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关键词:'D6375'
显示 1-30 共 67 条结果 关于 "D6375" 范围 论文
Jeff Beckman et al.
Biochemistry, 49(39), 8554-8563 (2010-08-28)
Continuous oxidative damage inflicted on DNA produces 7,8-dihydro-8-oxoguanine (8-oxoG), a commonly occurring lesion that can potentially cause cancer by producing G → T transversions during DNA replication. Mild oxidation of 8-oxoG leads to the formation of hydantoins, specifically guanidinohydantoin (Gh)
M Zofall et al.
Nucleic acids research, 28(21), 4382-4390 (2000-11-01)
Two new photoreactive dATP analogs, N(6)-[4-azidobenzoyl-(2-aminoethyl)]-2'-deoxyadenosine-5'-triphospha+ ++ te (AB-dATP) and N(6)-[4-[3-(trifluoromethyl)-diazirin-3-yl]benzoyl-(2-aminoethyl) ]-2 '-deoxyadenosine-5'-triphosphate (DB-dATP), were synthesized from 2'-deoxyadenosine-5'-monophosphate in a six step procedure. Synthesis starts with aminoethylation of dAMP and continues with rearrangement of N(1)-(2-aminoethyl)-2'-deoxyadenosine-5'-monophosphate to N(6)-(2-aminoethyl)-2'-deoxyadenosine-5'-monophosphate (N(6)-dAMP). Next, N(6)-dAMP
Rostislav Kuskovsky et al.
Analytical biochemistry, 568, 65-72 (2019-01-04)
Quantification of cellular deoxyribonucleoside mono- (dNMP), di- (dNDP), triphosphates (dNTPs) and related nucleoside metabolites are difficult due to their physiochemical properties and widely varying abundance. Involvement of dNTP metabolism in cellular processes including senescence and pathophysiological processes including cancer and
M Brut et al.
The European physical journal. E, Soft matter, 28(1), 17-25 (2009-01-14)
We present a new competitive method for the atomic scale treatment of macromolecular flexibility called Static Mode method. This method is based on the "induced-fit" concept, i.e. it maps the intrinsic deformations of a macromolecule subject to diverse external excitations.
Alireza Ariafard et al.
Inorganic chemistry, 51(15), 8002-8013 (2012-07-20)
Density functional theory has been used to investigate the oxidation of a guanine nucleotide by platinum(IV), a process that can be important in the degradation of DNA. For the first time, we have provided a comprehensive mechanism for all of
Jiafeng Geng et al.
The journal of physical chemistry. B, 121(38), 8975-8983 (2017-09-20)
Ultraviolet resonance Raman (UVRR) spectroscopy is a label-free method to define biomacromolecular interactions with anticancer compounds. Using UVRR, we describe the binding interactions of two Pt(II) compounds, cisplatin (cis-diamminedichloroplatinum(II)) and its isomer, transplatin, with nucleotides and genomic DNA. Cisplatin binds
R A Karaballi et al.
Physical chemistry chemical physics : PCCP, 17(33), 21356-21363 (2015-03-18)
Rapid detection of disease biomarkers at the patient point-of-care is essential to timely and effective treatment. The research described herein focuses on the development of an electrochemical surface-enhanced Raman spectroscopy (EC-SERS) DNA aptasensor capable of direct detection of tuberculosis (TB)
Iram Aziz et al.
Journal of bacteriology (2018-06-06)
The genome of the hyperthermophilic archaeon Pyrobaculum calidifontis contains an open reading frame Pcal_0041 annotated as PfkB family ribokinase consisting of phosphofructokinase and pyrimidine kinase domains. Among biochemically characterized enzymes, the Pcal_0041 protein was 37% identical to the phosphofructokinase (Ape_0012)
Wiebke Chemnitz Galal et al.
The Journal of biological chemistry, 287(20), 16220-16229 (2012-03-20)
In the presence of dATP, glycerol, and Tris buffer, the DNA primase isolated from Thermococcus kodakaraensis catalyzed the formation of dAMP and two products that were identified as dAMP-glycerol and dAMP-Tris. These products were formed by the T. kodakaraensis p41
Anne Giraut et al.
Chembiochem : a European journal of chemical biology, 10(13), 2246-2252 (2009-07-29)
In previous research we demonstrated that some amino acid derivatives of deoxyadenosine 5'-O-monophosphate act as substrates for incorporation into DNA by HIV-1 reverse transcriptase while retaining the canonical base-pair selectivity for all natural bases. Thus, some amino acids mimic the
M Paula Denofrio et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 11(2), 409-417 (2012-01-04)
UV-A (320-400 nm) and UV-B (280-320 nm) radiation causes damage to DNA and other biomolecules through reactions induced by different endogenous or exogenous photosensitizers. Lumazines are heterocyclic compounds present in biological systems as biosynthetic precursors and/or products of metabolic degradation.
Kar Yan Soh et al.
Journal of biochemistry, 164(2), 165-171 (2018-04-17)
Streptococcus pyogenes nuclease A (SpnA) and streptococcal 5' nucleosidase A (S5nA) are two recently described virulence factors from the human pathogen S. pyogenes. In vitro studies have shown that SpnA is a nuclease that cleaves ssDNA and dsDNA, including the
M Paula Denofrio et al.
Organic & biomolecular chemistry, 18(33), 6519-6530 (2020-07-07)
N-Methyl-β-carboline (βC) alkaloids, including normelinonine F (1b) and melinonine F (2b), have been found in a vast range of living species playing different biological, biomedical and/or pharmacological roles. Despite this, molecular bases of the mechanisms through which these alkaloids would
Katsuhiko Sumitomo et al.
