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Riccardo Bruni et al.
Journal of controlled release : official journal of the Controlled Release Society, 255, 94-107 (2017-04-12)
We explored the use of new drug-loaded nanocarriers and their targeted delivery to the kidney glomerulus and in particular to podocytes, in order to overcome the failure of current therapeutic regimens in patients with proteinuric (i.e. abnormal amount of proteins
Phthalocyanine-titanate nanotubes: a promising nanocarrier detectable by optical imaging in the so-called imaging window.
Paris J, et al.
Royal Society of Chemistry Advances, 5(9), 6315-6322 (2015)
Petra Halang et al.
Journal of bacteriology, 195(21), 4888-4899 (2013-08-27)
Vibrio cholerae is motile by its polar flagellum, which is driven by a Na(+)-conducting motor. The stators of the motor, composed of four PomA and two PomB subunits, provide access for Na(+) to the torque-generating unit of the motor. To
Debora Walker et al.
Advanced materials (Deerfield Beach, Fla.), 28(44), 9846-9850 (2016-10-08)
Immobilization of colloidal assemblies onto solid supports via a fast UV-triggered click-reaction is achieved. Transient assemblies of microparticles and colloidal materials can be captured and transferred to solid supports. The technique does not require complex reaction conditions, and is compatible
Xuanang Gong et al.
Carbohydrate polymers, 250, 116846-116846 (2020-10-15)
In this work, reversible addition-fragmentation chain transfer (RAFT) polymerization and Schiff base chemistry was combined to fabricate self-healing adhesives. An esterification reaction was first performed to prepare ethyl cellulose based macroinitiators. Then, a "grafting from" RAFT of vanillin methacrylate and
Rongqiang Liao et al.
Chembiochem : a European journal of chemical biology, 16(11), 1622-1628 (2015-06-03)
A targeting gene carrier for cancer-specific delivery was successfully developed through a "multilayer bricks-mortar" strategy. The gene carrier was composed of adamantane-functionalized folic acid (FA-AD), an adamantane-functionalized poly(ethylene glycol) derivative (PEG-AD), and β-cyclodextrin-grafted low-molecular-weight branched polyethylenimine (PEI-CD). Carriers produced by
So Young Park et al.
Chemical communications (Cambridge, England), 48(19), 2522-2524 (2012-01-31)
We report a new class of photosensitizer drug networks that can home into mitochondria and provide geospatial phototoxicity for tumors. We take advantage of the cleavable chemical network between the photosensitizer drug and poly(ethylene glycol), and find a significant increase
Hisako Hikiji et al.
Journal of materials science. Materials in medicine, 25(6), 1531-1538 (2014-02-28)
Rapid and efficient animal models are needed for evaluating the effectiveness of many new candidate bone regenerative materials. We developed an in vivo model screening for calvarial bone regeneration in lipopolysaccharide (LPS)-treated mice, in which materials were overlaid on the
Cai-Hua Jia et al.
Journal of agricultural and food chemistry, 63(47), 10280-10286 (2015-10-23)
Caffeic acid phenethyl ester (CAPE) and 4-vinylcatechol (4-VC) were prepared for studying their antioxidative activities in emulsion. Oil-in-water emulsions of stripped soybean oil containing 200 ppm of CAPE, 4-VC, or α-tocopherol were stored at 40 °C in the dark for
Suzanne M D'Addio et al.
Molecular pharmaceutics, 12(5), 1554-1563 (2015-03-27)
Tuberculosis (TB) remains a major global health concern, and new therapies are needed to overcome the problems associated with dosing frequency, patient compliance, and drug resistance. To reduce side effects associated with systemic drug distribution and improve drug concentration at
Bing-Feng Zhang et al.
Biomaterials, 61, 178-189 (2015-05-26)
The mitochondria-mediated apoptosis pathway is an effective option for cancer therapy due to the presence of cell-suicide weapons in mitochondria. However, anti-apoptotic proteins that are over-expressed in the mitochondria of many malignant tumors, such as Bcl-2 protein, could allow the
Armin Osmanagic et al.
The American journal of cardiology, 116(2), 225-229 (2015-05-15)
In patients with persistent atrial fibrillation (AF), the sinus rhythm (SR) can be restored by direct current cardioversion (DCC), although the recurrence of AF after successful DCC is common. We examined whether transesophageal echocardiography (TEE)-guided early DCC, compared with the
Konstantina C Fylaktakidou et al.
ChemMedChem, 6(1), 153-168 (2010-11-26)
Polyphosphorylated and perphosphorylated hexopyranose monosaccharides and disaccharides were synthesized from parent or partially protected carbohydrates as potential allosteric effectors of hemoglobin. A study toward the construction of seven- and eight-membered cyclic pyrophosphates was also performed on the sugars which had
Yanyan Jiang et al.
Macromolecular bioscience, 15(7), 965-978 (2015-03-27)
A novel gene transfection vector was fabricated based on the conjugation of human serum albumin (HSA) and maleimide end functionalized poly[(N,N-dimethylamino) ethyl methacrylate] (PDMAEMA). The bioconjugation was achieved in a site-specific manner to yield well-defined polymer-protein conjugates. The biohybrid was
Xian Zhang et al.
Toxicon : official journal of the International Society on Toxinology, 106, 89-96 (2015-09-28)
Ochratoxin A (OTA) is one of the most commonly occurring mycotoxins produced by some species of Aspergillus and can contaminate cereal and cereal products. A high-affinity anti-OTA monoclonal antibody (mAb) was generated from a hybridoma cell line 2D8 using splenocytes
Zenghui Cheng et al.
