D170305

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Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors.

Laura E Korhonen et al.

Journal of medicinal chemistry, 48(11), 3808-3815 (2005-05-27)

The purpose of this study was to determine the cytochrome P450 1A2 (CYP1A2) inhibition potencies of structurally diverse compounds to create a comprehensive three-dimensional quantitative structure-activity relationship (3D-QSAR) model of CYP1A2 inhibitors and to use this model to predict the

Diurnal rhythm of beta-carotene in photosynthetic alga Gonyaulax polyedra.

P Di Mascio et al.

Biological chemistry Hoppe-Seyler, 376(5), 297-301 (1995-05-01)

Carotenoids comprise one of the most widespread classes of pigments found in nature. Polyene pigments from the dinoflagellate Gonyaulax polyedra were extracted every hour over a 24 hour period and the levels of beta-carotene during the day-phase were found to

Disposition and metabolism of 1,4-dimethylnaphthalene in rat.

A Kilanowicz et al.

International journal of occupational medicine and environmental health, 13(4), 325-334 (2001-03-30)

The distribution, excretion and metabolism of 1,4-dimethylnaphthalene following i.p. administration of a single dose of 28 mg/kg to rats, was investigated using radiotracer [3H] and gas chromatography-mass spectrometry technique (GC-MS). After 72 h, about 97% of the given dose was

QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES.

A A Toropov et al.

European journal of medicinal chemistry, 43(4), 714-740 (2007-07-17)

Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and organic compounds of different classes by optimal descriptors. Statistical characteristics of the best model (vitamins) are the

Functionalized derivatives of 1,4-dimethylnaphthalene as precursors for biomedical applications: synthesis, structures, spectroscopy and photochemical activation in the presence of dioxygen.

Damir Posavec et al.

Organic & biomolecular chemistry, 10(35), 7062-7069 (2012-08-01)

Decomposition of endoperoxide containing molecules is an attractive approach for the delayed release of singlet oxygen under mild reaction conditions. Here we describe a new method for the adaptation of the corresponding decay times by controlling the supramolecular functional structure

Ralstonia sp. U2 naphthalene dioxygenase and Comamonas sp. JS765 nitrobenzene dioxygenase show differences in activity towards methylated naphthalenes.

Anne Tøndervik et al.

Journal of bioscience and bioengineering, 113(2), 173-178 (2011-11-01)

Methylsubstituted naphthalenes constitute a significant part of light gas oil fractions (LGO). These are toxic compounds with low fuel value, and can potentially be enzymatically modified to increase the fuel value and at the same time reduce toxicity. The first

Inhibition of DMBA carcinogenesis of hamster buccal pouch by phenanthrene and dimethylnaphthalene.

D S Malament et al.

Carcinogenesis, 2(8), 723-729 (1981-01-01)

Phenanthrene (Phe) and to a lesser degree 1,4-dimethylnaphthalene (DMeN) were each found to retard the development of epidermoid carcinomas in hamster buccal pouch induced by the thrice weekly application of a 0.5 per cent solution of 7,12-dimethylbenz[a]anthracene (DMBA) in heavy

The sprout inhibitors chlorpropham and 1,4-dimethylnaphthalene elicit different transcriptional profiles and do not suppress growth through a prolongation of the dormant state.

Michael A Campbell et al.

Plant molecular biology, 73(1-2), 181-189 (2010-02-06)

Chlorpropham (CIPC) and 1,4-dimethylnapthalene (DMN) are used to control postharvest sprouting of potato tubers. CIPC alters microtubule structure and function resulting in inhibition of cell division. The mechanism of action of DMN is unknown but, because it is a natural

Investigation of polycyclic aromatic hydrocarbons (PAHs) and cyclic terpenoid biomarkers in the sediments of fishing harbors in Taiwan.

Nien-Hsin Kao et al.

Marine pollution bulletin, 97(1-2), 319-332 (2015-06-08)

Three fishing harbors were investigated to study the polycyclic aromatic hydrocarbons in the sediments and trace possible anthropogenic sources by identification of cyclic terpenoid biomarkers. Seventeen terpanes, 10 steranes and 10 bicyclic sesquiterpanes in the marine diesel and the three

The sprout inhibitor 1,4-dimethylnaphthalene induces the expression of the cell cycle inhibitors KRP1 and KRP2 in potatoes.

Michael A Campbell et al.

Functional & integrative genomics, 12(3), 533-541 (2011-11-25)

The suppression of sprout growth is critical for the long-term storage of potato tubers. 1,4-Dimethylenapthlene (DMN) is a new class of sprout control agent but the metabolic mode of action for this compound has yet to be elucidated. Changes in

An aqueous concentration model for riverine spills.

D E Hibbs et al.

Journal of hazardous materials, 64(1), 37-53 (1999-05-25)

A numerical model is developed to predict the aqueous concentrations of sparingly soluble compounds resulting from oil, fuel, or chemical spills onto rivers. The model computes the concentration of compounds both in the slick phase and in the aqueous phase

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