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Sahul H Rajamohamed et al.
Plant foods for human nutrition (Dordrecht, Netherlands), 68(3), 306-312 (2013-08-06)
Glabrous or hairless canaryseed is a nutritional grain that could be a good addition to the diet if approved as a novel food. To assess the impact of thermal treatment on its digestibility; raw, roasted or boiled flours prepared from
ALPHA-CHYMOTRYPSIN AND THE NATURE OF ENZYME CATALYSIS.
C NIEMANN
Science (New York, N.Y.), 143(3612), 1287-1296 (1963-03-20)
PRSS1 c.623G>C (p.G208A) variant is associated with pancreatitis in Japan.
Atsushi Masamune et al.
Gut, 63(2), 366-366 (2013-05-21)
Jaroslaw Czubinski et al.
Food chemistry, 143, 418-426 (2013-09-24)
This study describes in vitro digestion of lupin seed globulins by pancreatin, trypsin and chymotrypsin. Lupin seed globulins turned out to be almost totally susceptible to chymotrypsin digestion. When panceratin or trypsin were used for digestion of lupin seed globulins
Zongyun Chen et al.
PloS one, 8(3), e57529-e57529 (2013-03-28)
Serine protease inhibitors act as modulators of serine proteases, playing important roles in protecting animal toxin peptides from degradation. However, all known serine protease inhibitors discovered thus far from animal venom belong to the Kunitz-type subfamily, and whether there are
Eleonora Petryayeva et al.
Analytical chemistry, 85(18), 8817-8825 (2013-08-29)
Paper-based assays are a promising diagnostic format for point-of-care applications, field deployment, and other low-resource settings. To date, the majority of efforts to integrate nanomaterials with paper-based assays have utilized gold nanoparticles. Here, we show that semiconductor quantum dots (QDs)
Y Birk
International journal of peptide and protein research, 25(2), 113-131 (1985-02-01)
Four decades of studies on the isolation, characterization, properties, structure, function and possible uses of the Bowman-Birk trypsin- and chymotrypsin-inhibitor from soybeans are reviewed. Starting from Bowman's Acetone Insoluble factor, designated Ai, AA and SBTIAA, the Bowman-Birk inhibitor (BBI) was
M A Abd El-Ghaffar et al.
Carbohydrate polymers, 92(2), 2095-2102 (2013-02-13)
Chitosan grafted with polymethyl methacrylate (PMMA-g-CS) was prepared via a free-radicals polymerization technique as a carrier for enzyme immobilization. α-Chymotrypsin (CT), as an enzyme model in this study, was immobilized onto the prepared PMMA-g-CS via covalent bonding. Calcium alginate (CA)
Vanessa Tubero Euzebio Alves et al.
Infection and immunity, 81(12), 4399-4407 (2013-09-18)
Protease-activated receptor 2 (PAR2) is implicated in the pathogenesis of chronic inflammatory diseases, including periodontitis; it can be activated by gingipain and produced by Porphyromonas gingivalis and by neutrophil protease 3 (P3). PAR2 activation plays a relevant role in inflammatory
J Abrudan et al.
Insect molecular biology, 22(2), 211-232 (2013-02-13)
As important vectors of human disease, phlebotomine sand flies are of global significance to human health, transmitting several emerging and re-emerging infectious diseases. The most devastating of the sand fly transmitted infections are the leishmaniases, causing significant mortality and morbidity
Parallel synthesis of isatin-based serine protease inhibitors
Shuttleworth SJ, et al.
Bioorganic & Medicinal Chemistry Letters, 10(22), 2501-2504 (2000)
Pharmacogenetic perturbations in humans as a tool to generate mechanistic insight.
Jose C Florez
Diabetes, 62(9), 3019-3021 (2013-08-24)
J Robyn et al.
Beneficial microbes, 3(4), 299-308 (2012-12-14)
Thermotolerant Campylobacter spp., specifically Campylobacter jejuni and Campylobacter coli, are the most common bacterial causes of human gastroenteritis in developed countries. Consumption of improperly prepared poultry products and cross contamination are among the main causes of human campylobacteriosis. The aim
Hu Wan et al.
PloS one, 8(1), e53343-e53343 (2013-01-12)
Kunitz-type serine protease inhibitors are involved in various physiological processes, such as ion channel blocking, blood coagulation, fibrinolysis, and inflammation. While spider-derived Kunitz-type proteins show activity in trypsin or chymotrypsin inhibition and K(+) channel blocking, no additional role for these
Sevil Ozcan et al.
Journal of medicinal chemistry, 56(10), 3783-3805 (2013-04-04)
Screening of the 50000 ChemBridge compound library led to the identification of the oxadiazole-isopropylamide 1 (PI-1833) which inhibited chymotrypsin-like (CT-L) activity (IC50 = 0.60 μM) with little effects on the other two major proteasome proteolytic activities, trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like
THE CHEMICAL MODIFICATION OF CHYMOTRYPSIN.
