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T J Caperna et al.
Domestic animal endocrinology, 45(3), 154-162 (2013-09-10)
Hepatic responses to proinflammatory signals are controlled by the activation of several transcription factors, including, nuclear factor-κ B (NF-κB). In this study, hepatocytes prepared from suckling pigs and maintained in serum-free monolayer culture were used to define a novel proinflammatory
M V Kolodzeĭskaia et al.
Ukrainskii biokhimicheskii zhurnal (1978), 60(4), 103-117 (1988-07-01)
Recent data on the nature of trypsin-, chymotrypsin-like proteinases of fish are generalized. Localization and secretion of these enzymes in pyloric appendages of fish are considered in detail. Trypsin and chymotrypsin are in the state of proenzymes and transform into
Farrukh Mansoor et al.
Journal of Asian natural products research, 16(2), 210-215 (2013-11-26)
The bioassay-guided fractionation of Daphne retusa Hemsl. has led to the isolation of a new aryl tetrahydronaphthalene lignan derivative named as daphnretusic acid (1), along with six new source compounds such as 5,7-dihydroxyflavone (2), 7-hydroxyflavone (3), 6-methoxyflavone (4), (+) pinoresinol
Jyotica Batra et al.
The Journal of biological chemistry, 288(14), 9848-9859 (2013-02-23)
Human chymotrypsin C (CTRC) is a pancreatic serine protease that regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. In cleaving these regulatory sites, which are characterized by multiple flanking acidic residues
Saad Khan et al.
PloS one, 7(11), e50547-e50547 (2012-12-12)
In the present study, withaferin A (WA), a steroidal lactone with anti-inflammatory and anti-tumor properties, inhibited proteasome activity and induced endoplasmic reticulum (ER) and cytoplasmic HSP accumulation in Xenopus laevis A6 kidney epithelial cells. Proteasomal inhibition by WA was indicated
Llinos G Harris et al.
Applied and environmental microbiology, 79(4), 1393-1395 (2012-12-12)
Staphylococcus aureus and Staphylococcus epidermidis biofilms cause chronic infections due to their ability to form biofilms. The excretions/secretions of Lucilia sericata larvae (maggots) have effective activity for debridement and disruption of bacterial biofilms. In this paper, we demonstrate how chymotrypsin
Estela Maria Gonçalves et al.
Cytokine, 64(1), 343-350 (2013-06-12)
Cancer-cachexia causes severe weight loss, particularly from the wasting of skeletal muscle, which occurs due to increased protein catabolism and/or decreased protein synthesis. The muscle protein degradation observed in cancer patients is mediated by a specific cytokine, proteolysis-inducing factor (PIF)
J Abrudan et al.
Insect molecular biology, 22(2), 211-232 (2013-02-13)
As important vectors of human disease, phlebotomine sand flies are of global significance to human health, transmitting several emerging and re-emerging infectious diseases. The most devastating of the sand fly transmitted infections are the leishmaniases, causing significant mortality and morbidity
Pharmacogenetic perturbations in humans as a tool to generate mechanistic insight.
Jose C Florez
Diabetes, 62(9), 3019-3021 (2013-08-24)
J Robyn et al.
Beneficial microbes, 3(4), 299-308 (2012-12-14)
Thermotolerant Campylobacter spp., specifically Campylobacter jejuni and Campylobacter coli, are the most common bacterial causes of human gastroenteritis in developed countries. Consumption of improperly prepared poultry products and cross contamination are among the main causes of human campylobacteriosis. The aim
Parallel synthesis of isatin-based serine protease inhibitors
Shuttleworth SJ, et al.
Bioorganic & Medicinal Chemistry Letters, 10(22), 2501-2504 (2000)
S Yamashita et al.
The British journal of surgery, 100(9), 1220-1228 (2013-06-15)
Pancreatic fistula (PF) remains the most serious complication after digestive surgery. It is difficult to prevent because of the inability to visualize the leakage of pancreatic juice during surgery or to evaluate the protease activity of leaked fluid, which is
Human pancreatic enzymes. Isolation and properties of a major form of chymotrypsin.
M H Coan et al.
Biochemistry, 10(14), 2711-2717 (1971-07-06)
Osvaldo E Sponton et al.
Food chemistry, 146, 577-582 (2013-11-02)
β-Lactoglobulin (BLG) is a member of lipocalin family, proteins with ability to bind small hydrophobic ligands, such as retinol, vitamins and fatty acids. Moreover, BLG is susceptible to protease action producing a wide range of polypeptides depending on the hydrolysis
N Tomita et al.
Biochemical and biophysical research communications, 158(2), 569-575 (1989-01-31)
The cDNA clone encoding human prechymotrypsinogen was isolated from a human pancreas cDNA library and its nucleotide sequence was determined. The sequence consists of a 16 bp 5' non-coding region, a 789 bp amino acid coding region and a 60
Chen Zhang et al.
