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Dae-Hyoung Yoo et al.
International journal of food sciences and nutrition, 66(8), 912-918 (2015-07-15)
Biological activities of soybean saponins are dependent on their metabolism by gut microbiota, which generate absorbable bioactive metabolites. Therefore, to enhance the pharmacological effect of soybean, we fermented defatted soybean powder (SP) with Lactobacillus pentosus var. plantarum C29 and measured
Vera van der Velpen et al.
The Journal of nutrition, 143(6), 774-780 (2013-04-26)
Isoflavones (genistein, daidzein, and glycitein) are suggested to have benefits as well as risks for human health. Approximately one-third of the Western population is able to metabolize daidzein into the more potent metabolite equol. Having little endogenous estradiol, equol-producing postmenopausal
K Higashi et al.
Biochimica et biophysica acta, 1221(1), 29-35 (1994-03-10)
An isoflavone compound, daidzein, inhibits the cell proliferation of Swiss 3T3 cells. Analysis of entry in S phase of Swiss 3T3 cells reveals that daidzein blocked cell cycle G1 phase progression 4.6 h after stimulation by bombesin plus insulin. After
Niranjan Koirala et al.
Journal of industrial microbiology & biotechnology, 41(11), 1647-1658 (2014-09-06)
Genistin and daidzein exhibit a protective effect on DNA damage and inhibit cell proliferation. Glycosylation and malonylation of the compounds increase water solubility and stability. Constructed pET15b-GmIF7GT and pET28a-GmIF7MAT were used for the transformation of Escherichia coli and bioconversion of
John Wei et al.
PloS one, 7(10), e47979-e47979 (2012-10-31)
Lipopolysaccharide (LPS), a component of gram-negative bacterial cell walls, has been shown to have a strong adjuvant effect towards inhaled antigens contributing to airway inflammation. Isoflavones are anti-inflammatory molecules present in abundant quantities in soybeans. We investigated the effect of
Ka H Wong et al.
Journal of ethnopharmacology, 164, 53-63 (2015-01-07)
Puerariae Lobatae Radix (PLR) and Puerariae Thomsonii Radix (PTR) are traditional Chinese medicines used for the treatment of diabetes and cardiovascular diseases. These two herbs are used interchangeably in clinical practice, even though they possess significantly different chemical profiles. In
Federica De Sanctis et al.
Food chemistry, 135(3), 1619-1625 (2012-09-08)
Wine white grape bunches of the Grechetto variety were dehydrated at 10, 20 and 30°C, RH 45% and forced air ventilation of 1.5m/s. Chemical and metabolic changes due to the effect of dehydration were studied at various stages of weight
Dapeng Chen et al.
Pharmaceutical biology, 50(12), 1561-1566 (2012-09-18)
Daidzein is a naturally occurring compound and has various health benefits. However, its effects on intestinal smooth muscle contractility remain unknown. The present study was to characterize the effects of daidzein on the contractility of isolated jejunal smooth muscle and
Lea Bredsdorff et al.
The American journal of clinical nutrition, 98(1), 209-216 (2013-05-24)
Epidemiologic studies have suggested that a higher intake of flavonoids may be associated with lower risk of ischemic heart disease. However, the traditional estimation of flavonoid intake by using dietary assessment methods is affected by subjective measures. We examined whether
S Heinonen et al.
Analytical biochemistry, 274(2), 211-219 (1999-10-21)
The metabolic products of daidzein and genistein, the principal isoflavones of soy, were examined. Six volunteers included soy into their normal diet for a 2-week period and urine samples were analyzed before and after soy consumption. Isolation and characterization of
Marta Moskot et al.
Metabolic brain disease, 30(5), 1257-1267 (2015-07-26)
Natural flavonoids such as genistein, kaempferol and daidzein were previously found to be able to reduce efficiency of glycosaminoglycan synthesis in cells of patients suffering from mucopolysaccharidoses, inherited metabolic diseases with often brain disease symptoms. This feature was employed to
Daidzein Augments Cholesterol Homeostasis via ApoE to Promote Functional Recovery in Chronic Stroke.
Eunhee Kim et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(45), 15113-15126 (2015-11-13)
Stroke is the world's leading cause of physiological disability, but there are currently no available agents that can be delivered early after stroke to enhance recovery. Daidzein, a soy isoflavone, is a clinically approved agent that has a neuroprotective effect
T Berman et al.
Environment international, 59, 478-484 (2013-08-22)
The Ministry of Health Biomonitoring Study estimated exposure of individuals in the Israeli population to bisphenol A (BPA), organophosphate (OP) pesticides, phthalates, cotinine, polycyclic aromatic hydrocarbons (PAHs), and the phytoestrogenic compounds genistein and daidzein. In 2011, 250 individuals (ages 20-74)
S S Masrudin et al.
Andrologia, 47(10), 1153-1159 (2015-01-21)
Pueraria mirifica (PM) extract contains phytoestrogen daidzein and genistein. In this study, we investigated the protective effect of PM extract, daidzein and genistein on a testosterone-induced prostatic hyperplasia in rats. Testosterone was administered at 3 mg kg(-1) to rats followed
Erik Ullerås et al.
Journal of applied toxicology : JAT, 28(8), 1045-1053 (2008-07-16)
The adrenal gland is a vulnerable target for toxic insult. Disruption of adrenal steroidogenesis and hormone secretion may cause serious effects on human health. A human in vitro model is needed to predict effects, and elucidate mechanisms of endocrine disruption
Quan Jiang et al.