International journal of biological macromolecules, 131, 387-395 (2019-03-19)
Utilization of natural sustainable feedstock to fabricate polymers has attracted remarkable attention. In this work, we reported a strategy to prepare a series of grafted copolymers from rosin, fatty acids and ethyl cellulose. The process involved the preparation of EC-based
Cornelia Podjaski et al.
Brain : a journal of neurology, 138(Pt 6), 1598-1612 (2015-04-24)
Blood-brain barrier function is driven by the influence of astrocyte-secreted factors. During neuroinflammatory responses the blood-brain barrier is compromised resulting in central nervous system damage and exacerbated pathology. Here, we identified endothelial netrin 1 induction as a vascular response to
Haijun Xiao et al.
International journal of nanomedicine, 10, 5309-5325 (2015-09-09)
To study the effects of X-shaped amphiphilic block copolymers on delivery of docetaxel (DTX) and the reduction-sensitive property on drug release, a novel reduction-sensitive amphiphilic copolymer, (PLGA)2-SS-4-arm-PEG2000 with a Gemini-like X-shape, was successfully synthesized. The formation of nanomicelles was proved
Hongyu Chen et al.
Molecular pharmaceutics, 12(6), 1885-1892 (2015-04-15)
Monitoring of drugs in vivo has been recognized as an urgent need for successful chemotherapy treatment. However, to find an appropriate tool for this purpose has been proved as a great challenge. Here, we report a PLA-PEG coated hollow X-ray
Petra Votavova et al.
Journal of biomedical nanotechnology, 11(9), 1662-1673 (2015-10-22)
Interleukin-2 (IL-2) possesses a strong stimulatory activity for activated T and NK cells and it is an attractive molecule for immunotherapy. Nevertheless, extremely short half-life and severe toxicities associated with high-dose IL-2 treatment are serious and limiting drawbacks. In order
Shaona Cao et al.
FEBS letters, 587(9), 1310-1315 (2013-03-12)
Non-photochemical quenching (NPQ) of chlorophyll fluorescence is thought to be an indicator of an essential regulation and photoprotection mechanism against high-light stress in photosynthetic organisms. In this report, special chemicals were used to perturb the kinetics of the ΔpH build-up
David W Baker et al.
Acta biomaterialia, 10(7), 2945-2955 (2014-04-15)
Plasticity of macrophage (MΦ) phenotypes exist in a spectrum from classically activated (M1) cells, to alternatively activated (M2) cells, contributing to both the normal healing of tissues and the pathogenesis of implant failure. Here, folate- and mannose-based optical probes were
Dan Heo et al.
Nanotechnology, 25(27), 275102-275102 (2014-06-25)
In this study, we developed the maleimidyl magnetic nanoplatform, which enables functional targeting of a biomarker-specific moiety for molecular imaging via MRI. The maleimide group of the maleimidyl magnetic nanoplatform is conjugated with a thiol group without additional crosslinkers and
Diego Sanchez et al.
Experimental gerontology, 67, 19-47 (2015-04-15)
A detailed knowledge of the mechanisms underlying brain aging is fundamental to understand its functional decline and the baseline upon which brain pathologies superimpose. Endogenous protective mechanisms must contribute to the adaptability and plasticity still present in the healthy aged
Seryoung Kim et al.
MicrobiologyOpen, 4(4), 632-643 (2015-06-16)
We previously reported that the alaE gene of Escherichia coli encodes the l-alanine exporter AlaE. The objective of this study was to elucidate the mechanism of the AlaE exporter. The minimum inhibitory concentration of l-alanine and l-alanyl-l-alanine in alaE-deficient l-alanine-nonmetabolizing
Amanda J Sutherland et al.
PloS one, 10(5), e0121966-e0121966 (2015-05-13)
Extracellular matrix (ECM)-based materials are attractive for regenerative medicine in their ability to potentially aid in stem cell recruitment, infiltration, and differentiation without added biological factors. In musculoskeletal tissue engineering, demineralized bone matrix is widely used, but recently cartilage matrix
Yinghuan Li et al.
International journal of pharmaceutics, 468(1-2), 133-141 (2014-04-09)
The tripeptide arginine-glycine-aspartate (RGD) was conjugated with various fatty alcohols to obtain RGDOCnH2n+1 (n=8, 10, 12, 14, 16, 18), which were incorporated into the bilayer of docetaxel liposomes to improve their tumor specificity. The fatty alcohols were accepted as linking
Tomoko Nakamoto et al.
Colloids and surfaces. B, Biointerfaces, 122, 316-323 (2014-07-30)
In recent years, various approaches have been taken to generate functional muscle tissue by tissue engineering. However, in vitro methods to generate smooth muscle with physiologically aligned structure remains limited. In order to mimic the in vivo highly organized structure
Deepak et al.
International journal of biological macromolecules, 164, 2370-2379 (2020-08-08)
The non-gelatinous and thermo-responsive properties were introduced in chitosan by incorporating the chain of poly(N-isopropylacrylamide) via reversible addition-fragmentation chain transfer (RAFT) polymerization. To achieve this, the reaction was carried out at 80 °C by modifying the chitosan(CS) with RAFT agent as
Jianqin Lu et al.
Biomaterials, 62, 176-187 (2015-06-10)
Camptothecin (CPT) is a potent antitumor agent and functions via inhibiting the activity of topoisomerase I during DNA replication. However, the clinical application of CPT has been greatly hindered by its extremely poor solubility, the instability of its active lactone
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