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[Dimethyl sulfoxide in experimental and clinical medicine. The achievements and prospects].
G M Iakovlev et al.
Eksperimental'naia i klinicheskaia farmakologiia, 55(4), 74-76 (1992-07-01)
Tian-Yu Fan et al.
International journal of clinical and experimental pathology, 7(10), 6662-6670 (2014-11-18)
Glioblastoma remains among the most devastating cancers with a median survival of less than 15 months and virtually no survival beyond five years. Currently, the treatment of glioma includes surgery, radiation therapy, chemotherapy, and comprehensive treatment. Intrinsic or acquired resistance
Anke Doller et al.
Experimental cell research, 330(1), 66-80 (2014-09-23)
The impact of the RNA-binding protein HuR for the post-transcriptional deregulation of tumor-relevant genes is well established. Despite of elevations in HuR expression levels, an increase in cytoplasmic HuR abundance in many cases correlates with a high grade of malignancy.
Divya Pathania et al.
British journal of pharmacology, 172(1), 50-63 (2014-07-23)
Pancreatic cancer is characterized by alterations in several key signalling proteins, including increased expression and activity of the Src tyrosine kinase and focal adhesion kinase (FAK), which have been linked to its chemoresistance. Sustained Src inhibition reactivates survival pathways regulated
Jannatul Firdous et al.
Acta biomaterialia, 10(11), 4606-4617 (2014-08-12)
Respiratory syncytial virus (RSV) is one of the most common causes of viral deaths in infants worldwide, yet no effective vaccines are available. Here, we report an osmotically active polysaccharide-based polysorbitol transporter (PST) prepared from sorbitol diacrylate and low-molecular-weight polyethylenimine
Hieng-Ming Ting et al.
Molecular plant, 8(3), 454-466 (2015-01-20)
Plants produce numerous terpenes and much effort has been dedicated to the identification and characterization of the terpene biosynthetic genes. However, little is known about how terpenes are transported within the cell and from the cell into the apoplast. To
Lai Wei et al.
International journal of molecular medicine, 34(5), 1257-1267 (2014-09-02)
Cirrhotic rats show higher expression levels of hepatic RhoA and Rho-kinase than normal healthy rats, and the activation of this signaling pathway leads to portal hypertension. Sodium ferulate (SF) has been shown to decrease the production of geranylgeranyl pyrophosphate (GGPP)
Kaiwen Chang et al.
Small (Weinheim an der Bergstrasse, Germany), 10(21), 4270-4275 (2014-07-23)
Stable full-color fluorescence patterning are achieved by multicolor polymer-dot inks. The fluorescent patterns show extraordinary stability upon various treatments, offering a superior combination of bright fluorescence, excellent photostability, chemical resistance, and eco-friendship.
Sabine Tricot et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 87(4), 357-368 (2015-02-24)
The recent introduction of mass cytometry, a technique coupling a cell introduction system generating a stream of single cells with mass spectrometry, has greatly increased the number of parameters that can be measured per single cell. As with all new
Ignacio M Larrayoz et al.
Journal of hypertension, 27(12), 2365-2376 (2009-09-05)
Inhibition of angiotensin II receptor type 1 (AT1) reduces chronic inflammation associated with hypertension. We asked whether AT1 receptor inhibition would reduce the innate inflammatory response induced by bacterial lipopolysaccharide (LPS). We used unstimulated human circulating monocytes obtained from healthy
Haiyan Qi et al.
CNS neuroscience & therapeutics, 20(11), 991-998 (2014-10-21)
The immunosuppressant drug rapamycin was reported to have an antiaging activity, which was attributed to the TORC1 inhibition that inhibits cell proliferation and increases autophagy. However, rapamycin also exhibits a number of harmful adverse effects. Whether rapamycin can be developed
Ahmadreza Sardarian et al.
Toxicology mechanisms and methods, 25(2), 98-104 (2014-11-25)
Cyclosporine A (CsA) is an immunosuppressive agent administered to transplant patients. A well-known reported oral side effect of CsA consumption is gingival overgrowth (GO). Changes in the expression of integrins occurring in the gingiva following CsA treatment have been reported
Zhuo-heng Li et al.
Photochemistry and photobiology, 90(6), 1368-1375 (2014-07-30)
Hypericin (HY) is a promising photosensitizer (PS) for use in photodynamic therapy (PDT). Port-wine stains (PWSs) are congenital superficial dermal capillary malformations. In this study, we evaluated the photocytotoxic effects of HY for PDT in human vascular endothelial cells and
Anna R Reynolds et al.
Drug and alcohol dependence, 156, 213-220 (2015-10-08)
Group 1 mGlu-family proteins (i.e., mGlu) consist of mGlu1 and mGlu5 and their activity may influence voluntary ethanol intake. The present studies sought to examine the influence of these receptors on the development of ethanol dependence using in vitro and
Bert E Stromberg et al.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 79(4), 290-295 (2015-10-02)
During the United States Department of Agriculture (USDA) National Animal Health Monitoring System's (NAHMS) 2007-2008 beef study, 567 producers from 24 US States were offered the opportunity to collect fecal samples from weaned beef calves and have them evaluated for
Xi Tang et al.
