D9766

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Membranoproliferative glomerulonephritis and C3 glomerulonephritis: frequency, clinical features, and outcome in children.

Yusuke Okuda et al.

Nephrology (Carlton, Vic.), 20(4), 286-292 (2014-12-20)

C3 glomerulonephritis (C3GN) is a recently described disease that is related to membranoproliferative glomerulonephritis (MPGN). We retrospectively compared the frequencies, clinical characteristics, treatment modalities, and outcomes of C3GN and MPGN in a cohort of Japanese children. Children who were pathologically

Role of adenosine signaling on pentylenetetrazole-induced seizures in zebrafish.

Anna Maria Siebel et al.

Zebrafish, 12(2), 127-136 (2015-01-07)

Adenosine is a well-known endogenous modulator of neuronal excitability with anticonvulsant properties. Thus, the modulation exerted by adenosine might be an effective tool to control seizures. In this study, we investigated the effects of drugs that are able to modulate

Dipyridamole and paracetamol overdose resulting in multi-organ failure.

P S Cullis et al.

Scottish medical journal, 58(3), e14-e17 (2013-08-21)

Dipyridamole intoxication is rare and few reports exist amongst the current literature. A case of dipyridamole and paracetamol overdose is described in a previously healthy 58-year-old woman, which resulted in multi-organ failure requiring dialysis, inotropic support, ventilation and extensive surgical

Investigating incoherence gives insight: clopidogrel is equivalent to extended-release dipyridamole plus aspirin in secondary stroke prevention.

Sarah Dewilde et al.

Journal of clinical epidemiology, 65(8), 835-845 (2012-06-26)

To identify confounding factors that may explain the incoherence between direct and indirect evidence in a published analysis comparing extended-release dipyridamole (ERDP) plus aspirin to clopidogrel for the reduction of stroke. An existing analysis was updated with new studies from

Adenosine-diphosphate (ADP) receptor antagonists for the prevention of cardiovascular disease in type 2 diabetes mellitus.

Nyoli Valentine et al.

The Cochrane database of systematic reviews, 11, CD005449-CD005449 (2012-11-16)

Cardiovascular disease (CVD) is the most prevalent complication of type 2 diabetes with an estimated 65% of people with type 2 diabetes dying from a cause related to atherosclerosis. Adenosine-diphosphate (ADP) receptor antagonists like clopidogrel, ticlopidine, prasugrel and ticagrelor impair

Evaluation of inhibitory effects of dipyridamole against bovine and equine piroplasmosis

Tuvshintulga B, et al.

The Journal of Protozoology, 26, 40-46 (2016)

Dependency of cardiac rubidium-82 imaging quantitative measures on age, gender, vascular territory, and software in a cardiovascular normal population.

John J Sunderland et al.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 22(1), 72-84 (2014-10-09)

Recent technological improvements to PET imaging equipment combined with the availability of software optimized to calculate regional myocardial blood flow (MBF) and myocardial flow reserve (MFR) create a paradigm shifting opportunity to provide new clinically relevant quantitative information to cardiologists.

AICAR Enhances the Phagocytic Ability of Macrophages towards Apoptotic Cells through P38 Mitogen Activated Protein Kinase Activation Independent of AMP-Activated Protein Kinase.

Hui Quan et al.

PloS one, 10(5), e0127885-e0127885 (2015-05-29)

Recent studies have suggested that 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) increases macrophage phagocytosis through adenosine monophosphate-activated protein kinase (AMPK). However, little information is available on the effects of AICAR on the clearance of apoptotic cells by macrophages, known as efferocytosis, which is essential

An in vitro methodology for forecasting luminal concentrations and precipitation of highly permeable lipophilic weak bases in the fasted upper small intestine.

Dimitrios Psachoulias et al.

Pharmaceutical research, 29(12), 3486-3498 (2012-08-15)

To develop an in vitro methodology for prediction of concentrations and potential precipitation of highly permeable, lipophilic weak bases in fasted upper small intestine based on ketoconazole and dipyridamole luminal data. Evaluate usefulness of methodology in predicting luminal precipitation of

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Lourdes Santana et al.

Journal of medicinal chemistry, 51(21), 6740-6751 (2008-10-07)

The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared and assayed 33 coumarin derivatives

The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.

David T Manallack et al.

