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Louise E See Hoe et al.
American journal of physiology. Heart and circulatory physiology, 307(6), H895-H903 (2014-07-27)
Cholesterol-rich caveolar microdomains and associated caveolins influence sarcolemmal ion channel and receptor function and protective stress signaling. However, the importance of membrane cholesterol content to cardiovascular function and myocardial responses to ischemia-reperfusion (I/R) and cardioprotective stimuli are unclear. We assessed
Gary Fraser et al.
Public health nutrition, 18(3), 537-545 (2014-03-19)
To compare cardiovascular risk factors between vegetarians and non-vegetarians in black individuals living in the USA. A cross-sectional analysis of a sub-set of 592 black women and men enrolled in the Adventist Health Study-2 (AHS-2) cohort of Seventh-day Adventists. Members
Xianglan Liu et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(7), 1275-1284 (2014-03-19)
Activation of the hypothalamus-adipocyte axis is associated with an antiobesity and anticancer phenotype in animal models of melanoma and colon cancer. Brain-derived neurotrophic factor (BDNF) is a key mediator in the hypothalamus leading to preferential sympathoneural activation of adipose tissue
Jian Zhu et al.
American journal of therapeutics, 22(2), 141-146 (2013-07-13)
The chronic inflammatory processes and endothelial dysfunction play important roles in the development of diabetic nephropathy (DN); the study aims to evaluate the effect of thymosin β4 (Tβ4), which has apparent anti-inflammatory properties and is capable of improving endothelial dysfunction
Toru Miyazaki et al.
International heart journal, 56(1), 29-36 (2014-12-17)
The aim of this study was to investigate the relationship between coronary microvascular function and smoking using the 3 parameters fractional flow reserve (FFR), coronary flow reserve (CFR(thermo)), and index of microcirculatory resistance (IMR) in patients with coronary artery disease
J M Rijks et al.
The Journal of clinical endocrinology and metabolism, 100(9), 3572-3580 (2015-07-18)
Despite stabilization of childhood overweight and obesity prevalence, there is a shift toward more severe degrees of obesity, which results in an increasing prevalence of children with morbid obesity. Prior studies demonstrated that lifestyle modification without ongoing treatment has only
Hui Fu et al.
Biochemical and biophysical research communications, 452(4), 881-887 (2014-09-10)
The purpose of this study is to determine whether IL-27 regulates macrophage ABCA1 expression, foam cell formation, and also explore the underlying mechanisms. Here, we revealed that IL-27 decreased lipid accumulation in THP-1 derived macrophages through markedly enhancing cholesterol efflux
Xiaohui Tong et al.
Naunyn-Schmiedeberg's archives of pharmacology, 388(8), 831-841 (2015-05-07)
1-[4-[2-(4-Bromobenzene-sulfonamino)ethyl]phenylsulfonyl]-3-(trans-4-methylcyclohexyl) urea (G004, CAS865483-06-3) is a synthetic sulfonylurea, incorporating the hypoglycemic active structure of glimepiride (CAS 93479-97-1) and anti-TXA2 receptor (TP) active structure of BM-531(CAS 284464-46-6). In this study, we evaluated the effect of G004 on hyperglycemia and dyslipidemia as
Hyun Kang et al.
Pharmaceutical biology, 53(3), 414-422 (2014-10-02)
Houttuynia cordata Thunb. (Saururaceae) is used traditionally in Asian countries to treat various disease symptoms. To study the effect of H. cordata ethyl acetate (HC-EA) extract on high-fat diet (HFD)-induced hepatic steatosis. HFD fed rats were orally dosed with HC-EA
Shih-Ting Huang et al.
International journal of oncology, 53(3), 1105-1117 (2018-06-30)
Paclitaxel (PTX) exhibits potent antineoplastic activity against various human malignancies; however, clinical application must overcome the inherent hydrophobicity of this molecule. The commercialized Taxol formulation utilizes Cremophor EL (CrEL)/ethanol as a solvent to stabilize and dispense PTX in an aqueous
Qian Ma et al.
Molecular pharmaceutics, 12(3), 665-674 (2015-01-15)
Probucol (PB), an antioxidant drug, is commonly used as a lipid concentration lowering drug to reduce blood plasma cholesterol levels in the clinic. However, the therapeutic effects of this drug are negatively impacted by its poor water solubility and low
Diana M Shih et al.
Journal of lipid research, 56(1), 22-37 (2014-11-08)
We performed silencing and overexpression studies of flavin containing monooxygenase (FMO) 3 in hyperlipidemic mouse models to examine its effects on trimethylamine N-oxide (TMAO) levels and atherosclerosis. Knockdown of hepatic FMO3 in LDL receptor knockout mice using an antisense oligonucleotide
Patrick Drücker et al.
Biochemical and biophysical research communications, 453(1), 143-147 (2014-09-30)
The integrity of supported phospholipid bilayer membranes is of crucial importance for the investigation of lipid-protein interactions. Therefore we recorded the formation of supported membranes on SiO2 and mica by quartz crystal microbalance and controlled the integrity by atomic force
Tsong-Ming Lu et al.
Plant foods for human nutrition (Dordrecht, Netherlands), 70(4), 395-400 (2015-09-20)
Onion (Allium cepa L.) is widely employed as a food ingredient as well as traditional remedy to treat fever, burns, and scurvy. The present study focused on the modulator efficacy of the quercetin rich onion juice on lipid profile and
Dustie N Butteiger et al.
