搜索范围
D5879
应用筛选条件
关键词:'D5879'
显示 31-60 #N/A 4916 条结果 关于 "D5879" 范围 论文
Hui Liu et al.
Journal of Alzheimer's disease : JAD, 48(4), 1019-1032 (2015-10-08)
Alzheimer's disease (AD) is the most common form of dementia with the accumulation of senile plaques and neurofibrillary tangles in the brain. Autophagy is the key machinery for mammalian cells to degrade damaged organelles and abnormal proteins. Enormous evidence suggests
Yan Liu et al.
Science translational medicine, 6(266), 266ra170-266ra170 (2014-12-17)
Doxorubicin is a highly effective anticancer chemotherapy agent, but its use is limited by its cardiotoxicity. To develop a drug that prevents this toxicity, we established a doxorubicin-induced cardiomyopathy model in zebrafish that recapitulates the cardiomyocyte apoptosis and contractility decline
Volodymyr Kuzmenko et al.
Materials science & engineering. C, Materials for biological applications, 58, 14-23 (2015-10-20)
The problem of recovery from neurodegeneration needs new effective solutions. Tissue engineering is viewed as a prospective approach for solving this problem since it can help to develop healthy neural tissue using supportive scaffolds. This study presents effective and sustainable
Simon A Dingsdag et al.
Organic & biomolecular chemistry, 13(1), 98-109 (2014-10-23)
The periodontal pathogen Porphyromonas gingivalis requires porphyrin supplementation for growth. Previously, in order to inhibit P. gingivalis growth, we synthesised very effective 'Trojan horse' ester and amide-linked deuterporphyrin-nitroimidazole (DPIX-Nim) adducts that exploited this requirement to transport metronidazole-derived antibiotics with excellent
Masayuki Morita et al.
Parasitology international, 64(1), 113-117 (2014-12-03)
We have reported that two endoperoxides, N-89 and N-251, synthesized in 2001, possess potent antimalarial activities. Aiming at their eventual use for curing malaria in humans, we have been investigating various aspects of their antimalarial actions. Here we show that
Jie Shen et al.
Journal of controlled release : official journal of the Controlled Release Society, 218, 2-12 (2015-10-02)
The objective of the present study was to determine whether an in vitro-in vivo correlation (IVIVC) can be established for polymeric microspheres that are equivalent in formulation composition but prepared with different manufacturing processes. Risperidone was chosen as a model
Katarzyna Kaczyńska et al.
Neuropeptides, 54, 29-34 (2015-09-08)
The study investigated the share of vagal input at infra- and supra-nodosal level and the contribution of CCK1 and CCK2 receptors to the cardiorespiratory responses produced by an intravenous injection of sulfated cholecystokinin octapeptide (CCK-8) in anesthetized rats. This compound
Liang Chen et al.
Journal of hazardous materials, 286, 624-631 (2015-02-11)
Fluorides negatively affect the development of organisms and are a threat to human health and environmental safety. In this study, Bombyx mori N cell line (BmN) were used to explore effects of NaF on insect cells. We found that 8h
Daimel Castillo-González et al.
Journal of chemical information and modeling, 55(10), 2094-2110 (2015-09-12)
Telomeres and telomerase are key players in tumorogenesis. Among the various strategies proposed for telomerase inhibition or telomere uncapping, the stabilization of telomeric G-quadruplex (G4) structures is a very promising one. Additionally, G4 stabilizing ligands also act over tumors mediated
Mei Fu et al.
PloS one, 9(12), e113669-e113669 (2014-12-06)
This study aimed to establish yak mammary epithelial cells (YMECs) for an in vitro model of yak mammary gland biology. The primary culture of YMECs was obtained from mammary gland tissues of lactating yak and then characterized using immunocytochemistry, RT-PCR
Huiyuan Wang et al.
Molecular pharmaceutics, 11(10), 3352-3360 (2014-08-01)
Drug resistance becomes a formidable challenge against effective cancer therapy. Defective apoptosis in cancer cells is a key factor responsible for chemoresistance or radioresistance. Promoting apoptosis is an important method to sensitize the resistant cells, thereby achieving successful treatment for
Fu-Chen Kung et al.
Materials science & engineering. C, Materials for biological applications, 45, 578-588 (2014-12-11)
Electrospun fiber sheets with various orientations (random, partially aligned, and aligned) and smooth and roughened casted membranes were prepared. Hydroxyapatite (HA) crystals were in situ formed on these material surfaces via immersion in 10× simulated body fluid solution. The size
Zheyi Hu et al.
PloS one, 10(2), e0116886-e0116886 (2015-02-18)
Multidrug efflux transporter P-glycoprotein (P-gp) is highly expressed on membrane of tumor cells and is implicated in resistance to tumor chemotherapy. HZ08 is synthesized and studied in order to find a novel P-gp inhibitor. MDCK-MDR1 monolayer transport, calcein-AM P-gp inhibition
Im-Hee Jung et al.
Tissue engineering. Part A, 20(15-16), 2189-2199 (2014-02-06)
Human periodontal ligament stem cells (hPDLSCs) are considered an appropriate cell source for therapeutic strategies. The aims of this study were to investigate the sustainability of bone morphogenetic protein 2 (BMP2) secretion and the bone regenerative capacity of hPDLSCs that
Hanna-Mari Koskimaa et al.
Journal of translational medicine, 13, 370-370 (2015-11-27)
HPV infections are detected in sexually naive children. This has raised the question about the role of early HPV infections in either protecting or predisposing to further HPV infections. HPV16-specific cell-mediated immunity (CMI) was studied in 10 case-children born to
Tadahiro Suzuki et al.
