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E3889
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Zhizi Jing et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(10), 4456-4467 (2013-03-08)
Inner hair cells (IHCs) of the cochlea use ribbon synapses to transmit auditory information faithfully to spiral ganglion neurons (SGNs). In the present study, we used genetic disruption of the presynaptic scaffold protein bassoon in mice to manipulate the morphology
Astrid Milić et al.
European journal of drug metabolism and pharmacokinetics, 39(4), 263-276 (2013-10-12)
The purpose of this study was to evaluate the impact of structural modifications on the 15-membered macrolactone ring and/or substituents on the in vitro ADME properties and in vivo pharmacokinetic (PK) profile for selected derivatives in rodents in comparison to
Hikaru Nishida et al.
PloS one, 10(6), e0128805-e0128805 (2015-06-19)
Branched-chain amino acids (BCAAs) and IGF-I, the secretion of which is stimulated by growth hormone (GH), prevent muscle atrophy. mTOR plays a pivotal role in the protective actions of BCAA and IGF-1. The pathway by which BCAA activates mTOR is
Weiqiang Li et al.
Biomaterials, 39, 75-84 (2014-12-06)
Neural crest stem cells (NCSCs), a population of multipotent cells that migrate extensively and give rise to diverse derivatives, including peripheral and enteric neurons and glia, craniofacial cartilage and bone, melanocytes and smooth muscle, have great potential for regenerative medicine.
Daisy J Vinter et al.
STAR protocols, 2(3), 100812-100812 (2021-09-30)
Significant regulation of gene expression is mediated at the translation level. Here, we describe protocols for imaging and analysis of translation at single mRNA resolution in both fixed and living Drosophila embryos. These protocols use the SunTag system, in which
Chengbiao Zhang et al.
American journal of physiology. Renal physiology, 308(11), F1288-F1296 (2015-04-03)
The aim of the present study is to examine the role of Kcnj10 (Kir.4.1) in contributing to the basolateral K conductance in the cortical thick ascending limb (cTAL) using Kcnj10(+/+) wild-type (WT) and Kcnj10(-/-) knockout (KO) mice. The patch-clamp experiments
Jalaj Gupta et al.
Oncotarget, 6(11), 8539-8551 (2015-04-22)
Colorectal cancer is a major health problem and the second cause of cancer related death in western countries. Signaling pathways that control tissue homeostasis are often deregulated during tumorigenesis and contribute to tumor development. Studies in mouse models have shown
Mariusz L Hartman et al.
Cancer letters, 499, 122-136 (2020-12-02)
BRAFV600- and MEK1/2-targeting therapies rarely produce durable response in melanoma patients. We investigated five BRAFV600E melanoma cell lines derived from drug-naïve tumor specimens to assess cell death response to encorafenib (Braftovi), a recently FDA-approved BRAFV600 inhibitor. Drug-naïve cell lines (i)
Rita Lopez et al.
Nucleic acids research, 43(9), 4463-4476 (2015-04-15)
Linker histones are involved in chromatin higher-order structure and gene regulation. We have successfully achieved partial phosphorylation of linker histones in chicken erythrocyte soluble chromatin with CDK2, as indicated by HPCE, MALDI-TOF and Tandem MS. We have studied the effects
Xintong Lv et al.
Molecular medicine reports, 12(5), 6663-6671 (2015-08-25)
Voltage-dependent calcium channels (VDCCs) are key elements in epileptogenesis. There are several binding-sites linked to calmodulin (CaM) and several potential CaM-dependent protein kinase II (CaMKII)-mediated phosphorylation sites in CaV1.2. The tremor rat model (TRM) exhibits absence‑like seizures from 8 weeks
Rishil J Kathawala et al.
Chinese journal of cancer, 34(3), 115-120 (2015-05-13)
ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 10 (ABCC10) proteins are efflux transporters that couple the energy derived from ATP hydrolysis to the translocation of toxic substances and chemotherapeutic drugs out of cells. Cabazitaxel is a
Sandra Kissing et al.
The Journal of biological chemistry, 290(22), 14166-14180 (2015-04-24)
The vacuolar H(+)-ATPase (v-ATPase) complex is instrumental in establishing and maintaining acidification of some cellular compartments, thereby ensuring their functionality. Recently it has been proposed that the transmembrane V0 sector of v-ATPase and its a-subunits promote membrane fusion in the
Ivana L Bussi et al.
The European journal of neuroscience, 40(1), 2299-2310 (2014-04-03)
Duration discrimination within the seconds-to-minutes range, known as interval timing, involves the interaction of cortico-striatal circuits via dopaminergic-glutamatergic pathways. Besides interval timing, most (if not all) organisms exhibit circadian rhythms in physiological, metabolic and behavioral functions with periods close to
Jing-Tian Qu et al.
Biological & pharmaceutical bulletin, 38(12), 1873-1878 (2015-12-04)
Wogonin, a natural flavonoid, is one of the bioactive compounds of the medicinal herb Eucommia ulmoides OLIV. widely used in southeastern Asia for treating hypertension. However, the molecular mechanisms for the therapeutic benefits remain largely unclear. The present study investigated
Jia Wei et al.
