D7802

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显示 31-60 共 163 条结果关于 "D7802" 范围论文

Simultaneous determination of puerarin, daidzin, daidzein, paeoniflorin, albiflorin, liquiritin and liquiritigenin in rat plasma and its application to a pharmacokinetic study of Ge-Gen Decoction by a liquid chromatography-electrospray ionization-tandem mass spectrometry.

Yan Yan et al.

Journal of pharmaceutical and biomedical analysis, 95, 76-84 (2014-03-19)

A liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method was developed and validated for simultaneous determination of seven constituents including puerarin, daidzin, daidzein, paeoniflorin, albiflorin, liquiritin and liquiritigenin in rat plasma using schisandrin as the internal standard (IS). The plasma samples

Isoflavones, genistein and daidzein, regulate mucosal immune response by suppressing dendritic cell function.

John Wei et al.

PloS one, 7(10), e47979-e47979 (2012-10-31)

Lipopolysaccharide (LPS), a component of gram-negative bacterial cell walls, has been shown to have a strong adjuvant effect towards inhaled antigens contributing to airway inflammation. Isoflavones are anti-inflammatory molecules present in abundant quantities in soybeans. We investigated the effect of

Inhibition of Cell Proliferation and MAP Kinase and Akt Pathways in Oral Squamous cell Carcinoma by Genistein and Biochanin A.

Tara L Johnson et al.

Evidence-based complementary and alternative medicine : eCAM, 7(3), 351-358 (2008-10-29)

High morbidity and mortality associated with oral squamous cell carcinoma (OSCC) are largely attributable to late stage diagnosis. Despite significant advances in therapeutic strategies, the five-year survival rate for oral cancer remains at about 50%. A chemopreventive approach may be

A urinary profile study of dietary phytoestrogens. The identification and mode of metabolism of new isoflavonoids.

G E Joannou et al.

The Journal of steroid biochemistry and molecular biology, 54(3-4), 167-184 (1995-08-01)

The metabolic fate of the dietary isoflavones daidzein and genistein was investigated in human volunteers challenged with soya. Urinary diphenols, isolated by partition chromatography on Sephadex LH-20, were characterized and identified by profile capillary gas chromatography (GC) and electron ionization

Anti-breast cancer potential of daidzein in rodents.

Xiaoping Liu et al.

Life sciences, 91(11-12), 415-419 (2012-12-12)

This study was carried out to explore anti-breast cancer potential of isoflavone daidzein or its related compounds using appropriate animal models and their anti-tumor mechanism. Daidzein or its major metabolite equol at a dose molar equivalent to tamoxifen [1.0 mg(2.7

Flavonoids for controlling starch digestion: structural requirements for inhibiting human alpha-amylase.

Elena Lo Piparo et al.

Journal of medicinal chemistry, 51(12), 3555-3561 (2008-05-30)

In this study we investigated the structural requirements for inhibition of human salivary alpha-amylase by flavonoids. Four flavonols and three flavones, out of the 19 flavonoids tested, exhibited IC50 values less than 100 microM against human salivary alpha-amylase activity. Structure-activity

Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition.

Suresh Awale et al.

Bioorganic & medicinal chemistry, 16(1), 181-189 (2007-10-24)

Human pancreatic cancer cells such as PANC-1 are known to exhibit marked tolerance to nutrition starvation that enables them to survive for prolonged period of time even under extremely nutrient-deprived conditions. Thus, elimination of this tolerance to nutrition starvation is

Pueraria mirifica leaves, an alternative potential isoflavonoid source.

Jutarmas Jungsukcharoen et al.

Bioscience, biotechnology, and biochemistry, 78(6), 917-926 (2014-07-19)

We investigated the major leaf isoflavonoid contents of Pueraria mirifica from three different cultivars (PM-III, PM-IV, and PM-V) using reverse RP-HPLC analysis. The proportions and net levels of puerarin, daidzin, genistin, and daidzein in P. mirifica leaves were found to

Investigations of analyte-specific response saturation and dynamic range limitations in atmospheric pressure ionization mass spectrometry.

Clint M Alfaro et al.

Analytical chemistry, 86(21), 10639-10645 (2014-10-01)

With this study, we investigated why some small molecules demonstrate narrow dynamic ranges in electrospray ionization-mass spectrometry (ESI-MS) and sought to establish conditions under which the dynamic range could be extended. Working curves were compared for eight flavonoids and two

Effects of soy phytoestrogens genistein and daidzein on breast cancer growth.

M L de Lemos

The Annals of pharmacotherapy, 35(9), 1118-1121 (2001-09-28)

To determine whether genistein and daidzein, the major phytoestrogens in soy, can stimulate breast cancer growth. Systematic search through primary English-language literature on MEDLINE (1966-January 2001), EMBASE (1982-January 2001) and Current Contents (1998-January 2001). Genistein and daidzein at low concentrations

7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists.

