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Pengzhi Qi et al.
Aquatic toxicology (Amsterdam, Netherlands), 226, 105554-105554 (2020-07-13)
The NF-E2-related factor 2 (Nrf2), an ubiquitous, evolutionarily conserved transcription factor, acts as a major sensor of oxidative stress in cells. In the present study, a Nrf2 homolog was newly identified in the thick shell mussel Mytilus coruscus. Accordingly, its
Sanja Milkovska-Stamenova et al.
Amino acids, 51(6), 891-901 (2019-04-10)
Milk processing relies on thermal treatments warranting microbiologically safe products with extended shelf life. However, elevated temperatures favor also Maillard reactions yielding the structurally diverse advanced glycation end products (AGEs). AGEs may alter protein functions and immunogenicity and also decrease
Ya-Fang Chen et al.
Journal of cellular physiology, 233(4), 3660-3671 (2017-10-17)
Cardiomyocyte death is an important pathogenic feature of ischemia and heart failure. Through this study, we showed the synergistic role of HIF-1α and FoxO3a in cardiomyocyte apoptosis subjected to hypoxia plus elevated glucose levels. Using gene specific small interfering RNAs
Chengying Xie et al.
Cancer science, 109(4), 1207-1219 (2018-02-16)
Abrogating tumor angiogenesis by inhibiting vascular endothelial growth factor receptor-2 (VEGFR2) has been established as a therapeutic strategy for treating cancer. However, because of their low selectivity, most small molecule inhibitors of VEGFR2 tyrosine kinase show unexpected adverse effects and
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Jon G Quatromoni et al.
Journal of immunotherapy (Hagerstown, Md. : 1997), 37(5), 283-292 (2014-05-09)
Despite recent advances in the development of novel therapies, esophageal carcinoma remains an aggressive cancer associated with a poor prognosis. The lack of a high throughput, reproducible syngeneic animal model that replicates human disease is partly responsible for the paucity
Chunwan Lu et al.
Cancer immunology research, 7(3), 414-427 (2019-01-06)
Despite the presence of CTLs in the tumor microenvironment, the majority of immunogenic human colon cancer does not respond to immune checkpoint inhibitor immunotherapy, and microsatellite instable (MSI) tumors are not naturally eliminated. The molecular mechanism underlying the inactivity of
Julia Schueler et al.
Cells, 8(7) (2019-07-22)
In up to 30% of non-small cell lung cancer (NSCLC) patients, the oncogenic driver of tumor growth is a constitutively activated epidermal growth factor receptor (EGFR). Although these patients gain great benefit from treatment with EGFR tyrosine kinase inhibitors, the
Yogesh Kumar et al.
Molecular cancer research : MCR, 14(11), 1097-1109 (2016-07-30)
Drosophila caudal-related homeobox transcription factor 2 (CDX2) drives differentiation of the intestinal epithelium. Loss of CDX2 expression has been reported in several colorectal cancers and cancer cell lines with a potential inverse correlation between CDX2 levels and tumor stage. Ubiquitination
Zhi-Biao Hu et al.
Fitoterapia, 146, 104716-104716 (2020-09-01)
A phytochemical investigation on the MeOH extract of the red alga Laurencia composita Yamada led to the discovery of six new highly halogenated sesquiterpenoids, including two bisabolane-type sesquiterpenoids (1 and 2), one nerolidol derivative (7), and three chamigrane-type sesquiterpenoids (9
Yi Zhu et al.
Molecular cancer research : MCR, 17(9), 1910-1919 (2019-06-14)
Chemotherapy-induced peripheral neuropathy (CIPN) is a major side effect of cancer therapy that frequently requires a reduction or cessation of treatments and negatively impacts the patient's quality of life. There is currently no effective means to prevent or treat CIPN.
Qiang Zhang et al.
Scientific reports, 7, 41192-41192 (2017-01-24)
Wider application of single-cell analysis has been limited by the lack of an easy-to-use and low-cost strategy for single-cell isolation that can be directly coupled to single-cell sequencing and single-cell cultivation, especially for small-size microbes. Herein, a facile droplet microfluidic
Suresh Govatati et al.
Arteriosclerosis, thrombosis, and vascular biology, 39(6), 1212-1226 (2019-05-03)
Objective- IL (interleukin)-33 has been shown to play a role in endothelial dysfunction, but its role in atherosclerosis is controversial. Therefore, the purpose of this study is to examine its role in vascular wall remodeling following injury. Approach and Results-
Gianluca Pontone et al.
JACC. Cardiovascular imaging, 12(6), 1007-1017 (2018-04-24)
This study aimed to evaluate the correlation between different haptoglobin (Hp) phenotypes and myocardial infarction characteristics as detected by cardiac magnetic resonance (CMR) in consecutive patients after ST-segment elevation myocardial infarction (STEMI). Hp is a plasma protein that prevents iron-mediated
Chengyun Wu et al.
Journal of integrative plant biology, 59(12), 851-865 (2017-08-18)
The exocyst is a well-known complex which tethers vesicles at the cell membrane before fusion. Whether an individual subunit can execute a unique function is largely unknown. Using yeast-two-hybrid (Y2H) analysis, we found that EXO70A1 interacted with the GOLD domain
Claudia I Chapuy et al.
