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Rajendra Kumar Gurumurthy et al.
Science signaling, 3(113), ra21-ra21 (2010-03-18)
Chlamydiae are obligate intracellular bacterial pathogens that have a major effect on human health. Because of their intimate association with their host, chlamydiae depend on various host cell functions for their survival. Here, we present an RNA-interference-based screen in human
Aaron Provence et al.
The Journal of pharmacology and experimental therapeutics, 364(1), 131-144 (2017-11-01)
Voltage-gated KV7 channels (KV7.1 to KV7.5) are important regulators of the cell membrane potential in detrusor smooth muscle (DSM) of the urinary bladder. This study sought to further the current knowledge of KV7 channel function at the molecular, cellular, and
James D Phelan et al.
Nature, 560(7718), 387-391 (2018-06-22)
B cell receptor (BCR) signalling has emerged as a therapeutic target in B cell lymphomas, but inhibiting this pathway in diffuse large B cell lymphoma (DLBCL) has benefited only a subset of patients1. Gene expression profiling identified two major subtypes
Garrett Rhodes et al.
Analytical cellular pathology (Amsterdam), 2021, 4793338-4793338 (2021-08-03)
Epithelial wound healing is essential to repair the corneal barrier function after injury and requires coordinated epithelial sheet movement over the wounded region. The presence and role of pannexin1 on multilayered epithelial sheet migration was examined in unwounded and wounded
Laëtitia Gorisse et al.
The Biochemical journal, 475(19), 3073-3086 (2018-09-07)
Axl is a tyrosine kinase receptor that is important for hematopoiesis, the innate immune response, platelet aggregation, engulfment of apoptotic cells and cell survival. Binding of growth arrest-specific protein 6 (Gas6) activates Axl signaling, but the mechanism of inactivation of
Chao Shan et al.
Journal of virology (2018-08-17)
Dengue virus (DENV) is the most prevalent mosquito-transmitted viral pathogen in humans. The recently licensed dengue vaccine has major weaknesses. Therefore, there is an urgent need to develop improved dengue vaccines. Here we report a virion assembly-defective DENV as a
Mikael Åberg et al.
Thrombosis and haemostasis, 111(4), 748-760 (2013-12-18)
The insulin-like growth factor 1 receptor (IGF-1R) is known to promote survival and has also been implicated in the pathogenesis of several disease states, including cardiovascular disorders and cancer. Recently, we showed that binding of coagulation factor VIIa (FVIIa) to
Adham Elsayed et al.
The journal of adhesive dentistry, 19(3), 221-228 (2017-06-10)
To test the bond strength and durability after artificial aging of so-called universal primers and universal multimode adhesives to lithium disilicate or zirconia ceramics. A total of 240 ceramic plates, divided into two groups, were produced and conditioned: 120 acid-etched
Marion Pauly et al.
Biochimica et biophysica acta. Molecular basis of disease, 1863(9), 2229-2239 (2017-06-20)
Besides its role in calcium (Ca2+) homeostasis, the sarco-endoplamic reticulum (SR/ER) controls protein folding and is tethered to mitochondria. Under pathophysiological conditions the unfolded protein response (UPR) is associated with disturbance in SR/ER-mitochondria crosstalk. Here, we investigated whether ER stress
Jianquan Li et al.
Scientific reports, 7, 41072-41072 (2017-01-24)
The mitotic checkpoint complex (MCC) is formed from two sub-complexes of CDC20-MAD2 and BUBR1-BUB3, and current models suggest that it is generated exclusively by the kinetochores after nuclear envelope breakdown (NEBD). However, neither sub-complex has been visualised in vivo, and
Liang Chen et al.
The journal of adhesive dentistry, 15(4), 325-331 (2013-03-28)
To evaluate the effect of the hydrophilicity of adhesives on the compatibility between one-bottle simplified adhesives and a dual-curing resin cement. Three experimental and two commercial adhesives (All-Bond Universal, OptiBond Allin- One) with the same or similar pH and various
Jong-Ho Cha et al.
Molecular cell, 71(4), 606-620 (2018-08-18)
Metformin has been reported to possess antitumor activity and maintain high cytotoxic T lymphocyte (CTL) immune surveillance. However, the functions and detailed mechanisms of metformin's role in cancer immunity are not fully understood. Here, we show that metformin increases CTL
Makoto Hirano et al.
Glycobiology, 22(1), 84-95 (2011-08-13)
Ischemia/reperfusion (I/R) is an important cause of acute renal failure. Recent studies have shown that the complement system mediated by the mannan-binding protein (MBP), which is a C-type serum lectin recognizing mannose, fucose and N-acetylglucosamine residues, plays a critical role
Matthew P Patricelli et al.
Cancer discovery, 6(3), 316-329 (2016-01-08)
KRAS gain-of-function mutations occur in approximately 30% of all human cancers. Despite more than 30 years of KRAS-focused research and development efforts, no targeted therapy has been discovered for cancers with KRAS mutations. Here, we describe ARS-853, a selective, covalent
Megan L Goodall et al.
Developmental cell, 37(4), 337-349 (2016-05-25)
Although autophagy controls cell death and survival, underlying mechanisms are poorly understood, and it is unknown whether autophagy affects only whether or not cells die or also controls other aspects of programmed cell death. MAP3K7 is a tumor suppressor gene
Jonathan Ausman et al.