Azadeh Matin et al.

Journal of medicinal chemistry, 52(21), 6835-6850 (2009-10-08)

Design, synthesis, and in vitro bioevaluation of a new class of potential dual PPARalpha and gamma agonists discovered through a structure-driven design paradigm are described. The 7-hydroxy-benzopyran-4-one moiety (includes flavones, flavanones, and isoflavones) is the key pharmacophore of these novel

Lactobacillus pentosus var. plantarum C29 increases the protective effect of soybean against scopolamine-induced memory impairment in mice.

Dae-Hyoung Yoo et al.

International journal of food sciences and nutrition, 66(8), 912-918 (2015-07-15)

Biological activities of soybean saponins are dependent on their metabolism by gut microbiota, which generate absorbable bioactive metabolites. Therefore, to enhance the pharmacological effect of soybean, we fermented defatted soybean powder (SP) with Lactobacillus pentosus var. plantarum C29 and measured

Isoflavone extraction from okara using water as extractant.

Lena Jankowiak et al.

Food chemistry, 160, 371-378 (2014-05-07)

We here report on the use of water as a 'green' extraction solvent for the isolation of isoflavones from okara, a by-product of soymilk production. At a low liquid-to-solid ratio of 20 to 1 and 20 °C, 47% of the

Induction of proto-oncogene BRF2 in breast cancer cells by the dietary soybean isoflavone daidzein.

Jana Koo et al.

BMC cancer, 15, 905-905 (2015-11-18)

BRF2 is a transcription factor required for synthesis of a small group of non-coding RNAs by RNA polymerase III. Overexpression of BRF2 can transform human mammary epithelial cells. In both breast and lung cancers, the BRF2 gene is amplified and

Daidzein inhibits insulin- or insulin-like growth factor-1-mediated signaling in cell cycle progression of Swiss 3T3 cells.

K Higashi et al.

Biochimica et biophysica acta, 1221(1), 29-35 (1994-03-10)

An isoflavone compound, daidzein, inhibits the cell proliferation of Swiss 3T3 cells. Analysis of entry in S phase of Swiss 3T3 cells reveals that daidzein blocked cell cycle G1 phase progression 4.6 h after stimulation by bombesin plus insulin. After

Glycosylation and subsequent malonylation of isoflavonoids in E. coli: strain development, production and insights into future metabolic perspectives.

Niranjan Koirala et al.

Journal of industrial microbiology & biotechnology, 41(11), 1647-1658 (2014-09-06)

Genistin and daidzein exhibit a protective effect on DNA damage and inhibit cell proliferation. Glycosylation and malonylation of the compounds increase water solubility and stability. Constructed pET15b-GmIF7GT and pET28a-GmIF7MAT were used for the transformation of Escherichia coli and bioconversion of

Estrogen receptor-mediated effects of isoflavone supplementation were not observed in whole-genome gene expression profiles of peripheral blood mononuclear cells in postmenopausal, equol-producing women.

Vera van der Velpen et al.

The Journal of nutrition, 143(6), 774-780 (2013-04-26)

Isoflavones (genistein, daidzein, and glycitein) are suggested to have benefits as well as risks for human health. Approximately one-third of the Western population is able to metabolize daidzein into the more potent metabolite equol. Having little endogenous estradiol, equol-producing postmenopausal

Dietary soy isoflavones increased hepatic protein disulfide isomerase content and suppressed its enzymatic activity in rats.

Chao Wu Xiao et al.

Experimental biology and medicine (Maywood, N.J.), 239(6), 707-714 (2014-03-29)

Protein disulfide isomerase (PDI) is a multifunctional protein and plays important roles in protein folding, triglyceride transfer, insulin degradation, and thyroid hormone transportation. This study examined the modulation of PDI expression by soy consumption using rat as a model. Sprague-Dawley

Oxidative metabolism of the soy isoflavones daidzein and genistein in humans in vitro and in vivo.

S E Kulling et al.

Journal of agricultural and food chemistry, 49(6), 3024-3033 (2001-06-21)

The soy isoflavones daidzein and genistein are found in high concentrations in human plasma and urine after soy consumption. However, in vitro and in vivo data regarding the oxidative metabolism of isoflavones in humans are scarce. Therefore, we have studied

Apoptotic effects of cooked and in vitro digested soy on human prostate cancer cells.

Xin Dong et al.

