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Andrea Romano et al.
Journal of bacteriology, 195(6), 1249-1254 (2013-01-15)
Lactic acid bacteria play a pivotal role in many food fermentations and sometimes represent a health threat due to the ability of some strains to produce biogenic amines that accumulate in foods and cause trouble following ingestion. These strains carry
Marc-Antoine Bazin et al.
Bioorganic & medicinal chemistry, 16(14), 6860-6866 (2008-06-19)
Nine usnic acid-amine conjugates were evaluated on murine and human cancer cell lines. The polyamine derivatives showed significant cytotoxicity in L1210 cells. Their activities appeared to be independent of the polyamine transport system (PTS). Indeed, their activities were similar in
M Teodorczyk et al.
Cell death and differentiation, 22(7), 1192-1202 (2015-01-24)
Cancer stem cells (CSCs) have been implicated in the initiation and maintenance of tumour growth as well as metastasis. Recent reports link stemness to epithelial-mesenchymal transition (EMT) in cancer. However, there is still little knowledge about the molecular markers of
S I Harik et al.
Cancer research, 39(12), 5010-5015 (1979-12-01)
Putrescine, spermidine, and spermine levels were determined in normal brain and central nervous system-related tumor tissues obtained at operation from 50 patients. The biochemical data were correlated with morphological histopathological descriptions of the same tissues. There was little variation in
Sara Callejón et al.
Journal of agricultural and food chemistry, 63(16), 4170-4178 (2015-03-31)
This work describes the identification and characterization of an amine oxidase from Kocuria varians LTH 1540 (syn. Micrococcus varians) primarily acting on putrescine. Data from MALDI-TOF MS/MS and the identification of Δ(1)-pyrroline as degradation product from putrescine indicate that the
Sehwon Koh et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(47), 15649-15665 (2015-11-27)
Cell therapy demonstrates great potential for the treatment of neurological disorders. Human umbilical tissue-derived cells (hUTCs) were previously shown to have protective and regenerative effects in animal models of stroke and retinal degeneration, but the underlying therapeutic mechanisms are unknown.
Chiao-Chi V Chen et al.
Brain structure & function, 220(4), 2073-2085 (2014-04-29)
White matter tracts are important for the trafficking of neural progenitor cells (NPCs) in both normal and pathological conditions, but the underlying mechanism is not clear. The directionality of white matter is advantageous for molecules or cells to distribute over
Spermine, spermidine and putrescine in fungal development.
L Stevens et al.
Advances in microbial physiology, 19, 63-148 (1979-01-01)
Leah A Gates et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(7), 1132-1136 (2014-04-23)
Furan is a liver toxicant and carcinogen in rodents. Although humans are most likely exposed to furan through a variety of sources, the effect of furan exposure on human health is still unknown. In rodents, furan requires metabolism to exert
Aleesha M McCormick et al.
Acta biomaterialia, 28, 33-44 (2015-09-24)
Immobilization of axon guidance cues offers a powerful tissue regenerative strategy to control the presentation and spatial location of these biomolecules. We use our previously developed immobilization strategy to specifically tether recombinant biotinylated nerve growth factor (bNGF) and biotinylated semaphorin3A
Michela Maifreni et al.
The Journal of dairy research, 80(1), 122-127 (2013-01-10)
The aim of the study was to identify the species of Enterobacteriaceae present in Montasio cheese and to assess their potential to produce biogenic amines. Plate count methods and an Enterobacterial Repetitive Intergenic Consensus Polymerase Chain Reaction (ERIC-PCR) approach, combined
Zeev Karpas et al.
Analytica chimica acta, 758, 122-129 (2012-12-19)
The performance of three different types of ion mobility spectrometer (IMS) devices: GDA2 with a radioactive ion source (Airsense, Germany), UV-IMS with a photo-ionization source (G.A.S. Germany) and VG-Test with a corona discharge source (3QBD, Israel) was studied. The gas-phase
Clara Ibáñez et al.
Journal of pharmaceutical and biomedical analysis, 110, 83-92 (2015-03-31)
In this work, the optimization of an effective protocol for cell metabolomics is described with special emphasis in the sample preparation and subsequent analysis of intracellular metabolites from adherent mammalian cells by capillary electrophoresis-mass spectrometry. As case study, colon cancer
An Extended-gate Type Organic FET Based Biosensor for Detecting Biogenic Amines in Aqueous Solution.
Tsuyoshi Minami et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 31(7), 721-724 (2015-07-15)
This study is the first to report on the detection of biogenic amines in an aqueous solution using an organic field-effect transistor (OFET) device with an extended gate electrode modified with a layer of diamine oxidase and a horseradish peroxidase
Francesco P Busardò et al.
Current neuropharmacology, 13(1), 47-70 (2015-06-16)
The illicit recreational drug of abuse, γ-hydroxybutyrate (GHB) is a potent central nervous system depressant and is often encountered during forensic investigations of living and deceased persons. The sodium salt of GHB is registered as a therapeutic agent (Xyrem®), approved
Arun Sreekumar et al.