Transfusion, 55(6 Pt 2), 1545-1554 (2015-03-13)
Daratumumab (DARA), a promising novel therapy for multiple myeloma, is an IgG1κ monoclonal antibody that recognizes CD38 on myeloma cells. During routine compatibility testing, we observed that the plasma of five of five DARA-treated patients demonstrated a positive antibody screen
Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage.
Weihua Zhou et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(4), 1104-1116 (2016-09-04)
Michael F Sharpnack et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 13(10), 1519-1529 (2018-07-19)
Despite apparently complete surgical resection, approximately half of resected early-stage lung cancer patients relapse and die of their disease. Adjuvant chemotherapy reduces this risk by only 5% to 8%. Thus, there is a need for better identifying who benefits from
Florencia Rago et al.
Molecular cancer therapeutics, 19(10), 2186-2195 (2020-08-05)
Uveal melanoma is a rare and aggressive cancer that originates in the eye. Currently, there are no approved targeted therapies and very few effective treatments for this cancer. Although activating mutations in the G protein alpha subunits, GNAQ and GNA11
Haifeng Zheng et al.
Frontiers in physiology, 11, 230-230 (2020-04-08)
Interstitial cells of Cajal (ICC) are pacemaker cells that generate electrical slow waves in gastrointestinal (GI) smooth muscles. Slow waves organize basic motor patterns, such as peristalsis and segmentation in the GI tract. Slow waves depend upon activation of Ca2+-activated
Valérie Robin et al.
Molecular therapy. Nucleic acids, 7, 81-89 (2017-06-19)
Spinal muscular atrophy (SMA) is a recessive disease caused by mutations in the SMN1 gene, which encodes the protein survival motor neuron (SMN), whose absence dramatically affects the survival of motor neurons. In humans, the severity of the disease is
Tamas Hatfaludi et al.
Antimicrobial agents and chemotherapy, 52(11), 4166-4171 (2008-08-30)
Two TolC homologs, PM0527 and PM1980, were identified for Pasteurella multocida. A pm0527 mutant displayed increased susceptibility to a range of chemicals, including rifampin (512-fold) and acridine orange (128-fold). A pm1980 mutant showed increased susceptibility to rifampin, ceftazidime, and vancomycin.
Jessica Joerling et al.
BMC veterinary research, 16(1), 169-169 (2020-05-31)
Swine dysentery (SD) is a diarrheal disease in fattening pigs that is caused by the strongly hemolytic species Brachyspira (B.) hyodysenteriae, B. hampsonii and B. suanatina. As weakly hemolytic Brachyspira spp. are considered less virulent or even non-pathogenic, the hemolysin
Seul Ki Kim et al.
Fertility and sterility, 103(6), 1425-1431 (2015-04-26)
To assess global methylation and acetylation level before and after swim-up in ejaculated human sperm. Prospective experimental study. University-based hospital. Semen samples were obtained from 50 healthy volunteers (single sample per person) between December 2012 and May 2014. The semen
Fabiana Morroni et al.
International journal of molecular sciences, 19(7) (2018-07-20)
Alzheimer's disease (AD) is the most common form of dementia among older people. Although soluble amyloid species are recognized triggers of the disease, no therapeutic approach is able to stop it. 6-(Methylsulfinyl)hexyl isothiocyanate (6-MSITC) is a major bioactive compound in
A R King et al.
British journal of pharmacology, 157(6), 974-983 (2009-06-03)
Monoacylglycerol lipase (MGL) is a presynaptic serine hydrolase that inactivates the endocannabinoid neurotransmitter, 2-arachidonoyl-sn-glycerol. Recent studies suggest that cysteine residues proximal to the enzyme active site are important for MGL function. In the present study, we characterize the role of
Wei Li et al.
Protein & cell, 11(3), 161-186 (2019-07-19)
The mechanisms underlying spatial and temporal control of cortical neurogenesis of the brain are largely elusive. Long non-coding RNAs (lncRNAs) have emerged as essential cell fate regulators. Here we found LncKdm2b (also known as Kancr), a lncRNA divergently transcribed from
Weizao Guo et al.
Chinese medical journal, 127(16), 2977-2981 (2014-08-19)
Advances in the understanding of cardiovascular pathogenesis have highlighted that inflammation plays a central role in atherosclerotic coronary heart disease. Therefore, exploring pharmacologically based anti-inflammatory treatments to be used in cardiovascular therapeutics is worthwhile to promote the discovery of novel
Alison C Macleod et al.
Molecular cancer therapeutics, 13(12), 2840-2851 (2014-09-26)
Resistant KIT mutations have hindered the development of KIT kinase inhibitors for treatment of patients with systemic mastocytosis. The goal of this research was to characterize the synergistic effects of a novel combination therapy involving inhibition of KIT and calcineurin
Antje Jilg et al.
Journal of pineal research, 66(3), e12553-e12553 (2019-01-09)
Mechanisms of hippocampus-related memory formation are time-of-day-dependent. While the circadian system and clock genes are related to timing of hippocampal mnemonic processes (acquisition, consolidation, and retrieval of long-term memory [LTM]) and long-term potentiation (LTP), little is known about temporal gating
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