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关键词:'D8402'
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Yutao Jiang et al.
Journal of chromatography. A, 1411, 63-68 (2015-08-11)
In this paper, we introduce a high throughput LCMS/UV/CAD/CLND system that improves upon previously reported systems by increasing both the quantitation accuracy and the range of compounds amenable to testing, in particular, low molecular weight "fragment" compounds. This system consists
E B Bhalerao et al.
Indian journal of physiology and pharmacology, 29(2), 83-88 (1985-04-01)
Patients suffering from pulmonary tuberculosis were investigated for the levels of isoniazid (INH) and its metabolites viz. acetyl-INH, mono and diacetyl hydrazines and ammonia. It was observed that 50% of the patients are slow inactivators of INH and almost all
B H Lauterburg et al.
The Journal of pharmacology and experimental therapeutics, 235(3), 566-570 (1985-12-01)
The plasma concentrations of isoniazid and its hydrazino metabolites, acetylisoniazid, acetylhydrazine and diacetylhydrazine, were measured by gas chromatography-mass spectrometry in 12 healthy subjects after the ingestion of 300 mg of isoniazid. The area under the plasma concentration-time curve of acetylisoniazid
W von Sassen et al.
Journal of chromatography, 338(1), 113-122 (1985-02-27)
A high-performance liquid chromatographic assay for the determination of isoniazid, acetylisoniazid, acetylhydrazine and diacetylhydrazine (plasma and urine) was developed. The m-chlorobenzoyl derivatives of isoniazid, acetylhydrazine and the internal standard propionylhydrazine were prepared, separated on a RP-18 column and detected at
Christopher Trent Brewer et al.
Toxicological sciences : an official journal of the Society of Toxicology, 168(1), 209-224 (2018-12-06)
In a mouse model, rifampicin and isoniazid combination treatment results in cholestatic liver injury that is associated with an increase in protoporphyrin IX, the penultimate heme precursor. Both ferrochelatase (FECH/Fech) and aminolevulinic acid synthase 1 (ALAS1/Alas1) are crucial enzymes in
S V Bhide et al.
Cancer letters, 23(2), 235-240 (1984-06-01)
Two hydrazine derivatives, monoacetyl hydrazine (MAH) and diacetyl hydrazine (DAH), have been tested for mutagenic response in the Salmonella/mammalian microsome assay and micronucleus test. MAH but not DAH, increased the revertant mutants in TA100 and TA1535 and also increased the
J A Timbrell et al.
Human toxicology, 3(6), 485-495 (1984-12-01)
The urinary metabolite profile of isoniazid has been studied in patients receiving the drug as therapy for tuberculosis and the profile in patients suffering liver damage due to isoniazid compared with that in control patients. There were no consistent differences
E B Bhalerao et al.
Indian journal of physiology and pharmacology, 29(3), 133-138 (1985-07-01)
Effect of isoniazid (INH) and its metabolites e.g. mono and diacetyl hydrazines (MAH and DAH respectively) was studied on circulating and tissue folates in mice (a species susceptible to INH tumorigenicity) and rats (a species resistant to INH carcinogenicity). It
Ramachandran Azhakar et al.
Dalton transactions (Cambridge, England : 2003), 41(5), 1529-1533 (2011-12-14)
The reaction of N-heterocyclic silylene (NHSi) L [L = CH{(C[double bond, length as m-dash]CH(2))(CMe)(2,6-iPr(2)C(6)H(3)N)(2)}Si] with benzoylhydrazine, 1,2-dicarbethoxyhydrazine, 1,2-diacetylhydrazine and 1,2-bis(tert-butoxycarbonyl)hydrazine in 1 : 1 molar ratio resulted in compounds 1-4 with an almost quantitative yield and five coordinate silicon atoms.
Qiqi Zhao et al.
Journal of agricultural and food chemistry, 56(13), 5254-5259 (2008-06-11)
A series of novel N-substituted phenoxysulfenyl- N'- tert-butyl- N, N'-diacylhydrazines were designed and synthesized as insect growth regulators via the key intermediates N-chlorosulfenyl- N'- tert-butyl- N, N'-diacylhydrazines. Compared to the parent compounds, these N-substituted phenoxysulfenyl derivatives displayed better solubility and
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