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D13208
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J Kowshik et al.
PloS one, 9(10), e109114-e109114 (2014-10-09)
Identifying agents that inhibit STAT-3, a cytosolic transcription factor involved in the activation of various genes implicated in tumour progression is a promising strategy for cancer chemoprevention. In the present study, we investigated the effect of dietary astaxanthin on JAK-2/STAT-3
P El Baze et al.
Archives of dermatological research, 275(4), 218-221 (1983-01-01)
The polyamines putrescine, spermidine, and spermine were detected and measured in both free and total forms in man in pure epidermis, pure dermis, suction blister fluid, blood, and 24-h urines. The technique employed for polyamine measurement consisted in liquid chromatography
Eva Vergaño-Vera et al.
Developmental neurobiology, 75(8), 823-841 (2014-12-03)
The transcription factor Nurr1 is expressed in the mouse olfactory bulb (OB), although it remains unknown whether it influences the generation of dopaminergic neurons (DA) (DA neurons) in cells isolated from this brain region. We found that expressing Nurr1 in
Qi Cai et al.
Biotechnology progress, 31(3), 823-831 (2015-04-01)
Cell-free protein synthesis (CFPS) systems allow for robust protein expression with easy manipulation of conditions to improve protein yield and folding. Recent technological developments have significantly increased the productivity and reduced the operating costs of CFPS systems, such that they
Putrescine, spermidine, spermine, and related polyamine alkaloids.
Stefan Bienz et al.
The Alkaloids. Chemistry and biology, 58, 83-338 (2003-01-22)
S S Goldman et al.
Journal of neuro-oncology, 4(1), 23-29 (1986-01-01)
The metabolism of the polyamines, putrescine, spermidine and spermine, was studied in human brain and brain tumors. Samples of brain and tumors were incubated with 3H-putrescine and the amounts of labeled polyamines were measured. The amount of putrescine conversion was
M Reeben et al.
Journal of neuroscience research, 45(5), 542-548 (1996-09-01)
Transgenic mice overexpressing ornithine decarboxylase (ODC) were recently generated (Halmekytö et al.: Biochem Biophys Res Commun 180:262-267, 1991). The dramatic ODC overexpression resulted in a very high accumulation of the polyamine putrescine in the brain. As elevated polyamine levels in
Maria Teresa Dell'Anno et al.
The Journal of clinical investigation, 124(7), 3215-3229 (2014-06-18)
Direct lineage reprogramming through genetic-based strategies enables the conversion of differentiated somatic cells into functional neurons and distinct neuronal subtypes. Induced dopaminergic (iDA) neurons can be generated by direct conversion of skin fibroblasts; however, their in vivo phenotypic and functional
Jia-Xuan Qiu et al.
Drug design, development and therapy, 9, 349-417 (2015-01-23)
Plumbagin (PLB) has exhibited a potent anticancer effect in preclinical studies, but the molecular interactome remains elusive. This study aimed to compare the quantitative proteomic responses to PLB treatment in human prostate cancer PC-3 and DU145 cells using the approach
Sebastian Finger et al.
Biological chemistry, 395(7-8), 769-778 (2014-07-09)
The binding of cationic polyamines to negatively charged lipid membranes is driven by electrostatic interactions and additional hydrophobic contributions. We investigated the effect of polyamines with different number of charges and charge separation on the phase transition behavior of vesicles
Jorrit De Waele et al.
Biomaterials, 41, 122-131 (2014-12-20)
Transplantation of neural stem cells (NSC) in diseased or injured brain tissue is widely studied as a potential treatment for various neurological pathologies. However, effective cell replacement therapy relies on the intrinsic capacity of cellular grafts to overcome hypoxic and/or
Fangfang Zeng et al.
Insect biochemistry and molecular biology, 113, 103213-103213 (2019-08-24)
Mosquitoes rely heavily on the olfactory system to find a host for a bloodmeal, plants for a source of energy and suitable sites for oviposition. Here, we examined a cluster of eight odorant receptors (ORs), which includes one OR, CquiOR1
Silvia Pérez-Magariño et al.
Journal of agricultural and food chemistry, 63(23), 5670-5681 (2015-06-02)
In sparkling wines, mannoproteins released during yeast autolysis largely affect their final quality. This process is very slow and may take several months. The aim of this work was to study the effect of several commercial dry yeast autolysates on
Carlos Gómez-Gallego et al.
The British journal of nutrition, 111(6), 1050-1058 (2013-11-16)
Infant microbiota is influenced by numerous factors, such as delivery mode, environment, prematurity and diet (breast milk or formula). In addition to its nutritional value, breast milk contains bioactive substances that drive microbial colonisation and support immune system development, which
Stephanie Graser et al.
Bone, 79, 150-161 (2015-06-03)
Patients suffering from the rare hereditary disease hypophosphatasia (HPP), which is based on mutations in the ALPL gene, tend to develop central nervous system (CNS) related issues like epileptic seizures and neuropsychiatric illnesses such as anxiety and depression, in addition
Xuesheng Zhang et al.
