CDS022173

应用筛选条件

关键词:'CDS022173'

显示 1-30 共 535 条结果关于 "CDS022173" 范围论文

Upregulation of miR-99a is associated with poor prognosis of acute myeloid leukemia and promotes myeloid leukemia cell expansion.

Xiaohui Si et al.

Oncotarget, 7(47), 78095-78109 (2016-11-02)

Leukemia stem cells (LSCs) can resist available treatments that results in disease progression and/or relapse. To dissect the microRNA (miRNA) expression signature of relapse in acute myeloid leukemia (AML), miRNA array analysis was performed using enriched LSCs from paired bone

A decrease in ubiquitination and resulting prolonged life-span of KIT underlies the KIT overexpression-mediated imatinib resistance of KIT mutation-driven canine mast cell tumor cells.

Masato Kobayashi et al.

Oncology reports, 38(4), 2543-2550 (2017-08-03)

Overexpression of KIT is one of the mechanisms that contributes to imatinib resistance in KIT mutation-driven tumors. Here, the mechanism underlying this overexpression of KIT was investigated using an imatinib-sensitive canine mast cell tumor (MCT) line CoMS, which has an

Wnt Signaling in Leukemia and Its Bone Marrow Microenvironment.

Yongsheng Ruan et al.

International journal of molecular sciences, 21(17) (2020-09-03)

Leukemia is an aggressive hematologic neoplastic disease. Therapy-resistant leukemic stem cells (LSCs) may contribute to the relapse of the disease. LSCs are thought to be protected in the leukemia microenvironment, mainly consisting of mesenchymal stem/stromal cells (MSC), endothelial cells, and

COVID-19: Discovery, diagnostics and drug development.

Tarik Asselah et al.

Journal of hepatology, 74(1), 168-184 (2020-10-11)

Coronavirus disease 2019 (COVID-19) started as an epidemic in Wuhan in 2019, and has since become a pandemic. Groups from China identified and sequenced the virus responsible for COVID-19, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and determined that

Ankyrin Repeat Domain 1 Overexpression is Associated with Common Resistance to Afatinib and Osimertinib in EGFR-mutant Lung Cancer.

Akiko Takahashi et al.

Scientific reports, 8(1), 14896-14896 (2018-10-07)

Overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is critical in combating EGFR-mutant non-small cell lung cancer (NSCLC). We tried to construct a novel therapeutic strategy to conquer the resistance to second-and third-generation EGFR-TKIs in EGFR-positive

Restriction of hepatitis B virus replication by c-Abl-induced proteasomal degradation of the viral polymerase.

Lidan Hou et al.

Science advances, 5(2), eaau7130-eaau7130 (2019-02-19)

About 257 million people with chronic infection of hepatitis B virus (HBV) worldwide are at high risk of developing terminal liver diseases. Reactivation of virus replication has been frequently reported in those patient populations receiving imatinib (an Abl kinase inhibitor)

Multiwalled Carbon Nanotubes/Gold Nanoparticles Hybrid Electrodes for Enzyme-Free Electrochemical Glucose Sensor.

Eagambaram Murugan et al.

Journal of nanoscience and nanotechnology, 19(12), 7596-7604 (2019-06-15)

We followed a facile strategy to fabricate glucose sensors using mildly oxidized multiwalled carbon nanotubes (MWCNTs), gold nanoparticles (AuNPs) and thiol acids including mercaptoacetic acid (MAA), mercaptopropionic acid (MPA), and mercaptosuccinic acid (MSA). The thiol acids separately bonded to MWCNTs

Anti-leukemic effect of PI3K inhibition on chronic myeloid leukemia (CML) cells: shedding new light on the mitigating effect of c-Myc and autophagy on BKM120 cytotoxicity.

Reza Shiri Heris et al.

Cell biology international, 44(5), 1212-1223 (2020-02-19)

The success in the identification of BCR/ABL tyrosine kinase role in the pathogenesis of chronic myeloid leukemia (CML) went as far as to find a path to cure this leukemia; however, compensatory activation of leukomogenic signals get across the message

Ffar2 expression regulates leukaemic cell growth in vivo.

Laure B Bindels et al.

British journal of cancer, 117(9), 1336-1340 (2017-09-06)

Activation of free fatty acid receptor 2 (FFAR2) by microbiota-derived metabolites (e.g., propionate) reduces leukaemic cell proliferation in vitro. This study aims to test whether Ffar2 expression per se also influences leukaemia cell growth in vivo. Bcr-Abl-expressing BaF cells were

Synthesis and Evaluation of Ga-68-Labeled Rhein for Early Assessment of Treatment-Induced Tumor Necrosis.

Aimi Zhang et al.

