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Delphine B Maurel et al.
Bone research, 7, 6-6 (2019-03-02)
Transgenic mice are widely used to delete or overexpress genes in a cell specific manner to advance knowledge of bone biology, function and disease. While numerous Cre models exist to target gene recombination in osteoblasts and osteoclasts, few target osteocytes
Cole Vonder Haar et al.
Experimental neurology, 317, 87-99 (2019-03-02)
Traumatic brain injury (TBI) affects at least 3 M people annually. In humans, repetitive mild TBI (rmTBI) can lead to increased impulsivity and may be associated with chronic traumatic encephalopathy. To better understand the relationship between repetitive TBI (rTBI), impulsivity and
Ann-Britt Marcher et al.
Scientific reports, 9(1), 2324-2324 (2019-02-23)
Non-alcoholic steatohepatitis (NASH) signified by hepatic steatosis, inflammation, hepatocellular injury, and fibrosis is a growing cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma. Hepatic fibrosis resulting from accumulation of extracellular matrix proteins secreted by hepatic myofibroblasts plays an important
Ziteng Deng et al.
Poultry science, 100(8), 101283-101283 (2021-07-07)
Dysfunction of the intestinal mucosal barrier of chicks caused by Salmonella pullorum is of great harm to the poultry industry. Probiotics are recognized for their beneficial health-promoting properties, promoting maintenance of bowel epithelial integrity and host immune system homeostasis. Our
Depicha Jindatip et al.
International journal of molecular sciences, 22(16) (2021-08-28)
Recently, another new cell type was found in the perivascular space called a novel desmin-immunopositive perivascular (DIP) cell. However, the differences between this novel cell type and other nonhormone-producing cells have not been clarified. Therefore, we introduced several microscopic techniques
Shengyang Qiu et al.
Biomolecules, 10(8) (2020-08-09)
Introduction: Colorectal Cancer (CRC) accounts for 9% of cancer deaths globally. Hormonal pathways play important roles in some cancers. This study investigated the association of CRC expression of neurotensin (NTS), NTS receptors 1 and 3 (NTSR1 and NTSR3) and clinical
Xing Feng et al.
DNA repair, 86, 102754-102754 (2019-12-04)
Radiation-induced lymphomagenesis results from a clonogenic lymphoid cell proliferation due to genetic alterations and immunological dysregulation. Mouse models had been successfully used to identify risk and protective factors for radiation-induced DNA damage and carcinogenesis. The mammalian SETD4 is a poorly
Jia Wang et al.
BMC veterinary research, 15(1), 323-323 (2019-09-08)
Transport stress not only causes physiological changes but also induces behavioral responses, including anxiety-like and depression-like behavioral responses in animals. The neuronal nitric oxide synthase (nNOS) plays a pivotal role in transport stress. This study aimed to investigate the effects
Paul R Manger et al.
Scientific reports, 11(1), 5486-5486 (2021-03-23)
To elucidate factors underlying the evolution of large brains in cetaceans, we examined 16 brains from 14 cetartiodactyl species, with immunohistochemical techniques, for evidence of non-shivering thermogenesis. We show that, in comparison to the 11 artiodactyl brains studied (from 11
Tzung-Hai Yen et al.
Journal of cellular and molecular medicine, 19(2), 463-473 (2014-11-13)
To assess effects of epidermal growth factor (EGF) and pegylated granulocyte colony-stimulating factor (P-GCSF; pegfilgrastim) administration on the cellular origin of renal tubular epithelium regenerating after acute kidney injury initiated by mercuric chloride (HgCl2 ). Female mice were irradiated and
Yasuharu Oishi et al.
Journal of applied physiology (Bethesda, Md. : 1985), 92(3), 1097-1103 (2002-02-14)
An original method to induce heat stress was used to clarify the time course of changes in heat shock proteins (HSPs) in rat skeletal muscles during recovery after a single bout of heat stress. One hindlimb was inserted into a
Laura K Olsen et al.
Brain, behavior, and immunity, 80, 525-535 (2019-04-29)
Evidence is accumulating to suggest that viral infections and consequent viral-mediated neuroinflammation may contribute to the etiology of idiopathic Parkinson's disease. Moreover, viruses have been shown to influence α-synuclein oligomerization as well as the autophagic clearance of abnormal intra-cellular proteins
Alexis Fenyi et al.
Cells, 10(1) (2021-01-16)
We investigated α-synuclein's (αSyn) seeding activity in tissue from the brain and enteric nervous system. Specifically, we assessed the seeding propensity of pathogenic αSyn in formalin-fixed tissue from the gastric cardia and five brain regions of 29 individuals (12 Parkinson's
Lenka Cernikova et al.
PLoS pathogens, 16(2), e1008317-e1008317 (2020-02-25)
Phosphorylated derivatives of phosphatidylinositol (PIPs) are key membrane lipid residues involved in clathrin-mediated endocytosis (CME). CME relies on PIP species PI(4,5)P2 to mark endocytic sites at the plasma membrane (PM) associated to clathrin-coated vesicle (CCV) formation. The highly diverged parasitic
Hugo Costa Neto et al.
Brazilian oral research, 35, e061-e061 (2021-06-03)
Inflammatory periapical lesions are characterized by infiltration of different immune cell types, the functions of which depend on an effective vascular network. This study aimed to evaluate the mast cells density (MCD) in inflamatory odontogenic cysts capsules concerning microvascular density
A new sensitive colorimetric assay for peroxidase using 3,3'-diaminobenzidine as hydrogen donor.
