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Ashley E Mahne et al.
Journal of immunology (Baltimore, Md. : 1950), 194(7), 3147-3155 (2015-03-04)
Therapeutic regulatory T cells (Tregs) can reverse pre-established autoimmune pathology. In this study, using a mouse model of autoimmune diabetes, we aimed to determine the means by which therapeutic Tregs control islet inflammation. Islet Ag-specific Tregs infiltrated inflamed islets soon
Ya-Hsin Hsiao et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(49), 16207-16219 (2014-12-05)
It has been recognized that the risk of cognitive decline during aging can be reduced if one maintains strong social connections, yet the neural events underlying this beneficial effect have not been rigorously studied. Here, we show that amyloid precursor
Emmanouil Papasavvas et al.
Immunology, 145(3), 380-390 (2015-02-17)
The identification of immune correlates of HIV control is important for the design of immunotherapies that could support cure or antiretroviral therapy (ART) intensification-related strategies. ART interruptions may facilitate this task through exposure of an ART partially reconstituted immune system
Ignacio Melero et al.
Cancer research, 75(3), 497-507 (2014-12-21)
Host responses are increasingly considered important for the efficacious response to experimental cancer therapies that employ viral vectors, but little is known about the specific nature of host responses required. In this study, we investigated the role of host type
Antonio G Soto et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(27), E3600-E3608 (2015-06-24)
Protease-activated receptor-1 (PAR1) is a G-protein-coupled receptor (GPCR) for the coagulant protease thrombin. Similar to other GPCRs, PAR1 is promiscuous and couples to multiple heterotrimeric G-protein subtypes in the same cell and promotes diverse cellular responses. The molecular mechanism by
Kenichi Asano et al.
Nature communications, 6, 7802-7802 (2015-07-22)
Lamina propria (LP) macrophages are constantly exposed to commensal bacteria, and are refractory to those antigens in an interleukin (IL)-10-dependent fashion. However, the mechanisms that discriminate hazardous invasion by bacteria from peaceful co-existence with them remain elusive. Here we show
Benish Fida et al.
Medical engineering & physics, 37(7), 705-711 (2015-05-20)
Accuracy of systems able to recognize in real time daily living activities heavily depends on the processing step for signal segmentation. So far, windowing approaches are used to segment data and the window size is usually chosen based on previous
Dong Yao et al.
Nanoscale, 7(44), 18570-18578 (2015-10-23)
As promising heavy metal-free emitting materials, Ag-In-Se nanocrystals (NCs) are conventionally synthesized using organic phosphine agents and exhibit near-infrared emissions. In this work, we demonstrate a rapid phosphine-free approach for synthesizing Ag-In-Se alloy NCs with the emissions tunable to the
Chittappen K Prajeeth et al.
Journal of neuroinflammation, 11, 180-180 (2014-11-14)
Theiler's murine encephalomyelitis virus (TMEV) infection represents a commonly used infectious animal model to study various aspects of the pathogenesis of multiple sclerosis (MS). In susceptible SJL mice, dominant activity of Foxp3(+) CD4(+) regulatory T cells (Tregs) in the CNS
Jessica D Sun et al.
Cancer biology & therapy, 16(3), 438-449 (2015-02-14)
Tumors often contain hypoxic regions resistant to chemo- and radiotherapy. TH-302 (T) is an investigational hypoxia-activated prodrug that selectively releases the DNA cross-linker bromo-isophosphoramide mustard under hypoxic conditions. This study evaluated the efficacy and safety profile of combining T with
Tejbeer Kaur et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(45), 15050-15061 (2015-11-13)
Macrophages are recruited into the cochlea in response to injury caused by acoustic trauma or ototoxicity, but the nature of the interaction between macrophages and the sensory structures of the inner ear remains unclear. The present study examined the role
Gaurav Kumar et al.
Virology, 471-473, 29-37 (2014-12-03)
Productive infection of human amniotic and endothelial cell lines with Japanese encephalitis virus (JEV) was established leading to the induction of NFκB and HLA-F, a non-classical MHC molecule. Induction of the HLA-F gene and protein in JEV-infected cells was shown
Themis Alissafi et al.
Journal of immunology (Baltimore, Md. : 1950), 194(12), 5812-5824 (2015-05-08)
Foxp3(+) regulatory T cell (Treg)-based immunotherapy holds promise for autoimmune diseases. However, this effort has been hampered by major caveats, including the low frequency of autoantigen-specific Foxp3(+) Tregs and lack of understanding of their molecular and cellular targets, in an
Roman Tatura et al.
Immunology, 146(1), 144-156 (2015-06-11)
The role of Foxp3(+) regulatory T (Treg) cells in the course of the early hyper-inflammatory and subsequent hypo-inflammatory phases of sepsis is ambiguous. Whereas Nrp1 expression has been reported to discriminate natural Treg cells from induced Treg cells, the Treg
Magdia De Jesus et al.
Immunology letters, 168(1), 64-72 (2015-09-20)
Members of the Candida genus, including C. albicans and C. tropicalis are opportunistic fungal pathogens that are increasingly associated with gastrointestinal infections and inflammatory bowel diseases. In healthy populations, however, C. albicans and C. tropicalis are considered benign members of
Peter T Sage et al.