Molecular imaging and biology, 22(3), 515-525 (2019-06-30)

This study aimed to synthesize a necrosis-avid agent using rhein as a precursor and labeled with gallium-68 (Ga-68) for positron emission tomography/computed tomography (PET/CT) imaging, to evaluate response to anticancer treatment in a mouse model. 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-conjugated rhein was

Dragon's blood extracts reduce radiation-induced peripheral blood injury and protects human megakaryocyte cells from GM-CSF withdraw-induced apoptosis.

Yuanyuan Ran et al.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 32(1), 84-93 (2015-11-04)

Dragon's blood (DB), a Chinese traditional herb, was shown to have certain protective effects on radiation-induced bone marrow injury due to the presence of several phenolic compounds. The 50% ethanol extracts (DBE) were separated from DB by the methods of

The novel anticancer agent JNJ-26854165 is active in chronic myeloid leukemic cells with unmutated BCR/ABL and T315I mutant BCR/ABL through promoting proteosomal degradation of BCR/ABL proteins.

Liangshun You et al.

Oncotarget, 8(5), 7777-7790 (2016-12-22)

Chronic myeloid leukemia (CML) is a clonal malignant disease caused by the expression of BCR/ABL. MDM2 (human homolog of the murine double minute-2) inhibitors such as Nutlin-3 have been shown to induce apoptosis in a p53-dependent manner in CML cells

Standardization of BCR-ABL1 quantification on the international scale in China using locally developed secondary reference panels.

Jia-Wei Zhang et al.

Experimental hematology, 81, 42-49 (2019-12-22)

For patients with chronic myeloid leukemia, reverse transcription quantitative polymerase chain reaction is widely used in laboratories to quantify BCR-ABL1 fusion gene transcripts for disease management. Many efforts have been made to standardize the BCR-ABL1 testing assay, including the primary

Targeting non-oncogene ROS pathway by alantolactone in B cell acute lymphoblastic leukemia cells.

Xiaoguang Xu et al.

Life sciences, 227, 153-165 (2019-04-21)

Alantolactone (ALT) is active component of natural product Inula helenium with a lot of pharmacological effects, including anti-tumor effect. The present work aimed to explore the antitumor effect of ALT in B cell acute lymphoblastic leukemia (B-ALL). B-ALL cells were

Stromal reaction inhibitor and immune-checkpoint inhibitor combination therapy attenuates excluded-type colorectal cancer in a mouse model.

Naoki Yorita et al.

Cancer letters, 498, 111-120 (2020-11-02)

Despite recent advances in cancer immunotherapy, the efficacy of colorectal cancer (CRC) immunotherapy regimens is limited. This study evaluated the combined effect of an anti-PD-1 antibody and a platelet-derived growth factor receptor inhibitor (imatinib) on CRC progression using an orthotopic

Evaluating the potential of kinase inhibitors to suppress DNA repair and sensitise ovarian cancer cells to PARP inhibitors.

Asima Mukhopadhyay et al.

Biochemical pharmacology, 167, 125-132 (2018-10-21)

PARP inhibitors (PARPi) represent a major advance in the treatment of ovarian cancer associated with defects in homologous recombination DNA repair (HRR), primarily due to mutations in BRCA genes. Imatinib and PI3K inhibitors are reported to downregulate HRR and, in

Neutrophil FcγRIIA promotes IgG-mediated glomerular neutrophil capture via Abl/Src kinases.

Hiroshi Nishi et al.

The Journal of clinical investigation, 127(10), 3810-3826 (2017-09-12)

The kidney glomerular capillaries are frequent sites of immune complex deposition and subsequent neutrophil accumulation in post-infectious and rapidly progressive glomerulonephritis. However, the mechanisms of neutrophil recruitment remain enigmatic, and there is no targeted therapeutic to avert this proximal event

Homoharringtonine enhances the effect of imatinib on chronic myelogenous leukemia cells by downregulating ZFX.

Jingjing Wu et al.

Molecular medicine reports, 20(4), 3233-3239 (2019-08-23)

Homoharringtonine (HHT) and imatinib have a synergistic effect in the clinical treatment of chronic myeloid leukemia (CML). The purpose of the present study was to explore the underlying mechanisms by which HHT enhanced imatinib sensitivity. K562 CML cells were treated

Human platelet lysate as validated replacement for animal serum to assess chemosensitivity.

Miriam Pons et al.

ALTEX, 36(2), 277-288 (2018-12-21)

Experiments with cultured mammalian cells represent an in vitro alternative to animal experiments. Fetal calf serum (FCS) is the most commonly used media supplement worldwide. FCS contains a mixture of largely undefined growth factors and cytokines, which support cell proliferation.

