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D-085
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Tracey A Quinn et al.
The Journal of endocrinology, 221(2), 347-362 (2014-03-07)
Antenatal stress disturbs the development of the fetal hypothalamic-pituitary-adrenal axis and adrenal steroidogenesis. We investigated the effect of brief maternal exposure to high glucocorticoids (dexamethasone (DEX)) at mid- and late-pregnancy on adrenal structure and production of steroids in spiny mouse.
Lancelot Wehmeyer et al.
The Journal of biological chemistry, 289(14), 10235-10251 (2014-02-22)
Cross-talk between the glucocorticoid receptor (GR) and other receptors is emerging as a mechanism for fine-tuning cellular responses. We have previously shown that gonadotropin-releasing hormone (GnRH) ligand-independently activates the GR and synergistically modulates glucocorticoid-induced transcription of an endogenous gene in
Stopping the swinging pendulum of postnatal corticosteroid use.
Sara B Demauro et al.
The Journal of pediatrics, 164(1), 9-11 (2013-12-24)
A Keith Stewart et al.
The New England journal of medicine, 372(2), 142-152 (2014-12-09)
Lenalidomide plus dexamethasone is a reference treatment for relapsed multiple myeloma. The combination of the proteasome inhibitor carfilzomib with lenalidomide and dexamethasone has shown efficacy in a phase 1 and 2 study in relapsed multiple myeloma. We randomly assigned 792
Aoshuang Chen et al.
Journal of immunology (Baltimore, Md. : 1950), 193(1), 35-39 (2014-06-06)
The immunosuppressant dexamethasone was shown to preferentially deplete CD4+ effector T cells while sparing regulatory T cells (Tregs) in vivo. In the current study, we show that it also preferentially depletes B-2 cells while sparing B-1 cells. In the ApoE(-/-)
Christopher Giuliano et al.
Postgraduate medicine, 124(3), 110-115 (2012-06-14)
Patients with migraine headaches are commonly encountered by clinicians both in the clinic and in the emergency department. Migraines impose a significant financial burden on patients, caregivers, and society. Up to 49% of patients treated acutely for migraine headache will
Question 1: Prednisolone or dexamethasone for acute exacerbations of asthma: do they have similar efficacy in the management of exacerbations of childhood asthma?
Elisabeth Redman et al.
Archives of disease in childhood, 98(11), 916-919 (2013-10-15)
Duohui Jing et al.
Blood, 125(2), 273-283 (2014-10-23)
Glucocorticoids are critical components of combination chemotherapy regimens in pediatric acute lymphoblastic leukemia (ALL). The proapoptotic BIM protein is an important mediator of glucocorticoid-induced apoptosis in normal and malignant lymphocytes, whereas the antiapoptotic BCL2 confers resistance. The signaling pathways regulating
Dawn E W Livingstone et al.
The Journal of endocrinology, 222(2), 257-266 (2014-05-30)
Patients with critical illness or hepatic failure exhibit impaired cortisol responses to ACTH, a phenomenon known as 'relative adrenal insufficiency'. A putative mechanism is that elevated bile acids inhibit inactivation of cortisol in liver by 5α-reductases type 1 and type
Fu-Ming Zi et al.
Cancer letters, 356(2 Pt B), 443-453 (2014-10-12)
Epidemiologic studies and meta-analyses have suggested that patients with type 2 diabetes mellitus (T2DM) have a higher incidence of malignancies, including myeloma. Metformin is a widely prescribed antidiabetic drug. Recently, researchers have shown that metformin has direct anticancer activity against
Amrinder J Kanwar et al.
Journal of cutaneous medicine and surgery, 17(4), 259-268 (2013-07-03)
The course of vitiligo is unpredictable. If the disease is spreading rapidly, the progression can be controlled with the use of systemic steroids daily or in pulsed form. The present study was planned to assess the efficacy of low-dose dexamethasone
Min Fan et al.
Journal of biomedical nanotechnology, 10(4), 592-602 (2014-04-17)
Soft tissue augmentation using various injectable fillers has gained popularity as more patients seek esthetic improvement through minimally invasive procedures requiring little or no recovery time. The currently available injectable skin fillers can be divided into three categories. With careful
Jun Ho Lee et al.
FEBS letters, 588(24), 4708-4719 (2014-12-03)
Thymic atrophy occurs during normal aging, and is accelerated by exposure to chronic stressors that elevate glucocorticoid levels and impair the naïve T cell output. The orexigenic hormone ghrelin was recently shown to attenuate age-associated thymic atrophy. Here, we report
Reply to T.L. Ng et al and L. Celio et al.
Fausto Roila et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 32(20), 2187-2188 (2014-06-11)
Acute migraine treatment in emergency settings.
Aaron Saguil et al.
American family physician, 89(9), 742-744 (2014-05-03)
S Choi et al.
British journal of anaesthesia, 112(3), 427-439 (2014-01-15)
Brachial plexus nerve blocks (BPBs) have analgesic and opioid sparing benefits for upper extremity surgery. Single-injection techniques are limited by the pharmacological duration and therapeutic index of local anaesthetics (LAs). Continuous catheter techniques, while effective can present management challenges. Off-label
María-Victoria Mateos et al.