Toxins, 7(1), 187-200 (2015-01-23)
Host plants excrete a glucosylation enzyme onto the plant surface that changes mycotoxins derived from fungal secondary metabolites to glucosylated products. Deoxynivalenol-3-glucoside (DON3G) is synthesized by grain uridine diphosphate-glucosyltransferase, and is found worldwide, although information on its toxicity is lacking.
Yongle Ruan et al.
Kidney international, 86(3), 525-537 (2014-04-04)
High-mobility group box 1 (HMGB1) is a chromatin-binding nuclear molecule that has potent proinflammatory effects once released by damaged cells. In some disease models, carbon monoxide (CO) exhibits anti-inflammatory and protective properties. Here, we investigated whether the protective effect of
Wenxing Song et al.
ACS biomaterials science & engineering, 3(6), 1027-1038 (2017-06-12)
Curcumin is a promising anticancer drug but its applications in cancer therapy are limited due to its poor solubility, short half-life, and low bioavailability. In this article, we present a curcumin loaded magnetic silk fibroin core-shell nanoparticle system for sustained
Shi Yun Leong et al.
PLoS pathogens, 11(3), e1004686-e1004686 (2015-03-10)
Human Enterovirus 71 (EV71) commonly causes Hand, Foot and Mouth Disease in young children, and occasional occurrences of neurological complications can be fatal. In this study, a high-throughput cell-based screening on the serine/threonine kinase siRNA library was performed to identify
In silico docking of forchlorfenuron (FCF) to septins suggests that FCF interferes with GTP binding.
Dimitrios Angelis et al.
PloS one, 9(5), e96390-e96390 (2014-05-03)
Septins are GTP-binding proteins that form cytoskeleton-like filaments, which are essential for many functions in eukaryotic organisms. Small molecule compounds that disrupt septin filament assembly are valuable tools for dissecting septin functions with high temporal control. To date, forchlorfenuron (FCF)
Jingjing Wang et al.
Journal of pharmacological sciences, 126(3), 198-207 (2014-10-25)
SKLB-M8, a derivative of millepachine, showed significant anti-proliferative effects in melanoma cell lines. In this study, we investigated the anti-melanoma and anti-angiogenic activity of SKLB-M8 on three melanoma cell lines (A2058, CHL-1, and B16F10) and human umbilical vein endothelial cells
Yanmei Zhang et al.
Journal of chromatography. A, 1388, 267-273 (2015-03-03)
In this study, capillary electrophoresis (CE) combined with HPLC-MS/MS were used as a powerful platform for screening of inhibitors of mammalian target of rapamycin (mTOR) in natural product extracts. The screening system has been established by using 5-carboxyfluorescein labeled substrate
Weihua Zhang et al.
Toxicology letters, 228(3), 140-146 (2014-05-27)
Prenatal alcohol exposure leads to congenital heart abnormal development, its mechanisms are still unknown. Recent reports have associated alcohol exposure with histone H3 acetylation. In the present study, we have performed the experiments to test the hypothesis that histone H3K14
Daniel Limonta et al.
Journal of medical virology, 86(8), 1437-1447 (2013-10-31)
Despite being the most significant arboviral disease worldwide, dengue has no antiviral treatment or reliable severity predictors. It has been shown that apoptotic cells from blood and tissues may be involved in the complex pathogenesis of dengue. However, very little
Sunghee Kim et al.
BMC complementary and alternative medicine, 14, 231-231 (2014-07-10)
Excessive pro-inflammatory cytokine production from activated microglia contributes to neurodegenerative diseases, thus, microglial inactivation may delay the progress of neurodegeneration by attenuating the neuroinflammation. Among 5 selected brown algae, we found the highest antioxidant and anti-neuroinflammatory activities from Myagropsis myagroides
Jie Lan et al.
Journal of immunology (Baltimore, Md. : 1950), 193(7), 3577-3589 (2014-08-26)
Latently HIV-1-infected cells are recognized as the last barrier toward viral eradication and cure. To purge these cells, we combined a provirus stimulant with a blocker of human CD59, a key member of the regulators of complement activation, to trigger
Anne M Terrell et al.
Experimental eye research, 131, 42-55 (2014-12-23)
The discovery of cytosolic RNA granule (RG) component proteins associated with human cataract has initiated investigations on post-transcriptional mechanisms of gene expression control in the lens. Application of established mouse lens epithelial cell lines (LECs) can provide rapid insights on
Guohai Sun et al.
Journal of proteomics, 109, 199-211 (2014-07-20)
Protein lysine acetylation is a dynamic and reversible post-modification that is known to play diverse functions in eukaryotes. Nevertheless, the composition and function of non-histone lysine acetylation in gametes remain unknown. In humans, only capacitated sperm have the capacity to
Laila Arzuman et al.
Anticancer research, 35(11), 6027-6039 (2015-10-28)
A great amount of research effort has been directed at platinum compounds that bind with DNA differently from cisplatin with the idea that the difference may translate into an altered spectrum of activity. Recently research has also been directed at
Zhiquan Huang et al.
Molecular carcinogenesis, 53(10), 777-786 (2013-05-11)
Resistance to cisplatin-based chemotherapy is responsible for the majority of deaths from head and neck squamous cell carcinoma (HNSCC). In this study, using genome-wide gene expression analysis to investigate potential molecular mediators of HNSCC chemoresistance, we identified SERPINB2, a known
2/164