The Journal of clinical investigation, 124(12), 5191-5204 (2014-10-28)
Follicular Tregs (Tfr cells) inhibit antibody production, whereas follicular Th cells (Tfh cells) stimulate it. Tfr cells are found in blood; however, relatively little is known about the developmental signals for these cells or their functions. Here we demonstrated that
Katalin Türmer et al.
Biochimica et biophysica acta, 1850(9), 1855-1861 (2015-05-31)
Actin filament bundling proteins mediate numerous processes in cells such as the formation of cell membrane protrusions or cell adhesions and stress fiber based locomotion. Among them alpha-actinin and fascin are the most abundant ones. This work characterizes differences in
Eric Dale Buras et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(8), 3537-3548 (2015-05-09)
Adipose tissue macrophages (ATMs) play an important role in the pathogenesis of obese type 2 diabetes. High-fat diet (HFD)-induced obesity has been shown to lead to ATM accumulation in rodents; however, the impact of hyperglycemia on ATM dynamics in HFD-fed
Andrea Rubboli et al.
The Journal of invasive cardiology, 26(11), 563-569 (2014-11-05)
To obtain further, and more focused, information on the efficacy and safety of the antithrombotic regimens, including triple therapy (TT) of warfarin, aspirin, and clopidogrel; dual therapy (DT) of warfarin and single antiplatelet agent (aspirin or clopidogrel); and dual-antiplatelet therapy
Nils H Jost et al.
Immunology and cell biology, 92(10), 860-871 (2014-07-30)
Cytomegalovirus (CMV) establishes lifelong chronic infection in its host with mostly asymptomatic or only mild disease, but under immunosuppressive conditions the virus can reactivate and infection can cause life-threatening disease. CMV has evolved several mechanisms to escape from host's immunity
Sergii Kravchenko et al.
The Analyst, 145(2), 656-666 (2019-12-05)
Complex loadings that appear on a surface with flexible spatial organisation can reveal anti-Sauerbrey behaviour due to their variable interfacial architecture even for an ultrathin monomolecular sensitive layer. The presented results demonstrate that compounds with branched and flexible structures may
Janneke van Blijswijk et al.
Journal of immunology (Baltimore, Md. : 1950), 194(1), 307-315 (2014-11-21)
Dendritic cells (DCs) are key regulators of innate and adaptive immunity. Our understanding of immune function has benefited greatly from mouse models allowing for selective ablation of DCs. Many such models rely on transgenic diphtheria toxin receptor (DTR) expression driven
Sherille D Bradley et al.
Cancer immunology research, 3(6), 602-609 (2015-03-22)
Oncogene activation in tumor cells induces broad and complex cellular changes that contribute significantly to disease initiation and progression. In melanoma, oncogenic BRAF(V600E) has been shown to drive the transcription of a specific gene signature that can promote multiple mechanisms
Thomas Brandt et al.
PloS one, 10(10), e0141257-e0141257 (2015-10-29)
Animal experiments report contradictory findings on the presence of a behavioural and neuronal anisotropy exhibited in vertical and horizontal capabilities of spatial orientation and navigation. We performed a pointing experiment in humans on the imagined 3-D direction of the location
Hanna Lee et al.
Food microbiology, 51, 74-80 (2015-07-19)
Microwave-powered cold plasma treatment (CPT) was evaluated as a means to improve the microbiological safety of fresh vegetables and dried fruits. The CPT at 900 W, conducted for 10 min using nitrogen as a plasma-forming gas, inactivated Salmonella Typhimurium inoculated on cabbage
Sofia N Nyström et al.
European journal of immunology, 44(12), 3621-3631 (2014-09-19)
Depletion of Foxp3(+) CD4(+) regulatory T cells (Treg) in adults results in chronic inflammation and autoimmune disease. However, the impact of transient Treg-cell depletion on self-reactive responses is poorly defined. Here, we studied the effect of transient depletion of Treg
Thiol self-assemble layer as inhibitor to protect B10 from seawater corrosion.
Xu F, et al.
Progress in Organic Coatings, 97(1), 82-90 (2016)
Mahua Dey et al.
Journal of immunology (Baltimore, Md. : 1950), 195(1), 367-376 (2015-05-31)
Dendritic cells (DCs) are professional APCs that are traditionally divided into two distinct subsets, myeloid DC (mDCs) and plasmacytoid DC (pDCs). pDCs are known for their ability to secrete large amounts of IFN-α. Apart from IFN-α production, pDCs can also
Hongseung Yeon et al.
Langmuir : the ACS journal of surfaces and colloids, 33(19), 4628-4637 (2017-04-20)
We report an experimental investigation of the influence of molecular-level order (crystallinity) within nonpolar monolayers on hydrophobic interactions. The measurements were performed using gold film-supported monolayers formed from alkanethiols (CH
Stefanie Kehrer et al.
Neuropsychologia, 74, 30-36 (2014-12-03)
The posterior parietal cortex (PPC) and the dorsolateral prefrontal cortex (DLPFC) are known to be part of a cortical network involved in visual spatial attention. Top-down control can modulate processing at target and distractor positions over a sequence of trials
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