Lab animal, 44(8), 311-316 (2015-07-23)
Custom diets are a convenient vector for oral administration of test articles, but the processing and physical form of a diet can affect its nutritional properties and how it is consumed. Here, the authors evaluated the feeding behavior and physiology
S Morel et al.
Thrombosis and haemostasis, 112(2), 390-401 (2014-05-16)
Ubiquitous reduction of the gap junction protein Connexin43 (Cx43) in mice provides beneficial effects on progression and composition of atherosclerotic lesions. Cx43 is expressed in multiple atheroma-associated cells but its function in each cell type is not known. To examine
Tomoya Araki et al.
Journal of controlled release : official journal of the Controlled Release Society, 200, 106-114 (2015-01-03)
The effects of photo-triggered tumor vascular treatment (PVT) on the structural and functional properties of tumor vasculature were assessed in Colon-26 (C26) and B16/BL6 (B16) tumor-bearing mice. Furthermore, anti-tumor efficacy of subsequently injected PEG liposomal paclitaxel (PL-PTX) was also evaluated.
Mingui Kong et al.
Investigative ophthalmology & visual science, 56(4), 2144-2150 (2015-03-05)
This study aimed to evaluate an association between hypertension and macular thickness. A total of 827 Korean adults composed of 163 pairs of twins and their family members were included in this population-based cross-sectional study. Macular thickness was measured with
Michael Kruse et al.
Molecular nutrition & food research, 59(3), 507-519 (2014-11-19)
Obesity is associated with hyperlipidemia, hepatic steatosis, and low-grade inflammation. Studies have shown that MUFA as well as PUFA have beneficial effects on blood lipids and the inflammatory state. This study investigates the effects of a daily supplementation of either
Ondrej Sochor et al.
The American journal of cardiology, 115(4), 405-410 (2014-12-30)
Smoke-free ordinance implementation and advances in smoking cessation (SC) treatment have occurred in the past decade; however, little is known about their impact on SC in patients with coronary artery disease. We conducted a retrospective cohort study of 2,306 consecutive
Tsuyoshi Nozue et al.
Lipids in health and disease, 14, 67-67 (2015-07-08)
The effects of statins on serum n-3 to n-6 polyunsaturated fatty acids (PUFAs) levels have not been fully evaluated. We examined the effects of two types of statins (rosuvastatin and pitavastatin) on serum PUFAs levels and their ratios in patients
Carine Sebaaly et al.
Food chemistry, 178, 52-62 (2015-02-24)
In this study, suitable formulations of natural soybean phospholipid vesicles were developed to improve the stability of clove essential oil and its main component, eugenol. Using an ethanol injection method, saturated (Phospholipon 80H, Phospholipon 90H) and unsaturated soybean (Lipoid S100)
Satoshi Shirao et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(5), 835-842 (2015-01-22)
Hyperlipidemia is a risk factor for abnormal cerebrovascular events. Rafts are cholesterol-enriched membrane microdomains that influence signal transduction. We previously showed that Rho-kinase-mediated Ca(2+) sensitization of vascular smooth muscle (VSM) induced by sphingosylphosphorylcholine (SPC) has a pivotal role in cerebral
Daniel E Platt et al.
Journal of thrombosis and thrombolysis, 39(1), 15-22 (2014-05-03)
A main underlying pathology of coronary artery disease is the deposition of cholesterol in the arteries supplying blood to the heart that leads to stenosis and myocardial infarction. We tested if dyslipidemia is a risk factor for coronary artery disease
D A Zamora et al.
Atherosclerosis, 241(1), 69-78 (2015-05-13)
Reactive oxygen species (ROS)-mediated formation of mixed disulfides between critical cysteine residues in proteins and glutathione, a process referred to as protein S-glutathionylation, can lead to loss of enzymatic activity and protein degradation. Since mitochondria are a major source of
Changjie Han et al.
The Journal of endocrinology, 221(3), 457-468 (2014-04-18)
MEX3C is an RNA-binding protein with unknown physiological function. We have recently reported that a Mex3c mutation in mice causes growth retardation and reduced adiposity, but how adiposity is reduced remains unclear. Herein, we show that homozygous Mex3c gene trap
Gemma Moiset et al.
Journal of the American Chemical Society, 136(46), 16167-16175 (2014-10-16)
Disaccharides are well-known for their membrane protective ability. Interaction between sugars and multicomponent membranes, however, remains largely unexplored. Here, we combine molecular dynamics simulations and fluorescence microscopy to study the effect of mono- and disaccharides on membranes that phase separate
Mei-Ling Yeh et al.
Western journal of nursing research, 37(12), 1517-1530 (2014-09-04)
Auricular acupoint stimulation has become a popular weight loss method. However, its efficacy for obesity treatment has not been fully studied. This study aimed to investigate the effect of a 10-week intervention of auricular electrical stimulation combined with auricular acupressure
Seyedeh Hoda Alavizadeh et al.
International journal of pharmaceutics, 473(1-2), 326-333 (2014-07-23)
SPI-077, cisplatin stealth liposome, is the best illustration of poor cisplatin release from liposomes and the subsequent negligible therapeutic activity. For this reason, optimizing drug release kinetics is desirable. In this report, cisplatin was encapsulated in liposomes composed of different
Melia Karakose et al.
Archives of endocrinology and metabolism, 59(1), 42-46 (2015-05-01)
Patients with incidental nonfunctioning adrenal adenoma are associated with increased risk of obesity, impaired glucose tolerance and dyslipidemia. We aimed to investigate the relationship between thyroid function, serum lipids and insulin resistance in patients with nonfunctioning adrenal incidentaloma. Forty patients
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