Biotechnology progress, 29(2), 493-504 (2013-01-16)
Delayed wound healing in many chronic wounds has been linked to the degradation of fibronectin (FN) by abnormally high protease levels. We sought to develop a proteolytically stable and functionally active form of FN. For this purpose, we conjugated 3.35
Crystal structure of delta-chymotrypsin bound to a peptidyl chloromethyl ketone inhibitor
Mac Sweeney A, et al.
Acta Crystallographica Section D, Biological Crystallography, 56(3), 280-286 (2000)
Hu Wan et al.
PloS one, 8(1), e53343-e53343 (2013-01-12)
Kunitz-type serine protease inhibitors are involved in various physiological processes, such as ion channel blocking, blood coagulation, fibrinolysis, and inflammation. While spider-derived Kunitz-type proteins show activity in trypsin or chymotrypsin inhibition and K(+) channel blocking, no additional role for these
Kamaldeen A Muili et al.
The Journal of biological chemistry, 288(1), 570-580 (2012-11-14)
Biliary pancreatitis is the leading cause of acute pancreatitis in both children and adults. A proposed mechanism is the reflux of bile into the pancreatic duct. Bile acid exposure causes pancreatic acinar cell injury through a sustained rise in cytosolic
Zongyun Chen et al.
PloS one, 8(3), e57529-e57529 (2013-03-28)
Serine protease inhibitors act as modulators of serine proteases, playing important roles in protecting animal toxin peptides from degradation. However, all known serine protease inhibitors discovered thus far from animal venom belong to the Kunitz-type subfamily, and whether there are
Sevil Ozcan et al.
Journal of medicinal chemistry, 56(10), 3783-3805 (2013-04-04)
Screening of the 50000 ChemBridge compound library led to the identification of the oxadiazole-isopropylamide 1 (PI-1833) which inhibited chymotrypsin-like (CT-L) activity (IC50 = 0.60 μM) with little effects on the other two major proteasome proteolytic activities, trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like
Angela M Mitchell et al.
Journal of virology, 87(23), 13035-13041 (2013-09-13)
Proteasome inhibitors (e.g., bortezomib, MG132) are known to enhance adeno-associated virus (AAV) transduction; however, whether this results from pleotropic proteasome inhibition or off-target serine and/or cysteine protease inhibition remains unresolved. Here, we examined recombinant AAV (rAAV) effects of a new
Jiayi Zhou et al.
Journal of gastroenterology and hepatology, 26(8), 1238-1246 (2011-06-03)
Chronic pancreatitis is a persistent inflammatory disorder characterized by destruction of the pancreatic parenchyma, maldigestion, and chronic pain. Mutations in the chymotrypsin C (CTRC) gene encoding the digestive enzyme CTRC have been shown to increase the risk of chronic pancreatitis
Asad Raza et al.
Journal of visualized experiments : JoVE, (70)(70), e50081-e50081 (2012-12-18)
Hydrogels are hydrophilic crosslinked polymers that provide a three-dimensional microenvironment with tissue-like elasticity and high permeability for culturing therapeutically relevant cells or tissues. Hydrogels prepared from poly(ethylene glycol) (PEG) derivatives are increasingly used for a variety of tissue engineering applications
Chad Cummings et al.
Biomaterials, 34(30), 7437-7443 (2013-07-16)
Polymer-based protein engineering (PBPE) offers an attractive method to predictably modify and enhance enzyme structure and function. Using polymers that respond to stimuli such as temperature and pH, enzyme activity and stability can be predictably modified without a dependence on
ALPHA-CHYMOTRYPSIN AND THE NATURE OF ENZYME CATALYSIS.
C NIEMANN
Science (New York, N.Y.), 143(3612), 1287-1296 (1963-03-20)
Bin Hu et al.
The Analyst, 136(18), 3599-3601 (2011-07-08)
The high-throughput and sensitive characterization of native proteins in biological samples is of increasing interest in multiple disciplines. Extractive electrospray ionization (EESI) forms ions of native proteins including lysozyme, α-chymotrypsin, myoglobin, human serum albumin, RNAse A and blood hemoglobin in
W Russ Algar et al.
ACS nano, 6(12), 11044-11058 (2012-12-12)
Semiconductor nanocrystals, or quantum dots (QDs), are one of the most widely utilized nanomaterials for biological applications. Their cumulative physicochemical and optical properties are both unique among nanomaterials and highly advantageous. In particular, Förster resonance energy transfer (FRET) has been
Voltage dependence of Na-Ca exchange in barnacle muscle cells. I. Na-Na exchange activated by alpha-chymotrypsin.
H Rasgado-Flores et al.
Annals of the New York Academy of Sciences, 779, 236-248 (1996-04-15)
THE CHEMICAL MODIFICATION OF CHYMOTRYPSIN.
G H DIXON et al.
Canadian journal of biochemistry, 42, 695-714 (1964-05-01)
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