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D Rendina et al.
Minerva endocrinologica, 38(2), 211-215 (2013-06-05)
Multiple symmetric lipomatosis (MSL, OMIM 151800), is a rare disease characterised by the growth of uncapsulated masses of abnormal adipose tissue around the neck, shoulders or other parts of the trunk and typically associated with high ethanol intake. We describe
Lotfi Benboubker et al.
The New England journal of medicine, 371(10), 906-917 (2014-09-04)
The combination melphalan-prednisone-thalidomide (MPT) is considered a standard therapy for patients with myeloma who are ineligible for stem-cell transplantation. However, emerging data on the use of lenalidomide and low-dose dexamethasone warrant a prospective comparison of the two approaches. We randomly
N H Waldron et al.
British journal of anaesthesia, 110(2), 191-200 (2012-12-12)
The analgesic efficacy and adverse effects of a single perioperative dose of dexamethasone are unclear. We performed a systematic review to evaluate the impact of a single i.v. dose of dexamethasone on postoperative pain and explore adverse events associated with
T Maślanka et al.
Polish journal of veterinary sciences, 16(2), 219-222 (2013-08-27)
Recently, we found that dexamethasone caused a depletion of CD25- CD4+ T cells, but it increased the number of CD25highCD4+ and CD25lowCD4+ T cells. We also determined meloxicam-induced increase in the number of CD25highCD4+ T cells. In view of this
Sara Bringhen et al.
Blood, 124(1), 63-69 (2014-05-24)
This multicenter, open-label phase 2 trial determined the safety and efficacy of carfilzomib, a novel and irreversible proteasome inhibitor, in combination with cyclophosphamide and dexamethasone (CCyd) in patients with newly diagnosed multiple myeloma (NDMM) ≥65 years of age or who
Kota Ohashi et al.
[Rinsho ketsueki] The Japanese journal of clinical hematology, 54(7), 670-674 (2013-08-06)
We report a 53-year-old male with POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome who relapsed after autologous peripheral stem cell transplantation (ASCT), but responded extremely well to lenalidomide (LEN) plus low dose dexamethasone (Ld) therapy. The patient
Olivier Aubert et al.
Transplantation, 97(9), 946-952 (2014-04-25)
This prospective monocentric study investigated the effect of corticosteroids plus bortezomib to reduce anti-HLA antibodies before renal transplantation. Included were 23 patients with stable immunization against HLA and awaiting a kidney transplant (KT). Treatment consisted of bortezomib (1.3 mg/m) plus
T Stathas et al.
European review for medical and pharmacological sciences, 17(11), 1455-1466 (2013-06-19)
Nasal polyposis (NP) is a chronic inflammatory disease of the upper airways, that characterized by inflammatory cells infiltration, extracellular matrix accumulation and oedema. Interleukin-6 (IL-6) is a multifunctional cytokine, implicated in various inflammatory conditions, including NP pathogenesis. Macrophage migration inhibitory
Aprepitant versus dexamethasone to prevent delayed emesis after chemotherapy.
Terry L Ng et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(20), 2184-2185 (2014-06-11)
Giada Bianchi et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(20), 2125-2132 (2014-06-04)
A previously healthy 62-year-old man presented to his primary care physician with a 3-month history of fatigue and unremitting back pain. Physical examination revealed mucosal pallor, point tenderness at T10-T12, and a normal neurologic examination with preserved lower extremity strength
Grant E Keeney et al.
Pediatrics, 133(3), 493-499 (2014-02-12)
Dexamethasone has been proposed as an equivalent therapy to prednisone/prednisolone for acute asthma exacerbations in pediatric patients. Although multiple small trials exist, clear consensus data are lacking. This systematic review and meta-analysis aimed to determine whether intramuscular or oral dexamethasone
Sa Luo et al.
Toxicology letters, 229(1), 85-92 (2014-06-10)
Various therapeutic regimes have been proposed with limited success for treatment of phosgene-induced acute lung injury (P-ALI). Corticoids were shown to be efficacious against chlorine-induced lung injury but there is still controversy whether this applies also to P-ALI. This study
Weiping Qin et al.
Biochemical and biophysical research communications, 450(2), 979-983 (2014-06-28)
Glucocorticoids stimulate muscle atrophy through a cascade of signals that includes activation of FoxO transcription factors which then upregulate multiple genes to promote degradation of myofibrillar and other muscle proteins and inhibit protein synthesis. Our previous finding that glucocorticoids upregulate
Sanjay Mahant et al.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 150(5), 872-879 (2014-02-05)
To determine whether dexamethasone use in children undergoing tonsillectomy is associated with increased risk of postoperative bleeding. Retrospective cohort study using a multihospital administrative database. Thirty-six US children's hospitals. Children undergoing same-day tonsillectomy between the years 2004 and 2010. We
Jing Gong et al.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 29(6), 561-564 (2013-06-12)
To observe the expressions of IL-21 and its receptor (IL-21R) in the lungs of chronic asthmatic mice, and investigate the effects of dexamethasone (Dex) on their expressions. Thirty-three specific pathogen free (SPF) BALB/c female mice were randomly divided into control
Nayera H K El Sherif et al.