The New England journal of medicine, 369(5), 438-447 (2013-08-02)
For patients with smoldering multiple myeloma, the standard of care is observation until symptoms develop. However, this approach does not identify high-risk patients who may benefit from early intervention. In this randomized, open-label, phase 3 trial, we randomly assigned 119
Marielle Perry et al.
American journal of hematology, 89(10), 969-973 (2014-07-22)
Indolent non-hodgkin lymphomas (iNHL) are a rare cause of monoclonal immunoglobulin deposits-related glomerulopathy (mIgGN). In patients with iNHL-related mIgGN, whether treatment should include either single or a combination of drug(s) to target the malignant clone and renal inflammation remains elusive.
Garry Whitehead et al.
Brain : a journal of neurology, 136(Pt 12), 3753-3765 (2013-11-26)
The neuroendocrine response to episodes of acute stress is crucial for survival whereas the prolonged response to chronic stress can be detrimental. Learning and memory are particularly susceptible to stress with cognitive deficits being well characterized consequences of chronic stress.
S Vincent Rajkumar
American journal of hematology, 89(10), 999-1009 (2014-09-17)
Multiple myeloma accounts for approximately 10% of hematologic malignancies. The diagnosis requires 10% or more clonal plasma cells on bone marrow examination or a biopsy proven plasmacytoma plus evidence of associated end-organ damage. If end-organ damage is not present, the
Morie A Gertz
American journal of hematology, 89(12), 1132-1140 (2014-11-20)
Immunoglobulin light chain amyloidosis is a clonal, nonproliferative plasma cell disorder in which fragments of immunoglobulin light chain are deposited in tissues. Clinical features depend on organs involved but can include restrictive cardiomyopathy, nephrotic syndrome, hepatic failure, peripheral/autonomic neuropathy, and
Shirzad Nasiri et al.
The American surgeon, 79(12), 1258-1262 (2013-12-20)
Voice alteration is one of the most common complications after thyroidectomy. It has a serious effect on social communication and economic and psychosocial status of patients. It has been hypothesized that inflammation and edema in the surgery site has a
Current treatment for multiple myeloma.
David Avigan et al.
The New England journal of medicine, 371(10), 961-962 (2014-09-04)
Katja Rezonja et al.
Anesthesia and analgesia, 118(4), 755-763 (2014-03-22)
Corticosteroids are frequently used during anesthesia to provide substitution therapy in patients with adrenal insufficiency, as a first-line treatment of several life-threatening conditions, to prevent postoperative nausea and vomiting, and as a component of multimodal analgesia. For these last 2
Chengyun Wang et al.
Experimental eye research, 129, 74-82 (2014-12-03)
Dexamethasone is a glucocorticoid that is widely used in the ophthalmic arena. The recent FDA approved dexamethasone implant can provide a three month efficacy but with high rate of drug related cataract and high intraocular pressure (IOP). It seems that
Xiu-Fang Xin et al.
Molecular plant-microbe interactions : MPMI, 26(8), 861-867 (2013-07-03)
The pleiotropic drug resistance (PDR) proteins belong to the super-family of ATP-binding cassette (ABC) transporters. AtPDR8, also called PEN3, is required for penetration resistance of Arabidopsis to nonadapted powdery mildew fungi. During fungal infection, plasma-membrane-localized PEN3 is concentrated at fungal
Hikaru Yagi et al.
[Rinsho ketsueki] The Japanese journal of clinical hematology, 54(12), 2171-2176 (2014-01-24)
A 56-year-old male presented with pathological rib fracture and lumbago in 2006. He was diagnosed with multiple myeloma (IgG-lambda type, D&S stage IIIA, ISS 2). He was treated with VAD therapy and tandem auto-PBSCT, and achieved CR in 2007. He
Florian A Britto et al.
American journal of physiology. Endocrinology and metabolism, 307(11), E983-E993 (2014-10-16)
REDD1 (regulated in development and DNA damage response 1) has been proposed to inhibit the mechanistic target of rapamycin complex 1 (mTORC1) during in vitro hypoxia. REDD1 expression is low under basal conditions but is highly increased in response to
Regina M Myers et al.
Cancer, 120(9), 1417-1425 (2014-01-30)
The authors prospectively assessed anxiety, depression, and behavior in children with standard-risk acute lymphoblastic leukemia (SR-ALL) during the first year of therapy and identified associated risk factors. A cohort study was performed of 159 children (aged 2 years-9.99 years) with
Hiroyuki Takamatsu et al.
Anticancer research, 33(12), 5681-5685 (2013-12-11)
Post-autologous stem cell transplantation (ASCT) consolidation and maintenance therapies in multiple myeloma (MM) have recently been the central focus of studies. However, there have been no reports of Japanese patients with MM treated with post-ASCT consolidation/maintenance therapies. We retrospectively evaluated
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