Cell death & disease, 9(3), 298-298 (2018-02-22)
Mitochondria are in a constant balance of fusing and dividing in response to cellular cues. Fusion creates healthy mitochondria, whereas fission results in removal of non-functional organelles. Changes in mitochondrial dynamics typify several human diseases. However, the contribution of mitochondrial
Charles Lu et al.
PloS one, 7(4), e34833-e34833 (2012-05-05)
Tumor suppressor gene TUSC2/FUS1 (TUSC2) is frequently inactivated early in lung cancer development. TUSC2 mediates apoptosis in cancer cells but not normal cells by upregulation of the intrinsic apoptotic pathway. No drug strategies currently exist targeting loss-of-function genetic abnormalities. We
Pengli Zheng et al.
Nature, 601(7891), 132-138 (2021-12-17)
Organelles move along differentially modified microtubules to establish and maintain their proper distributions and functions1,2. However, how cells interpret these post-translational microtubule modification codes to selectively regulate organelle positioning remains largely unknown. The endoplasmic reticulum (ER) is an interconnected network of
Ahmad F Alghanem et al.
Angiogenesis, 20(3), 341-358 (2017-03-09)
Regulator of calcineurin 1 (RCAN1) is an endogenous inhibitor of the calcineurin pathway in cells. It is expressed as two isoforms in vertebrates: RCAN1.1 is constitutively expressed in most tissues, whereas transcription of RCAN1.4 is induced by several stimuli that
Bassil Dekky et al.
Oncotarget, 9(30), 21366-21382 (2018-05-17)
The epithelial mesenchymal transition (EMT) is a key process for cancer cell invasion and migration. This complex program whereby epithelial tumor cells loose polarity and acquire mesenchymal phenotype is driven by the regulation of cell-cell adhesion and cell-substrate interactions. We
Yan Yih Goh et al.
The American journal of pathology, 177(6), 2791-2803 (2010-10-19)
Adipose tissue secretes adipocytokines for energy homeostasis, but recent evidence indicates that some adipocytokines also have a profound local impact on wound healing. Upon skin injury, keratinocytes use various signaling molecules to promote reepithelialization for efficient wound closure. In this
Christoph Reinhardt et al.
Nature, 483(7391), 627-631 (2012-03-13)
The gut microbiota is a complex ecosystem that has coevolved with host physiology. Colonization of germ-free (GF) mice with a microbiota promotes increased vessel density in the small intestine, but little is known about the mechanisms involved. Tissue factor (TF)
Björn Koos et al.
The Journal of physiology, 596(7), 1227-1241 (2018-01-26)
Na+ conducting hypertonicity-induced cation channels (HICCs) are key players in the volume restoration of osmotically shrunken cells and, under isotonic conditions, considered as mediators of proliferation - thereby opposing apoptosis. In an siRNA screen of ion channels and transporters in
Stephanie Hampp et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(30), E4311-E4319 (2016-07-14)
DNA damage tolerance facilitates the progression of replication forks that have encountered obstacles on the template strands. It involves either translesion DNA synthesis initiated by proliferating cell nuclear antigen monoubiquitination or less well-characterized fork reversal and template switch mechanisms. Herein
J Matthew Rhett et al.
The Journal of membrane biology, 245(7), 411-422 (2012-07-20)
Gap junctions (GJs) are aggregates of channels that provide for direct cytoplasmic connection between cells. Importantly, this connection is thought responsible for cell-to-cell transfer of the cardiac action potential. The GJ channels of ventricular myocytes are composed of connexin43 (Cx43).
Ahmed M Fahmy et al.
PloS one, 13(10), e0205189-e0205189 (2018-10-05)
Hepatitis C virus (HCV) infection is known to induce autophagosome accumulation as observed by the typical punctate cytoplasmic distribution of LC3B-II in infected cells. Previously, we showed that viral RNA-dependent RNA polymerase (NS5B) interacts with ATG5, a major component of
Wen-Hao Yang et al.
Cancer research, 78(14), 3761-3768 (2018-05-24)
Programmed death-ligand 1 (PD-L1) is a well-known immune checkpoint protein that helps cancer cells evade immune response. Anti-PD-L1 immune therapy has been approved for the treatment of several advanced human cancers. Therefore, further understanding of the regulatory mechanisms of PD-L1
Paulina Sosicka et al.
Biochimica et biophysica acta. Molecular cell research, 1864(5), 825-838 (2017-02-09)
SLC35A4 has been classified in the SLC35A subfamily based on amino acid sequence homology. Most of the proteins belonging to the SLC35 family act as transporters of nucleotide sugars. In this study, the subcellular localization of endogenous SLC35A4 was determined
Tomohisa Toda et al.
Cell stem cell, 21(5), 618-634 (2017-09-19)
Neural progenitor cells (NeuPCs) possess a unique nuclear architecture that changes during differentiation. Nucleoporins are linked with cell-type-specific gene regulation, coupling physical changes in nuclear structure to transcriptional output; but, whether and how they coordinate with key fate-determining transcription factors
Grit Pattschull et al.
Cell reports, 27(12), 3533-3546 (2019-06-20)
YAP and TAZ, downstream effectors of the Hippo pathway, are important regulators of proliferation. Here, we show that the ability of YAP to activate mitotic gene expression is dependent on the Myb-MuvB (MMB) complex, a master regulator of genes expressed
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