Nature, 457(7231), 910-914 (2009-02-13)
Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the identification of critical biomarkers for cancer invasion and disease aggressiveness. Although gene and protein expression have
Ping-Hsing Tsai et al.
Journal of the Chinese Medical Association : JCMA, 78(6), 353-359 (2015-05-30)
Human induced pluripotent stem cells (iPSCs) morphologically and functionally resemble human embryonic stem cells, which presents the opportunity to use patient-specific somatic cells for disease modeling and drug screening. In order to take one step closer to clinical applications, it
Sarah Moyon et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(1), 4-20 (2015-01-09)
The declining efficiency of myelin regeneration in individuals with multiple sclerosis has stimulated a search for ways by which it might be therapeutically enhanced. Here we have used gene expression profiling on purified murine oligodendrocyte progenitor cells (OPCs), the remyelinating
H Yamazaki et al.
Journal of neurology, neurosurgery, and psychiatry, 49(2), 209-210 (1986-02-01)
The contents of free and conjugated polyamines in cyst fluids of brain tumours were analysed. The putrescine and N1-acetylspermidine levels in cyst fluids of malignant brain tumours were significantly higher than those of benign tumours. The free spermidine levels in
Nutrition reviews, 50(3), 81-83 (1992-03-01)
Putrescine addition to a complete crystalline amino acid diet elicited a growth response in young chicks, suggesting that putrescine may be an essential nutrient in avians. However, high dietary putrescine levels can depress weight gain.
Radika Soysa et al.
The Biochemical journal, 452(3), 423-432 (2013-03-29)
The TcPOT1.1 gene from Trypanosoma cruzi encodes a high affinity putrescine-cadaverine transporter belonging to the APC (amino acid/polyamine/organocation) transporter superfamily. No experimental three-dimensional structure exists for any eukaryotic member of the APC family, and thus the structural determinants critical for
Tin-Tin Win-Shwe et al.
Toxicology letters, 228(3), 207-215 (2014-05-13)
Dendrimers are highly branched spherical nanomaterials produced for use in diagnostic and therapeutic applications such as a drug delivery system. The toxicological profiles of dendrimers are largely unknown. We investigated the in vivo effects of nasal exposure to polyamidoamine (PAMAM)
Maria Lauda Tomasi et al.
Experimental cell research, 319(12), 1902-1911 (2013-04-17)
Methionine adenosyltransferase (MAT) is an essential enzyme that is responsible for the biosynthesis of S-adenosylmethionine (SAMe), the principal methyl donor and precursor of polyamines. MAT1A is expressed in normal liver and MAT2A is expressed in all extrahepatic tissues. MAT2A expression
T L Sourkes et al.
Agents and actions, 11(1-2), 20-27 (1981-04-01)
The catabolism of 14C-putrescine (1,4-tetramethylene-diamine) to labeled CO2 in small laboratory animals has been studied extensively in order to establish the influence of nutritional, endocrine and other factors on this process. Special attention has been paid to treatments that are
Ricardo Souza Reis et al.
Journal of proteomics, 130, 170-179 (2015-10-06)
Somatic embryogenesis, an important biotechnological technique, has great potential for application in sugarcane breeding and micropropagation. Polyamines have been associated with the regulation of several physiological processes, including the acquisition of embryogenic competence and somatic embryogenesis. In this study, we
A A Amin et al.
Pakistan journal of biological sciences : PJBS, 16(24), 1894-1903 (2014-02-13)
The response of chickpea (Cicer arientinum L. cv. Giza 3) to treatment with two plant growth regulators putrescine (Put) and Indole-3-butyric acid (IBA) at 25, 50 and 100 mg L(-1) applied either alone or in combinations was studied. Spraying of
Regulation of the biosynthesis of putrescine, spermidine and spermine in fungi.
L Stevens
Medical biology, 59(5-6), 308-313 (1981-12-01)
Neil Renwick et al.
The Journal of clinical investigation, 123(6), 2694-2702 (2013-06-04)
MicroRNAs (miRNAs) are excellent tumor biomarkers because of their cell-type specificity and abundance. However, many miRNA detection methods, such as real-time PCR, obliterate valuable visuospatial information in tissue samples. To enable miRNA visualization in formalin-fixed paraffin-embedded (FFPE) tissues, we developed
Joydeep Das et al.
Scientific reports, 5, 13921-13921 (2015-09-12)
Hexavalent chromium [Cr(VI)], an environmental toxicant, causes severe male reproductive abnormalities. However, the actual mechanisms of toxicity are not clearly understood and have not been studied in detail. The present in vitro study aimed to investigate the mechanism of reproductive
María Marina et al.
Journal of experimental botany, 64(5), 1393-1402 (2013-02-06)
This work investigated the roles of the tetraamine thermospermine (TSpm) by analysing its contribution to Arabidopsis basal defence against the biotrophic bacterium Pseudomonas viridiflava. The participation of polyamine oxidases (PAOs) in TSpm homeostasis and TSpm-mediated defence was also investigated. Exogenous
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