.

The Biochemical journal, 242(1), 163-169 (1987-02-15)

From the structure-activity relationships of known competitive inhibitors, coumalic acid (2-oxo-1,2H-pyran-5-carboxylic acid) was deduced to be a potential syncatalytic inhibitor for chick-embryo prolyl 4-hydroxylase. The compound caused time-dependent inactivation, the reaction rate being first-order. The inactivation constant was 0.094 min-1

Characterization and expression of enzymatically active recombinant filarial prolyl 4-hydroxylase.

A Merriweather et al.

Molecular and biochemical parasitology, 116(2), 185-197 (2001-08-28)

The cuticle of parasitic nematodes consists primarily of a network of collagen molecules. The enzyme responsible for collagen maturation is prolyl 4-hydroxylase, making this enzyme a central activity in cuticle biosynthesis and a potentially important chemotherapeutic target. Adult and embryonic

Molecular docking and ligand specificity in fragment-based inhibitor discovery.

Yu Chen et al.

Nature chemical biology, 5(5), 358-364 (2009-03-24)

Fragment screens have successfully identified new scaffolds in drug discovery, often with relatively high hit rates (5%) using small screening libraries (1,000-10,000 compounds). This raises two questions: would other noteworthy chemotypes be found were one to screen all commercially available

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