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A Reiner et al.
Journal of neuroscience methods, 103(1), 23-37 (2000-11-14)
Biotinylated dextran amines (BDA) are highly sensitive tools for anterograde and retrograde pathway tracing studies of the nervous system. BDA can be reliably delivered into the nervous system by iontophoretic or pressure injection and visualized with an avidin-biotinylated HRP (ABC)
Do Hyung Kim et al.
Nanoscale research letters, 7(1), 91-91 (2012-01-31)
Sorafenib-incoporated nanoparticles were prepared using a block copolymer that is composed of dextran and poly(DL-lactide-co-glycolide) [DexbLG] for antitumor drug delivery. Sorafenib-incorporated nanoparticles were prepared by a nanoprecipitation-dialysis method. Sorafenib-incorporated DexbLG nanoparticles were uniformly distributed in an aqueous solution regardless of
Editorial comment.
Joseph G Barone
Urology, 81(5), 1045-1046 (2013-04-24)
Elisa Crisci et al.
Molecular immunology, 63(2), 343-354 (2014-10-06)
Cellular therapies using immune cells and in particular dendritic cells (DCs) are being increasingly applied in clinical trials and vaccines. Their success partially depends on accurate delivery of cells to target organs or migration to lymph nodes. Delivery and subsequent
Xiao-Yu Tao et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(24), 3738-3742 (2013-05-01)
The column chromatography on silica gel, Sephadex LH-20 and semi-preparative HPLC were used to separate and purify the compounds from the EtOAc extract of medium and MeOH extract of cell cultures of Morus alba. Eight compounds were isolated. Based on
Savita Bisht et al.
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology, 1(4), 415-425 (2010-01-06)
Chemotherapy is a major therapeutic approach for the treatment of localized and metastasized cancers. Whereas potent chemotherapeutic agents seem promising in the test tube, clinical trials often fail due to unfavorable pharmacokinetics, poor delivery, low local concentrations, and limited accumulation
Noelle Layer et al.
JAMA ophthalmology, 132(7), 832-837 (2014-05-03)
Optisol-GS, the most common corneal storage medium in the United States, contains antibacterial but no antifungal supplementation. Most postkeratoplasty endophthalmitis and keratitis cases are now of a fungal origin. To assess the efficacy and safety of voriconazole and amphotericin B
Samuel Christen et al.
Urology, 83(4), 920-922 (2014-01-15)
Various biological and artificial materials have been introduced for endoscopic treatment of vesicoureteral reflux. Over the past years, dextranomer combined with hyaluronic acid (Dx/Ha) has been established as the most commonly used tissue-augmenting substance for subureteral injection because of its
Veronica L Novosad et al.
American journal of physiology. Gastrointestinal and liver physiology, 305(6), G418-G426 (2013-07-23)
Injury to the intestinal mucosa is a life-threatening problem in a variety of clinical disorders, including hemorrhagic shock, trauma, burn, pancreatitis, and heat stroke. The susceptibility to injury of different regions of intestine in these disorders is not well understood.
Kazuyoshi Motomura et al.
BMC medical imaging, 13, 32-32 (2013-09-14)
We previously demonstrated that superparamagnetic iron oxide (SPIO)-enhanced MR imaging is promising for the detection of metastases in sentinel nodes localized by CT-lymphography in patients with breast cancer. The purpose of this study was to determine the predictive criteria of
Marisa A Gallicchio et al.
Biochimica et biophysica acta, 1833(12), 2922-2932 (2013-06-12)
Chronic hyperglycaemia during diabetes leads to non-enzymatic glycation of proteins to form advanced glycation end products (AGEs) that contribute to nephropathy. We describe AGE uptake in LLC-PK1 and HK2 proximal tubule cell lines by macropinocytosis, a non-specific, endocytic mechanism. AGE-BSA
Mohammad Moeini et al.
Biochimica et biophysica acta, 1840(1), 605-614 (2013-10-23)
Currently available methods for contrast agent-based magnetic resonance imaging (MRI) and computed tomography (CT) of articular cartilage can only detect cartilage degradation after biochemical changes have occurred within the tissue volume. Differential adsorption of solutes to damaged and intact surfaces
Ana Luisa Miranda-Vilela et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(4), 3391-3403 (2013-12-03)
Dextran-functionalized maghemite fluid (DexMF) has been tested to treat Ehrlich-solid-tumor-bearing mice, evidencing its potential use in mediating magnetohyperthermia in breast cancer treatment. However, although magnetic nanoparticles tend to accumulate in tumor tissues, part of the nanomaterial can reach the blood
Xing-Bo Li et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(10), 1543-1547 (2013-08-21)
Sixteen compounds were isolated from Conioselinum vaginatum by silica column chromatography over silica gel and Sephadex LH-20, as well as recrystallization. On the basis of their physical and chemical properties and spectral data, their structures were identified as ligustilide (1)
R Shelma et al.