Oncotarget, 5(5), 1352-1362 (2014-03-25)
The development of effective therapies inhibiting prostate cancer progression and metastasis may substantially impact prostate cancer mortality and potentially reduce the rates of invasive treatments by enhancing the safety of active surveillance strategies. Hepsin (HPN) is a cell surface serine
Mark H Christensen et al.
Neuropharmacology, 85, 263-283 (2014-05-28)
The younger an individual starts smoking, the greater the likelihood that addiction to nicotine will develop, suggesting that neurobiological responses vary across age to the addictive component of cigarettes. Cholinergic neurons of the laterodorsal tegmental nucleus (LDT) are importantly involved
Franca Vulinovic et al.
Human mutation, 35(9), 1114-1122 (2014-06-17)
A three-nucleotide (GAG) deletion (ΔE) in TorsinA (TOR1A) has been identified as the most common cause of dominantly inherited early-onset torsion dystonia (DYT1). TOR1A encodes a chaperone-like AAA+-protein localized in the endoplasmic reticulum. Currently, only three additional, likely mutations have
Chantal Zevenbergen et al.
The Journal of clinical endocrinology and metabolism, 99(11), E2429-E2436 (2014-08-21)
Thyroid hormones (TH) are important for normal brain development and abnormal TH regulation in the brain results in neurocognitive impairments. The type 2 deiodinase (D2) is important for local TH control in the brain by generating the active hormone T3
Temmei Ito et al.
Biomedical materials (Bristol, England), 10(1), 015025-015025 (2015-03-03)
In order to obtain a hydroxyapatite (HAp)-poly(ethylene glycol) (PEG) composite, tetra amine-terminated PEG was crosslinked using disuccinimidyl tartrate to obtain a PEG hydrogel. Using two kinds of chelators with different stability constants for Ca ion (N-(2-hydroxyethyl) ethylenediamine-N,N',N'-triacetic acid (EDTA-OH, 8.14)
Minjia Sheng et al.
Journal of peptide science : an official publication of the European Peptide Society, 20(10), 803-810 (2014-06-27)
LfcinB9 is a peptide derived from lactoferricin B. In the present study, the effect and relative mechanism of LfcinB9 on human ovarian cancer cell line (SK-OV-3) in vitro and in vivo was investigated. The data obtained indicated that LfcinB9 exhibited
Mohammad Fallahi-Sichani et al.
Molecular systems biology, 11(3), 797-797 (2015-03-31)
Drugs that inhibit RAF/MEK signaling, such as vemurafenib, elicit profound but often temporary anti-tumor responses in patients with BRAF(V) (600E) melanoma. Adaptive responses to RAF/MEK inhibition occur on a timescale of hours to days, involve homeostatic responses that reactivate MAP
Kazushi Aoto et al.
Human molecular genetics, 24(3), 698-713 (2014-10-09)
Congenital brain and craniofacial defects often occur together as a consequence of their developmental dependency on common progenitor tissue interactions and signaling pathways during embryogenesis. A classic example of this is perturbation of midline embryo development, and disruption of Hedgehog
Hao Guo et al.
Archives of oral biology, 60(1), 199-207 (2014-12-03)
Ubiquitous environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) cause abnormalities in reproduction and development. TCDD inhibits the development of teeth, and its effects depend on its dose and the developmental stage of the tooth. Our aim here was to investigate the
Kélen Fabíola Arroteia et al.
PloS one, 9(8), e103566-e103566 (2014-08-02)
The epididymis has an important role in the maturation of sperm for fertilization, but little is known about the epididymal molecules involved in sperm modifications during this process. We have previously described the expression pattern for an antigen in epididymal
Rajaneesh Karimpurath Gopinath et al.
Genome biology and evolution, 6(10), 2851-2865 (2014-10-16)
Hsp90 is one of the most abundant and conserved proteins in the cell. Reduced levels or activity of Hsp90 causes defects in many cellular processes and also reveals genetic and nongenetic variation within a population. Despite information about Hsp90 protein-protein
Antoine Larrieu et al.
Nature communications, 6, 6043-6043 (2015-01-17)
Activated forms of jasmonic acid (JA) are central signals coordinating plant responses to stresses, yet tools to analyse their spatial and temporal distribution are lacking. Here we describe a JA perception biosensor termed Jas9-VENUS that allows the quantification of dynamic
Scutellariae radix induces apoptosis in chemoresistant SCC-25 human tongue squamous carcinoma cells.
Byul-Bora Choi et al.
The American journal of Chinese medicine, 43(1), 167-181 (2015-02-03)
Scutellariae radix is one of the most widely used anticancer herbal medicines in several Asian countries, including Korea, Japan, and China. Squamous cell carcinoma (SCC) is one of the most common head and neck carcinomas, which is highly invasive and
Phanuel Saroni Arwa et al.
Journal of ethnopharmacology, 174, 410-418 (2015-09-01)
Garcinia brasiliensis, a plant native to the Brazilian Amazon Rainforest, is used in traditional medicine to treat inflammation of the urinary tract, peptic ulcers, arthritis and other conditions. The purposes of this study were to analyze the chemical constituents of
Sana Thabet et al.
Applied and environmental microbiology, 80(24), 7527-7535 (2014-09-28)
We have investigated the antimicrobial effects of photocatalysis on the yeast model Saccharomyces cerevisiae. To accurately study the antimicrobial mechanisms of the photocatalytic process, we focused our investigations on two questions: the entry of the nanoparticles in treated cells and
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