E4786

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The effect of combined treatment with risperidone and antidepressants on the MK-801-induced deficits in the social interaction test in rats.

Katarzyna Kamińska et al.

Pharmacological reports : PR, 67(6), 1183-1187 (2015-10-21)

Several clinical reports have suggested that augmentation of atypical antipsychotics' activity by antidepressants may efficiently improve the treatment of negative and some cognitive symptoms of schizophrenia. The aim of the present study was to investigate the effect of antidepressant mirtazapine

The Escitalopram versus Electric Current Therapy for Treating Depression Clinical Study (ELECT-TDCS): rationale and study design of a non-inferiority, triple-arm, placebo-controlled clinical trial.

André Russowsky Brunoni et al.

Sao Paulo medical journal = Revista paulista de medicina, 133(3), 252-263 (2015-07-16)

Major depressive disorder (MDD) is a common psychiatric condition, mostly treated with antidepressant drugs, which are limited due to refractoriness and adverse effects. We describe the study rationale and design of ELECT-TDCS (Escitalopram versus Electric Current Therapy for Treating Depression

Colorimetric method for the estimation of escitalopram oxalate in tablet dosage form

Vetrichelvan T, et al.

Indian Journal of Pharmaceutical Sciences, 72(2), 269-269 (2010)

Thermostabilization, expression, purification, and crystallization of the human serotonin transporter bound to S-citalopram

Coleman JA, et al.

Journal of Visualized Experiments, e54792-e54792 (2016)

Acute serotonergic treatment changes the relation between anxiety and HPA-axis functioning and periaqueductal gray activation.

Dietmar Hestermann et al.

Behavioural brain research, 273, 155-165 (2014-07-22)

Serotonergic (5-HT) drugs are widely used in the clinical management of mood and anxiety disorders. However, it is reported that acute 5-HT treatment elicits anxiogenic-like behavior. Interestingly, the periaqueductal gray (PAG), a midbrain structure which regulates anxiety behavior - has

Rixing Lin et al.

eLife, 12 (2023-07-11)

Pharmacotherapies for the treatment of major depressive disorder were serendipitously discovered almost seven decades ago. From this discovery, scientists pinpointed the monoaminergic system as the primary target associated with symptom alleviation. As a result, most antidepressants have been engineered to

Treatment-emergent and trajectory-based peripheral gene expression markers of antidepressant response.

Laura M Fiori et al.

Translational psychiatry, 11(1), 439-439 (2021-08-23)

Identifying biomarkers of antidepressant response may advance personalized treatment of major depressive disorder (MDD). We aimed to identify longitudinal changes in gene expression associated with response to antidepressants in a sample of MDD patients treated with escitalopram. Patients (N = 153) from

Prenatal stress, regardless of concurrent escitalopram treatment, alters behavior and amygdala gene expression of adolescent female rats.

David E Ehrlich et al.

Neuropharmacology, 97, 251-258 (2015-06-03)

Depression during pregnancy has been linked to in utero stress and is associated with long-lasting symptoms in offspring, including anxiety, helplessness, attentional deficits, and social withdrawal. Depression is diagnosed in 10-20% of expectant mothers, but the impact of antidepressant treatment

Modulation of the antioxidant nuclear factor (erythroid 2-derived)-like 2 pathway by antidepressants in rats

Martin-Hernandez D, et al.

Neuropharmacology, 103, 79-91 (2016)

Modulation of Monoaminergic Systems by Antidepressants in the Frontal Cortex of Rats After Chronic Mild Stress Exposure.

David Martín-Hernández et al.

Molecular neurobiology, 56(11), 7522-7533 (2019-05-06)

The standard pharmacological treatment of the major depressive disorder (MDD) is still grounded in a monoaminergic approach. Consequently, antidepressant treatments pursue to heighten serotonergic and noradrenergic neurotransmissions. Thus, the aim of this study was to assess the impact of exposure

Uncovering Functional Contributions of PMAT (Slc29a4) to Monoamine Clearance Using Pharmacobehavioral Tools.

Jasmin N Beaver et al.

Cells, 11(12) (2022-06-25)

Plasma membrane monoamine transporter (PMAT, Slc29a4) transports monoamine neurotransmitters, including dopamine and serotonin, faster than more studied monoamine transporters, e.g., dopamine transporter (DAT), or serotonin transporter (SERT), but with ~400-600-fold less affinity. A considerable challenge in understanding PMAT's monoamine clearance

Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells.

Alexander Carpinteiro et al.

Cell reports. Medicine, 1(8), 100142-100142 (2020-11-10)

The acid sphingomyelinase/ceramide system plays an important role in bacterial and viral infections. Here, we report that either pharmacological inhibition of acid sphingomyelinase with amitriptyline, imipramine, fluoxetine, sertraline, escitalopram, or maprotiline or genetic downregulation of the enzyme prevents infection of

Escitalopram

Waugh J and Goa KL

CNS Drugs, 17(5), 343-362 (2003)

Effects of serotonergic medications on locomotor performance in humans with incomplete spinal cord injury.

Kristan A Leech et al.

Journal of neurotrauma, 31(15), 1334-1342 (2014-04-20)

Incomplete spinal cord injury (iSCI) often results in significant motor impairments that lead to decreased functional mobility. Loss of descending serotonergic (5HT) input to spinal circuits is thought to contribute to motor impairments, with enhanced motor function demonstrated through augmentation

Prolonged administration of antidepressant drugs leads to increased binding of [(3)H]MPEP to mGlu5 receptors.

Gabriel Nowak et al.

Neuropharmacology, 84, 46-51 (2014-05-07)

Metabotropic glutamate 5 (mGlu5) receptors are functionally connected with NMDA receptors. The antidepressant activity of the NMDA receptor antagonist ketamine in both preclinical and clinical studies, along with the antidepressant-like activities of negative allosteric modulators (NAMs) of mGlu5, led us

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