The Journal of surgical research, 197(1), 126-138 (2015-04-29)
Macrophages can be polarized into proinflammatory (M1) and anti-inflammatory (M2) subtypes. However, whether macrophage polarization plays a role in necrotizing enterocolitis (NEC) remains unknown. Macrophages were derived from the THP-1 human monocyte cell line. Apoptosis of human fetal small intestinal
Yukihiro Nakamura
Frontiers in synaptic neuroscience, 11, 26-26 (2019-10-22)
The exogenous Ca2+ chelator EGTA (ethylene glycol tetraacetic acid) has been widely used to probe the coupling distance between Ca2+ channels and vesicular Ca2+ sensors for neurotransmitter release. Because of its slow forward rate for binding, EGTA is thought to
Sui Lin et al.
The Journal of biological chemistry, 290(30), 18559-18574 (2015-06-07)
Pulmonary surfactant, a mixture of proteins and phospholipids, plays an important role in facilitating gas exchange by maintaining alveolar stability. Saturated phosphatidylcholine (SatPC), the major component of surfactant, is synthesized both de novo and by the remodeling of unsaturated phosphatidylcholine
Thomas J Macartney et al.
Bio-protocol, 7(22), e2614-e2614 (2017-11-20)
We recently reported an Affinity-directed PROtein Missile (AdPROM) system for the targeted proteolysis of endogenous proteins of interest (POI) ( Fulcher et al., 2016 and 2017). AdPROM consists of the Von Hippel Lindau (VHL) protein, a Cullin 2 E3 ligase
Daniele Lettieri Barbato et al.
Scientific reports, 5, 13091-13091 (2015-08-12)
Adipose tissue metabolically adapts to external stimuli. We demonstrate that the induction of the thermogenic program in white adipocytes, through cold exposure in mice or in vitro adrenergic stimulation, is accompanied by a decrease in the intracellular content of glutathione
You Ning et al.
Stem cells international, 2015, 672312-672312 (2015-08-05)
Neural stem cells (NSCs) harbor the potential to differentiate into neurons, astrocytes, and oligodendrocytes under normal conditions and/or in response to tissue damage. NSCs open a new way of treatment of the injured central nervous system and neurodegenerative disorders. Thus
Xia Li et al.
CNS neuroscience & therapeutics, 20(11), 951-960 (2014-07-22)
Our previous studies indicate that glycine can inhibit N-methyl-D-aspartate receptor (NMDAR) responses induced by high concentrations of NMDA in rat hippocampal neurons. The present study was designed to observe whether D-serine induces inactivation of NMDARs in cultured rat hippocampal neurons
Kurt J Sales et al.
Molecular human reproduction, 20(11), 1144-1157 (2014-08-12)
The interplay between inflammation, cervical cancer and HIV acquisition in women is poorly understood. We have previously shown that seminal plasma (SP) can promote cervical tumour cell growth in vitro and in vivo via the activation of potent inflammatory pathways.
Minori Numamoto et al.
Journal of biochemistry, 157(1), 53-64 (2014-10-15)
The Saccharomyces cerevisiae Siw14, a tyrosine phosphatase involved in the response to caffeine, participates in regulation of the phosphorylation and intracellular localization of Gln3, a GATA transcriptional activator of nitrogen catabolite repression-sensitive genes. In Δsiw14 cells, the phosphorylation level of
M J Laye et al.
Disease markers, 2015, 806418-806418 (2015-03-31)
High levels of cardiovascular fitness (CRF) and physical activity (PA) are associated with decreased mortality and risk to develop metabolic diseases. The independent contributions of CRF and PA to metabolic disease risk factors are unknown. We tested the hypothesis that
Tao Liu et al.
Journal of cardiovascular pharmacology and therapeutics, 20(4), 414-427 (2015-01-24)
Dantrolene, which is primarily used to treat malignant hyperthermia, has recently been suggested for the prevention of arrhythmogenesis in various animal models. In this study, the effects of dantrolene treatment on electrophysiological properties and ventricular arrhythmias (VAs) in rats with
Noa Hasky et al.
Human reproduction (Oxford, England), 30(5), 1089-1101 (2015-03-23)
Can gonadotrophin-releasing hormone agonists (GnRH-a) preserve long-term fertility when administered prior to and concomitantly with chemotherapy? GnRH-a display a differential protective effect on fertility, depending upon the specific chemotherapy-induced mechanism of ovarian injury. The role of GnRH-a in fertility preservation
Ellen Zuther et al.
Scientific reports, 5, 12199-12199 (2015-07-16)
During low temperature exposure, Arabidopsis thaliana and many other plants from temperate climates increase in freezing tolerance in a process termed cold acclimation. However, the correct timing and rate of deacclimation, resulting in loss of freezing tolerance and initiation of
Saurabh Mishra et al.
Journal of immunotoxicology, 12(1), 56-63 (2014-02-12)
5-Fluorouracil (5-FU) is a widely used anti-cancer agent; however, it induces immunosuppression in patients undergoing a chemotherapy regime. The mode of action by which 5-FU induces immunosuppression is primarily via inhibition of hematopoietic growth factors. In the present study, immunoprotective
Annalucia Carbone et al.
Journal of cellular and molecular medicine, 18(8), 1631-1643 (2014-06-05)
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) gene, with most of the mortality given by the lung disease. Human amniotic mesenchymal stromal (stem) cells (hAMSCs) hold great promise for regenerative medicine in the
Sung-Kuk Cho et al.
Biochemical and biophysical research communications, 467(4), 1063-1069 (2015-10-07)
Reelin, a large secreted extracellular matrix glycoprotein, plays a key role in neuronal migration during cortical development and promotes neuronal maturation. The signaling pathway regulating neuronal maturation in the postnatal period are relatively less well understood. In this study, we
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