CN
Search Within
DUO92012
应用筛选条件
关键词:'DUO92012'
显示 1-30 共 399 条结果 关于 "DUO92012" 范围 论文
Jing Jiao et al.
Methods in molecular biology (Clifton, N.J.), 1510, 287-293 (2016-10-21)
Determining protein acetylation by immunoprecipitation and immunoblotting can be challenging, especially if the tissue of interest is low in quantity, and when good quality acetylation site-specific antibodies are not available. Proximity ligation assays allow a sensitive and quantitative method to
Fredrick J Rosario et al.
The Journal of physiology, 595(13), 4189-4206 (2017-04-05)
Folate deficiency during pregnancy is associated with restricted fetal growth, although the underlying mechanisms are poorly understood. Here we show that mechanistic target of rapamycin (mTOR) functions as a folate sensor in primary human trophoblast (PHT) cells. Folate sensing by
Shyue-Fang Battaglia-Hsu et al.
Nucleic acids research, 46(15), 7844-7857 (2018-07-18)
The molecular mechanisms that underlie the neurological manifestations of patients with inherited diseases of vitamin B12 (cobalamin) metabolism remain to date obscure. We observed transcriptomic changes of genes involved in RNA metabolism and endoplasmic reticulum stress in a neuronal cell
Hongyu Zhang et al.
Nature communications, 9(1), 4272-4272 (2018-10-17)
Impaired hippocampal synaptic plasticity contributes to cognitive impairment in Huntington's disease (HD). However, the molecular basis of such synaptic plasticity defects is not fully understood. Combining live-cell nanoparticle tracking and super-resolution imaging, we show that AMPAR surface diffusion, a key
Qin Wang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(6), 3119-3132 (2018-02-07)
IL-1 signaling is adhesion-restricted in many cell types, but the mechanism that drives it is not defined. We screened for proteins recruited to nascent adhesions in IL-1-treated human fibroblasts with tandem mass tag-mass spectrometry. We used fibronectin bead preparations to
Marcos Daniel Septimio Lanza et al.
Journal of applied oral science : revista FOB, 25(6), 700-707 (2017-12-07)
Due to increasing of aesthetic demand, ceramic crowns are widely used in different situations. However, to obtain long-term prognosis of restorations, a good conversion of resin cement is necessary. To evaluate the degree of conversion (DC) of one light-cure and
Erratum. DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver. Diabetes 2017;66:2571-2582.
Xin Tong et al.
Diabetes, 66(12), 3144-3144 (2017-10-11)
Yojiro Makino et al.
Biochemical and biophysical research communications, 484(2), 269-277 (2017-01-25)
Cancer-associated inflammation develops resistance to the epidermal growth-factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in non-small cell lung cancers (NSCLCs) harboring oncogenic EGFR mutations. Stat3-mediated interleukin (IL)-6 signaling and Smad-mediated transforming growth factor-β (TGF-β) signaling pathways play crucial regulatory roles
Annabel Christ et al.
Developmental cell, 22(2), 268-278 (2012-02-22)
Sonic hedgehog (SHH) is a regulator of forebrain development that acts through its receptor, patched 1. However, little is known about cellular mechanisms at neurulation, whereby SHH from the prechordal plate governs specification of the rostral diencephalon ventral midline (RDVM)
Ian D Peikon et al.
Nucleic acids research, 45(12), e115-e115 (2017-04-28)
The function of a neural circuit is determined by the details of its synaptic connections. At present, the only available method for determining a neural wiring diagram with single synapse precision-a 'connectome'-is based on imaging methods that are slow, labor-intensive
Jingxian Chen et al.
Journal of translational medicine, 16(1), 233-233 (2018-08-22)
NLRP3 inflammasome is involved in the inflammatory responses during acute lung injury (ALI). RIP3 triggered NLRP3 inflammasome activation independent of necroptosis induction has recently been documented. In this study, the role of RIP3 in the activation of NLRP3 inflammasome in
Kuan-Wei Chen et al.
Biochimica et biophysica acta. Gene regulatory mechanisms, 1860(2), 270-281 (2017-01-01)
As mesoderm-derived cell lineage commits to myogenesis, a spectrum of signaling molecules, including insulin growth factor (IGF), activate signaling pathways and ultimately instruct chromatin remodeling and the transcription of myogenic genes. MyoD is a key transcription factor during myogenesis. In
Gunisha Sagar et al.
Gut, 65(7), 1165-1174 (2015-06-11)
New-onset diabetes and concomitant weight loss occurring several months before the clinical presentation of pancreatic cancer (PC) appear to be paraneoplastic phenomena caused by tumour-secreted products. Our recent findings have shown exosomal adrenomedullin (AM) is important in development of diabetes
Xiaofan Li et al.
Journal of virology, 92(14) (2018-04-27)
Cancer-causing herpesviruses infect nearly every human and persist indefinitely in B lymphocytes in a quiescent state known as latency. A hallmark of this quiescence or latency is the presence of extrachromosomal viral genomes with highly restricted expression of viral genes.
Suiping Zhou et al.