Herzog V and Fahimi HD
Analytical Biochemistry, 55, 554-562 (1973)
Soledad Bárez-López et al.
Thyroid : official journal of the American Thyroid Association, 29(11), 1669-1682 (2019-07-31)
Background: Mutations in the thyroid hormone (TH) transporter monocarboxylate transporter 8 (MCT8) lead to peripheral hyperthyroidism and profound psychomotor alterations in humans. Mice lacking Mct8 present peripheral hyperthyroidism but no gross neurological abnormalities due to brain compensatory mechanisms involving the
Alexandre Simões Garcia et al.
Virchows Archiv : an international journal of pathology, 474(6), 745-754 (2019-02-17)
This study aimed to analyze the immunoexpression of cancer stem cell markers, CD44v6, and podoplanin in 91 patients with lip squamous cell carcinomas (LSCC). The immunostaining of podoplanin and CD44v6 was evaluated in ten high-power fields (× 400 magnification) at the
Tatiane Moreno Ferrarias Epiphanio et al.
PloS one, 14(3), e0211898-e0211898 (2019-03-26)
Non-Hodgkin lymphomas are among the most common types of tumors in dogs, and they are currently accepted as comparative models of the disease in humans. Aberrant patterns of DNA methylation seem to play a key role in the development of
Samaneh Keshavarz et al.
Biochimica et biophysica acta. Molecular cell research, 1866(2), 296-304 (2018-12-07)
Bone marrow (BM) is a source of mesenchymal stromal cells (MSCs) and endothelial progenitor cells (EPCs). MSCs provide a specific niche in the BM and biological features of EPCs may be changed with this niche. Stromal cell-derived factor 1 (SDF-1)
Ivana Perić et al.
Scientific reports, 11(1), 17747-17747 (2021-09-09)
Deregulation of synaptic function and neurotransmission has been linked with the development of major depression disorder (MDD). Tianeptine (Tian) has been used as antidepressant with anxiolytic properties and recently as a nootropic to improve cognitive performance, but its mechanism of
Fang Li et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(11), 15252-15268 (2020-09-23)
Sphingolipids have been implicated in mammalian placental development and function, but their regulation in the placenta remains unclear. Herein we report that alkaline ceramidase 2 (ACER2) plays a key role in sustaining the integrity of the placental vasculature by regulating
Arooj Mohsin Alvi et al.
Oxidative medicine and cellular longevity, 2021, 9966663-9966663 (2021-08-24)
Epilepsy is a neurodegenerative brain disorder characterized by recurrent seizure attacks. Numerous studies have suggested a strong correlation between oxidative stress and neuroinflammation in several neurodegenerative disorders including epilepsy. This study is aimed at investigating the neuroprotective effects of the
Jean-Philippe Leduc-Gaudet et al.
The Journal of physiology, 597(7), 1975-1991 (2019-01-08)
Recent evidence suggests that impaired mitophagy, a process in charge of removing damaged/dysfunctional mitochondria and in part regulated by Parkin, could contribute to the ageing-related loss of muscle mass and function. In the present study, we show that Parkin overexpression
Successful Preclinical Development of Gene Therapy for Recombinase-Activating Gene-1-Deficient SCID.
Laura Garcia-Perez et al.
Molecular therapy. Methods & clinical development, 17, 666-682 (2020-04-24)
Recombinase-activating gene-1 (RAG1)-deficient severe combined immunodeficiency (SCID) patients lack B and T lymphocytes due to the inability to rearrange immunoglobulin and T cell receptor genes. Gene therapy is an alternative for those RAG1-SCID patients who lack a suitable bone marrow donor.
Mammalian AMP-activated protein kinase subfamily.
Stapleton D, et al.
The Journal of Biological Chemistry, 271, 611-614 (1996)
Ana Miryam Costa de Medeiros et al.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 267(2), 303-310 (2009-05-26)
This study evaluated the expression of fibronectin, tenascin and type I collagen in ameloblastomas and adenomatoid odontogenic tumors (AOTs) aiming to contribute with the comprehension of the differences in the biological behavior of these tumors. Immunohistochemical technique was performed in
Yao-Feng Zhu et al.
Neural regeneration research, 15(4), 724-730 (2019-10-23)
Astrocytes and astrocyte-related proteins play important roles in maintaining normal brain function, and also regulate pathological processes in brain diseases and injury. However, the role of astrocytes in the dopamine-depleted striatum remains unclear. A rat model of Parkinson's disease was
Pedro Lax et al.
Chronobiology international, 33(4), 374-391 (2016-03-24)
The melanopsin system consists of intrinsically photosensitive retinal ganglion cells containing the photopigment melanopsin (mRGCs). These mRGCs mediate several non-image-forming visual functions, including light entrainment of circadian rhythms. Here we evaluate age-related alterations of the melanopsin system and circadian rhythms
Hee Jin Park et al.
International journal of molecular sciences, 22(5) (2021-04-04)
Systemic sclerosis (SSc) is an autoimmune disorder characterized by fibrosis of the skin and internal organs. Despite several studies on SSc treatments, effective treatments for SSc are still lacking. Since evidence suggests an association between intestinal microbiota and SSc, we
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