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DUO94004
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Jane Antony et al.
EMBO reports, 19(8) (2018-06-17)
In ovarian cancer, the prometastatic RTK AXL promotes motility, invasion and poor prognosis. Here, we show that reduced survival caused by AXL overexpression can be mitigated by the expression of the GPI-anchored tumour suppressor OPCML Further, we demonstrate that AXL
Ioannis M Roussis et al.
PloS one, 11(1), e0147967-e0147967 (2016-01-30)
Techniques for studying RNA-protein interactions have lagged behind those for DNA-protein complexes as a consequence of the complexities associated with working with RNA. Here we present a method for the modification of the existing In Situ Hybridisation-Proximity Ligation Assay (ISH-PLA)
Christina Servas et al.
Cellular signalling, 36, 163-175 (2017-05-11)
Apoptosis and the response to cell stress are evolutionary highly conserved mechanisms. Both processes require strict regulation, which is often performed by protein kinases. The mammalian Sterile 20-like kinase 1 (MST1) is a pro-apoptotic protein kinase, which is activated and
Eric Dietel et al.
Oncogenesis, 7(8), 64-64 (2018-08-25)
Breast cancer is the most common female cancerous disease and the second most cause of cancer death in women. About 20-30% of these tumors exhibit an amplification of the HER2/ErbB2 receptor, which is coupled to a more aggressive and invasive
Ding-Yu Lee et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(8), 2072-2077 (2017-02-09)
Histone deacetylases (HDACs) and microRNAs (miRs) have emerged as two important epigenetic factors in the regulation of vascular physiology. This study aimed to elucidate the relationship between HDACs and miRs in the hemodynamic modulation of endothelial cell (EC) dysfunction. We
Edgar Angelats et al.
Frontiers in cell and developmental biology, 6, 67-67 (2018-08-04)
Endocannabinoids are important players in neural development and function. They act via receptors, whose activation inhibits cAMP production. The aim of the paper was to look for calcium- and cAMP-signaling cross-talk mediated by cannabinoid CB1 receptors (CB1R) and to assess
Rosario Avolio et al.
Nucleic acids research, 46(22), 12067-12086 (2018-09-28)
Syndesmos (SDOS) is a functionally poorly characterized protein that directly interacts with p53 binding protein 1 (53BP1) and regulates its recruitment to chromatin. We show here that SDOS interacts with another important cancer-linked protein, the chaperone TRAP1, associates with actively
A functional glycoproteomics approach identifies CD13 as a novel E-selectin ligand in breast cancer.
M A Carrascal et al.
Biochimica et biophysica acta. General subjects, 1862(9), 2069-2080 (2018-05-20)
The glycan moieties sialyl-Lewis-X and/or -A (sLeX/A) are the primary ligands for E-selectin, regulating subsequent tumor cell extravasation into distant organs. However, the nature of the glycoprotein scaffolds displaying these glycans in breast cancer remains unclear and constitutes the focus
Dhirendra P Singh et al.
Archives of toxicology, 92(5), 1767-1783 (2018-04-07)
Chronic obstructive pulmonary disease (COPD) is predicted to become the third leading cause of death and disability worldwide by 2030; with cigarette smoking (active or passive) being one of the chief cause of its occurrence. Cigarette smoke exposure has been
Adriana Cassaro et al.
Hematological oncology, 39(3), 364-379 (2021-01-27)
Wnt/Fzd signaling has been implicated in hematopoietic stem cell maintenance and in acute leukemia establishment. In our previous work, we described a recurrent rearrangement involving the WNT10B locus (WNT10BR ), characterized by the expression of WNT10BIVS1 transcript variant, in acute
Jung Jin Lim et al.
Endocrinology, 158(4), 993-1004 (2017-03-23)
The destiny of the ovarian follicle (growth or atresia) is tightly regulated by the actions and interactions of endocrine, paracrine, and autocrine factors. Although androgens are known to be important in the regulation of folliculogenesis, whether they facilitate or suppress
Extranuclear signaling by ovarian steroids in the regulation of sexual receptivity.
Paul E Micevych et al.
Hormones and behavior (2018-05-14)
Xiaoli Xu et al.
Journal of molecular cell biology, 10(5), 460-474 (2018-09-06)
Human flap endonuclease 1 (FEN1) is a structure-specific, multi-functional endonuclease essential for DNA replication and repair. We and others have shown that during DNA replication, FEN1 processes Okazaki fragments via its interaction with the proliferating cell nuclear antigen (PCNA). Alternatively
Jun-Ho Cho et al.
Experimental cell research, 368(1), 50-58 (2018-04-18)
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is implicated in cell death in addition to a role as a glycolytic enzyme. In particular, when cells are exposed to cellular stressors involving nitric oxide (NO) production, GAPDH can undergo NO-induced S-nitrosylation and S-nitrosylated GAPDH has
Fangfang Duan et al.