Journal of medicinal chemistry, 53(16), 6153-6163 (2010-07-31)
Daidzein (1) is a natural estrogenic isoflavone. We report here that 1 can be transformed into anti-estrogenic ligands by simple alkyl substitutions of the 7-hydroxyl hydrogen. To test the effect of such structural modifications on the hormonal activities of the
Yu Qin et al.
The Journal of nutrition, 144(1), 49-54 (2013-11-15)
Daidzein (one of the major isoflavones) can be metabolized to equol in certain individuals. The effects of isoflavones alone and equol status on lipid profiles are still controversial. To evaluate the 6-mo effects of daidzein on cardiovascular risk factors in
Thomas Clavel et al.
International journal of systematic and evolutionary microbiology, 60(Pt 7), 1527-1531 (2009-08-18)
The C3H/HeJBir mouse model of intestinal inflammation was used for isolation of a Gram-positive, rod-shaped, non-spore-forming bacterium (B7(T)) from caecal suspensions. On the basis of partial 16S rRNA gene sequence analysis, strain B7(T) was a member of the class Actinobacteria
Chengjun Yu et al.
Progress in neuro-psychopharmacology & biological psychiatry, 43, 157-167 (2012-12-27)
Daidzein is one of the most important isoflavones present in soy and it is unique as it can be further metabolized to equol, a compound with greater estrogenic activity than other isoflavones. The potential role of daidzein in the prevention
Petra H M Peeters et al.
The Journal of nutrition, 137(5), 1294-1300 (2007-04-24)
Dietary phytoestrogens may play a role in chronic disease occurrence. The aim of our study was to assess the variability of plasma concentrations in European populations. We included 15 geographical regions in 9 European countries (Denmark, France, Germany, Greece, Italy
Lena Jankowiak et al.
Food chemistry, 160, 371-378 (2014-05-07)
We here report on the use of water as a 'green' extraction solvent for the isolation of isoflavones from okara, a by-product of soymilk production. At a low liquid-to-solid ratio of 20 to 1 and 20 °C, 47% of the
Lin Li et al.
Nutrition and cancer, 65(3), 390-397 (2013-03-28)
To assess dietary isoflavone intake between population and hospital outpatient controls and examine if cancer risks estimated for isoflavone using hospital outpatient controls would be different from those using population controls. Three parallel case-control studies on leukemia, breast, and colorectal
Di Xu et al.
Drug development and industrial pharmacy, 41(4), 552-559 (2014-02-06)
In this study, the in vivo oral absorption of a nanocrystal tablet formulation of a BCS II poorly water-soluble drug was compared with that of its water-soluble salt form. Silybin is used as the model drug, and its nanosuspension was
Kelly R Walsh et al.
The American journal of clinical nutrition, 85(4), 1050-1056 (2007-04-07)
Although soy isoflavonoids have a number of health-promoting benefits, information concerning the sites of their absorption and metabolism in humans remains limited. Isoflavonoid absorption from the gut requires deconjugation of glucosides to aglycones. The objective was to investigate the role
Nora E Gray et al.
Cancer prevention research (Philadelphia, Pa.), 2(2), 134-142 (2009-01-15)
Dehydroepiandrosterone (DHEA) is used as a dietary supplement and can be metabolized to androgens and/or estrogens in the prostate. We investigated the hypothesis that DHEA metabolism may be increased in a reactive prostate stroma environment in the presence of proinflammatory
Antioxidant activity of phytoestrogen type isoflavones in biomimetic environments
Voicescu M, et al.
New. J. Chem., 40(1), 606-612 (2016)
Ziming Shi et al.
European journal of drug metabolism and pharmacokinetics, 40(3), 255-266 (2014-05-03)
Tectorigenin (Te) is a main active component in the flowers of Pueraria thomsonii Benth. and the rhizomes of Belamcanda chinensis (L.) DC. Previously, we have reported the pharmacokinetic properties of Te in rat plasma. The purpose of this study was
Yuanyang Guo et al.
Wei sheng wu xue bao = Acta microbiologica Sinica, 52(6), 696-702 (2012-09-01)
To screen and identify a bacterium capable of converting daidzein to S-equol. We used antibiotics to limit unrelated bacterial growth and enrich the target bacteria, and isolated the aim bacterial strain from rat intestine. The metabolite of daidzein was tested
Jun-Seong Park et al.
Bioorganic & medicinal chemistry letters, 18(18), 5006-5009 (2008-08-30)
One new ortho-dihydroxyisoflavone, 7,3',4'-trihydroxyisoflavone (2), and two known ortho-dihydroxyisoflavone derivatives were isolated from 5-year-old Doenjang (Korean fermented soypaste), and evaluated as potent antioxidant by comparing with other known isoflavones. 7,8,4'-Trihydroxyisoflavone (1), 7,3',4'-trihydroxyisoflavone (2), and 6,7,4'-trihydroxyisoflavone (3) inhibited DPPH (Diphenyl-1-picryl hydrazyl)
Agnes Emma Daruházi et al.
Journal of pharmaceutical and biomedical analysis, 84, 112-116 (2013-07-03)
Isoflavonoids are widespread constituents in medical plants especially in legumes (Fabaceae), but occur in other different plant families as well (Rosaceae, Iridaceae, Amaranthaceae). Their antioxidant, estrogen-like, anti-inflammatory and analgesic effects make them promising compounds in therapy of important disorders especially
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