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Dong Jin Lee et al.
International journal of pharmaceutics, 471(1-2), 127-134 (2014-05-27)
In this study, polypeptide-based nanoparticles [constituted using poly(L-lysine) coupled with deoxycholic acid (DOCA) and conjugated with 2,3-dimethylmaleic acid (DMA)] have high tumor selectivity once electrostatically switched by the acidic milieu of solid tumors. These nanoparticles exhibited a significantly increased in
Enhanced activity of immobilized dimethylmaleic anhydride-protected poly- and monoclonal antibodies.
E Hadas et al.
Journal of chromatography, 510, 303-309 (1990-06-27)
The effect of reversible protection of the free amino groups of poly- and monoclonal antibodies by dimethylmaleic anhydride on their binding activity following immobilization onto various carriers was studied. The treatment with dimethylmaleic anhydride resulted in a 1.6-1.8-fold increase in
Hui Yu et al.
Theranostics, 9(23), 7033-7050 (2019-10-30)
The drug resistance in cancer treatment with DOX is mainly related to the overexpression of drug efflux proteins, residing in the plasma and nuclear membranes. Delivering DOX into the mitochondria, lacking drug efflux proteins, is an interesting method to overcome
Qing Zhou et al.
Theranostics, 7(7), 1806-1819 (2017-06-24)
Poly(β-L-malic acid) (PMLA), a natural aliphatic polyester, has been proven to be a promising carrier for anti-cancer drugs. In spite of excellent bio-compatibility, the application of PMLA as the drug carrier for cancer therapy is limited by its low cellular
N Endo et al.
Journal of immunological methods, 104(1-2), 253-258 (1987-11-23)
A novel method of covalent modification of antibodies at their amino groups with retention of antigen-binding activity is described. The procedure is as follows: (a) blockade of those amino groups of antibodies whose integrity is essential to their antigen-binding activity
Boya Zhang et al.
Journal of materials chemistry. B, 8(17), 3939-3948 (2020-04-03)
Doxorubicin (DOX) is a widely-used anticancer drug, but its cardiotoxicity severely hampers its potency in chemotherapy. Herein, human serum albumin (HSA) is engaged as a biocompatible nanocarrier to load a pH-sensitive DOX prodrug, DMDOX, generating HSA-DMDOX nanoparticles via self-assembly driven
J P Lavergne et al.
FEBS letters, 236(2), 345-351 (1988-08-29)
Proteins extracted from the 60 S rat liver ribosomal subunit with 50% ethanol/0.5 M K Cl produced only a partial reactivation of the corresponding core particles. In contrast, the same split proteins were able to reactivate the core particles prepared
A tumor-acidity-activated charge-conversional nanogel as an intelligent vehicle for promoted tumoral-cell uptake and drug delivery.
Jin-Zhi Du et al.
Angewandte Chemie (International ed. in English), 49(21), 3621-3626 (2010-04-15)
Yue Ding et al.
Acta biomaterialia, 123, 335-345 (2021-01-22)
Multidrug resistance (MDR) induced by the overexpression of P-glycoprotein (P-gp) transporters mainly leads to chemotherapy (CT) failure. Herein, a NIR/pH dual-sensitive charge-reversal polypeptide nanocomposite (PDA-PLC) was developed for co-delivering a nitric oxide (NO) donor and doxorubicin (DOX). Under near-infrared (NIR)
Bo Reum Lee et al.
International journal of pharmaceutics, 392(1-2), 78-82 (2010-03-20)
A novel synthetic nanocomplex was constructed from glycol chitosan (GCS) grafted with 2,3-dimethylmaleic anhydride (DMA) (denoted as 'GCD' hereafter) and lysozyme (isoelectric point=10.9) as a model protein. This is a core-shell supramolecular assemble formed through electrostatic interactions between anionic GCD
Hyeong Sup Yu et al.
Pharmaceutics, 11(6) (2019-06-05)
As caterpillars detect the presence of predators and secrete poison, herein, we show an innovative and highly effective cancer therapeutic system using biocompatible chitosan nanofiber (CNf) installed with a pH-responsive motif that senses tumor extracellular pH, pHe, prior to delivering
M Gerl et al.
Biochemistry, 27(11), 4089-4096 (1988-05-31)
Apoferritin from horse spleen is composed of 24 subunits that undergo partial dissociation after chemical modification with 2,3-dimethylmaleic anhydride (DMMA), yielding dimeric, trimeric, and tetrameric intermediates, stable at pH 8.5 and 0 degrees C. Deacylation at neutral pH and elevated
M A Nieto et al.
Biochemistry, 27(15), 5635-5640 (1988-07-26)
Treatment of nucleosomal particles and isolated core-histone octamers with dimethylmaleic anhydride, but not with acetic anhydride, is accompanied by a biphasic release of the two H2A.H2B dimers, the first dimer being more easily released than the second. With both kinds
Journal of the Chemical Society. Perkin Transactions 1, 2567-2567 (1993)
C Hikita et al.
The Journal of biological chemistry, 274(25), 17671-17676 (1999-06-11)
When an intercalated epithelial cell line was seeded at low density and allowed to reach confluence, it located the anion exchanger band 3 in the apical membrane and an H+-ATPase in the basolateral membrane. The same clonal cells seeded at
Junjie Liu et al.