Journal of pediatric hematology/oncology, 36(7), 518-523 (2014-08-12)
Endothelial dysfunction has been reported in children with acute lymphoblastic leukemia (ALL). The aim of this study is to assess Von Willebrand Factor antigen (VWF antigen) and Factor VIII (FVIII) in newly diagnosed ALL patients, in relation to peripheral blast
Shaji K Kumar et al.
The Lancet. Oncology, 15(13), 1503-1512 (2014-12-03)
The combination of bortezomib, lenalidomide, and dexamethasone is a highly effective therapy for newly diagnosed multiple myeloma. Ixazomib is an investigational, oral, proteasome inhibitor with promising anti-myeloma effects and low rates of peripheral neuropathy. In a phase 1/2 trial we
Elizabeth E Sweeney et al.
Cancer research, 74(23), 7060-7068 (2014-10-12)
Hormone replacement therapy (HRT) is widely used to manage menopausal symptoms in women and can be comprised of an estrogen alone or an estrogen combined with a progestin. The Women's Health Initiative demonstrated in their randomized trials that estrogen alone
[New and old medications for croup and seizures in children. Oral dexamethasone and buccal midazolam may provide better treatment].
Axelsson Inge et al.
Lakartidningen, 110(48), 2163-2163 (2014-01-18)
Clinically relevant genetic advances in endocrinology.
Angela Rogers et al.
Clinical medicine (London, England), 13(3), 299-305 (2013-06-14)
Chao H Yang et al.
JAMA dermatology, 150(4), 426-428 (2014-02-21)
Cryoglobulins are cold-precipitating immunoglobulins that occur secondary to lymphoproliferative disorders, chronic viral infections, and autoimmune disorders. The treatment of cryoglobulinemia should target the underlying disorder; however, such an approach may be difficult, and therapeutic options remain limited for type I
Hyperkalemia: a clue to the diagnosis of adrenal insufficiency.
Daniel El Fassi et al.
Circulation, 128(24), 2620-2621 (2013-12-18)
Shankar Swaminathan et al.
Journal of biomedical nanotechnology, 9(6), 998-1007 (2013-07-19)
Nanosponges (NS) were synthesized by crosslinking of beta cyclodextrins with diphenyl carbonate. It is a hyper-branched polymer with an ultra high encapsulation efficiency leading to formation of colloidal systems. Dexamethasone (DEX) on the other hand is a poorly soluble drug
Kasima Ekthuwapranee et al.
The Journal of steroid biochemistry and molecular biology, 145, 38-48 (2014-10-12)
Glucocorticoids, hormones that are released in response to stress, induce neuronal cell damage. The hippocampus is a primary target of glucocorticoids in the brain, the effects of which include the suppression of cell proliferation and diminished neurogenesis in the dentate
Yasunobu Sekiguchi et al.
Journal of clinical and experimental hematopathology : JCEH, 53(1), 21-28 (2013-06-27)
A 56-year-old man developed epistaxis, hoarseness, and swelling of a finger in March 2010. On the basis of biopsies of the masses in the pharynx and finger, he was diagnosed with extramedullary plasmablastic plasmacytoma, with somewhat immature CD45(+), MPC-1(-), and
Perineural vs intravenous administration of dexamethasone: more data are available.
E Albrecht et al.
British journal of anaesthesia, 114(1), 160-160 (2014-12-17)
Chenming Yang et al.
Journal of biomedical nanotechnology, 9(9), 1617-1623 (2013-08-29)
The purpose of this research was to investigate the possibility of dexamethasone (DEX)-loaded PLGA-TPGS nanoparticles (NPs) in rabbits after intravitreal administration for the treatment of posterior segment diseases. The DEX-loaded PLGA-TPGS NPs were fabricated and characterized in terms of surface
A Oestmann et al.
Deutsche medizinische Wochenschrift (1946), 139(30), 1518-1520 (2014-07-30)
A 54-year old man had suffered from advanced multiple myeloma for two years. After initially good response the myeloma was refractrory to treatment with dexamethasone, cyclophosphamide, bortezomibe, zoledronate and additionally doxorubicine. The patient then complained of dyspnea without clinical signs
Perineural dexamethasone and multimodal perineural analgesia: how much is too much?
Brian A Williams et al.
Anesthesia and analgesia, 118(5), 912-914 (2014-05-02)
Alice Pham et al.
Obstetrics and gynecology, 120(6), 1451-1458 (2012-11-22)
To estimate the beneficial and harmful effects of dexamethasone for prevention of postoperative nausea and vomiting in women undergoing laparoscopic gynecologic surgery. We searched the following bibliographic databases: MEDLINE (from 1946 to January 2012), Embase (from 1980 to 2012 week
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