Journal of medicinal chemistry, 48(10), 3449-3462 (2005-05-13)

A surface on the androgen receptor that allosterically regulates coactivator binding.

Eva Estébanez-Perpiñá et al.

Proceedings of the National Academy of Sciences of the United States of America, 104(41), 16074-16079 (2007-10-04)

Current approaches to inhibit nuclear receptor (NR) activity target the hormone binding pocket but face limitations. We have proposed that inhibitors, which bind to nuclear receptor surfaces that mediate assembly of the receptor's binding partners, might overcome some of these

A multifunctional drug combination shows highly potent therapeutic efficacy against human cancer xenografts in athymic mice.

Xiu-Jun Liu et al.

PloS one, 9(12), e115790-e115790 (2014-12-23)

The tumor microenvironment plays a crucial role during tumor development. Integrated combination of drugs that target tumor microenvironment is a promising approach to anticancer therapy. Here, we report a multifunctional combination of low-cytotoxic drugs composed of dipyridamole, bestatin and dexamethasone

Dipyridamole, cerebrovascular disease, and the vasculature.

Subrata Chakrabarti et al.

Vascular pharmacology, 48(4-6), 143-149 (2008-03-18)

Stroke is a leading cause of morbidity and mortality and the most common cause of neurological disability in older individuals. Prevention of recurrent stroke includes risk factor modification as well as the use of therapies that inhibit platelet activation. One

Transport mechanisms of a novel antileukemic and antiviral compound 9-norbornyl-6-chloropurine.

Pavla Plačková et al.

Journal of enzyme inhibition and medicinal chemistry, 30(1), 57-62 (2014-04-01)

6-Chloropurines substituted at the position 9 with variously modified bicyclic skeletons represent promising antiviral and anticancer agents. This work aimed to investigate the transport mechanisms of 9-[(1R*,2R*,4S*)-bicyclo[2.2.1]hept-2-yl]-6-chloro-9H-purine (9-norbornyl-6-chloropurine, NCP) and their relationship to the metabolism and biological activity of the

Site specific solubility improvement using solid dispersions of HPMC-AS/HPC SSL--mixtures.

Damir Elmar Zecevic et al.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 87(2), 264-270 (2014-04-29)

Many upcoming drug candidates are pH-dependent poorly soluble weak bases in the pH range of the gastrointestinal tract. This often leads to a high in vivo variability and bioavailability issues. Aiming to overcome these limitations, the design of solid dispersions

Small molecule regulators of autophagy identified by an image-based high-throughput screen.

Lihong Zhang et al.

Proceedings of the National Academy of Sciences of the United States of America, 104(48), 19023-19028 (2007-11-21)

Autophagy is a lysosome-dependent cellular catabolic mechanism mediating the turnover of intracellular organelles and long-lived proteins. Reduction of autophagy activity has been shown to lead to the accumulation of misfolded proteins in neurons and may be involved in chronic neurodegenerative

Adenosine transport, erythrocyte deformability and microvascular dysfunction: an unrecognized potential role for dipyridamole therapy.

Jignesh Bhavsar et al.

Clinical hemorheology and microcirculation, 44(3), 193-205 (2010-04-07)

Reperfusion injury and no-reflow phenomenon are known entities that contribute to persistent impairment in myocardial perfusion and regional myocardial dysfunction following restoration of epicardial coronary blood flow after a myocardial infarction. Following prolonged ischemia, oxidative stress and inflammation-mediated alterations in

Dipyridamole in antithrombotic treatment.

Wolfgang G Eisert

Advances in cardiology, 47, 78-86 (2012-08-22)

The antithrombotic activity of dipyridamole was initially discovered in an in vivo experiment about half a century ago. At that time science had not appreciated the complexity of the regulation of local thrombus formation. Inhibition of platelets has been the

Long-term effects of secondary prevention on cognitive function in stroke patients.

Abdel Douiri et al.

Circulation, 128(12), 1341-1348 (2013-08-13)

Limited long-term follow-up data exist on the impact of appropriate secondary prevention therapies on cognitive function in patients after first-ever stroke. The aim of this study is to determine the effect of secondary prevention of vascular events on cognitive function

Prognostic implication of Doppler echocardiographic derived coronary flow reserve in patients with left bundle branch block.

Lauro Cortigiani et al.