G H DIXON et al.
Canadian journal of biochemistry, 42, 695-714 (1964-05-01)
[Stages of hydrolysis catalyzed by trypsin and chymotrypsin].
V M Krutiakov
Izvestiia Akademii nauk SSSR. Seriia biologicheskaia, 5, 671-680 (1973-09-01)
Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold.
J J Perona et al.
The Journal of biological chemistry, 272(48), 29987-29990 (1997-12-31)
Angela M Mitchell et al.
Journal of virology, 87(23), 13035-13041 (2013-09-13)
Proteasome inhibitors (e.g., bortezomib, MG132) are known to enhance adeno-associated virus (AAV) transduction; however, whether this results from pleotropic proteasome inhibition or off-target serine and/or cysteine protease inhibition remains unresolved. Here, we examined recombinant AAV (rAAV) effects of a new
Crystal structure of delta-chymotrypsin bound to a peptidyl chloromethyl ketone inhibitor
Mac Sweeney A, et al.
Acta Crystallographica Section D, Biological Crystallography, 56(3), 280-286 (2000)
Randy Adjonu et al.
Food chemistry, 136(3-4), 1435-1443 (2012-12-01)
Heat pre-treated and non heat pre-treated whey protein isolate (WPI) were hydrolysed using α-chymotrypsin (chymotrypsin), pepsin and trypsin. The in vitro antioxidant activity, ACE-inhibition activity and surface hydrophobicities of the hydrolysates were measured in order to determine if peptides with
W Russ Algar et al.
ACS nano, 6(12), 11044-11058 (2012-12-12)
Semiconductor nanocrystals, or quantum dots (QDs), are one of the most widely utilized nanomaterials for biological applications. Their cumulative physicochemical and optical properties are both unique among nanomaterials and highly advantageous. In particular, Förster resonance energy transfer (FRET) has been
Bin Hu et al.
The Analyst, 136(18), 3599-3601 (2011-07-08)
The high-throughput and sensitive characterization of native proteins in biological samples is of increasing interest in multiple disciplines. Extractive electrospray ionization (EESI) forms ions of native proteins including lysozyme, α-chymotrypsin, myoglobin, human serum albumin, RNAse A and blood hemoglobin in
Chad Cummings et al.
Biomaterials, 34(30), 7437-7443 (2013-07-16)
Polymer-based protein engineering (PBPE) offers an attractive method to predictably modify and enhance enzyme structure and function. Using polymers that respond to stimuli such as temperature and pH, enzyme activity and stability can be predictably modified without a dependence on
Jiayi Zhou et al.
Journal of gastroenterology and hepatology, 26(8), 1238-1246 (2011-06-03)
Chronic pancreatitis is a persistent inflammatory disorder characterized by destruction of the pancreatic parenchyma, maldigestion, and chronic pain. Mutations in the chymotrypsin C (CTRC) gene encoding the digestive enzyme CTRC have been shown to increase the risk of chronic pancreatitis
Asad Raza et al.
Journal of visualized experiments : JoVE, (70)(70), e50081-e50081 (2012-12-18)
Hydrogels are hydrophilic crosslinked polymers that provide a three-dimensional microenvironment with tissue-like elasticity and high permeability for culturing therapeutically relevant cells or tissues. Hydrogels prepared from poly(ethylene glycol) (PEG) derivatives are increasingly used for a variety of tissue engineering applications
Alpha-chymotrypsin: a case study of substituent constants and regression analysis in enzymic structure--activity relationships.
C Hansch et al.
Journal of pharmaceutical sciences, 59(6), 731-743 (1970-06-01)
Kamaldeen A Muili et al.
The Journal of biological chemistry, 288(1), 570-580 (2012-11-14)
Biliary pancreatitis is the leading cause of acute pancreatitis in both children and adults. A proposed mechanism is the reflux of bile into the pancreatic duct. Bile acid exposure causes pancreatic acinar cell injury through a sustained rise in cytosolic
M V Kolodzeĭskaia et al.
Ukrainskii biokhimicheskii zhurnal (1978), 60(4), 103-117 (1988-07-01)
Recent data on the nature of trypsin-, chymotrypsin-like proteinases of fish are generalized. Localization and secretion of these enzymes in pyloric appendages of fish are considered in detail. Trypsin and chymotrypsin are in the state of proenzymes and transform into
Jyotica Batra et al.
The Journal of biological chemistry, 288(14), 9848-9859 (2013-02-23)
Human chymotrypsin C (CTRC) is a pancreatic serine protease that regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. In cleaving these regulatory sites, which are characterized by multiple flanking acidic residues
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