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Stian Henriksen et al.
Journal of virology, 90(22), 10398-10413 (2016-10-30)
The minor capsid protein of human BK polyomavirus (BKPyV), VP2, and its N-terminally truncated form, VP3, are both important for viral entry. The closely related simian virus 40 (SV40) reportedly produces an additional truncated form of VP2/3, denoted VP4, apparently
Valentina C Sladky et al.
Developmental cell, 52(3), 335-349 (2020-01-28)
E2F transcription factors control the cytokinesis machinery and thereby ploidy in hepatocytes. If or how these proteins limit proliferation of polyploid cells with extra centrosomes remains unknown. Here, we show that the PIDDosome, a signaling platform essential for caspase-2-activation, limits hepatocyte
Agnes Schröder et al.
International journal of molecular sciences, 22(13) (2021-07-03)
Orthodontic treatment to correct dental malocclusions leads to the formation of pressure zones in the periodontal ligament resulting in a sterile inflammatory reaction, which is mediated by periodontal ligament fibroblasts (PDLF). Leptin levels are elevated in obesity and chronic inflammatory
Alan J Ryan et al.
Journal of anatomy, 227(6), 732-745 (2014-11-21)
Scaffolds which aim to provide an optimised environment to regenerate bone tissue require a balance between mechanical properties and architecture known to be conducive to enable tissue regeneration, such as a high porosity and a suitable pore size. Using freeze-dried
Antón L Martínez et al.
PloS one, 16(3), e0248139-e0248139 (2021-03-11)
This work tries to help overcome the lack of relevant translational screening assays, as a limitation for the identification of novel analgesics for neuropathic pain. Hyperexcitability and neurite shortening are common adverse effects of antiviral and antitumor drugs, leading to
Xue Sun et al.
STAR protocols, 2(4), 100794-100794 (2021-10-12)
This CloneSeq protocol combines clonal expansion inside 3D hydrogel spheres and droplet-based RNA sequencing to resolve the limited sensitivity of single-cell approaches. CloneSeq can reveal rare subpopulations and support cellular stemness. CloneSeq can be adapted to different biological systems to
Chinthasagar Bastian et al.
Neurobiology of disease, 126, 47-61 (2018-06-27)
White matter (WM) is injured in most strokes, which contributes to functional deficits during recovery. Casein kinase 2 (CK2) is a protein kinase that is expressed in brain, including WM. To assess the impact of CK2 inhibition on axon recovery
Kirankumar B Gudagudi et al.
Cytotechnology, 72(2), 189-202 (2020-01-30)
Adult skeletal muscle stem cells, satellite cells, remain in an inactive or quiescent state in vivo under physiological conditions. Progression through the cell cycle, including activation of quiescent cells, is a tightly regulated process. Studies employing in vitro culture of
Debora Lia et al.
Journal of cell science, 131(12) (2018-06-01)
Accumulation of 8-oxoguanine (8-oxoG) in mitochondrial DNA and mitochondrial dysfunction have been observed in cells deficient for the DNA glycosylase OGG1 when exposed to oxidative stress. In human cells, up to eight mRNAs for OGG1 can be generated by alternative
Zhe A Cheng et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 6(2), 1800361-1800361 (2019-01-30)
While new biomaterials for regenerative therapies are being reported in the literature, clinical translation is slow. Some existing regenerative approaches rely on high doses of growth factors, such as bone morphogenetic protein-2 (BMP-2) in bone regeneration, which can cause serious
Subha Kalyaanamoorthy et al.
Scientific reports, 10(1), 16262-16262 (2020-10-03)
Off-target interactions of drugs with the human ether-à-go-go related gene 1 (hERG1) channel have been associated with severe cardiotoxic conditions leading to the withdrawal of many drugs from the market over the last decades. Consequently, predicting drug-induced hERG-liability is now
Ingrid E Frohner et al.
Science signaling, 13(616) (2020-01-30)
The methyl-esterification of the C-terminal leucine of the protein phosphatase 2A (PP2A) catalytic (C) subunit is essential for the assembly of specific trimeric PP2A holoenzymes, and this region of the C subunit also contains two threonine and tyrosine phosphorylation sites.
Meera Saxena et al.
Cancer research, 80(17), 3631-3648 (2020-06-27)
Pygopus 2 (Pygo2) is a coactivator of Wnt/β-catenin signaling that can bind bi- or trimethylated lysine 4 of histone-3 (H3K4me2/3) and participate in chromatin reading and writing. It remains unknown whether the Pygo2-H3K4me2/3 association has a functional relevance in breast
Fiona Schedel et al.
Pigment cell & melanoma research, 33(1), 63-73 (2019-08-14)
Ulceration of melanoma is associated with neutrophil infiltrates and lower survival rates opposite to non-ulcerated melanoma. Neutrophils release neutrophil extracellular traps (NETs) that are chromatin structures loaded with antimicrobial proteins. Since NETs have been correlated with tumor progression, we investigated
Sevil Köse et al.
Experimental hematology, 57, 30-41 (2017-10-17)
Granulocyte colony-stimulating factor (G-CSF) is a well-known hematopoietic stem cell (HSC)-mobilizing agent used in both allogeneic and autologous transplantation. However, a proportion of patients or healthy donors fail to mobilize a sufficient number of cells. New mobilization agents are therefore
Michela Grillo et al.
