Journal of analytical toxicology, 37(4), 227-232 (2013-03-08)
In cases of sexual assault, victims often present too late for the detection of ethanol in biological samples. An ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method was developed and validated for the determination of ethyl glucuronide (EtG) and ethyl sulfate
Alcohol and alcoholism (Oxford, Oxfordshire), 48(1), 74-82 (2012-10-09)
Ethyl glucuronide (EtG) and ethyl sulphate (EtS) are minor metabolites of ethanol, and their presence in urine provides a strong indication of recent alcohol administration. In this study, we performed a drinking experiment to investigate the kinetics of EtG and
Alcohol and alcoholism (Oxford, Oxfordshire), 47(3), 267-272 (2012-02-18)
Ethyl glucuronide (EtG) in hair is a proposed biomarker for alcohol consumption. This study compares hair EtG concentrations with self-reported alcohol consumption data, in individuals with a range of alcohol use. Hair was collected from 100 participants with a range
Alcohol and alcoholism (Oxford, Oxfordshire), 47(5), 552-557 (2012-06-14)
To compare the sensitivity of whole blood phosphatidylethanol (PEth) with serum carbohydrate-deficient transferrin (CDT) as biomarkers of current regular alcohol consumption, during outpatient treatment for alcohol-related problems. Urinary ethyl glucuronide (EtG) and ethyl sulfate (EtS), and clinical assessment, were used
Journal of analytical toxicology, 39(1), 17-23 (2014-10-03)
The Society of Hair Testing (SoHT) has provided cutoffs for the quantification of ethyl glucuronide (EtG) in hair to indicate occasional or chronic/excessive alcohol consumption. Although several sensitive methods have been reported, past proficiency test results show a lack of
The validation of a robust quantification procedure for EtG in hair using GC-NCI-MS is presented. Aqueous extraction is followed by complete lyophylization of the extract and derivatization with pentafluoropropionic anhydride (PFPA) under controlled temperature and duration. Clean-up of extracts was
Although excessive alcohol consumption plays a major role in fatal events, the role of alcohol use as a possible contributing factor at the time of death is not easy to establish due to lack of suitable biomarkers for postmortem analyses.
Annales de biologie clinique, 70(6), 629-634 (2012-12-05)
Ethylglucuronide (EtG) is a biomarker of ethanol consumption, and the authors propose an overview of its potential use in clinical or forensic cases. This metabolite presents a higher half-life and is therefore detectable longer than ethanol itself, and allows, in
RN in rehab program challenged flawed alcohol tests. Case on point: Berry v. National Medical Services, Inc., 257 P.3d 287 (8/12/2011)-KS.
Drug metabolism and disposition: the biological fate of chemicals, 41(3), 568-574 (2012-12-12)
Ethyl glucuronide (EtG) determination is increasingly used in clinical and forensic toxicology to document ethanol consumption. The enzymes involved in EtG production, as well as potential interactions with common drugs of abuse, have not been extensively studied. Activities of human
Analytical and bioanalytical chemistry, 403(3), 769-776 (2012-03-28)
Ethyl glucuronide (EtG) analysis in hair is a suitable method for the retrospective determination of previous alcohol consumption. According to the German guidelines, EtG abstinence is improbable at c(EtG) > 7 pg/mg in the proximal 3 cm of scalp hair. The chromatography
Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharamcologie clinique, 19(3), e473-e482 (2012-11-06)
Ethyl glucuronide (EtG) is arising as a promising biomarker of heavy prenatal alcohol exposure, however its transfer across the human placenta is still unclear and is currently being investigated using the ex vivo placental perfusion model. This model allows for
Alcohol consumption during pregnancy can lead to Fetal Alcohol Spectrum Disorder (FASD), and because maternal self-reports are often unreliable, biomarkers of alcohol use are sometimes necessary to accurately determine fetal risk. Ethyl glucuronide (EtG), a direct metabolite of ethanol, has
Journal of applied behavior analysis, 45(1), 161-165 (2012-03-10)
This study assessed the effects of a contingency management (CM) intervention for alcohol consumption in 10 alcohol-dependent participants. An ABCA design was used. Vouchers were provided contingent on results of ethyl glucuronide (EtG) urine tests (an alcohol biomarker with a
Clinica chimica acta; international journal of clinical chemistry, 415, 322-329 (2012-11-28)
