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显示 1-30 共 146 条结果 关于 "D5671" 范围 论文
Ute Nazet et al.
Cells, 10(2) (2021-02-05)
Genetic predisposition, traumatic events, or excessive mechanical exposure provoke arthritic changes in the temporomandibular joint (TMJ). We analysed the impact of mechanical stress that might be involved in the development and progression of TMJ osteoarthritis (OA) on murine synovial fibroblasts
Henry S Young et al.
Bioscience reports, 40(10) (2020-10-24)
Protein disulphide isomerase A3 (PDIA3) is an endoplasmic reticulum (ER)-resident disulphide isomerase and oxidoreductase with known substrates that include some extracellular matrix (ECM) proteins. PDIA3 is up-regulated in invasive breast cancers and correlates in a mouse orthotopic xenograft model with
Prashant Rawat et al.
Molecular cell, 81(5), 1013-1026 (2021-02-07)
In response to stress, human cells coordinately downregulate transcription and translation of housekeeping genes. To downregulate transcription, the negative elongation factor (NELF) is recruited to gene promoters impairing RNA polymerase II elongation. Here we report that NELF rapidly forms nuclear
Marta Ząbczyńska et al.
Biomolecules, 10(2) (2020-01-26)
Antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) are involved in destruction of thyroid tissue in Hashimoto's thyroiditis (HT). N-glycosylation of the Fc fragment affects the effector functions of IgG by enhancing or suppressing the cytotoxicity effect. The aim of
Rahul Khatri et al.
Stem cell research & therapy, 12(1), 121-121 (2021-02-14)
Type 1 diabetes mellitus (T1D) is characterized by the autoimmune destruction of the pancreatic β cells. The transplantation of mesenchymal stromal/stem cells (MSC) was reported to rescue the damaged pancreatic niche. However, there is an ongoing discussion on whether direct
Massiel Cepeda-Molero et al.
PLoS pathogens, 13(10), e1006706-e1006706 (2017-10-31)
Enteropathogenic E. coli (EPEC) is a human pathogen that causes acute and chronic pediatric diarrhea. The hallmark of EPEC infection is the formation of attaching and effacing (A/E) lesions in the intestinal epithelium. Formation of A/E lesions is mediated by
Charles J d'Adhemar et al.
PloS one, 9(6), e100816-e100816 (2014-07-01)
The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4 (TLR4), and particularly its adaptor protein MyD88, as one potential mediator of this resistance. This study
Lynda Vuong et al.
Cancer research, 79(7), 1480-1492 (2019-01-25)
A combination therapy approach is required to improve tumor immune infiltration and patient response to immune checkpoint inhibitors that target negative regulatory receptors. Galectin-3 is a β-galactoside-binding lectin that is highly expressed within the tumor microenvironment of aggressive cancers and
Xiaohe Tian et al.
Science advances, 6(4), eaat0919-eaat0919 (2020-02-12)
Tight control on the selectivity of nanoparticles' interaction with biological systems is paramount for the development of targeted therapies. However, the large number of tunable parameters makes it difficult to identify optimal design "sweet spots" without guiding principles. Here, we
Jennifer A Mohawk et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(40), 7958-7967 (2019-08-20)
The transcription factor, myocyte enhancer factor-2 (MEF2), is required for normal circadian behavior in Drosophila; however, its role in the mammalian circadian system has not been established. Of the four mammalian Mef2 genes, Mef2d is highly expressed in the suprachiasmatic
Anthony Laugeray et al.
Neurotoxicity research, 33(1), 87-112 (2017-09-08)
We recently demonstrated that perinatal exposure to the glutamate-related herbicide, glufosinate ammonium, has deleterious effects on neural stem cell (NSC) homeostasis within the sub-ventricular zone (SVZ), probably leading to ASD-like symptoms in offspring later in life. In the present study
Stian Henriksen et al.
Journal of virology, 88(13), 7556-7568 (2014-04-25)
The human fetal glial cell line SVG was generated in 1985 by transfecting primary fetal brain cells with a plasmid containing an origin-defective mutant of simian virus 40 (SV40). The cells, which express SV40 large T-antigen, support the replication of
Zahra Alvandi et al.
PloS one, 15(11), e0241646-e0241646 (2020-11-13)
The proto-oncogene Src is ubiquitously expressed and is involved in cellular differentiation. However, the role of Src in embryonic stem (ES) cell osteogenic differentiation is largely unknown. Using the small molecule inhibitor PP2, c-Src specific siRNAs, and tet-inducible lentiviral vectors
Michela Rossini et al.
Cells, 10(8) (2021-08-28)
Presenilin 2 (PS2), one of the three proteins in which mutations are linked to familial Alzheimer's disease (FAD), exerts different functions within the cell independently of being part of the γ-secretase complex, thus unrelated to toxic amyloid peptide formation. In
Dimitra Aravani et al.
Apoptosis : an international journal on programmed cell death, 25(9-10), 648-662 (2020-07-07)
Vascular smooth muscle cells (VSMCs) are the main structural cell of blood vessels, and VSMC apoptosis occurs in vascular disease, after injury, and in vessel remodeling during development. Although VSMC apoptosis is viewed as silent, recent studies show that apoptotic
Pablo Garcia-Valtanen et al.