Scientific reports, 9(1), 13947-13947 (2019-09-29)
The use of DNA markers has revolutionized selection in crop breeding by linkage mapping and QTL analysis, but major problems still remain for polyploid species where marker-assisted selection lags behind the situation in diploids because of its high genome complexity.
Toxic effects and DNA transformation
Savkovic S J
Journal of Separation Science, 6, 15-19 (2018)
Lisbeth Munksgaard Nielsen et al.
The Journal of chemical physics, 136(6), 064302-064302 (2012-03-01)
The degree of electronic coupling between DNA bases is a topic being up for much debate. Here we report on the intrinsic electronic properties of isolated DNA strands in vacuo free of solvent, which is a good starting point for
A F M Tariqul Islam et al.
Cellular signalling, 48, 25-37 (2018-04-27)
To study the dynamics and mechanisms controlling activation of the heterotrimeric G protein Gα2βγ in Dictyostelium in response to stimulation by the chemoattractant cyclic AMP (cAMP), we monitored the G protein subunit interaction in live cells using bioluminescence resonance energy
Julia Romanova et al.
TheScientificWorldJournal, 2012, 454176-454176 (2012-06-02)
Examination of the effects of mononucleotides on Sma nuc endonuclease originated from Gram negative bacterium Serratia marcescens displayed that any mononucleotide produced by Sma nuc during hydrolysis of DNA or RNA may regulate the enzyme activity affecting the RNase activity
Kathryn W Woodburn et al.
Antibiotics (Basel, Switzerland), 9(1) (2020-01-17)
Acne vulgaris, caused by the Gram-positive bacterium Cutibacterium acnes, is a prevalent dermatologic condition with substantial cutaneous and psychological morbidity. Mild acne is treated with topical antibiotics with more severe inflammatory forms requiring the prolonged use of oral antibiotics, resulting
Rajagopal Chattopadhyaya et al.
Journal of biomolecular structure & dynamics, 30(4), 394-406 (2012-06-13)
The effect of exposing 2'-deoxyadenosine (dA), 5'-dAMP, 3'-dAMP, dApA, dA(pdA)(19,) and poly(dA): oligo(dT) to iron/H(2)O(2) in the presence and absence of ethanol or NADH has been studied. HPLC retention times, enzyme treatments, radio-labeled substrates, UV absorption spectra, and fast atom
Y Hamano et al.
British poultry science, 57(5), 643-654 (2016-10-22)
The present study was conducted to determine the effects of acetylated wood powder (AW) as a new feed additive on performance, liver and muscle metabolism of amino acids and fatty acids and nucleotide-related substances of meat in broiler chickens. It
Yuki Kataoka et al.
Molecular cancer research : MCR, 18(9), 1354-1366 (2020-05-30)
DNA replication stress (DRS) is a predominant cause of genome instability, a driver of tumorigenesis and malignant progression. Nucleoside analogue-type chemotherapeutic drugs introduce DNA damage and exacerbate DRS in tumor cells. However, the mechanisms underlying the antitumor effect of these
Alicia del Prado et al.
Nucleic acids research, 40(9), 3886-3897 (2012-01-03)
Bacteriophage Φ29 genome consists of a linear double-stranded DNA with a terminal protein (TP) covalently linked to each 5' end (TP-DNA) that together with a specific sequence constitutes the replication origins. To initiate replication, the DNA polymerase forms a heterodimer
Derya Kapusuz et al.
Journal of biomaterials applications, 32(1), 114-125 (2017-06-02)
The encapsulation mechanism of DNA in sol-gel derived silica has been explored in order to elucidate the effect of DNA conformation on encapsulation and to identify the nature of chemical/physical interaction of DNA with silica during and after sol-gel transition.
Saswata Karmakar et al.
Nature chemistry, 7(9), 752-758 (2015-08-21)
Formaldehyde is universally used to fix tissue specimens, where it forms hemiaminal and aminal adducts with biomolecules, hindering the ability to retrieve molecular information. Common methods for removing these adducts involve extended heating, which can cause extensive degradation of nucleic
Anthony R Martin et al.
Organic & biomolecular chemistry, 7(21), 4369-4377 (2009-10-16)
We previously reported the synthesis of a borononucleotide analogue of thymidine monophosphate and its association towards the formation of a new borono-linked dinucleotide. Here we describe the completion of the set of four 2'-deoxyborononucleotide analogues of natural nucleotide monophosphates, namely
T Iu Nikolaienko et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 83(4), 16-28 (2011-12-08)
Exhaustive conformational analysis of the 5'-deoxyadenylic acid molecule, has been carried out by the quantum-mechanical density functional theory method at the MP2/6-311++G(d,p)//DFT B3LYP/6-31G(d,p) theory level. As many as 726 of its conformations have been revealed with the relative gas phase
Gudrun Stengel et al.
Journal of virology, 85(2), 957-967 (2010-11-12)
The origin-specific replication of the herpes simplex virus 1 genome requires seven proteins: the helicase-primase (UL5-UL8-UL52), the DNA polymerase (UL30-UL42), the single-strand DNA binding protein (ICP8), and the origin-binding protein (UL9). We reconstituted these proteins, excluding UL9, on synthetic minicircular
Kathryn W Woodburn et al.
Journal of fungi (Basel, Switzerland), 6(3) (2020-09-26)
Cutaneous invasive fungal wound infections after life-threatening dismounted complex blast injury (DCBI) and natural disasters complicate clinical care. These wounds often require aggressive repeated surgical debridement, can result in amputations and hemipelvectomies and have a 38% mortality rate. Given the
Vibrational relaxation of functional groups in dAMP molecules probed with UV resonance Raman spectroscopy
Muntean C M, et al.
Revista de Chimie (Bucharest, Romania), 71(1) (2020)
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