European heart journal, 34(5), 364-373 (2012-09-26)

Myocardial ischaemia during pharmacological stress echocardiography is a strong prognostic predictor in patients with a left bundle branch block (LBBB). However, the additive value of Doppler-derived coronary flow reserve (CFR) during pharmacological stress testing remains to be investigated in this

Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

Jenny M Pedersen et al.

Journal of medicinal chemistry, 51(11), 3275-3287 (2008-05-07)

The chemical space of registered oral drugs was explored for inhibitors of the human multidrug-resistance associated protein 2 (MRP2; ABCC2), using a data set of 191 structurally diverse drugs and drug-like compounds. The data set included a new reference set

CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer.

Erika Y Faraoni et al.

Cancer research, 83(7), 1111-1127 (2023-02-01)

The microenvironment that surrounds pancreatic ductal adenocarcinoma (PDAC) is profoundly desmoplastic and immunosuppressive. Understanding triggers of immunosuppression during the process of pancreatic tumorigenesis would aid in establishing targets for effective prevention and therapy. Here, we interrogated differential molecular mechanisms dependent

Chimeric constructs between human and rat equilibrative nucleoside transporters (hENT1 and rENT1) reveal hENT1 structural domains interacting with coronary vasoactive drugs.

M Sundaram et al.

The Journal of biological chemistry, 273(34), 21519-21525 (1998-08-15)

We have recently isolated cDNAs from human placenta and rat jejunum encoding the prototypic human and rat equilibrative nitrobenzylthioinosine (NBMPR)-sensitive nucleoside transporters hENT1 and rENT1. The two proteins (456 and 457 residues, Mr 50,000) are 78% identical in amino acid

Prediction of drug intestinal absorption by new linear and non-linear QSPR.

Alan Talevi et al.

European journal of medicinal chemistry, 46(1), 218-228 (2010-11-30)

In order to minimize the high attrition rate that usually characterizes drug research and development projects, current medicinal chemists aim to characterize both pharmacological and ADME profiles at the beginning of drug R&D initiatives. Thus, the development of ADME High-Throughput

Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma.

Wenjie He et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(9), 3446-3454 (2013-05-18)

Multiple myeloma (MM) is characterized by osteolytic bone lesions with uncoupled bone remodeling. In this study, we examined the effects of adenosine and its receptors (A1R, A2AR, A2BR, and A3R) on osteoblast and osteoclast differentiation of cells derived from patients

Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine.

Birte Niemann et al.

Nature, 609(7926), 361-368 (2022-07-06)

Brown adipose tissue (BAT) dissipates energy1,2 and promotes cardiometabolic health3. Loss of BAT during obesity and ageing is a principal hurdle for BAT-centred obesity therapies, but not much is known about BAT apoptosis. Here, untargeted metabolomics demonstrated that apoptotic brown

Possible involvement of sphingomyelin in the regulation of the plasma sphingosine 1-phosphate level in human subjects.

Ryunosuke Ohkawa et al.

Clinical biochemistry, 48(10-11), 690-697 (2015-04-12)

Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid mediator. Although the plasma S1P concentration is reportedly determined by cellular components, including erythrocytes, platelets, and vascular endothelial cells, the possible involvement of other factors, such as serum sphingomyelin (SM) and autotaxin (ATX)

Effect of dipyridamole during acute stroke: exploring antithrombosis and neuroprotective benefits.

C D d'Esterre et al.

Annals of the New York Academy of Sciences, 1207, 71-75 (2010-10-20)

Currently, many stroke-prone individuals take antithrombotic drugs, which have known antiplatelet properties, to decrease stroke incidence. There is now evidence that this regimen could also reduce stroke severity through neuroprotective, nonplatelet mechanisms that include anti-inflammatory processes. Inflammation was found to

Dipyridamole activates adenosine A2B receptor and AMPK/cAMP signaling and promotes myogenic differentiation of myoblastic C2C12 cells.

Miguel Marco-Bonilla et al.

Frontiers in pharmacology, 14, 1247664-1247664 (2023-09-29)

Introduction: Sarcopenia is defined as a loss of muscle mass and strength. ATP homeostasis is crucial during myogenesis. We determined how the purinergic system modulates myogenesis using dipyridamole (blocks adenosine taken up by the cells) and tenofovir (inhibits ATP release)

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