Environmental toxicology and pharmacology, 38(3), 881-890 (2014-12-03)
In the present study, the toxic effects of the oral exposure of 2-hydroxylated dioxin (2-HODD) in ICR male mice were examined. The mice were administered different doses (0.2, 2.0 and 20.0mg/kg) of 2-HODD. After 14 days of exposure, the oxidative
Paola Castro-Garcia et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(4), 1480-1492 (2015-02-01)
We studied potential changes in the subventricular zone (SVZ) stem cell niche of the senescence-accelerated mouse prone-8 (SAM-P8) aging model. Bromodeoxyuridine (BrdU) assays with longtime survival revealed a lower number of label-retaining stem cells in the SAM-P8 SVZ compared with
M C de Mello et al.
Neurochemistry international, 22(3), 249-253 (1993-03-01)
Cultured retina cells from chick embryos took up [3H]putrescine and approx 10.8% of the incorporated amine was converted into [3H]GABA. The putrescine-derived GABA accumulated in a pool that was released in the medium at a rate corresponding to 3.66% of
Fabrizio Pietrini et al.
Journal of environmental management, 162, 221-231 (2015-08-09)
Eucalyptus is a promising species for ecological restoration but plant performances under environmental constraints need to be better investigated. In particular, the toxic effects of metals on this plant species are poorly described in the literature. In this work, morpho-physiological and
Synne M Andersen et al.
The British journal of nutrition, 110(11), 1968-1977 (2013-05-10)
In the present study, quadruplicate groups of juvenile Atlantic salmon (Salmo salar) were fed plant protein-based diets with increasing arginine inclusions (range 28·8-37·4 g/kg DM) to investigate whether arginine supplementation affects growth and lipid accumulation through an elevated polyamine turnover. Dietary
Carlos A Ruiz et al.
The Journal of biological chemistry, 290(34), 20774-20781 (2015-07-04)
The vast majority of newly synthesized acetylcholinesterase (AChE) molecules do not assemble into catalytically active oligomeric forms and are rapidly degraded intracellularly by the endoplasmic reticulum-associated protein degradation pathway. We have previously shown that AChE in skeletal muscle is regulated
DE-Geng Zhang et al.
Oncology letters, 9(1), 47-54 (2014-12-02)
Recently, an increasing number of studies have demonstrated that lung cancer is a stem cell disease. However, ideal cell surface markers for isolating stem cells in lung cancer are yet to be identified. In the present study, a cell population
Juhani Jänne et al.
Journal of cellular and molecular medicine, 9(4), 865-882 (2005-12-21)
The polyamines putrescine, spermidine and spermine are natural components of all living cells. Although their exact cellular functions are still largely unknown, a constant supply of these compounds is required for mammalian cell proliferation to occur. Studies with animals displaying
C Löser et al.
Pancreas, 5(2), 119-127 (1990-03-01)
We investigated the total, free, and acetylated polyamine concentrations in pancreatic tissue, serum, and urine of 20 patients with pancreatic cancer, 30 healthy volunteers, and 40 patients with nonmalignant, gastrointestinal diseases by reversed-phase liquid chromatography. Tissue concentrations in carcinoma compared
Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines.
H Tabor et al.
Advances in enzymology and related areas of molecular biology, 36, 203-268 (1972-01-01)
Yuxuan Wu et al.
Cell research, 25(1), 67-79 (2014-12-06)
Spermatogonial stem cells (SSCs) can produce numerous male gametes after transplantation into recipient testes, presenting a valuable approach for gene therapy and continuous production of gene-modified animals. However, successful genetic manipulation of SSCs has been limited, partially due to complexity
Leona Wunderlichová et al.
Food microbiology, 34(2), 268-276 (2013-04-02)
Formation of biogenic amines may occur in food due to metabolic activities of contaminating Gram-negative bacteria. Putrescine is assumed to be the major biogenic amine associated with microbial food spoilage. Gram-negative bacteria can form putrescine by three metabolic pathways that
Chi Yang et al.
PloS one, 7(10), e47314-e47314 (2012-10-17)
The phosphate starvation response in bacteria has been studied extensively for the past few decades and the phosphate-limiting signal is known to be mediated via the PhoBR two-component system. However, the global DNA binding profile of the response regulator PhoB
The roles of the polyamines, putrescine, spermidine, and spermine in normal and malignant tissues.
D H Russell
Life sciences, 13(12), 1635-1647 (1973-12-16)
Christine Frederickx et al.
Journal of forensic sciences, 59(1), 242-249 (2013-08-29)
This study investigated the role of odorant cues used during host-habitat location by the generalist parasitoid, Nasonia vitripennis Walker. Nasonia vitripennis is a common parasitoid of Dipteran pupae found in association with decaying carrion. Behavioral assays were used to investigate
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