CN
Search Within
D120804
应用筛选条件
关键词:'D120804'
显示 1-30 共 125 条结果 关于 "D120804" 范围 论文
Thu-Thuy Nguyen et al.
Pathogens (Basel, Switzerland), 8(3) (2019-07-20)
Sexual stage induction under in vitro conditions is useful for biological and molecular studies of Babesia parasites. Therefore, in the present study, we induced B. ovata tick stages using the chemical inducers: xanthurenic acid (XA), dithiothreitol (DTT) and tris (2-carboxyethyl)
Michael Maes et al.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 21(5), 383-401 (2020-02-08)
Objectives: Stable-phase schizophrenia comprises two distinct entities namely Major Neuro-Cognitive Psychosis (MNP) and simple NP (SNP), which are defined by neuroimmune and neurocognitive abnormalities.Methods: This study investigates associations of psychomotor retardation (PMR), clinical and biomarker characteristics of schizophrenia. We recruited
G M Pollack et al.
Toxicology and applied pharmacology, 79(2), 257-267 (1985-06-30)
The degree of exposure to the plasticizer di(2-ethylhexyl) phthalate (DEHP) was assessed in 11 patients undergoing maintenance hemodialysis for the treatment of renal failure. The amount of DEHP leached from the dialyzer during a 4-hr dialysis session was estimated by
Buranee Kanchanatawan et al.
Metabolic brain disease, 33(4), 1053-1067 (2018-03-13)
Deficit schizophrenia is characterized by neurocognitive impairments and changes in the patterning of IgA/IgM responses to plasma tryptophan catabolites (TRYCATs). In the current study, supervised pattern recognition methods, including logistic regression analysis (LRA), Support Vector Machine (SVM), and Soft Independent
Giulia Siciliano et al.
Frontiers in microbiology, 11, 269-269 (2020-04-08)
The egress and fertilization of Plasmodium gametes and development of a motile ookinete are the first crucial steps that mediate the successful transmission of the malaria parasites from humans to the Anopheles vector. However, limited information exists about the cell
Harouna Soré et al.
Phytochemistry, 174, 112336-112336 (2020-03-21)
Targeting the transmissible stages of the Plasmodium parasite that develop in the human and mosquito host is a crucial strategy for malaria control and elimination. Medicinal plants offer a prolific source for the discovery of new antimalarial compounds. The recent
Celia Miguel-Blanco et al.
Nature communications, 8, 15160-15160 (2017-05-18)
Plasmodium falciparum stage V gametocytes are responsible for parasite transmission, and drugs targeting this stage are needed to support malaria elimination. We here screen the Tres Cantos Antimalarial Set (TCAMS) using the previously developed P. falciparum female gametocyte activation assay
Laddawan Senggunprai et al.
The Journal of pharmacology and experimental therapeutics, 327(3), 789-798 (2008-09-26)
Natriuretic substances are a group of molecules affecting sodium homeostasis in the body. Recently, two new molecules having natriuresis effects, xanthurenic acid 8-O-beta-d-glucoside and xanthurenic acid 8-O-sulfate (XA sulfate), have been isolated from human urine. In the present study, we
Miki Terakata et al.
The Journal of nutrition, 143(7), 1046-1051 (2013-05-24)
In mammals, nicotinamide (Nam) is biosynthesized from l-tryptophan (l-Trp). The enzymes involved in the initial step of the l-Trp→Nam pathway are l-Trp-2,3-dioxygenase (TDO) and indoleamine-2,3-dioxygenase (IDO). We aimed to determine whether tdo-knockout (tdo(-/-)) mice fed a diet without preformed niacin
Shankar S Iyer et al.
Cell, 173(5), 1123-1134 (2018-05-19)
Genome-wide association studies have identified risk loci associated with the development of inflammatory bowel disease, while epidemiological studies have emphasized that pathogenesis likely involves host interactions with environmental elements whose source and structure need to be defined. Here, we identify
Kinga Molnár et al.
Pharmaceutics, 13(1) (2021-01-21)
By being an antagonist of glutamate and other receptors, kynurenic acid serves as an endogenous neuroprotectant in several pathologies of the brain. Unfortunately, systemic administration of kynurenic acid is hindered by its low permeability through the blood-brain barrier. One possibility
Gara Arteaga-Henriquez et al.
Progress in neuro-psychopharmacology & biological psychiatry, 107, 110226-110226 (2020-12-22)
It is unclear how the tryptophan (TRP) breakdown pathway relates to the activated inflammatory state of patients with major depressive disorder (MDD). We determined in two different cohorts of patients with MDD (n = 281) and healthy controls (HCs) (n = 206) collected for
Un-Ho Jin et al.
The Journal of biological chemistry, 294(29), 11342-11353 (2019-06-07)
The aryl hydrocarbon receptor (AhR) plays an important role in maintaining cellular homeostasis and also in pathophysiology. For example, the interplay between the gut microbiome and microbially derived AhR ligands protects against inflammation along the gut-brain axis. The AhR and
J D Shoemaker et al.
Journal of chromatography, 562(1-2), 125-138 (1991-01-02)
Eighty-five clinical urine samples and nineteen urine samples previously found by other laboratories to suggest genetic metabolic defects were prepared for trimethylsilylation by treatment with urease, followed by azeotropic dehydration. The "Target Analyte Search" program provided with the VG Trio
Nisha Dahiya et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 23(14), 1743-1752 (2016-12-04)
NeemAzal® (NA) is a quantified extract from seed kernels of neem, Azadirachta indica A.Juss. (Meliaceae), with a wide spectrum of biological properties, classically ascribed to its limonoid content. NA contains several azadirachtins (A to L), azadirachtin A (AzaA) being its
R De Smet et al.