The international journal of biochemistry & cell biology, 45(2), 401-407 (2012-11-21)
Peroxiredoxin 6 (Prdx6) is a 1-Cys member of the peroxiredoxin superfamily that plays an important role in antioxidant defense. Glutathionylation of recombinant Prdx6 mediated by π glutathione S-transferase (GST) is required for reduction of the oxidized Cys and completion of
Nauana Somensi et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 42(6), 2507-2522 (2017-08-30)
Heat shock protein 70 (HSP70) has been recently described with extracellular actions, where it is actively released in inflammatory conditions. Acting as DAMPs (damage associated molecular pattern), extracellular HSP70 (eHSP70) interacts with membrane receptors and activates inflammatory pathways. At this
Barry D Kyle et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37(12), 3759-3773 (2017-02-06)
Large conductance, Ca2+-activated K+ (BK) channels control cerebrovascular tone; however, the regulatory processes influencing these channels remain poorly understood. Here, we investigate the cellular mechanisms underlying the enhancement of BK current in rat cerebral arteries by nitric oxide (NO) signaling.
Laurent Gagnoux-Palacios et al.
The Journal of cell biology, 217(11), 3839-3852 (2018-09-23)
Finely tuned regulation of epithelial cell death maintains tissue integrity and homeostasis. At the cellular level, life and death decisions are controlled by environmental stimuli such as the activation of death receptors. We show that cell polarity and adherens junction
Sugiko Watanabe et al.
Scientific reports, 8(1), 10888-10888 (2018-07-20)
Chromatin dynamics mediated by post-translational modifications play a crucial role in cellular response to genotoxic stress for the maintenance of genome integrity. MDC1 is a pivotal chromatin adaptor in DNA damage response (DDR) and its methylation is essential to recruit
Karen S Moulton et al.
JCI insight, 3(4) (2018-02-23)
Phosphatase and tensin homolog (PTEN) is an essential regulator of the differentiated vascular smooth muscle cell (SMC) phenotype. Our goal was to establish that PTEN loss promotes SMC dedifferentiation and pathological vascular remodeling in human atherosclerotic coronary arteries and nonatherosclerotic
Chien-Cheng Chen et al.
The Journal of biological chemistry, 292(30), 12560-12576 (2017-06-04)
The mechanisms whereby progesterone (P4), acting via the progesterone receptor (PR), inhibits proinflammatory/contractile gene expression during pregnancy are incompletely defined. Using immortalized human myometrial (hTERT-HM) cells stably expressing wild-type PR-A or PR-B (PRWT), we found that P4 significantly inhibited IL-1β
Michelle M Williams et al.
Molecular cancer research : MCR, 15(3), 259-268 (2017-01-01)
An estimated 40,000 deaths will be attributed to breast cancer in 2016, underscoring the need for improved therapies. Evading cell death is a major hallmark of cancer, driving tumor progression and therapeutic resistance. To evade apoptosis, cancers use antiapoptotic Bcl-2
Kristin Feltmann et al.
Alcoholism, clinical and experimental research, 42(2), 338-351 (2017-12-06)
Reduced dopamine D2 receptor (D2R) ligand binding has repeatedly been demonstrated in the striatum of humans with alcohol use disorder (AUD). The attenuated D2R binding has been suggested to reflect a reduced D2R density, which in turn has been proposed
Yifeng Xu et al.
Methods in molecular biology (Clifton, N.J.), 1830, 325-335 (2018-07-26)
In plants, a lot of transcription factors fulfill their roles in gene regulation through the interaction with other regulatory proteins and co-factors. Thus, confirmation of protein-protein interaction is key to understand the precise function of transcription factors. Many methods have
Carolyn C Tu et al.
Journal of virology, 92(5) (2017-12-15)
Human cytomegalovirus (HCMV) is a prevalent pathogen that establishes lifelong infection in the host. Virus persistence is aided by extensive manipulation of the host immune system, particularly cytokine and chemokine signaling pathways. The HCMV UL111A gene encodes cmvIL-10, an ortholog
Jay S Naik et al.
Pflugers Archiv : European journal of physiology, 470(4), 633-648 (2018-01-31)
Following chronic hypoxia (CH), the systemic vasculature exhibits blunted vasoconstriction due to endothelial-dependent hyperpolarization (EDH). Previous data demonstrate that subsequent to CH, EDH-mediated vasodilation switches from a reliance on SKca and IKca channels to activation of the endothelial BKca channels
Julia M Fraile et al.
The Journal of biological chemistry, 293(6), 2183-2194 (2017-12-24)
Deubiquitinases are proteases with a wide functional diversity that profoundly impact multiple biological processes. Among them, the ubiquitin-specific protease 36 (USP36) has been implicated in the regulation of nucleolar activity. However, its functional relevance in vivo has not yet been
Maria I Toki et al.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 13(12), 1884-1896 (2018-09-30)
Programmed death 1/programmed death ligand 1 (PD-L1) axis inhibitors have been proven effective, especially in patients with tumors expressing PD-L1. Their clinical efficacy in patients with EGFR-activating mutations is still unclear, whereas KRAS mutations seem to be associated with good
A Frappaolo et al.
Methods in cell biology, 137, 85-103 (2017-01-10)
Cytokinesis separates the cytoplasmic organelles and the duplicated genome into two daughter cells at the end of cell division. In animal cell cytokinesis, assembly and constriction of the contractile apparatus must be finely coordinated with plasma membrane remodeling and vesicle
Sung-Ho Jung et al.
The Journal of prosthetic dentistry, 98(4), 270-276 (2007-10-16)
Many studies concerned with the microleakage of endodontically treated teeth restored with posts and cores and subjected to loading can be found in the literature. However, no studies have investigated microleakage under dynamic loading with simultaneous dye penetration, which is
1/14