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Stephen J Glynn et al.
Organic & biomolecular chemistry, 13(13), 3887-3899 (2015-02-12)
The green tea polyphenol epigallocatechin-3-gallate (EGCG) was reported to effectively antagonize the ability of Bortezomib (BZM) to induce apoptosis in cancer cells. This interaction was attributed to the formation of a covalent adduct between a phenolic moiety of EGCG with
Epinephrine and norepinephrine in pregnancy. A comparative study of the adrenal gland and catechol output in different species of animals and man.
M Goodall et al.
American journal of obstetrics and gynecology, 111(7), 896-904 (1971-12-01)
Abhishek Chauhan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1001, 66-74 (2015-08-11)
In the present communication, uniformly sized molecularly imprinted polymer (MIP) as nanospheres were synthesized based on precipitation polymerization using dual-template imprinting approach and used it as sorbent for solid phase extraction of six urinary benzene metabolites (UBMs). This approach in
David S Goldstein et al.
Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 14(6), 363-368 (2005-01-25)
Oral L-threo-3,4-dihydroxyphenylserine (L-DOPS), a synthetic catechol amino acid, increases standing blood pressure and improves standing ability in patients with neurogenic orthostatic hypotension, by conversion of L-DOPS to norepinephrine (NE) outside the brain. This study assessed the pharmacokinetics of L-DOPS, NE
Atsunori Yafune et al.
Toxicology letters, 219(3), 203-210 (2013-03-29)
We have previously reported that hepatocarcinogens increase liver cells expressing p21(Cip1), a G1 checkpoint protein and M phase proteins after 28-day treatment in rats. This study aimed to identify early prediction markers of carcinogens available in many target organs after
Wai Mun Loke et al.
The Journal of nutrition, 139(12), 2309-2314 (2009-10-09)
Flavonoids are phytochemicals that are widespread in the human diet. Despite limitations in their bioavailability, experimental and epidemiological data suggest health benefits of flavonoid consumption. Valid biomarkers of flavonoid intake may be useful for estimating exposure in a range of
Gayathri Swaminath et al.
The Journal of biological chemistry, 280(23), 22165-22171 (2005-04-09)
The beta(2) adrenergic receptor (beta(2)AR) is a prototypical family A G protein-coupled receptor (GPCR) and an excellent model system for studying the mechanism of GPCR activation. The beta(2)AR agonist binding site is well characterized, and there is a wealth of
Deniz Ekinci et al.
European journal of medicinal chemistry, 49, 68-73 (2012-01-17)
Several 5,10-dihydroindeno[1,2-b]indole derivatives incorporating methoxy, hydroxyl, and halogen (F, Cl, and Br) moieties on the indene fragment of the molecule were prepared and tested against five carbonic anhydrase (CA, EC 4.2.1.1) isoforms. The inhibitory potencies of these compounds against the
Viviana Scognamiglio et al.
Analytica chimica acta, 751, 161-170 (2012-10-23)
In this paper we propose the construction and application of a portable multi-purpose biosensor array for the simultaneous detection of a wide range of endocrine disruptor chemicals (EDCs), based on the recognition operated by various enzymes and microorganisms. The developed
Sudeshna Chandra et al.
Analytica chimica acta, 795, 8-14 (2013-09-04)
Polyaniline-iron oxide magnetic nanohybrid was synthesized and characterized using various spectroscopic, microstructural and electrochemical techniques. The smart integration of Fe3O4 nanoparticles within the polyaniline (PANI) matrix yielded a mesoporous nanohybrid (Fe3O4@PANI) with high surface area (94 m(2) g(-1)) and average
Alessio Innocenti et al.
Bioorganic & medicinal chemistry, 16(15), 7424-7428 (2008-06-27)
Inhibition of 12 mammalian isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1), CA I-XIV, with a series of phenols was investigated. The inhibition profile by phenols of these CAs was distinct from those of the sulfonamides and their isosteres
Rohini Karandikar et al.
Applied biochemistry and biotechnology, 177(2), 318-333 (2015-07-24)
The first step involved in the degradation of phthalate isomers (phthalate, isophthalate and terephthalate) is the double hydroxylation by respective aromatic-ring hydroxylating dioxygenases. These are two component enzymes consisting of 'oxygenase' and 'reductase' components. Soil isolate Pseudomonas aeruginosa strain PP4
Delgerbat Boldbaatar et al.
Journal of ethnopharmacology, 155(1), 599-606 (2014-06-15)
Leptopyrum fumarioides has been used in the traditional medicine of Mongolia for the treatment of various diseases, including drug intoxications. However, since there is only sparse information about its chemistry, active components, and pharmacological and toxicological effects, the major aim
Hélène Marie et al.
PloS one, 7(11), e50326-e50326 (2012-12-12)
This study deals with the anchorage of polyelectrolyte films onto titanium surfaces via a cathecol-based linker for biomedical applications. The following study uses a molecule functionalized with a catechol and a carboxylic acid: 3-(3,4-dihydroxyphenyl)propanoic acid. This molecule is anchored to
H S Purba et al.
British journal of clinical pharmacology, 23(4), 447-453 (1987-04-01)
The metabolism of 17 alpha-ethinyloestradiol (EE2) to catechol and reactive metabolites by human liver microsomes was investigated. 2-Hydroxyethinyloestradiol (2-OHEE2) was either the sole or principal metabolite. Small amounts of 6-hydroxyethinyloestradiol and 16-hydroxyethinyloestradiol were produced by some of the livers. EE2
Robert W Murdoch et al.