Targeting c-kit inhibits gefitinib resistant NSCLC cell growth and invasion through attenuations of stemness, EMT and acquired resistance.

Yueling Zhou et al.

American journal of cancer research, 10(12), 4251-4265 (2021-01-09)

EGFR tyrosine kinase inhibitors (TKIs) are the first-line drugs for NSCLC. But, the acquired resistance limited their efficacy, so that the patients deteriorate eventually. Therefore, it is necessary to clarify the mechanism of the acquired resistance and overcome it for

Imatinib accelerates progenitor cell-mediated liver regeneration in choline-deficient ethionine-supplemented diet-fed mice.

András Rókusz et al.

International journal of experimental pathology, 97(5), 389-396 (2016-12-06)

Severe chronic hepatic injury can induce complex reparative processes. Ductular reaction and the appearance of small hepatocytes are standard components of this response, which is thought to have both adverse (e.g. fibrosis, carcinogenesis) and beneficial (regeneration) consequences. This complex tissue

KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia.

Chengwan Zhang et al.

Theranostics, 11(6), 2691-2705 (2021-01-19)

Rationale: Despite landmark therapy of chronic myelogenous leukemia (CML) with tyrosine kinase inhibitors (TKIs), drug resistance remains problematic. Cancer pathogenesis involves epigenetic dysregulation and in particular, histone lysine demethylases (KDMs) have been implicated in TKI resistance. We sought to identify

c-Abl Kinase Is Required for Satellite Cell Function Through Pax7 Regulation.

Fabián Montecino et al.

Frontiers in cell and developmental biology, 9, 606403-606403 (2021-03-30)

Satellite cells (SCs) are tissue-specific stem cells responsible for adult skeletal muscle regeneration and maintenance. SCs function is critically dependent on two families of transcription factors: the paired box (Pax) involved in specification and maintenance and the Muscle Regulatory Factors

Imatinib blocks tyrosine phosphorylation of Smad4 and restores TGF-I? growth-suppressive signaling in BCR-ABL1-positive leukemia.

Wang, et al.

Signal transduction and targeted therapy, 8, 120-120 (2023)

Tumor cell oxidative metabolism as a barrier to PD-1 blockade immunotherapy in melanoma.

Yana G Najjar et al.

JCI insight, 4(5) (2019-02-06)

The tumor microenvironment presents physical, immunologic, and metabolic barriers to durable immunotherapy responses. We have recently described roles for both T cell metabolic insufficiency as well as tumor hypoxia as inhibitory mechanisms that prevent T cell activity in murine tumors

Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity.

Nicholas Sciascia et al.

eLife, 9 (2020-02-15)

Topoisomerase II (TOP2) relieves topological stress in DNA by introducing double-strand breaks (DSBs) via a transient, covalently linked TOP2 DNA-protein intermediate, termed TOP2 cleavage complex (TOP2cc). TOP2ccs are normally rapidly reversible, but can be stabilized by TOP2 poisons, such as

Discoidin Domain Receptor-1 (DDR1) is Involved in Angiolymphatic Invasion in Oral Cancer.

Yu-Lian Chen et al.

Cancers, 12(4) (2020-04-05)

The discoidin domain receptor-1 (DDR1) is a non-integrin collagen receptor recently implicated in the collective cell migration of other cancer types. Previously, we identified an elevated expression of DDR1 in oral squamous cell carcinoma (OSCC) cells. Through the data mining

Expansion of BCR/ABL1

Leo Edlinger et al.

British journal of haematology, 179(2), 229-241 (2017-07-15)

The p21-activated kinases (PAKs) are key nodes in oncogenic signalling pathways controlling growth, survival, and motility of cancer cells. Their activity is increased in many human cancers and is associated with poor prognosis. To date, PAK deregulation has mainly been

Tyrosine Kinase Inhibitors Regulate OPG through Inhibition of PDGFRβ.

Susannah O'Sullivan et al.

PloS one, 11(10), e0164727-e0164727 (2016-10-14)

Nilotinib and imatinib are tyrosine kinase inhibitors (TKIs) used in the treatment of chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). In vitro, imatinib and nilotinib inhibit osteoclastogenesis, and in patients they reduce levels of bone resorption. One of

CircRNA_000543 knockdown sensitizes nasopharyngeal carcinoma to irradiation by targeting miR-9/platelet-derived growth factor receptor B axis.

Li Chen et al.

Biochemical and biophysical research communications, 512(4), 786-792 (2019-04-01)

Radiation therapy is the mainstay of salvage therapy for nasopharyngeal carcinoma (NPC). However, radiation therapy efficacy is limited by radioresistance that can cause local recurrence and distant metastases. Circular RNAs (circRNAs) have been involved in radioresistant esophageal cancer cells. In

1/18