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Rajendra Kumar Gurumurthy et al.
Science signaling, 3(113), ra21-ra21 (2010-03-18)
Chlamydiae are obligate intracellular bacterial pathogens that have a major effect on human health. Because of their intimate association with their host, chlamydiae depend on various host cell functions for their survival. Here, we present an RNA-interference-based screen in human
Aaron Provence et al.
The Journal of pharmacology and experimental therapeutics, 364(1), 131-144 (2017-11-01)
Voltage-gated KV7 channels (KV7.1 to KV7.5) are important regulators of the cell membrane potential in detrusor smooth muscle (DSM) of the urinary bladder. This study sought to further the current knowledge of KV7 channel function at the molecular, cellular, and
James D Phelan et al.
Nature, 560(7718), 387-391 (2018-06-22)
B cell receptor (BCR) signalling has emerged as a therapeutic target in B cell lymphomas, but inhibiting this pathway in diffuse large B cell lymphoma (DLBCL) has benefited only a subset of patients1. Gene expression profiling identified two major subtypes
Laëtitia Gorisse et al.
The Biochemical journal, 475(19), 3073-3086 (2018-09-07)
Axl is a tyrosine kinase receptor that is important for hematopoiesis, the innate immune response, platelet aggregation, engulfment of apoptotic cells and cell survival. Binding of growth arrest-specific protein 6 (Gas6) activates Axl signaling, but the mechanism of inactivation of
Chao Shan et al.
Journal of virology (2018-08-17)
Dengue virus (DENV) is the most prevalent mosquito-transmitted viral pathogen in humans. The recently licensed dengue vaccine has major weaknesses. Therefore, there is an urgent need to develop improved dengue vaccines. Here we report a virion assembly-defective DENV as a
Adham Elsayed et al.
The journal of adhesive dentistry, 19(3), 221-228 (2017-06-10)
To test the bond strength and durability after artificial aging of so-called universal primers and universal multimode adhesives to lithium disilicate or zirconia ceramics. A total of 240 ceramic plates, divided into two groups, were produced and conditioned: 120 acid-etched
Marion Pauly et al.
Biochimica et biophysica acta. Molecular basis of disease, 1863(9), 2229-2239 (2017-06-20)
Besides its role in calcium (Ca2+) homeostasis, the sarco-endoplamic reticulum (SR/ER) controls protein folding and is tethered to mitochondria. Under pathophysiological conditions the unfolded protein response (UPR) is associated with disturbance in SR/ER-mitochondria crosstalk. Here, we investigated whether ER stress
Jianquan Li et al.
Scientific reports, 7, 41072-41072 (2017-01-24)
The mitotic checkpoint complex (MCC) is formed from two sub-complexes of CDC20-MAD2 and BUBR1-BUB3, and current models suggest that it is generated exclusively by the kinetochores after nuclear envelope breakdown (NEBD). However, neither sub-complex has been visualised in vivo, and
Liang Chen et al.
The journal of adhesive dentistry, 15(4), 325-331 (2013-03-28)
To evaluate the effect of the hydrophilicity of adhesives on the compatibility between one-bottle simplified adhesives and a dual-curing resin cement. Three experimental and two commercial adhesives (All-Bond Universal, OptiBond Allin- One) with the same or similar pH and various
Jong-Ho Cha et al.
Molecular cell, 71(4), 606-620 (2018-08-18)
Metformin has been reported to possess antitumor activity and maintain high cytotoxic T lymphocyte (CTL) immune surveillance. However, the functions and detailed mechanisms of metformin's role in cancer immunity are not fully understood. Here, we show that metformin increases CTL
Makoto Hirano et al.
Glycobiology, 22(1), 84-95 (2011-08-13)
Ischemia/reperfusion (I/R) is an important cause of acute renal failure. Recent studies have shown that the complement system mediated by the mannan-binding protein (MBP), which is a C-type serum lectin recognizing mannose, fucose and N-acetylglucosamine residues, plays a critical role
Jonathan Ausman et al.
Cell death & disease, 9(3), 298-298 (2018-02-22)
Mitochondria are in a constant balance of fusing and dividing in response to cellular cues. Fusion creates healthy mitochondria, whereas fission results in removal of non-functional organelles. Changes in mitochondrial dynamics typify several human diseases. However, the contribution of mitochondrial
Charles Lu et al.
PloS one, 7(4), e34833-e34833 (2012-05-05)
Tumor suppressor gene TUSC2/FUS1 (TUSC2) is frequently inactivated early in lung cancer development. TUSC2 mediates apoptosis in cancer cells but not normal cells by upregulation of the intrinsic apoptotic pathway. No drug strategies currently exist targeting loss-of-function genetic abnormalities. We
Ahmad F Alghanem et al.
Angiogenesis, 20(3), 341-358 (2017-03-09)
Regulator of calcineurin 1 (RCAN1) is an endogenous inhibitor of the calcineurin pathway in cells. It is expressed as two isoforms in vertebrates: RCAN1.1 is constitutively expressed in most tissues, whereas transcription of RCAN1.4 is induced by several stimuli that
Bassil Dekky et al.
Oncotarget, 9(30), 21366-21382 (2018-05-17)
The epithelial mesenchymal transition (EMT) is a key process for cancer cell invasion and migration. This complex program whereby epithelial tumor cells loose polarity and acquire mesenchymal phenotype is driven by the regulation of cell-cell adhesion and cell-substrate interactions. We
Yan Yih Goh et al.