Microbiology (Reading, England), 159(Pt 3), 621-632 (2013-01-19)
Sphingomonas Ibu-2 has the unusual ability to cleave the acid side chain from the pharmaceutical ibuprofen and related arylacetic acid derivatives to yield corresponding catechols under aerobic conditions via a previously uncharacterized mechanism. Screening a chromosomal library of Ibu-2 DNA
Su Duy Nguyen et al.
Free radical research, 38(9), 969-976 (2004-12-29)
Paraoxonasel (PON1), one of HDL-asssociated antioxidant proteins, is known to be sensitive to oxidative stress. Here, the effect of endogenous reducing compounds on Cu(2+)-mediated inactivation of PON1 was examined. Cu(2+)-mediated inactivation of PON1 was enhanced remarkably by catecholamines, but not
O Tsypik et al.
TSitologiia i genetika, 47(1), 11-16 (2013-02-23)
Streptomyces globisporus 1912 lnd-cluster region which flanks structural lndZ5-lndZ6 genes contains four open reading frames lndW, lndW2, lndYR and lndY. The latter one encodes putative proteinase which can regulate landomycin production and morphogenesis like LndYR. However, results of lndY overexpression
Mei-Chi Chang et al.
PloS one, 9(7), e101959-e101959 (2014-07-23)
Chewing of betel quid (BQ) increases the risk of oral cancer and oral submucous fibrosis (OSF), possibly by BQ-induced toxicity and induction of inflammatory response in oral mucosa. Primary gingival keratinocytes (GK cells) were exposed to areca nut (AN) components
Ruth A Livingstone et al.
The Journal of chemical physics, 137(18), 184304-184304 (2012-11-21)
Time-resolved photoelectron imaging was used to investigate the dynamical evolution of the initially prepared S(1) (ππ*) excited state of phenol (hydroxybenzene), catechol (1,2-dihydroxybenzene), resorcinol (1,3-dihydroxybenzene), and hydroquinone (1,4-dihydroxybenzene) following excitation at 267 nm. Our analysis was supported by ab initio
Hakki Mevlut Ozcan et al.
Artificial cells, nanomedicine, and biotechnology, 42(4), 256-261 (2013-02-01)
In this study, a novel fresh broad (Vicia faba) tissue homogenate-based biosensor for determination of phenolic compounds was developed. The biosensor was constructed by immobilizing tissue homogenate of fresh broad (Vicia faba) on to glassy carbon electrode. For the stability
Daniel P Poole et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(4), G248-G259 (2015-07-04)
Activated G protein-coupled receptors traffic to endosomes and are sorted to recycling or degradative pathways. Endosomes are also a site of receptor signaling of sustained and pathophysiologically important processes, including inflammation. However, the mechanisms of endosomal sorting of receptors and
Fate of microbial metabolites of dietary polyphenols in rats: is the brain their target destination?
Mattia Gasperotti et al.
ACS chemical neuroscience, 6(8), 1341-1352 (2015-04-22)
Different polyphenol compounds are ingested when consuming a serving of fruits rich in polyphenols, spanning from one-phenol hydroxybenzoic acid to more complex polymeric compounds. Only a minor quantity of the polyphenols (5-10%) is absorbed. The remainder reaches the colon and
Yuta Saito et al.
Macromolecular rapid communications, 34(8), 630-634 (2013-03-20)
Porous surface patterns are used in a wide variety of practical applications. Honeycomb-patterned porous polymer films are good templates for preparing porous surfaces due to their simple fabrication and the arrangement of pores on the surface. Catechol groups include in
R D Irons
Journal of toxicology and environmental health, 16(5), 673-678 (1985-01-01)
Occupational exposure to benzene has long been associated with toxicity to the blood and bone marrow, including lymphocytopenia, pancytopenia, aplastic anemia, acute myelogenous leukemia, and possibly lymphoma. A variety of studies have established that benzene itself is not the toxic
Christian J Kastrup et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(52), 21444-21449 (2012-12-14)
The treatment of diseased vasculature remains challenging, in part because of the difficulty in implanting drug-eluting devices without subjecting vessels to damaging mechanical forces. Implanting materials using adhesive forces could overcome this challenge, but materials have previously not been shown
Ren-Qi Wang et al.
Analytica chimica acta, 853, 608-616 (2014-12-04)
A hydrophilic interaction liquid chromatography (HILIC) method was developed to measure the composition of humic substances from river, reservoir, and treated wastewater based on their physicochemical properties. The current method fractionates the humic substances into four well-defined groups based on
Rogelio Recio-Vega et al.
Journal of applied toxicology : JAT, 33(9), 906-914 (2012-06-26)
Lung cancer is the most common cancer in the world. The main cause of lung cancer is cigarette smoke; however, other important genetic and environmental risk factors play a significant role in the development of lung cancer. Among these factors
Shengnan Shi et al.
Bioresource technology, 193, 281-287 (2015-07-06)
Arthrobacter sp. W1 was used to characterize the pathways involved in cometabolic degradation of carbazole (CA) with phenol as the primary substrate. To clarify the upper pathway of cometabolic degradation CA, Escherichia coli strain BL21 expressing phenol hydroxylase from strain
Sebastian Lorenz Knackstedt et al.
Science immunology, 4(40) (2019-10-20)
Neutrophils are essential innate immune cells that extrude chromatin in the form of neutrophil extracellular traps (NETs) when they die. This form of cell death has potent immunostimulatory activity. We show that heme-induced NETs are essential for malaria pathogenesis. Using
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