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M Christensen et al.
Journal of inherited metabolic disease, 30(2), 248-255 (2007-03-06)
Massive urinary excretion of xanthurenic acid, 3-hydroxykynurenine and kynurenine, known as xanthurenic aciduria or hydroxykynureninuria, in a young Somali boy suggested kynureninase deficiency. Mutation analysis of KYNU encoding kynureninase of the index case revealed homozygosity for a c.593 A >
Adoracion Pegalajar-Jurado et al.
Scientific reports, 8(1), 12204-12204 (2018-08-17)
Metabolites detectible in human biofluids are attractive biomarkers for the diagnosis of early Lyme disease (ELD), a vector-borne infectious disease. Urine represents an easily obtained clinical sample that can be applied for diagnostic purposes. However, few studies have explored urine
Buranee Kanchanatawan et al.
Molecular neurobiology, 55(6), 5184-5201 (2017-09-07)
Evidence indicates that schizophrenia and in particular negative symptoms and deficit schizophrenia are accompanied by neurocognitive impairments and changes in the patterning of the tryptophan catabolite (TRYCAT) pathway. This cross-sectional study was carried out to examine the associations between cognitive
Minerva Camacho-Nuez et al.
Parasites & vectors, 10(1), 568-568 (2017-11-15)
Bovine babesiosis is a tick-borne disease caused by the protozoan parasites of the genus Babesia. In their host vector, Babesia spp. undergo sexual reproduction. Therefore, the development of sexual stages and the subsequent formation of the zygote are essential for
Ling Li et al.
Molecular cell, 80(3), 525-540 (2020-10-18)
Well-balanced and timed metabolism is essential for making a high-quality egg. However, the metabolic framework that supports oocyte development remains poorly understood. Here, we obtained the temporal metabolome profiles of mouse oocytes during in vivo maturation by isolating large number of
Chiaki Hiratsuka et al.
Journal of nutritional science and vitaminology, 60(4), 255-260 (2014-10-10)
We have previously reported that dietary supplementation with up to 5.0 g/d of L-tryptophan (L-Trp) for 21 d has no adverse effects, judging from the levels of general blood variables, in healthy women. We performed a randomized, double-blind, placebo-controlled, crossover
Emme C K Lin et al.
Bioorganic & medicinal chemistry letters, 22(2), 868-871 (2012-01-06)
AX10185, the phenyl amide of xanthurenic acid, was found to be a sub-100nM inhibitor of Lp-PLA(2). However, in the presence of EDTA the inhibitory activity of AX10185 was extinguished while the enzymatic activity of Lp-PLA(2) did not change. Subsequent metal
He Lin et al.
BMC pharmacology & toxicology, 21(1), 59-59 (2020-08-09)
Non-alcoholic fatty liver is one of the most common comorbidities of diabetes. It can cause disturbance of glucose and lipid metabolism in the body, gradually develop into liver fibrosis, and even cause liver cirrhosis. Mangiferin has a variety of pharmacological
Arthur M Talman et al.
Malaria journal, 13, 315-315 (2014-08-16)
Gametogenesis and fertilization play crucial roles in malaria transmission. While male gametes are thought to be amongst the simplest eukaryotic cells and are proven targets of transmission blocking immunity, little is known about their molecular organization. For example, the pathway
Alex Gomez-Gomez et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1060, 347-354 (2017-07-01)
Acute intermittent porphyria (AIP) is a rare metabolic disorder due to a deficiency of porphobilinogen deaminase, the third enzyme of the heme biosynthetic pathway. This low enzymatic activity may predispose to the appearance of acute neurological attacks. Seminal studies suggested
Wenjun Zhou et al.
Brain, behavior, and immunity, 46, 147-153 (2015-02-01)
Chronic pain frequently co-occurs with major depressive disorder but the mechanisms are poorly understood. We investigated the contribution of indoleamine 2,3-dioxygenase-1 (IDO1), a rate-limiting enzyme in the conversion of tryptophan to neurotoxic metabolites, to this comorbidity using the spared nerve
Ahsan F Bairam et al.
Archives of insect biochemistry and physiology, 104(3), e21671-e21671 (2020-04-01)
Sulfoconjugation plays a vital role in the detoxification of xenobiotics and in the metabolism of endogenous compounds. In this study, we aimed to identify new members of the sulfotransferase (SULT) superfamily in the silkworm Bombyx mori. Based on amino acid
P Calandra
Acta vitaminologica et enzymologica, 29(1-6), 158-160 (1975-01-01)
The pattern of tryptophan metabolites "via kynurenine" was determined in the epidermis of man and mouse using semiquantitative method of one- and two-dimensional thin-layer-chromatography. In the epidermis of healthy man the following metabolites were present: tryptophan, kynurenine, anthranilic acid, 3-hydroxyanthranilic
Rebeca Carballar-Lejarazú et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(37), 22805-22814 (2020-08-26)
A Cas9/guide RNA-based gene drive strain, AgNosCd-1, was developed to deliver antiparasite effector molecules to the malaria vector mosquito, Anopheles gambiae The drive system targets the cardinal gene ortholog producing a red-eye phenotype. Drive can achieve 98 to 100% in
Xu Wang et al.