Clinical chemistry, 47(5), 901-909 (2001-04-28)
Several studies have pointed to a release of drugs or protein-bound solutes from their binding sites during heparinization. The effect is attributed to the metabolism of triglycerides to free fatty acids (FFAs), which compete with drugs for protein binding sites.
Navaporn Posayapisit et al.
International journal for parasitology, 51(8), 635-642 (2021-03-14)
Antimalarial drugs capable of targeting multiple parasite stages, particularly the transmissible stages, can be valuable tools for advancing the malaria elimination agenda. Current antifolate drugs such as pyrimethamine can inhibit replicative parasite stages in both humans and mosquitoes, but antifolate
Yao Qi et al.
Molecular bioSystems, 10(10), 2617-2625 (2014-07-22)
Rheumatoid arthritis (RA) is a chronic systemic inflammatory and autoimmune disease accompanied by the destruction and deformities of joints. Adjuvant-induced arthritis (AIA) is one of the excellent animal models of RA used to understand disease pathogenesis and screen potential drugs.
Poliana Coelho Cabral et al.
Nephrology (Carlton, Vic.), 10(5), 459-463 (2005-10-14)
The objective of this study was to assess the vitamin A and zinc serum levels in patients undergoing haemodialysis (HD) in the city of Recife, in the north-eastern region of Brazil. The study comprised 55 patients and 28 healthy controls.
Tibebu Habtewold et al.
Malaria journal, 18(1), 24-24 (2019-01-27)
The development of malaria transmission-blocking strategies including the generation of malaria refractory mosquitoes to replace the wild populations through means of gene drives hold great promise. The standard membrane feeding assay (SMFA) that involves mosquito feeding on parasitized blood through
Sergio Lario et al.
Scientific reports, 7(1), 17774-17774 (2017-12-21)
Gastric carcinogenesis is a multifactorial process described as a stepwise progression from non-active gastritis (NAG), chronic active gastritis (CAG), precursor lesions of gastric cancer (PLGC) and gastric adenocarcinoma. Gastric cancer (GC) 5-year survival rate is highly dependent upon stage of
Iu E Shilov et al.
Vestnik Rossiiskoi akademii meditsinskikh nauk, (1)(1), 35-41 (2013-06-29)
The essential amino acid tryptophan is metabolized on the methoxyindole pathway to serotonin, melatonin and 5-hydroxyindoleacetic acid and on the kynurenine pathway to kynurenine and related neuroactive metabolites, including 3-hydroxykynurenine, kynurenic acid, quinolinic acid and xanthurenic acid. Kynurenine and related
Thiamine deficiency and unexplained encephalopathy in hemodialysis and peritoneal dialysis patients.
S C Hung et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 38(5), 941-947 (2001-10-31)
Patients with end-stage renal disease undergoing regular dialysis are prone to encephalopathy, but the cause is often unclear. Dialysis patients are at risk for thiamine deficiency, which may mimic many uremic complications, including encephalopathy. To determine whether unexplained encephalopathy in
Joachim Jankowski et al.
Arteriosclerosis, thrombosis, and vascular biology, 23(7), 1231-1238 (2003-05-10)
Diadenosine polyphosphates have been demonstrated to be involved in the control of vascular tone as well as the growth of vascular smooth muscle cells and hence, possibly, in atherogenesis. In this study we investigated the question of whether diadenosine polyphosphates
Han Gao et al.
Current biology : CB, 28(17), 2763-2776 (2018-08-28)
Ookinete gliding motility is essential for penetration of the mosquito midgut wall and transmission of malaria parasites. Cyclic guanosine monophosphate (cGMP) signaling has been implicated in ookinete gliding. However, the upstream mechanism of how the parasites activate cGMP signaling and
Antoine Lefèvre et al.
Talanta, 195, 593-598 (2019-01-11)
In this study, we validated a method for quantifying 20 tryptophan (Trp) catabolites by liquid chromatography coupled with high resolution mass spectrometry (LC-HRMS) in 4 different matrices (urine, serum, intestinal contents and liver). The detection limit for all metabolites ranged
Raquel Azevedo et al.
Frontiers in microbiology, 10, 3048-3048 (2020-02-11)
Coendemicity between the human immunodeficiency virus (HIV) and Plasmodium parasites, the causative agents of acquired immunodeficiency syndrome (AIDS) and malaria, respectively, occurs in several regions around the world. Although the impact of the interaction between these two organisms is not
Alba M Garcia-Lino et al.
Food chemistry, 344, 128665-128665 (2020-12-01)
ATP-binding cassette transporter G2 (ABCG2) is involved in the secretion of several compounds in milk. The in vitro and in vivo interactions between tryptophan-related compounds and ABCG2 were investigated. The tryptophan metabolome was determined by liquid chromatography-tandem mass spectrometry in
Kentaro Kato et al.
Parasitology international, 58(4), 394-400 (2009-08-12)
In Plasmodium berghei, the orthologous gene of P. falciparum calcium-dependent protein kinase 4 (PfCDPK4) was reported to be essential for the exflagellation of male gametocytes. To elucidate the role of PfCDPK4 in P. falciparum gametogenesis, we characterized the biological function
Elena Lantero et al.
Biomolecules, 10(8) (2020-08-06)
Innovative antimalarial strategies are urgently needed given the alarming evolution of resistance to every single drug developed against Plasmodium parasites. The sulfated glycosaminoglycan heparin has been delivered in membrane feeding assays together with Plasmodium berghei-infected blood to Anopheles stephensi mosquitoes.
1/5