Nanoscale, 10(28), 13737-13750 (2018-07-12)
Poor drug delivery to solid tumors remains a great challenge for effective antitumor therapy. Herein, multistage stimuli-responsive nanovectors based on hollow mesoporous silica nanoparticles (HMSNs) were prepared to avoid delivery barriers for improved penetration and programmed tumor therapy. The versatile
Li Luo et al.
Bioconjugate chemistry, 29(9), 2936-2944 (2018-08-28)
Melittin (MLT), as a natural active biomolecule, can penetrate the tumor cell membrane to play a role in cancer treatment and will attract more attention in future development of antitumor drugs. The main component of natural bee venom MLT was
Heejun Shin et al.
Biomaterials, 197, 32-40 (2019-01-15)
Anticancer immunotherapy is emerging as a promising tumor treatment that can replace the conventional tumor treatment such as surgery, radiation and chemo drug, but its therapeutic effect against solid tumor is limited due to the tumor microenvironment (TME). Herein, to
Jiaju Zhong et al.
Biomaterials, 65, 43-55 (2015-07-06)
Tumor cell nucleus-targeted delivery of antitumor agents is of great interest in cancer therapy, since the nucleus is one of the most frequent targets of drug action. Here we report a smart polymeric conjugate platform, which utilizes stimulus-responsive strategies to
J. Controlled Release, 28, 203-203 (1994)
M A Nieto et al.
Molecular and cellular biochemistry, 86(1), 55-63 (1989-03-16)
Yeast 60S ribosomal subunits have been dissociated by reversible modification with dimethylmaleic anhydride. Treatment with 40 mumol reagent/ml releases 35% of the protein, producing core particles inactive in polyphenylalanine synthesis, which are totally or highly deficient in 17 different proteins.
Xiaowen Liu et al.
Biomacromolecules, 17(1), 173-182 (2015-12-15)
Intracellularly-acting therapeutic proteins are considered promising alternatives for the treatment of various diseases. Major limitations of their application are low efficiency of intracellular delivery and possible reduction of protein activity during derivatization. Herein, we report pH-sensitive covalent modification of proteins
J P Lavergne et al.
FEBS letters, 232(1), 29-34 (1988-05-09)
In reconstitution experiments of active 60 S subunits from inactive core particles obtained by using dimethyl maleic anhydride (DMMA), we observed that the phosphoproteins P1-P2 were extracted from the subunit by DMMA as a complex with other proteins. This complex
Huma Rashid et al.
Molecular and cellular biochemistry, 246(1-2), 171-177 (2003-07-05)
In order to study the role of membrane proteins in bilirubin (BR) binding phenomenon, selective removal of membrane proteins was carried out using various reagents, namely, ethylenediamine tetraacetic acid (EDTA), sodium hydroxide (NaOH), 3,5-diiodosalicylic acid, lithium salt (LIS), dimethylmaleic anhydride
Preparation and structural characterization of nucleosomal core particles lacking one H2A.H2B dimer.
S de la Escalera et al.
Biochemical and biophysical research communications, 157(2), 541-547 (1988-12-15)
Nucleosomal core particles lacking one H2A.H2B dimer, (H2A.H2B)1 (H3.H4)2/DNA (146 bp), have been prepared by treatment of nucleosomal cores with dimethylmaleic anhydride, a reversible reagent for protein amino groups. The preparative procedure is simple, produces quantitative conversion of nucleosomal cores
Ung Yeol Lee et al.
International journal of pharmaceutics, 471(1-2), 166-172 (2014-05-27)
Multimeric grain-marked micelles consisting of an inner core micelle (for Fe3O4 encapsulation) and outer multi-grain micelles (for chlorin e6 (Ce6, a model drug) encapsulation) were fabricated using a micelle-to-micelle conjugation method. Grain micelles (mono-thiol functionalized micelles) were chemically linked to
J I Raeside et al.
Biochemical and biophysical research communications, 183(3), 1254-1259 (1992-03-31)
The metabolism of 19-norandrostenedione and [3H] 19-nortestosterone was examined in porcine Leydig cell preparations in the absence, or presence, of a 4-azasteroid inhibitor of 5 alpha-reductase. Evidence for a major production of 5 alpha-estrane-3 beta, 17 beta-diol and 3 beta-hydroxy-5
Se Rim Yoon et al.
Journal of biomedical materials research. Part A, 100(8), 2027-2033 (2012-05-15)
A charge-converting and pH-dependent nanocarrier was achieved by conjugating 2,3-dimethylmaleic anhydride (DMMA) to the amino group of an octadecyl grafted poly (2-hydroxyethyl aspartamide) (PHEA-g-C(18)-NH(2)) backbone, thereby forming a spherical micelle. PHEA, a poly(amino acid)s derivative, was derived from poly(succinimide), which
S Tsunoda et al.
The Journal of pharmacology and experimental therapeutics, 290(1), 368-372 (1999-06-25)
We attempted to develop a novel method for the chemical modification of cytokines with synthetic polymers to increase in vivo therapeutic efficacy. A pH-reversible amino-protective reagent, dimethylmaleic anhydride (DMMAn), was used for polymer conjugation of tumor necrosis factor-alpha (TNF-alpha) with
J Pavel et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(5), 2140-2145 (1998-04-16)
COPI-coated vesicles mediate protein transport within the early secretory pathway. Their coat consists of ADP ribosylation factor (ARF1, a small guanosine nucleotide binding protein), and coatomer, a cytosolic complex composed of seven subunits, alpha- to zeta-coat proteins (COPs). For coat
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