CN
Search Within
C8981
应用筛选条件
关键词:'C8981'
显示 1-30 共 281 条结果 关于 "C8981" 范围 论文
Felix M Rivas et al.
Journal of medicinal chemistry, 52(7), 1795-1798 (2009-03-12)
The antiseizure activity of benzodiazepines (BDZs) 1-5 in mice and rats as animal models is described. These BDZs have selective efficacy for alpha2beta3gamma2 and alpha3beta3gamma2 GABA(A)-receptors. Significant anticonvulsant activity with little or no motor impairment and therapeutic indexes (TI) of
Ana R Ribeiro et al.
Journal of chromatography. A, 1418, 140-149 (2015-10-04)
The fate and removal of organic micropollutants in the environment is a demanding issue evidenced by the recent European policy. This work presents an analytical method for the trace quantification of 37 micropollutants including Priority Substances (Directive 2013/39/EU), substances of
Clara Boix et al.
Talanta, 131, 719-727 (2014-10-05)
This work describes a rapid analytical method based on direct sample injection of water samples for the simultaneous identification/quantification of 40 emerging compounds, including pharmaceuticals and drugs of abuse. The water samples were analyzed by ultra-high-performance liquid chromatography coupled to
Rita Celano et al.
Journal of chromatography. A, 1355, 26-35 (2014-06-19)
Pharmaceutical and personal care products (PPCPs) are one of the most important classes of emerging contaminants. The potential of ecological and environmental impacts associated with PPCPs are of particular concern because they continually penetrate the aquatic environment. This work describes
Michael H Parker et al.
Journal of medicinal chemistry, 52(23), 7528-7536 (2009-04-25)
In seeking broad-spectrum anticonvulsants to treat epilepsy and other neurological disorders, we synthesized and tested a group of sulfamide derivatives (4a-k, 5), which led to the clinical development of 4a (JNJ-26990990). This compound exhibited excellent anticonvulsant activity in rodents against
Inge Anita Meijer et al.
Muscle & nerve, 49(1), 134-138 (2013-07-31)
Erythromelalgia due to heterozygous gain-of-function SCN9A mutations usually presents as a pure sensory-autonomic disorder characterized by recurrent episodes of burning pain and redness of the extremities. We describe a patient with an unusual phenotypic presentation of gross motor delay, childhood-onset
M Muz et al.
Environmental technology, 35(9-12), 1055-1063 (2014-04-08)
The fate and removal of six selected endocrine disrupting compounds in a lab-scale anaerobic/aerobic (A/O) sequencing batch reactor (SBR), operating at 5 days, solids retention time (SRT) were investigated. A carbamazepine (CBZ), acetaminophen (ATP), diltiazem (DTZ), butyl benzyl phthalate (BBP)
Armel Stockis et al.
Epilepsy research, 113, 19-27 (2015-05-20)
This phase I, open-label study investigated the effects of steady-state brivaracetam administration on steady-state pharmacokinetics of carbamazepine, and steady-state carbamazepine administration on single-dose and steady-state pharmacokinetics of brivaracetam, in 14 healthy participants who received brivaracetam 200mg single doses on days
Ji-Yoon Lee et al.
Chemico-biological interactions, 229, 109-118 (2015-01-28)
We investigated to compare species differences in amitriptyline (AMI) metabolism among mouse, rat, dog, and human liver microsomes. We developed a method for simultaneous determination of metabolic stability and metabolite profiling using predictive multiple reaction monitoring information-dependent acquisition-enhanced product ion
Yousheng Xiao et al.
The Cochrane database of systematic reviews, 1, CD008781-CD008781 (2012-01-20)
The efficacy and safety of vigabatrin (VGB) as an add-on therapy for refractory epilepsy has been well established. However, this needs to be weighed against the risk of the development of visual field defects. Whether VGB monotherapy is an effective
Peter J Larkin et al.
Applied spectroscopy, 68(7), 758-776 (2014-07-12)
Polymorph detection, identification, and quantitation in crystalline materials are of great importance to the pharmaceutical industry. Vibrational spectroscopic techniques used for this purpose include Fourier transform mid-infrared (FT-MIR) spectroscopy, Fourier transform near-infrared (FT-NIR) spectroscopy, Raman spectroscopy, and terahertz (THz) and
Fadil E Skrijelj et al.
Vojnosanitetski pregled, 71(4), 404-407 (2014-05-03)
Carbamazepine can lead to aggravation of epileptic seizures in generalized epilepsies (primary or secondary) with clinical manifestations of absence (typical or atypical) and/or myoclonic seizures. However, some focal epilepsies can be also aggravated by the introduction of carbamazepine. We presented
Nadeem Siddiqui et al.
Bioorganic & medicinal chemistry letters, 17(1), 255-259 (2006-10-19)
A series of sulphonamide derivatives (1-11) were synthesized in good yield and evaluated for their possible anticonvulsant activity and neurotoxic study. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. Majority
Graham Powell et al.
The Cochrane database of systematic reviews, 12(12), CD007124-CD007124 (2014-12-04)
Epilepsy is defined as the tendency to spontaneous, excessive neuronal discharge manifesting as seizures. It is a common disorder with an incidence of 50 per 100,000 per year and a prevalence of 0.5% to 1% in the developed world (Hauser
Fahimeh Kamarei et al.
Journal of chromatography. A, 1306, 89-96 (2013-08-06)
The retention behavior of carbamazepine eluted in SFC was studied by changing the back pressure between 100 and 200bar and the volumetric flow rate between 0.5 and 5mL/min. Carbamazepine was eluted under linear conditions from a silica column with 90:10%
Xiwei Zheng et al.