PloS one, 15(12), e0244255-e0244255 (2020-12-18)
Reactive oxygen species are bona fide intracellular second messengers that influence cell metabolism and aging by mechanisms that are incompletely resolved. Mitochondria generate superoxide that is dis-mutated to hydrogen peroxide, which in turn oxidises cysteine-based enzymes such as phosphatases, peroxiredoxins
Pablo García-Valtanen et al.
Autophagy, 10(9), 1666-1680 (2014-07-22)
It has not been elucidated whether or not autophagy is induced by rhabdoviral G glycoproteins (G) in vertebrate organisms for which rhabdovirus infection is lethal. Our work provides the first evidence that both mammalian (vesicular stomatitis virus, VSV) and fish
Trond Are Mannsåker et al.
International journal of molecular sciences, 22(22) (2021-11-28)
Melanomas have a high potential to metastasize to the brain. Recent advances in targeted therapies and immunotherapies have changed the therapeutical landscape of extracranial melanomas. However, few patients with melanoma brain metastasis (MBM) respond effectively to these treatments and new
F Ruffinatti et al.
Current Alzheimer research, 15(11), 986-1004 (2018-06-14)
It is well known that alterations in astrocytes occur in Alzheimer's disease and reactive astrogliosis is one of the hallmarks of the disease. Recently, data has emerged that suggests that alterations in astrocytes may also occur early in the pathogenesis
Kazuki Suda et al.
Biochemical and biophysical research communications, 511(2), 434-439 (2019-02-25)
Misfolded and aggregated proteins are eliminated to maintain protein homeostasis. Autophagy contributes to the removal of protein aggregates. However, if and how proteotoxic stress induces autophagy is poorly understood. Here we show that proteotoxic stress after treatment with azetidine-2-carboxylic acid
George R R Bell et al.
Nature communications, 12(1), 6148-6148 (2021-11-18)
During chemotaxis, neutrophils use cell surface G Protein Coupled Receptors to detect chemoattractant gradients. The downstream signaling system is wired with multiple feedback loops that amplify weak inputs and promote spatial separation of cell front and rear activities. Positive feedback could
Vito Rt Zanotelli et al.
Molecular systems biology, 16(12), e9798-e9798 (2020-12-29)
Cells react to their microenvironment by integrating external stimuli into phenotypic decisions via an intracellular signaling network. To analyze the interplay of environment, local neighborhood, and internal cell state effects on phenotypic variability, we developed an experimental approach that enables
James D Wade et al.
Frontiers in physiology, 11, 579117-579117 (2020-12-18)
Intracellular signaling pathways are at the core of cellular information processing. The states of these pathways and their inputs determine signaling dynamics and drive cell function. Within a cancerous tumor, many combinations of cell states and microenvironments can lead to
Camille Leonetti et al.
Molecular neurodegeneration, 12(1), 20-20 (2017-02-25)
The ability of oligodendrocyte progenitor cells (OPCs) to give raise to myelin forming cells during developmental myelination, normal adult physiology and post-lesion remyelination in white matter depends on factors which govern their proliferation, migration and differentiation. Tissue plasminogen activator (tPA)
Agnes Schröder et al.
Immunology and cell biology, 99(1), 84-96 (2020-09-06)
Myeloid cells regulate bone density in response to increased salt (NaCl) intake via the osmoprotective transcription factor, nuclear factor of activated T cells-5 (NFAT-5). Because orthodontic tooth movement (OTM) is a pseudoinflammatory immunological process, we investigated the influence of NaCl
Elisa Bacelo et al.
Nanomaterials (Basel, Switzerland), 9(4) (2019-04-11)
Rheumatoid arthritis (RA) is an autoimmune disease that affects the synovial cavity of joints, and its pathogenesis is associated with an increased expression of pro-inflammatory cytokines, namely tumour necrosis factor-alpha (TNF-α). It has been clinically shown to have an adequate
Xin Xie et al.
Journal of cellular physiology, 233(11), 8884-8895 (2018-06-01)
Signaling by the transforming growth factor-β (TGF-β) is an essential pathway regulating a variety of cellular events. TGF-β is produced as a latent protein complex and is required to be activated before activating the receptor. The mechanical force at the cell
Zlata Vershinin et al.
The Journal of biological chemistry, 291(13), 6786-6795 (2016-02-05)
Lysine methylation of non-histone proteins has emerged as a key regulator of many cellular functions. Although less studied than other post-translational modifications such as phosphorylation and acetylation, the number of known methylated non-histone proteins is rapidly expanding. We have identified
Victoria Gillan et al.
Frontiers in cellular and infection microbiology, 7, 452-452 (2017-12-07)
Resistance to anthelmintic drugs is a major problem in the global fight against parasitic nematodes infecting humans and animals. While previous studies have identified mutations in drug target genes in resistant parasites, changes in the expression levels of both targets
Federico Alessandro Ruffinatti et al.
ACS sensors, 5(8), 2388-2397 (2020-07-24)
Ca2+ is among the most important intracellular second messengers participating in a plethora of biological processes, and the measurement of Ca2+ fluctuations is significant in the phenomenology of the underlying processes. Aequorin-based Ca2+ probes represent an invaluable tool for reliable
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