Food chemistry, 135(3), 1643-1652 (2012-09-08)

Previous laboratory and animal studies reported that soy isoflavones were major bioactive compounds in soy to exert chemoprotection of prostate cancer. However, these studies cannot reflect the realistic effects that soy may induce through diets, and little is known about

Ectopic expression of a stress-inducible glycosyltransferase from saffron enhances salt and oxidative stress tolerance in Arabidopsis while alters anchor root formation.

Oussama Ahrazem et al.

Plant science : an international journal of experimental plant biology, 234, 60-73 (2015-03-26)

Glycosyltransferases play diverse roles in cellular metabolism by modifying the activities of regulatory metabolites. Three stress-regulated UDP-glucosyltransferase-encoding genes have been isolated from the stigmas of saffron, UGT85U1, UGT85U2 and UGT85V1, which belong to the UGT85 family that includes members associated

Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora.

I R Rowland et al.

Nutrition and cancer, 36(1), 27-32 (2000-05-08)

The soy isoflavones, daidzein and genistein, and the lignans, matairesinol and secoisolariciresinol, are phytoestrogens metabolized extensively by the intestinal microflora. Considerable important evidence is already available that shows extensive interindividual variation in isoflavone metabolism, and we have investigated the extent

Soy consumption alters endogenous estrogen metabolism in postmenopausal women.

X Xu et al.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 9(8), 781-786 (2000-08-22)

Isoflavones are soy phytoestrogens that have been suggested to be anticarcinogenic. Our previous study in premenopausal women suggested that the mechanisms by which isoflavones exert cancer-preventive effects may involve modulation of estrogen metabolism away from production of potentially carcinogenic metabolites

Preparation and evaluation of surface-bonded tricationic ionic liquid silica as stationary phases for high-performance liquid chromatography.

Lizhen Qiao et al.

Journal of chromatography. A, 1396, 62-71 (2015-04-22)

Two tricationic ionic liquids were prepared and then bonded onto the surface of supporting silica materials through "thiol-ene" click chemistry as new stationary phases for high-performance liquid chromatography. The obtained columns of tricationic ionic liquids were evaluated respectively in the

The transgenic Arabidopsis plant system, pER8-GFP, as a powerful tool in searching for natural product estrogen-agonists/antagonists.

Fang-Rong Chang et al.

Journal of natural products, 68(7), 971-973 (2005-07-26)

The transgenic Arabidopsis plant system, pER8-GFP, may be used as a powerful tool in searching for natural estrogen-agonists/antagonists. Among selected plant extracts and natural products, the method was able to distinguish active extracts (e.g., Glycine max and Pueraria lobata) and

Differential kinetics at PK/PEPCK branch point in the cestode, Raillietina echinobothrida.

Bidyadhar Das et al.

Experimental parasitology, 153, 151-159 (2015-03-31)

Pyruvate kinase (PK; EC 2.7.1.40) and phosphoenolpyruvate carboxykinase (PEPCK; EC 4.1.1.32) are essential regulatory enzymes of glucose oxidation in helminths, the PK/PEPCK branch point being the first divergent step between carbohydrate catabolism of the parasites and their hosts. Recently, PEPCK

Comparison of the effects of mesquite pod and Leucaena extracts with phytoestrogens on the reproductive physiology and sexual behavior in the male rat

Retana-Marquez S, et al.

Physiology & Behavior, 164, 1-10 (2016)

Inhibition of DMBA-induced Oral Squamous Cells Carcinoma Growth by Brazilian Red Propolis in Rodent Model.

Danielle R Ribeiro et al.

Basic & clinical pharmacology & toxicology, 117(2), 85-95 (2015-01-06)

We investigated the effect of oral administration of hydroalcoholic extract of Brazilian red propolis (HERP) on DMBA-induced oral squamous cell carcinomas (OSCC) in rodents. The chemical components of the HERP were assessed by high-performance liquid chromatography (HPLC). Carcinogenesis was topically

Screening of potentially hormonally active chemicals using bioluminescent yeast bioreporters.

John Sanseverino et al.

Toxicological sciences : an official journal of the Society of Toxicology, 107(1), 122-134 (2008-11-11)

Saccharomyces cerevisiae bioluminescent bioreporter assays were developed previously to assess a chemical's estrogenic or androgenic disrupting potential. S. cerevisiae BLYES, S. cerevisiae BLYAS, S. cerevisiae BLYR, were used to assess their reproducibility and utility in screening 68, 69, and 71

Analysis of daidzein in nanoparticles after oral co-administration with sodium caprate to rats by ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry.

Yiran Ma et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 907, 21-26 (2012-09-27)

An ultra-performance-liquid-chromatography-quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF-MS) method was developed and validated for the quantitation of daidzein (DZ) in rat plasma. Ethylparaben was chosen as internal standards (IS). DZ was linear over the range of 0.001-5 μg/mL. The lower limit of quantification

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