Journal of hepatology, 68(6), 1191-1202 (2018-02-18)
Aberrant oncogenic mRNA translation and protein O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) are general features during tumorigenesis. Nevertheless, whether and how these two pathways are interlinked remain unknown. Our previous study indicated that ribosomal receptor for activated C-kinase 1 (RACK1) promoted chemoresistance and
Gui-Li Yang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(5), 2001-2012 (2017-02-12)
Vascular hyperpermeability is critical in ischemic diseases, including stroke and myocardial infarction, as well as in inflammation and cancer. It is well known that the VEGF-VEGFR2 signaling pathways are pivotal in promoting vascular permeability; however, counterbalancing mechanisms that restrict vascular
Sheila Butler et al.
BioMed research international, 2018, 2438145-2438145 (2018-10-12)
The aim of this study was to evaluate the influence of multimode MDP-based primers and different application protocols on the bond strength of a representative resin cement to an yttrium stabilized tetragonal zirconia (Y-TZP) ceramic. The occlusal dentin from 60
Yoko Takahashi et al.
Anticancer research, 38(7), 4257-4266 (2018-07-05)
Erythropoietin-producing hepatocellular receptor-2 (EphA2) is overexpressed in ovarian cancer. The N-terminals of EphA2 are processed by membrane-type 1 matrix metalloproteinase (MT1-MMP) and can subsequently induce ligand-independent signal activation to promote motility, invasion, and metastasis. The aim of this study was
Shenyi Lian et al.
Nucleic acids research, 45(11), 6546-6571 (2017-05-10)
Phosphatase of regenerating liver (PRL-3) promotes cell invasiveness, but its role in genomic integrity remains unknown. We report here that shelterin component RAP1 mediates association between PRL-3 and TRF2. In addition, TRF2 and RAP1 assist recruitment of PRL-3 to telomeric
Nardhy Gomez-Lopez et al.
Reproductive sciences (Thousand Oaks, Calif.), 24(10), 1382-1401 (2017-01-27)
Inflammasomes are cytosolic multiprotein complexes that orchestrate inflammation in response to pathogens and endogenous danger signals. Herein, we determined whether the chorioamniotic membranes from women in spontaneous preterm labor with acute histologic chorioamnionitis (1) express major inflammasome components; (2) express
Joshua R Brickner et al.
Nature, 551(7680), 389-393 (2017-11-17)
DNA repair is essential to prevent the cytotoxic or mutagenic effects of various types of DNA lesions, which are sensed by distinct pathways to recruit repair factors specific to the damage type. Although biochemical mechanisms for repairing several forms of
Jing Wang et al.
Journal of cell science, 130(23), 3975-3987 (2017-10-14)
The small GTPase Arf4 and the Arf GTPase-activating protein (GAP) ASAP1 cooperatively sequester sensory receptor cargo into transport carriers targeted to primary cilia, but the input that drives Arf4 activation in this process remains unknown. Here, we show, by using
Rita Hleihel et al.
Retrovirology, 15(1), 33-33 (2018-04-19)
Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy secondary to chronic human T-cell lymphotropic virus 1 infection, triggered by the virally encoded oncoprotein Tax. The transforming activity and subcellular localization of Tax is strongly influenced by posttranslational modifications, among which
Svetlana Petruk et al.
Molecular cell, 66(2), 247-257 (2017-04-16)
Recruitment of transcription factors (TFs) to repressed genes in euchromatin is essential to activate new transcriptional programs during cell differentiation. However, recruitment of all TFs, including pioneer factors, is impeded by condensed H3K27me3-containing chromatin. Single-cell and gene-specific analyses revealed that
Jean Defourny et al.
Mechanisms of development (2018-10-09)
Many of the mutations in GJB2 and GJB6, which encode connexins 26 and 30 (Cx26 and Cx30), impair the formation of membrane channels and cause autosomal syndromic and non-syndromic hearing loss. In cochlear non-sensory supporting cells, Cx26 and Cx30 form
Correction: Regulation of the DNA Repair Complex during Somatic Hypermutation and Class-Switch Recombination.
Anjani Kumar et al.
Journal of immunology (Baltimore, Md. : 1950), 201(11), 3472-3473 (2018-10-31)
Ana Maria Estivalete Marchionatti et al.
Brazilian oral research, 31, e64-e64 (2017-07-06)
The aim of this systematic review was to compare the clinical performance and failure modes of teeth restored with intra-radicular retainers. A search was performed on PubMed/Medline, Central and ClinicalTrials databases for randomized clinical trials comparing clinical behavior and failures
Kangmei Chen et al.
Theranostics, 8(2), 423-436 (2018-01-02)
Human growth factor receptor-bound protein-7 (GRB7) is a pivotal mediator involved in receptor tyrosine kinase signaling and governing diverse cellular processes. Aberrant upregulation of GRB7 is frequently associated with the progression of human cancers. However, the molecular mechanisms leading to
Louise H Jørgensen et al.
The American journal of pathology, 187(2), 457-474 (2016-12-03)
The cytoskeleton is an integral part of skeletal muscle structure, and reorganization of the cytoskeleton occurs during various modes of remodeling. We previously found that the extracellular matrix protein secreted protein acidic and rich in cysteine (SPARC) is up-regulated and
Eva De Mol et al.
Structure (London, England : 1993), 26(1), 145-152 (2017-12-12)
The androgen receptor is a transcription factor that plays a key role in the development of prostate cancer, and its interactions with general transcription regulators are therefore of potential therapeutic interest. The mechanistic basis of these interactions is poorly understood
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