Journal of biomedical nanotechnology, 9(2), 167-176 (2013-05-01)
The overall goal of this paper was to enhance the bioavailability of orally delivered insulin. A mucoadhesive amphiphilic chitosan derivative, lauroyl sulphated chitosan (LSCS) was used as the oral carrier for insulin. Trans epithelial electrical resistance experiment was performed on
Bruno B Averbeck et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(29), 9497-9505 (2014-07-18)
Frontal-striatal circuits underlie important decision processes, and pathology in these circuits is implicated in many psychiatric disorders. Studies have shown a topographic organization of cortical projections into the striatum. However, work has also shown that there is considerable overlap in
Ram Prakash Chauhan et al.
Journal of biomedical nanotechnology, 9(3), 323-334 (2013-04-30)
The physical and chemical properties of the nanoparticles influence their pharmacokinetics and ability to accumulate in tumors. In this paper we report a facile method to conjugate folic acid molecule to iron oxide nanoparticles to increase the specific uptake of
P Roderick et al.
Health technology assessment (Winchester, England), 9(49), iii-iiv (2005-12-13)
To assess the benefits in terms of reductions in the risks of deep vein thrombosis (DVT) and of pulmonary embolism (PE), and hazards in terms of major bleeding, of: (i) mechanical compression; (ii) oral anticoagulants; (iii) dextran; and (iv) regional
Elizabeth M Bradshaw et al.
Nature neuroscience, 16(7), 848-850 (2013-05-28)
In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444(C) risk allele was associated with greater cell surface expression of CD33 in the monocytes (t50 = 10.06, P(joint) = 1.3 × 10(-13)) of young
M H Hemmelder et al.
The Journal of laboratory and clinical medicine, 132(5), 390-403 (1998-11-21)
Fractional dextran clearances have been extensively used to study glomerular size selectivity. We report on an analysis of different laboratory procedures involved in measuring fractional dextran clearances. The deproteinization of plasma samples by 20% trichloroacetic acid (TCA) revealed a protein
Sophie R Van Tomme et al.
Expert review of medical devices, 4(2), 147-164 (2007-03-16)
The rapid development of protein-based pharmaceuticals over recent decades has tremendously increased the need for suitable delivery systems, guaranteeing a safe and controlled delivery of proteinacious drugs. Hydrogels offer good opportunities as protein delivery systems or tissue engineering scaffolds owing
Trypan blue vital dye staining vs TUNEL technique to detect corneal endothelium toxic effects.
Sertan Goktas et al.
JAMA ophthalmology, 132(12), 1491-1491 (2014-09-19)
Qing-Qing Wang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(3), 366-370 (2013-05-15)
To study the chemical constituents of Rhododendron seniavinii. Compounds were isolated from the aqueous extract of the leaves of R. seniavinii by using Sephadex LH-20, ODS open column chromatography and other means. Their structures were elucidated according to spectral data
Norman Chieng et al.
International journal of pharmaceutics, 454(1), 167-173 (2013-07-23)
The purpose of this study is to investigate the use of multivariate data analysis for powder X-ray diffraction-pair-wise distribution function (PXRD-PDF) data to detect phase separation in freeze-dried binary amorphous systems. Polymer-polymer and polymer-sugar binary systems at various ratios were
Boon M Teo et al.
Biochimica et biophysica acta, 1830(10), 4838-4847 (2013-07-03)
Liposomes have gained immerse attention in the field of drug delivery as carriers of therapeutic molecules. Their modification with a polymer either to make them stealth (e.g. using PEG) and/or more stable (e.g. using poly(dopamine) (PDA)) is a crucial aspect
Melda Altikatoglu et al.
Artificial cells, blood substitutes, and immobilization biotechnology, 40(4), 261-265 (2012-01-28)
In the present study, the stabilizing effect of dextrans as additives on the denaturation and inactivation of glucose oxidase (GOD) was investigated. Three different molecular weighted dextrans (M(w) 17.5, 75, 188 kD) were used with different concentrations. Dramatically increased enzyme
Ai Q Li et al.
American journal of physiology. Cell physiology, 308(2), C164-C175 (2014-11-08)
Among emerging antidiabetic agents, glucagon-like peptide-1 (GLP-1)-based therapies carry special cardiovascular implications, exerting both direct and indirect effects. The control of vascular permeability is of pivotal importance in vascular pathologies. The objective of the present study was to determine the
Yonggang Liu et al.
Langmuir : the ACS journal of surfaces and colloids, 28(8), 3831-3839 (2012-02-02)
We studied the interfacial tension between coexisting phases of aqueous solutions of dextran and polyethylene glycol. First, we characterized the phase diagram of the system and located the binodal. Second, the tie lines between the coexisting phases were determined using
Jorawer S Singh et al.
Experimental eye research, 115, 239-245 (2013-07-09)
Corneal endothelial cells form a leaky barrier on the posterior surface of the cornea, allowing influx of nutrient-carrying aqueous humor through the paracellular space and efflux of excess fluid. Corneal edema arises when the density of these non-proliferative endothelial cells
Kelli G Sharp et al.
Experimental neurology, 257, 186-204 (2014-04-22)
As part of the NIH "Facilities of Research Excellence-Spinal Cord Injury" project to support independent replication, we repeated key parts of a study reporting robust engraftment of neural stem cells (NSCs) treated with growth factors after complete spinal cord transection
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