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Juraiporn Somboonwong et al.
Life sciences, 139, 46-51 (2015-08-19)
Diabetes mellitus is associated with disturbed zinc homeostasis and down-regulation of zinc transporter 8 (ZnT8); these changes contribute to the defective biosynthesis, storage, and secretion of insulin. Previous studies have reported an improvement in diabetic status and insulin levels in
Philippe Bellemère et al.
Techniques in hand & upper extremity surgery, 15(4), 247-252 (2011-11-23)
Trapeziectomy associated with a pyrocarbon implant is a recent procedure for thumb basal joint osteoarthritis. The investigators report Pi pyrocarbon implant technique (Tornier Bioprofile, Grenoble, France) for primary thumb basal joint osteoarthritis. The key points of the procedure are preservation
Taek Lee et al.
ACS nano, 9(7), 6675-6682 (2015-07-03)
RNA nanotechnology offers advantages to construct thermally and chemically stable nanoparticles with well-defined shape and structure. Here we report the development of an RNA-QD (quantum dot) chimera for resistive biomolecular memory application. Each QD holds two copies of the pRNA
Giulia Maria Camerino et al.
Human molecular genetics, 23(21), 5720-5732 (2014-06-12)
Weakness and fatigability are typical features of Duchenne muscular dystrophy patients and are aggravated in dystrophic mdx mice by chronic treadmill exercise. Mechanical activity modulates gene expression and muscle plasticity. Here, we investigated the outcome of 4 (T4, 8 weeks
HuaPing Li et al.
Cancer cell international, 15, 52-52 (2015-06-09)
Aberrant expression of heparanase (Hpa) is associated with apoor prognosis in ovarian and cervical cancer patients. Inhibitors of Hpa can prevent the growth and metastasis of malignant tumor cells, and suramin may be such a compound that has strong anti-proliferative
Hua Zhang et al.
Journal of virology, 89(19), 10031-10043 (2015-07-24)
Enterovirus 71 (EV71) recruits various cellular factors to assist in the replication and translation of its genome. Identification of the host factors involved in the EV71 life cycle not only will enable a better understanding of the infection mechanism but
Wenzhen Liao et al.
Journal of agricultural and food chemistry, 63(29), 6525-6534 (2015-07-15)
Dictyophora indusiata polysaccharide (DP1) was successfully chelated with zinc chloride to achieve its enhanced antiproliferative activity. The obtained DP1-Zn complex showed significant antiproliferative activity (18.1 ± 2.84% viability of MCF-7 cells at 250 μg/mL) on a group of human cancer
H C Ying et al.
European journal of gynaecological oncology, 36(1), 16-20 (2015-04-16)
The authors utilized a microRNA (miRNA) array to compare the differentially expressed miRNAs in platinum-resistant associated ovarian cancer cells. The differential expression of microRNA between COC1 (DDP-sensitive) and platinum-resistant COC1/DDP (DDP-resistant) tumor cell lines was determined using microarray. Expression levels
G Heers et al.
Zeitschrift fur Orthopadie und Unfallchirurgie, 150(3), 324-328 (2012-04-21)
The aim of this study was to make a mid-term evaluation of an unconstrained pyrocarbon prosthesis (Ascension®) in the treatment of idiopathic degenerative arthritis of the proximal interphalangeal joint of the hand. 13 implants (10 patients) were clinically and radiologically
Ashok Jain et al.
Cancer letters, 365(1), 122-131 (2015-05-26)
Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), found in cooked meat, is a known food carcinogen that causes several types of cancer, including breast cancer, as PhIP metabolites produce DNA adduct and DNA strand breaks. Curcumin, obtained from the rhizome of Curcuma longa, has potent
Chikkanna K Raghavendra et al.
Steroids, 94, 21-30 (2014-12-24)
Tender cluster beans (CBs; Cyamopsis tetragonoloba) are observed to possess anti-lithogenic potential in experimental mice. Formation of cholesterol gallstones in gallbladder is controlled by procrystallizing and anticrystallizing factors present in bile in addition to supersaturation of cholesterol. This study aimed
Ralf Der et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(45), E6224-E6232 (2015-10-28)
Grounding autonomous behavior in the nervous system is a fundamental challenge for neuroscience. In particular, self-organized behavioral development provides more questions than answers. Are there special functional units for curiosity, motivation, and creativity? This paper argues that these features can
Seung Mo Yuk et al.
BMC urology, 15, 37-37 (2015-05-09)
We designed this experiment to elucidate the relationship between the expression of brain derived-neurotrophic factor (BDNF), the expression of granulocyte-colony stimulating factor (G-CSF), and the development of overactive bladder (OAB). In our previous study, the urothelium was observed to be
Peng Yu et al.
Plant physiology, 169(1), 690-704 (2015-07-23)
Plants have evolved a unique plasticity of their root system architecture to flexibly exploit heterogeneously distributed mineral elements from soil. Local high concentrations of nitrate trigger lateral root initiation in adult shoot-borne roots of maize (Zea mays) by increasing the
Yuping Zhou et al.
Journal of the American Society for Mass Spectrometry, 23(5), 899-907 (2012-02-22)
Covalent labeling along with mass spectrometry is a method that is increasingly used to study protein structure. Recently, it has been shown that diethylpyrocarbonate (DEPC) is a powerful labeling reagent because it can modify up to 30% of the residues
Yanlin Zhang et al.
