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New protein?protein interactions of mitochondrial connexin 43 in mouse heart.
Denuc A, et al.
Journal of Cellular and Molecular Medicine, 20(5), 794-803 (2016)
Alexander Brobeil et al.
Biomolecules, 5(2), 485-504 (2015-04-22)
The present study shows a new connection of protein tyrosine phosphatase interacting protein 51 (PTPIP51) to the nuclear factor κB (NFκB) signalling pathway. PTPIP51 mRNA and protein expression is regulated by RelA. If bound to the PTPIP51 promoter, RelA repress
Clariss Limso et al.
FEBS letters, 594(6), 1088-1100 (2019-11-19)
Cell surface translocation of the chaperone glucose-regulated protein 78 kDa (GRP78) is a key event that promotes cancer cell survival during endoplasmic reticulum (ER) stress. Here, we identify Gα-interacting vesicle-associated protein (GIV) - an enhancer of prosurvival signaling during ER stress
Arathi Rajan et al.
American journal of cancer research, 12(1), 17-47 (2022-02-11)
BRCA1 mutation carriers have a greater risk of developing cancers in hormone-responsive tissues like breasts and ovaries. However, this tissue-specific incidence of BRCA1 related cancers remains elusive. The majority of the BRCA1 mutated breast cancers exhibit typical histopathological features of
Ioannis M Roussis et al.
PloS one, 11(1), e0147967-e0147967 (2016-01-30)
Techniques for studying RNA-protein interactions have lagged behind those for DNA-protein complexes as a consequence of the complexities associated with working with RNA. Here we present a method for the modification of the existing In Situ Hybridisation-Proximity Ligation Assay (ISH-PLA)
Jane Antony et al.
EMBO reports, 19(8) (2018-06-17)
In ovarian cancer, the prometastatic RTK AXL promotes motility, invasion and poor prognosis. Here, we show that reduced survival caused by AXL overexpression can be mitigated by the expression of the GPI-anchored tumour suppressor OPCML Further, we demonstrate that AXL
Omesha N Perera et al.
Science advances, 5(10), eaav4409-eaav4409 (2019-10-17)
Telomerase is a ribonucleoprotein complex that catalyzes addition of telomeric DNA repeats to maintain telomeres in replicating cells. Here, we demonstrate that the telomerase protein hTERT performs an additional role at telomeres that is independent of telomerase catalytic activity yet
Francesco Napoletano et al.
Cell reports, 36(11), 109694-109694 (2021-09-16)
Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin relaxation and consequent unscheduled mobilization of transposable elements (TEs) are emerging as key contributors of aging and aging-related pathologies, including Alzheimer's disease (AD) and cancer. However, the mechanisms governing heterochromatin
Christina Servas et al.
Cellular signalling, 36, 163-175 (2017-05-11)
Apoptosis and the response to cell stress are evolutionary highly conserved mechanisms. Both processes require strict regulation, which is often performed by protein kinases. The mammalian Sterile 20-like kinase 1 (MST1) is a pro-apoptotic protein kinase, which is activated and
Eric Dietel et al.
Oncogenesis, 7(8), 64-64 (2018-08-25)
Breast cancer is the most common female cancerous disease and the second most cause of cancer death in women. About 20-30% of these tumors exhibit an amplification of the HER2/ErbB2 receptor, which is coupled to a more aggressive and invasive
Ding-Yu Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(8), 2072-2077 (2017-02-09)
Histone deacetylases (HDACs) and microRNAs (miRs) have emerged as two important epigenetic factors in the regulation of vascular physiology. This study aimed to elucidate the relationship between HDACs and miRs in the hemodynamic modulation of endothelial cell (EC) dysfunction. We
Jose Manuel Garcia-Heredia et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 23(14), 3871-3883 (2017-02-06)
Purpose: Cancer stem cells (CSC) are self-renewing tumor cells, with the ability to generate diverse differentiated tumor cell subpopulations. They differ from normal stem cells in the deregulation of the mechanisms that normally control stem cell physiology. CSCs are the
Ngoc Uyen Nhi Nguyen et al.
Nature, 582(7811), 271-276 (2020-06-06)
A major factor in the progression to heart failure in humans is the inability of the adult heart to repair itself after injury. We recently demonstrated that the early postnatal mammalian heart is capable of regeneration following injury through proliferation
Edgar Angelats et al.
Frontiers in cell and developmental biology, 6, 67-67 (2018-08-04)
Endocannabinoids are important players in neural development and function. They act via receptors, whose activation inhibits cAMP production. The aim of the paper was to look for calcium- and cAMP-signaling cross-talk mediated by cannabinoid CB1 receptors (CB1R) and to assess
Mamoru Yotsuya et al.
Scientific reports, 9(1), 56-56 (2019-01-13)
The degeneration of articular cartilage underscores the clinical pathology of temporomandibular joint osteoarthritis (TMJ-OA) and is promoted through dysfunctional biochemical or biophysical signaling. Transduction of these signals has a multifaceted regulation that includes important cell-matrix derived interactions. The matrix encapsulating
Laura Mediani et al.