Recent alcohol intake can be monitored by the measurement of indirect biomarkers. Elevated levels of liver enzymes (i.e. gamma-glutamyl transferase (GGT), alanine amino transferase (ALT) and aspartate amino transferase (AST)) in blood are commonly used in clinical practice as an
A versatile UHPLC-MSMS method for simultaneous quantification of various alcohol intake related compounds in human urine and blood
Monosik R and Dragsted LO
Analytical Methods : Advancing Methods and Applications, 8, 6865-6871 (2016)
Alcohol and alcoholism (Oxford, Oxfordshire), 48(1), 83-87 (2012-09-28)
Hair ethyl glucuronide (EtG) is a promising biomarker of moderate-to-heavy alcohol consumption and may have utility in detecting and monitoring alcohol use in clinical populations where alcohol use is of particular importance. This study evaluated the relationship between hair EtG
International journal of legal medicine, 126(5), 757-764 (2012-07-04)
Ethyl glucuronide (EtG) and ethyl sulfate (EtS) are commonly used alcohol markers for previous alcohol consumption. Nevertheless, the optimum EtG cutoff for urinary abstinence tests is still being discussed, and no cutoff has been recommended for EtS yet. The aim
Grinding procedure influence on LC-MS/MS determination of ethyl glucuronide concentrations in hair.
Alcoholism, clinical and experimental research, 37(1), 150-155 (2012-06-26)
It is important to monitor alcohol use in the care of patients with liver disease, but patient self-report can be unreliable. We therefore evaluated the performance of urine ethyl glucuronide (EtG) and ethyl sulfate (EtS) in detecting alcohol use in
Urine ethyl glucuronide (EtG) is considered as a specific marker of recent ethanol consumption. We describe false-positive DRI(®) EIA EtG enzyme immunoassay results caused by propyl glucuronides in urine after using a propanol-based hand sanitizer. EtG screening was done with
The restriction of zero tolerance when driving (ZTD) imposed on drivers in Switzerland means that they may drink no alcohol at all before driving and basically consume only moderate amounts of alcohol at any other time. The Institute of Traffic
Journal of addiction medicine, 6(4), 243-246 (2012-10-17)
Many physicians are referred to state physician health programs (PHPs) for evaluation, monitoring, and treatment of mental health and substance use disorders. Most PHPs are "diversion" or "safe haven" programs, meaning that physicians who suffer from alcohol or drug problems
Sensitive detection of anionic metabolites of drugs by positive ion mode HPLC-PIESI-MS
Guo H, et al.
International Journal of Mass Spectrometry, 389, 14-25 (2015)
A simplified approach for determination of urinary ethyl glucuronide by gas chromatography-mass spectrometry
Ghosh S, et al.
Journal of analytical science and technology, 12, 1-9 (2021)
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 19(4), 369-376 (2013-01-03)
The accurate assessment of drinking by patients with alcoholic liver disease is important both before and after liver transplantation. Unfortunately, self-reports by these individuals often underestimate their actual alcohol consumption. Several recently developed biochemical measures can provide additional information on
International journal of legal medicine, 126(5), 791-799 (2012-07-10)
Despite the growing importance of ethyl glucuronide (EtG) in hair for detection of chronic excessive alcohol consumption, the mechanism of incorporation is not yet clear. Deposition from sweat is believed to be the main route. In order to get more
This study investigated the relationship between ethanol intake in rats and the resulting level of ethyl glucuronide (EtG) in rat hair. Rats (n = 50) consumed a 10% ethanol solution for 4 weeks, then EtG was extracted from samples of
Nederlands tijdschrift voor geneeskunde, 157(23), A5713-A5713 (2013-06-07)
In this article, we report on the usefulness of physicians testing for carbohydrate deficient transferrin (CDT) and ethyl glucuronide (EtG) when there are doubts about alcohol use by their patients. A 44-year-old male consulted his general practitioner with depressive symptoms
Journal of investigative surgery : the official journal of the Academy of Surgical Research, 18(4), 167-176 (2005-08-30)
Bacterial translocation is an important phenomenon in clinical medicine and leads to an increase in patient morbidity and mortality by multiple organ failure. The selectin family plays an important role in the pathogenesis of inflammation, causing an increase in leukocyte-endothelium