PloS one, 10(7), e0131559-e0131559 (2015-07-02)
Gliadins are the major components of storage proteins in wheat grains, and they play an essential role in the dough extensibility and nutritional quality of flour. Because of the large number of the gliadin family members, the high level of
Dan Zhu et al.
Nanoscale, 7(44), 18671-18676 (2015-10-27)
Enzyme complexes are assembled at the two-dimensional lipid membrane or prearranged on three-dimensional scaffolding proteins to regulate their catalytic activity in cells. Inspired by nature, we have developed gold nanoparticle-based spherical DNAzymes (SNAzymes) with programmably engineered activities by exploiting poly-adenine
Christine Martineau et al.
Applied and environmental microbiology, 81(15), 5003-5014 (2015-05-17)
Hyphomicrobium spp. are commonly identified as major players in denitrification systems supplied with methanol as a carbon source. However, denitrifying Hyphomicrobium species are poorly characterized, and very few studies have provided information on the genetic and physiological aspects of denitrification
Yuping Zhou et al.
Journal of the American Society for Mass Spectrometry, 23(4), 708-717 (2012-02-03)
Covalent labeling and mass spectrometry are seeing increased use together as a way to obtain insight into the 3-dimensional structure of proteins and protein complexes. Several amino acid specific (e.g., diethylpyrocarbonate) and non-specific (e.g., hydroxyl radicals) labeling reagents are available
I-Fang Cheng et al.
Lab on a chip, 15(14), 2950-2959 (2015-06-19)
We present an antibody-free approach for the high-purity and high-throughput dielectrophoretic (DEP) isolation of circulating tumour cells (CTCs) from blood in a microfluidic chip. A hydrodynamic sheath flow is designed upstream in the chip to direct the suspension samples to
Yaling Yin et al.
Experimental and therapeutic medicine, 8(1), 38-48 (2014-06-20)
The aim of the present study was to evaluate the protective effect of the ultrafiltration extract of Xin Mai Jia (XMJ) on a human umbilical vein endothelial cell (HUVEC) injury model induced by hydrogen peroxide (H
M Milano et al.
Journal of applied toxicology : JAT, 36(1), 151-160 (2015-04-11)
Airborne exposure to particulate matter with diameter < 10 mcM (PM10) has been linked to an increased risk of thromboembolic events, but the mechanisms are not completely understood. The aim of this study was to evaluate the effect of PM10 phagocytosis on
Shani Levy et al.
Cell, 184(11), 2973-2987 (2021-05-05)
Stony corals are colonial cnidarians that sustain the most biodiverse marine ecosystems on Earth: coral reefs. Despite their ecological importance, little is known about the cell types and molecular pathways that underpin the biology of reef-building corals. Using single-cell RNA
Nicolas Dreux et al.
Infection and immunity, 83(4), 1305-1317 (2015-01-22)
A critical step in the life cycle of all organisms is the duplication of the genetic material during cell division. Ribonucleotide reductases (RNRs) are essential enzymes for this step because they control the de novo production of the deoxyribonucleotides required
Tianyi Zhou et al.
Biomedical microdevices, 17(1), 2-2 (2015-02-06)
Accurate positioning of primary mouse hippocampal neurons on electrodes enables the recording from and stimulation of specified individual neurons on a multi-electrode array (MEA). In this work, positive dielectrophoresis (DEP) is applied to actively recruit hippocampal neurons to the electrodes
Ignasi Roca et al.
Journal of bacteriology, 190(14), 4849-4858 (2008-05-27)
The Streptococcus pyogenes genome harbors two clusters of class Ib ribonucleotide reductase genes, nrdHEF and nrdF*I*E*, and a second stand-alone nrdI gene, designated nrdI2. We show that both clusters are expressed simultaneously as two independent operons. The NrdEF enzyme is
Jason Shearer et al.
Inorganic chemistry, 50(4), 1173-1175 (2011-01-22)
The influence of a single octarepeat expansion on the Cu(II) and Zn(II) coordination environments within the octarepeat domain of the human prion protein is examined. Using X-ray absorption spectroscopy and diethyl pyrocarbonate labeling studies, we find that at low copper
Bin Song et al.
Biological research, 48, 23-23 (2015-05-07)
Hepcidin, encoding by HAMP gene, is the pivotal regulator of iron metabolism, controlling the systemic absorption and transportation of irons from intracellular stores. Abnormal levels of HAMP expression alter plasma iron parameters and lead to iron metabolism disorders. Therefore, it
Ryouhei Narumi et al.
FEBS letters, 586(19), 3172-3178 (2012-07-10)
We have identified 15 residues from the surface of sarcoplasmic reticulum Ca(2+)-pump ATPase, by mass spectrometry using diethylpyrocarbonate modification. The reactivity of 9 residues remained high under all the conditions. The reactivity of Lys-515 at the nucleotide site was severely
Zoltán Ivics et al.
Nature protocols, 9(4), 773-793 (2014-03-15)
We describe a protocol for high-efficiency germline transgenesis and sustained transgene expression in two important biomedical models, the mouse and the rat, by using the Sleeping Beauty transposon system. The procedure is based on co-injection of synthetic mRNA encoding the
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