EMBO reports, 22(5), e51740-e51740 (2021-03-20)
Stress granules (SGs) are dynamic condensates associated with protein misfolding diseases. They sequester stalled mRNAs and signaling factors, such as the mTORC1 subunit raptor, suggesting that SGs coordinate cell growth during and after stress. However, the molecular mechanisms linking SG
Sebastián Giulianelli et al.
Medicina, 72(4), 315-320 (2012-08-16)
In C4-HD murine mammary carcinomas and in human breast cancer T47D cells, we showed that medroxyprogesterone acetate (MPA) induces a nuclear physical association between estrogen receptor alpha (ERa) and progesterone receptors (PR). The blockade of ERa inhibits cell proliferation mediated
Yan Yan et al.
Nature communications, 6, 8979-8979 (2015-12-01)
AMP-activated protein kinase (AMPK) inhibits several anabolic pathways such as fatty acid and protein synthesis, and identification of AMPK substrate specificity would be useful to understand its role in particular cellular processes and develop strategies to modulate AMPK activity in
Veerle Fleskens et al.
Cell reports, 26(13), 3600-3612 (2019-03-28)
The Foxp3 transcription factor is a crucial determinant of both regulatory T (TREG) cell development and their functional maintenance. Appropriate modulation of tolerogenic immune responses therefore requires the tight regulation of Foxp3 transcriptional output, and this involves both transcriptional and
Cesar A G Arrais et al.
The Journal of prosthetic dentistry, 97(2), 99-106 (2007-03-08)
The effectiveness of bond strength using dual-polymerizing cementing systems ([DCSs] defined as the combination of dual-polymerizing bonding agents and resin cements) used with indirect restorations has not been evaluated when used solely with the autopolymerizing mode. This study evaluated the
Graziela Galhano et al.
Indian journal of dental research : official publication of Indian Society for Dental Research, 20(3), 332-336 (2009-11-04)
To compare the push-out strength of bovine- and human-root dentin and, thus, evaluate the suitability of bovine-root dentin to substitute human-root dentin for bond strength testing. Ten single-rooted human-teeth and ten bovine incisors were prepared using a #3 bur of
Suet-Ying Kwan et al.
Cancers, 12(1) (2020-01-08)
Uterine serous carcinoma (USC) is the most aggressive form of endometrial cancer, with poor survival rates and high recurrence risk. Therefore, the purpose of this study was to identify therapeutic targets that could aid in the management of USC. By
Byeongjin Moon et al.
Cells, 10(6) (2021-06-03)
Tim-4 promotes the engulfment of apoptotic cells or exogenous particles by securing them on phagocytes. It is unable to transduce signals by itself but helps other engulfment receptors sense and internalize them. However, the identity of the engulfment receptors collaborating
Rosario Avolio et al.
Nucleic acids research, 46(22), 12067-12086 (2018-09-28)
Syndesmos (SDOS) is a functionally poorly characterized protein that directly interacts with p53 binding protein 1 (53BP1) and regulates its recruitment to chromatin. We show here that SDOS interacts with another important cancer-linked protein, the chaperone TRAP1, associates with actively
Amanda Almeida de Oliveira et al.
International journal of molecular sciences, 20(13) (2019-06-30)
While precise mechanisms underlying cardiovascular diseases (CVDs) are still not fully understood, previous studies suggest that the innate immune system, through Toll-like receptor 4 (TLR4), plays a crucial part in the pathways leading to these diseases, mainly because of its
A functional glycoproteomics approach identifies CD13 as a novel E-selectin ligand in breast cancer.
M A Carrascal et al.
Biochimica et biophysica acta. General subjects, 1862(9), 2069-2080 (2018-05-20)
The glycan moieties sialyl-Lewis-X and/or -A (sLeX/A) are the primary ligands for E-selectin, regulating subsequent tumor cell extravasation into distant organs. However, the nature of the glycoprotein scaffolds displaying these glycans in breast cancer remains unclear and constitutes the focus
Simone Grandini et al.
The International journal of prosthodontics, 18(5), 399-404 (2005-10-14)
Restoration of root-treated teeth is routinely performed in clinical practice with a choice of therapeutic options, considering many factors to provide optimal mechanical properties, esthetics, and longevity. The aim of the present work was to present a preliminary clinical report
Anna Bianchi-Smiraglia et al.
Nature communications, 12(1), 6091-6091 (2021-10-21)
Physiological changes in GTP levels in live cells have never been considered a regulatory step of RAC1 activation because intracellular GTP concentration (determined by chromatography or mass spectrometry) was shown to be substantially higher than the in vitro RAC1 GTP
Dhirendra P Singh et al.
Archives of toxicology, 92(5), 1767-1783 (2018-04-07)
Chronic obstructive pulmonary disease (COPD) is predicted to become the third leading cause of death and disability worldwide by 2030; with cigarette smoking (active or passive) being one of the chief cause of its occurrence. Cigarette smoke exposure has been
Adriana Cassaro et al.
Hematological oncology, 39(3), 364-379 (2021-01-27)
Wnt/Fzd signaling has been implicated in hematopoietic stem cell maintenance and in acute leukemia establishment. In our previous work, we described a recurrent rearrangement involving the WNT10B locus (WNT10BR ), characterized by the expression of WNT10BIVS1 transcript variant, in acute
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