The American journal of pathology, 177(6), 2791-2803 (2010-10-19)
Adipose tissue secretes adipocytokines for energy homeostasis, but recent evidence indicates that some adipocytokines also have a profound local impact on wound healing. Upon skin injury, keratinocytes use various signaling molecules to promote reepithelialization for efficient wound closure. In this
Christoph Reinhardt et al.
Nature, 483(7391), 627-631 (2012-03-13)
The gut microbiota is a complex ecosystem that has coevolved with host physiology. Colonization of germ-free (GF) mice with a microbiota promotes increased vessel density in the small intestine, but little is known about the mechanisms involved. Tissue factor (TF)
Björn Koos et al.
The Journal of physiology, 596(7), 1227-1241 (2018-01-26)
Na+ conducting hypertonicity-induced cation channels (HICCs) are key players in the volume restoration of osmotically shrunken cells and, under isotonic conditions, considered as mediators of proliferation - thereby opposing apoptosis. In an siRNA screen of ion channels and transporters in
J Matthew Rhett et al.
The Journal of membrane biology, 245(7), 411-422 (2012-07-20)
Gap junctions (GJs) are aggregates of channels that provide for direct cytoplasmic connection between cells. Importantly, this connection is thought responsible for cell-to-cell transfer of the cardiac action potential. The GJ channels of ventricular myocytes are composed of connexin43 (Cx43).
Ahmed M Fahmy et al.
PloS one, 13(10), e0205189-e0205189 (2018-10-05)
Hepatitis C virus (HCV) infection is known to induce autophagosome accumulation as observed by the typical punctate cytoplasmic distribution of LC3B-II in infected cells. Previously, we showed that viral RNA-dependent RNA polymerase (NS5B) interacts with ATG5, a major component of
Wen-Hao Yang et al.
Cancer research, 78(14), 3761-3768 (2018-05-24)
Programmed death-ligand 1 (PD-L1) is a well-known immune checkpoint protein that helps cancer cells evade immune response. Anti-PD-L1 immune therapy has been approved for the treatment of several advanced human cancers. Therefore, further understanding of the regulatory mechanisms of PD-L1
Paulina Sosicka et al.
Biochimica et biophysica acta. Molecular cell research, 1864(5), 825-838 (2017-02-09)
SLC35A4 has been classified in the SLC35A subfamily based on amino acid sequence homology. Most of the proteins belonging to the SLC35 family act as transporters of nucleotide sugars. In this study, the subcellular localization of endogenous SLC35A4 was determined
Tomohisa Toda et al.
Cell stem cell, 21(5), 618-634 (2017-09-19)
Neural progenitor cells (NeuPCs) possess a unique nuclear architecture that changes during differentiation. Nucleoporins are linked with cell-type-specific gene regulation, coupling physical changes in nuclear structure to transcriptional output; but, whether and how they coordinate with key fate-determining transcription factors
Feike Hao et al.
Journal of cell science, 131(3) (2017-12-10)
In response to amino acid supply, mTORC1, a master regulator of cell growth, is recruited to the lysosome and activated by the small GTPase Rheb. However, the intracellular localization of Rheb is controversial. In this study, we showed that a
Kai Gao et al.
Shanghai kou qiang yi xue = Shanghai journal of stomatology, 20(3), 256-259 (2011-07-23)
To test and compare the marginal leakage of radicular dentin cemented with three resin cements. Nine extracted maxillary incisors after endodontically treated were divided into 3 groups(n=3).Fiber posts were inserted using three resin cements: One-Step Plus/DuoLink (OD),ParaCore Automix (PA) and
Kai-Hui Chan et al.
American journal of translational research, 9(3), 1173-1182 (2017-04-08)
Although signal transduction of transforming growth factor-betas (TGF-βs) is well characterized in individual cell types, data about TGF-β signaling in a cellular context is still scarce. In this study, we used ex vivo tubule cultures from adult rat testis to
Costanza Giampietro et al.
Scientific reports, 7, 43669-43669 (2017-03-04)
Intraneural accumulation of misfolded proteins is a common feature of several neurodegenerative pathologies including Alzheimer's and Parkinson's diseases, and Familial Encephalopathy with Neuroserpin Inclusion Bodies (FENIB). FENIB is a rare disease due to a point mutation in neuroserpin which accelerates
Hainan Liu et al.
Biochimica et biophysica acta. Molecular cell research, 1865(8), 1060-1072 (2018-05-08)
The transcription factor Runx1 is an essential regulator of definitive hematopoiesis, megakaryocyte (MK) maturation, and lymphocyte differentiation. Runx1 mutations that interfere with its transcriptional activity are often present in leukemia patients. Recent work demonstrated that the transcriptional activity of Runx1
Jessica E M Dunleavy et al.
PLoS genetics, 13(11), e1007078-e1007078 (2017-11-15)
The katanin microtubule-severing proteins are essential regulators of microtubule dynamics in a diverse range of species. Here we have defined critical roles for the poorly characterised katanin protein KATNAL2 in multiple aspects of spermatogenesis: the initiation of sperm tail growth
M Bobrich et al.
International journal of obesity (2005), 35(11), 1385-1394 (2011-01-27)
We investigated the expression of protein tyrosine phosphatase-interacting protein 51 (PTPIP51) and its interaction with protein tyrosine phosphatase 1B (PTP1B) and 14-3-3β in mice exhibiting insulin resistance and obesity. A total of 20 mice were included in the study. Eight
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