The EMBO journal, 39(13), e104168-e104168 (2020-05-13)
Morphogenesis of many protozoans depends on a polarized establishment of cytoskeletal structures. In malaria-causing parasites, this can be observed when a round zygote develops into an elongated motile ookinete within the mosquito stomach. This morphogenesis is mediated by the pellicle
Kynurenine pathway metabolites: relevant to vitamin B-6 deficiency and beyond.
Matthew A Ciorba
The American journal of clinical nutrition, 98(4), 863-864 (2013-08-30)
Synchronous electrosynthesis of poly (xanthurenic acid)-reduced graphene oxide nanocomposite for highly sensitive impedimetric detection of DNA.
Yang T, et al.
ACS Applied Materials & Interfaces, 5(9), 3495-3499 (2013)
Plasmodium falciparum Gametocyte Culture and Mosquito Infection Through Artificial Membrane Feeding.
Abhai K Tripathi et al.
Journal of visualized experiments : JoVE, (161) (2020-07-28)
Malaria remains one of the most important public health problems, causing significant morbidity and mortality. Malaria is a mosquito borne disease transmitted through an infectious bite from the female Anopheles mosquito. Malaria control will eventually rely on a multitude of
Katsumi Shibata et al.
Journal of nutritional science and vitaminology, 60(4), 261-268 (2014-10-10)
The adverse effects of D-tryptophan and the possibility of it being a surrogate index for predicting adverse effects in rats were investigated. Male rats were fed one of several test diets (20% casein diets with 0% (control), 0.1%, 0.2%, 0.3%
Electrochemical determination of ascorbic acid using poly (xanthurenic acid) and multi-walled carbon nanotubes
Lin K-C, et al.
International Journal of Electrochemical Science, 7(12), 12752-12763 (2012)
Meicheng Su et al.
Journal of dairy science, 103(11), 9851-9859 (2020-09-15)
Tryptophan and metabolites have important biological functions in humans. Milk is an important source of tryptophan intake. In this study, we developed a method to detect levels of tryptophan and 12 metabolites in milk. The analytes were extracted by using
Photooxidation of Lens Proteins with Xanthurenic Acid: A Putative Chromophore for Cataractogenesis.
Roberts J E, et al.
Photochemistry and Photobiology, 74(5), 740-744 (2001)
Janette Reader et al.
Malaria journal, 14, 213-213 (2015-05-23)
The discovery of malaria transmission-blocking compounds is seen as key to malaria elimination strategies and gametocyte-screening platforms are critical filters to identify active molecules. However, unlike asexual parasite assays measuring parasite proliferation, greater variability in end-point readout exists between different
Comment on 'The photosensitiser xanthurenic acid is not present in normal human lenses' by P.G. Hains et al. [Exp. Eye Res. 77 (2003) 547-553].
Halina Z Malina
Experimental eye research, 79(3), 443-445 (2004-09-01)
Nhat M Pham et al.
Clinical journal of the American Society of Nephrology : CJASN, 3(1), 85-90 (2007-11-30)
Protein-bound solutes are poorly cleared by peritoneal dialysis. We examined the hypothesis that plasma concentrations of bound solutes would therefore rise as residual renal function is lost. Clearances of urea indican and p-cresol sulfate were measured in peritoneal dialysis patients
Yuanyuan Liu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1105, 93-103 (2018-12-24)
Gancao Fuzi decoction (GFD) is a classic Chinese medicine formula for the treatment of rheumatic and rheumatoid arthritis. The main active components of GFD are alkaloids, flavonoids and saponins. This study aimed to clarify the pharmacodynamic effects of the active
Katsumi Shibata et al.
Bioscience, biotechnology, and biochemistry, 79(1), 103-108 (2014-09-26)
The conversion of tryptophan (Trp) → nicotinamide (Nam) is an important pathway for supplying vitamin niacin. We reported the following two phenomena: (1) severe food restriction led to an increase in the Trp → Nam conversion compared with free-access control
Yoshihide Ogawa et al.
Frontiers in bioscience : a journal and virtual library, 9, 2901-2908 (2004-09-09)
Ascorbic acid overload and vitamin B6 deficiency have been implicated in the development of hyperoxalemia in dialysis patients, but there is still disagreement about this. Hemodialysis patients who are exposed long-term hyperoxalemia may develop secondary oxalosis with an increased risk
Synthesis of silica-gel immobilized xanthurenic acid and its application to the preconcentration/determination of trace metals in natural water samples
Kasahara I, et al.
Bunseki Kagaku, 47(12), 1061-1067 (1998)
Akira Kushida et al.
Journal of insect physiology, 58(1), 83-88 (2011-11-01)
Sulfotransferase enzymes are known to regulate physiologically active substances such as steroids and catecholamines in mammals. Although invertebrates also express sulfotransferases, their biological function is mostly unclear. In a previous study, we reported that 4-nitrocatechol and the gallete ester are
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