Journal of chromatography. A, 1400, 82-90 (2015-05-20)
A hybrid method was examined for increasing the binding capacity and activity of protein-based affinity columns by using a combination of protein cross-linking/modification and covalent immobilization. Various applications of this approach in the study of drug-protein interactions and in use
Sandeep Grover et al.
Pharmacogenetics and genomics, 24(2), 94-112 (2013-12-18)
A considerable heterogeneity exists in the literature on the role of different HLA alleles in carbamazepine (CBZ)-induced cutaneous adverse drug reactions (cADRs) of varying severity among diverse ethnic groups. The aim of the present study was to understand and summarize
Dennis J Pelletier et al.
Journal of chemical information and modeling, 47(3), 1196-1205 (2007-04-13)
The identification of phospholipidosis (PPL) during preclinical testing in animals is a recognized problem in the pharmaceutical industry. Depending on the intended indication and dosing regimen, PPL can delay or stop development of a compound in the drug discovery process.
Clare London et al.
Bioorganic & medicinal chemistry letters, 18(5), 1696-1701 (2008-02-05)
A series of imidazopyridines were evaluated as potential sodium channel blockers for the treatment of neuropathic pain. Several members were identified with good hNa(v)1.7 potency and excellent rat pharmacokinetic profiles. Compound 4 had good efficacy (52% and 41% reversal of
Pil H Lee et al.
Bioorganic & medicinal chemistry letters, 20(1), 69-73 (2009-12-08)
A multiple linear regression QSAR model was developed based on a set of 61 compounds with internally consistent permeability data measured across Franz cell. The data was normalized using a mean permeability value of a reference compound, 3-isobutyl-1-methylxanthine (IBMX). The
Sang Yoon Lee et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(2), 131-138 (2014-08-26)
1. The herb-drug interaction potential of Hwang-Ryun-Hae-Dok-Tang (HR) extracts mediated by cytochrome P450 (CYP) inhibition was determined using human liver microsomes. 2. HR strongly inhibited CYP1A2 and moderately inhibited CYP2C19, CYP2D6, and CYP3A4 (testosterone) but not CYP2A6, CYP2B6, CYP2C8, CYP2C9, and CYP3A4
Woong-Kee Choi et al.
Journal of separation science, 38(11), 1872-1880 (2015-03-27)
A new, rapid, and sensitive liquid chromatography with tandem mass spectrometry method was developed for the determination of vitisin B and validated in rat plasma and urine using carbamazepine as an internal standard. The plasma (0.05 mL) or urine (0.2
Xing-Peng Chen et al.
Pharmacology, 96(3-4), 107-111 (2015-07-24)
The objective of this work was to investigate the effect of orally administered silibinin on the pharmacokinetics of ivabradine and its active metabolite N-desmethylivabradine in rats. Twelve healthy male Sprague-Dawley rats were randomly divided into 2 groups: the control group
Terence A Ketter et al.
Journal of affective disorders, 169 Suppl 1, S24-S33 (2014-12-24)
Bipolar depression is more pervasive than mania, but has fewer evidence-based treatments. Using data from multicenter, randomized, double-blind, placebo-controlled trials and meta-analyses, we assessed the number needed to treat (NNT) for response and the number needed to harm (NNH) for
Takashi Azuma et al.
Environmental science and pollution research international, 22(23), 18676-18686 (2015-07-17)
Pollution status of six anticancer agents in the river water and effluents of sewage treatment plants (STPs) in Japan was surveyed with comparative analysis of the levels of four microbial and one psychotropic pharmaceuticals widely used for therapeutic medication. The
Evan A Thomas et al.
Epilepsia, 54(7), 1195-1202 (2013-04-10)
A common notion of the mechanism by which the antiepileptic drugs (AEDs) carbamazepine and phenytoin act is that they block sodium channels by binding preferentially to the inactivated state, thereby allowing normal neuronal firing while blocking ictal activity. However, these
Zhong-Tai Piao et al.
European journal of medicinal chemistry, 43(6), 1216-1221 (2007-10-24)
A series of 7-benzylamino-2H-1,4-benzoxazin-3(4H)-ones were synthesized using 2-amino-5-nitrophenol as a starting material. Their anticonvulsant activities were evaluated by the maximal electroshock test (MES test) and their neurotoxicity was evaluated by the rotarod neurotoxicity test (Tox.). The MES test showed that
Mona Darwish et al.
Clinical therapeutics, 37(2), 325-337 (2014-12-03)
Polypharmacy is common in psychiatry practice and can lead to an increased risk of drug interactions. Armodafinil, a wakefulness-promoting agent, has been studied as adjunctive therapy for the treatment of major depressive episodes associated with bipolar I disorder. Armodafinil and
Emilie Lacaze et al.
Environmental pollution (Barking, Essex : 1987), 202, 177-186 (2015-04-02)
The potential toxicity of pharmaceuticals towards aquatic invertebrates is still poorly understood and sometimes controversial. This study aims to document the in vitro genotoxicity and immunotoxicity of psychotropic drugs and antibiotics on Mytilus edulis. Mussel hemocytes were exposed to fluoxetine, paroxetine
Solomon Matongo et al.
Environmental science and pollution research international, 22(13), 10298-10308 (2015-02-25)
Selected pharmaceuticals including antibiotics, antipyretics, a stimulant, an antiepileptic and an antipsychotic drug were determined in wastewater, surface water and sediment along the Umgeni River which is the main source of water to Durban City in KwaZulu-Natal, South Africa. Samples
1/10