Viruses, 12(5) (2020-05-28)
White adipose tissue (WAT) produces interleukin-10 and other immune suppressors in response to pathogen-associated molecular patterns (PAMPs). It also homes a subset of B-cells specialized in the production of IL-10, referred to as regulatory B-cells. We investigated whether viral stimuli
Smita Krishnaswamy et al.
PloS one, 13(10), e0203389-e0203389 (2018-10-30)
Cellular regulatory networks are not static, but continuously reconfigure in response to stimuli via alterations in protein abundance and confirmation. However, typical computational approaches treat them as static interaction networks derived from a single time point. Here, we provide methods
Zlata Vershinin et al.
Scientific reports, 10(1), 17068-17068 (2020-10-15)
P21-activated kinase 4 (PAK4), a member of serine/threonine kinases family is over-expressed in numerous cancer tumors and is associated with oncogenic cell proliferation, migration and invasion. Our recent work demonstrated that the SET-domain containing protein 6 (SETD6) interacts with and
Thorsten Krause et al.
Naunyn-Schmiedeberg's archives of pharmacology, 391(8), 859-873 (2018-05-26)
About half of the cardiac serine/threonine phosphatase activity is due to the activity of protein phosphatase type 1 (PP1). The activity of PP1 can be inhibited by an endogenous protein for which the expression inhibitor-2 (I-2) has been coined. We
Michela Grillo et al.
PloS one, 15(12), e0244255-e0244255 (2020-12-18)
Reactive oxygen species are bona fide intracellular second messengers that influence cell metabolism and aging by mechanisms that are incompletely resolved. Mitochondria generate superoxide that is dis-mutated to hydrogen peroxide, which in turn oxidises cysteine-based enzymes such as phosphatases, peroxiredoxins
Marta Palomo-Guerrero et al.
eLife, 8 (2019-12-24)
Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty acids, and its intracellular levels highly fluctuate depending on glucose
Nathalie Meyer-Schaller et al.
Developmental cell, 48(4), 539-553 (2019-02-05)
Epithelial-mesenchymal transition (EMT) enables cells to gain migratory and invasive features underlined by major transcriptional and epigenetic reprogramming. However, most studies have focused on the endpoints of the EMT process, and the epistatic hierarchy of the transcriptional networks underlying EMT
Zay Yar Oo et al.
Molecular oncology, 13(7), 1503-1518 (2019-05-03)
Drugs such as gemcitabine that increase replication stress are effective chemotherapeutics in a range of cancer settings. These drugs effectively block replication and promote DNA damage, triggering a cell cycle checkpoint response through the ATR-CHK1 pathway. Inhibiting this signalling pathway
Ming Fang Hsu et al.
Scientific reports, 8(1), 731-731 (2018-01-18)
The purpose of this study was to develop a gellan gum-based multifunctional embolic agent. Calibrated spherical gellan gum and nanoparticle-containing gellan gum microspheres were prepared via water-in oil emulsification method. Self-assembled nanoparticles composed of short-chain hyaluronic acid and polyethylenimine as
Hazar Abusalamah et al.
Virus research, 286, 198088-198088 (2020-07-08)
Pyruvate is the end product of glycolysis and transported into the mitochondria for use in the tricarboxylic acid (TCA) cycle. It is also a common additive in cell culture media. We discovered that inclusion of sodium pyruvate in culture media
Biswa Nath Sharma et al.
Antimicrobial agents and chemotherapy, 58(11), 6724-6734 (2014-08-27)
The human JC polyomavirus (JCPyV) causes the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML). A growing number of patients with induced or acquired immunosuppression are at risk for infection, and no effective antiviral therapy is presently available. The widely used
Anne Heller et al.
Ecotoxicology and environmental safety, 173, 469-481 (2019-02-26)
Exposure to lanthanides (Ln) poses a serious health risk to animals and humans. Since Ln are mainly excreted with urine, we investigated the effect of La, Ce, Eu, and Yb exposure on renal rat NRK-52E and human HEK-293 cells for
Camille Leonetti et al.
Molecular neurodegeneration, 12(1), 20-20 (2017-02-25)
The ability of oligodendrocyte progenitor cells (OPCs) to give raise to myelin forming cells during developmental myelination, normal adult physiology and post-lesion remyelination in white matter depends on factors which govern their proliferation, migration and differentiation. Tissue plasminogen activator (tPA)
Xin Xie et al.
Journal of cellular physiology, 233(11), 8884-8895 (2018-06-01)
Signaling by the transforming growth factor-β (TGF-β) is an essential pathway regulating a variety of cellular events. TGF-β is produced as a latent protein complex and is required to be activated before activating the receptor. The mechanical force at the cell
Elisa Bacelo et al.
Nanomaterials (Basel, Switzerland), 9(4) (2019-04-11)
Rheumatoid arthritis (RA) is an autoimmune disease that affects the synovial cavity of joints, and its pathogenesis is associated with an increased expression of pro-inflammatory cytokines, namely tumour necrosis factor-alpha (TNF-α). It has been clinically shown to have an adequate
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